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E.M. Pauli and R.M. Juza
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18. Arita NA, et al. Laparoscopic repair reduces inci­dence of surgical site infections for all ventral hernias. Surg Endosc. 2014;29(7):1769–80.
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23. Horan TC, et al. CDC defi nitions of nosocomial surgi­cal site infections, 1992: a modifi cation of CDC defi ­nitions of surgical wound infections. Infect Control Hosp Epidemiol. 1992;13(10):606–8.
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25. Blatnik JA, et al. Does a history of wound infection predict postoperative surgical site infection after ven­tral hernia repair? Am J Surg. 2012;203(3):370–4. discussion 374.
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29. Harth KC, Rosen MJ. Endoscopic versus open com­ponent separation in complex abdominal wall recon­struction. Am J Surg. 2010;199(3):342–6. discussion 346–7.
30. Albright E, et al. The component separation technique for hernia repair: a comparison of open and endo­scopic techniques. Am Surg. 2011;77(7):839–43.
31. Giurgius M, et al. The endoscopic component separa­tion technique for hernia repair results in reduced morbidity compared to the open component separa­tion technique. Hernia. 2012;16(1):47–51.
32. Fox M, et al. Laparoscopic component separation reduces postoperative wound complications but does not alter recurrence rates in complex hernia repairs. Am J Surg. 2013;206(6):869–74. discussion 874–5.
33. Satterwhite TS, et al. Outcomes of complex abdomi­nal herniorrhaphy: experience with 106 cases. Ann Plast Surg. 2012;68(4):382–8.
34. Rosen MJ, et al. Evaluation of surgical outcomes of retro-rectus versus intraperitoneal reinforcement with bio-prosthetic mesh in the repair of contaminated ven­tral hernias. Hernia. 2013;17(1):31–5.
20 Managing Complications of Open Hernia Repair
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35. McLanahan D, et al. Retrorectus prosthetic mesh repair of midline abdominal hernia. Am J Surg. 1997;173(5):445–9.
36. Gurusamy KS, Allen VB. Wound drains after inci­sional hernia repair. Cochrane Database Syst Rev. 2013;12:CD005570.
37. Bercial ME, et al. Suction drains, quilting sutures, and fi brin sealant in the prevention of seroma formation in abdominoplasty: which is the best strategy? Aesthetic Plast Surg. 2012;36(2):370–3.
38. Kohler G, et al. Prevention of subcutaneous seroma formation in open ventral hernia repair using a new low-thrombin fi brin sealant. World J Surg. 2014;38(11):2797–803.
39. Falagas ME, Kasiakou SK. Mesh-related infections after hernia repair surgery. Clin Microbiol Infect. 2005;11(1):3–8.
40. Kaufman Z, Engelberg M, Zager M. Fecal fi stula: a late complication of Marlex mesh repair. Dis Colon Rectum. 1981;24(7):543–4.
41. Kunishige T, et al. A defect of the abdominal wall with intestinal fi stulas after the repair of incisional hernia using Composix Kugel Patch. Int J Surg Case Rep. 2013;4(9):793–7.
42. Krpata DM, et al. Outcomes of simultaneous large complex abdominal wall reconstruction and enterocu­taneous fi stula takedown. Am J Surg. 2013; 205(3):354–8. discussion 358-9.
43. Carbonell AM, et al. Outcomes of synthetic mesh in contaminated ventral hernia repairs. J Am Coll Surg. 2013;217(6):991–8.
44. Blatnik JA, et al. Predicting severe postoperative respiratory complications following abdominal wall reconstruction. Plast Reconstr Surg. 2012; 130(4):836–41.
45. Fischer JP, et al. Validated model for predicting post­operative respiratory failure: analysis of 1706 abdom­inal wall reconstructions. Plast Reconstr Surg. 2013;132(5):826e–35.
46. Ma Q, Xue FS, Li RP. Analysis of risk factors, mor­bidity, and cost associated with respiratory complica­tions following abdominal wall reconstruction. Plast Reconstr Surg. 2015;135(2):459e–60.
47. Fischer JP, et al. Analysis of risk factors, morbidity, and cost associated with respiratory complications following abdominal wall reconstruction. Plast Reconstr Surg. 2014;133(1):147–56.
48. Levey AS, et al. Defi nition and classifi cation of chronic kidney disease: a position statement from Kidney Disease: Improving Global Outcomes (KDIGO). Kidney Int. 2005;67(6):2089–100.
49. Yussim A, Yampolski I, Greif F, Mor E. Acute kidney injury after complex incisional hernia in transplant recipients. Transplant Proc. 2012;94(10S):1024.
50. Kirkpatrick AW, et al. Intra-abdominal hypertension and the abdominal compartment syndrome: updated consensus defi nitions and clinical practice guidelines from the World Society of the Abdominal
Compartment Syndrome. Intensive Care Med. 2013;39(7):1190–206.
51. Cheatham ML, et al. Results from the International Conference of experts on intra-abdominal hyperten­sion and abdominal compartment syndrome. II. Recommendations. Intensive Care Med. 2007; 33(6):951–62.
52. Malbrain ML, et al. Results from the International Conference of experts on intra-abdominal hyperten­sion and abdominal compartment syndrome. I. Defi nitions. Intensive Care Med. 2006;32(11): 1722–32.
53. Malbrain ML, et al. Incidence and prognosis of intraabdominal hypertension in a mixed population of critically ill patients: a multiple-center epidemiologi­cal study. Crit Care Med. 2005;33(2):315–22.
54. Petro C, Raigani S, Orenstein S, Klick J, Rowbottom J, Novitsky Y, Rosen M. Permissive abdominal hyper­tension following open incisional hernia repair: a novel concept. Hernia. 2014;18 Suppl 1:S78.
55. Cobb WS, et al. Incisional herniorrhaphy with intra­peritoneal composite mesh: a report of 95 cases. Am Surg. 2003;69(9):784–7.
56. Petersen S, et al. Deep prosthesis infection in inci­sional hernia repair: predictive factors and clinical outcome. Eur J Surg. 2001;167(6):453–7.
57. Heniford BT, et al. Laparoscopic repair of ventral her­nias: nine years’ experience with 850 consecutive her­nias. Ann Surg. 2003;238(3):391–9. discussion 399–400.
58. Bellon JM, et al. Macrophage response to experimen­tal implantation of polypropylene prostheses. Eur Surg Res. 1994;26(1):46–53.
59. Amid PK. Classifi cation of biomaterials and their related complications in abdominal wall hernia sur­gery. Hernia. 1997;1:15–21.
60. Cobb WS, Kercher KW, Heniford BT. The argument for lightweight polypropylene mesh in hernia repair. Surg Innov. 2005;12(1):63–9.
61. Cobb WS, et al. Textile analysis of heavy weight, mid-weight, and light weight polypropylene mesh in a porcine ventral hernia model. J Surg Res. 2006;136(1):1–7.
62. Schmidbauer S, et al. Heavy-weight versus low­weight polypropylene meshes for open sublay mesh repair of incisional hernia. Eur J Med Res. 2005;10(6):247–53.
63. Orenstein SB, et al. Comparative analysis of histo­pathologic effects of synthetic meshes based on mate­rial, weight, and pore size in mice. J Surg Res. 2012;176(2):423–9.
64. Blatnik JA, et al. In vivo analysis of the morphologic characteristics of synthetic mesh to resist MRSA adherence. J Gastrointest Surg. 2012;16(11): 2139–44.
65. Sanders D, et al. An in vitro study assessing the effect of mesh morphology and suture fi xation on bacterial adherence. Hernia. 2013;17(6):779–89.
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66. Asarias JR, et al. Infl uence of mesh materials on the expression of mediators involved in wound healing. J Invest Surg. 2011;24(2):87–98.
67. Nguyen PT, Asarias JR, Pierce LM. Infl uence of a new monofi lament polyester mesh on infl ammation and matrix remodeling. J Invest Surg. 2012;25(5): 330–9.
68. Mavros MN, et al. Risk factors for mesh-related infec­tions after hernia repair surgery: a meta-analysis of cohort studies. World J Surg. 2011;35(11): 2389–98.
69. Balen EM, et al. Repair of ventral hernias with expanded polytetrafl uoroethylene patch. Br J Surg. 1998;85(10):1415–8.
70. Leber GE, et al. Long-term complications associated with prosthetic repair of incisional hernias. Arch Surg. 1998;133(4):378–82.
71. Vrijland WW, et al. Intraperitoneal polypropylene mesh repair of incisional hernia is not associated with entero­cutaneous fi stula. Br J Surg. 2000;87(3):348–52.
72. Zuvela M, et al. Central rupture and bulging of low­weight polypropylene mesh following recurrent inci­sional sublay hernioplasty. Hernia. 2014;18(1): 135–40.
73. Petro CC, Nahabet EH, Criss CN, Orenstein SB, von Recum HA, Novitsky YW, Rosen MJ. Central failures of lightweight monofi lament polyester mesh causing hernia recurrence: a cautionary note. Hernia. 2015;19(1):155–9.
74. Samama CM, et al. Venous thromboembolism pre­vention in surgery and obstetrics: clinical practice guidelines. Eur J Anaesthesiol. 2006; 23(2):95–116.
75. Huber O, et al. Postoperative pulmonary embolism after hospital discharge. An underestimated risk. Arch Surg. 1992;127(3):310–3.
76. Westling A, et al. Incidence of deep venous thrombo­sis in patients undergoing obesity surgery. World J Surg. 2002;26(4):470–3.
77. Pauli EM, Wang J, Petro CC, Juza RM, Novitsky YW, Rosen MJ. Posterior component separation with transversus abdominis release successfully addresses recurrent ventral hernias following ante­rior component separation. Hernia. 2015; 19(2):285–91.
78. Krpata DM, et al. Posterior and open anterior compo­nents separations: a comparative analysis. Am J Surg. 2012;203(3):318–22. discussion 322.

Laparoscopic Ventral Hernia Repair

David M. Krpata and Yuri W. Novitsky

Introduction

Ventral herniorrhaphies are among the most com­monly performed operations by general surgeons throughout the world. Incisional hernias, with a reported incidence of up to 20%, have become an increasing problem due to the increasing number of laparotomies performed. In the United States, approximately 175,000 ventral abdominal her­nias are repaired each year. Surgical approaches to ventral herniorrhaphy have been a subject of research and technical modifi cations for many years. Although the routine use of prosthetic reinforcement for the repair of herniations in adults has been contested, existing evidence strongly supports tension-free hernia repairs in most patients [ popularization of tension-free repairs using pros­thetic meshes, the recurrence rates are typically less than 20% [ 1 , 2 ].
Large abdominal incisions and wide tissue
dissection with the creation of large fl aps are
1 , 2 ]. With the development and
2 1
needed for open placement of adequately sized mesh [ 3 ]; however, this dissection may result in high incidence of postoperative morbidity and wound complications. Not surprisingly, with the advent of minimally invasive surgery, the use of laparoscopy for ventral hernia repairs has become standard [ 47 ]. The mesh is placed as an intra- peritoneal underlay with wide coverage of the hernia defect. Avoidance of large incisions has substantially reduced wound complications [ 4 , 6 ]. Overall, the clinical benefi ts of laparoscopic ventral hernia repair (LVHR) include a faster convalescence, fewer complications and, impor­tantly, a low recurrence rate [ 47 ]. Additionally, the laparoscopic approach can be employed for the management of more complex hernia loca­tions, such as suprapubic ventral hernias. In this chapter, we will discuss the technical aspects of the traditional laparoscopic repairs and address potential pitfalls and contraindications.

Preoperative preparation and patient selection

D. M. Krpata , M.D. (*) General Surgery, Cleveland Clinic Comprehensive Hernia Center , Cleveland , OH , USA
krpatad@ccf.org
e-mail: Y. W. Novitsky , M.D., F.A.C.S.
Department of Surgery , Case Comprehensive Hernia Center, University Hospitals Case Medical Center , Cleveland , OH , USA
Y.W. Novitsky (ed.), Hernia Surgery, DOI 10.1007/978-3-319-27470-6_21
The workup of a ventral hernia patient includes a thorough history and physical examinations. It is important to obtain all old operative reports. All pertinent comorbidities, including smoking, diabetes, and obesity, must be optimized. Bowel preparation is not given. Abdominal imaging (with Ultrasound or CT scan) is essentially uniform
223© Springer International Publishing Switzerland 2016
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D.M. Krpata and Y.W. Novitsky
except for small defects. Information gleaned from abdominal imaging may not only allow to delineate the defect(s), but may also affect a given patient’s suitability for a laparoscopic repair. In our practice, relative contraindications to a laparoscopic approach include hernias wider than 8–10 cm, signifi cant overlying skin changes, previous intra-peritoneal mesh, as well as repairs in clean-contaminated or contaminated settings.

Techniques of Laparoscopic VHR

After general anesthesia is induced, the patient is positioned supine with the arms adducted and “tucked” at the sides (Fig. 21.1 ). This allows for adequate space for both primary surgeon and an assistant on the same side of the patient. We use two monitors placed on each side of the patient. In most cases, the bladder and stomach are decompressed with catheters. An antibiotic, usu­ally a fi rst-generation cephalosporin , is given prophylactically before the incision was made and repeated if the operation lasts longer than 4 hours. We routinely use an Ioban™ drape (3M Company, St. Paul, MN) to minimize mesh con­tact with the patient skin. Laparoscopic hernia repair is performed by using a 30° angled laparo-
Fig. 21.1 Patient positioning. The arms should be “tucked” to allow for operating surgeon and assistant to stand on the same side and minimize potential interfer­ence of the outstretched arms with instrument handles
scope, 5-mm bowel graspers, scissors, and clip appliers.
Safe access to the peritoneal cavity is a key fi rst step in LVHR. The access is gained using either a cut-down technique, an optical trocar, or a Veress needle. Regardless of the method cho­sen, access to the abdominal cavity must be per­formed away from any previous incisions. A window of access is usually present, even in the multiply operated abdomen, at the costal margin between the mid-clavicular or anterior axillary lines. We prefer an optical trocar technique in the left upper quadrant just off the rib. Once access is established, it is imperative to confi rm that no inadvertent injuries to the abdominal organs or vessels occurred. Any uncertainties must be fol­lowed by a laparoscopic exploration. One should have a very low threshold to convert to open if the safety of the initial access cannot be confi rmed.
After pneumoperitoneum is established, we typically place an additional 5-mm trocar under direct vision laterally along the anterior-to-mid­axillary line. If adhesions are extensive, a third 5-mm trocar is placed to allow for two working ports and a camera on the same side. Furthermore, two additional 5-mm trocars are placed on the contralateral side to facilitate intra-abdominal mesh introduction and fi xation. This strategy involves utilization of fi ve 5-mm trocars (Fig. 21.2 ). For smaller defects, the number of the access ports could be reduced. However, fewer working ports result in poor triangulation, reduced effi ciency, and diffi culties with mesh positioning and tacking. Given a very low morbidity and scar­ring associated with a 5-mm port, additional access sites are well worth it. We strongly advise to have at least two trocars on each side of the abdomen for most, if not all, cases.
Following trocar placement , adhesiolysis is performed sharply with limited use of electrosur­gery or ultrasonic coagulators. This is another critical step for a safe LVHR. Inadvertent and unrecognized bowel injuries can cause signifi ­cant morbidity and even mortality. Missed enter­otomy during LVHR remains the most common reason for malpractice litigation. Reduction of the hernia contents is performed using blunt graspers and sharp dissection from the inside and
21 Laparoscopic Ventral Hernia Repair
Fig. 21.2 Typical trocar strategy for our standard laparoscopic ventral hernia repair
225
5 mm
5 mm
is facilitated by manual compression from the outside. The hernia sac is usually left in situ.
Once the adhesiolysis is completed, the her­nia defect is measured to determine an appropri­ate size of a prosthetic mesh. The borders of the defect are delineated with a combination of lapa­roscopic vision and external palpation. The edges of the defect are marked externally. We utilize trans-abdominal spinal needles to obtain precise dimensions of the hernia defect (Fig. 21.3 ). This maneuver is especially impor- tant in obese patients with large defects as the externally measured defect size can be dramati­cally overestimated. A ruler is placed through a 5-mm port, and the dimensions of the hernia defect are measured directly. Additionally, defect closure could be performed and is addressed in detail in Chapter 22 .
The mesh is then tailored to overlap all mar­gins of the hernia by at least 5 cm. Our general rule of thumb is to obtain overlap of 25–30% of the defects size on each side. Once the mesh is cut to the desirable size, four size-0 permanent monofi lament or ePTFE sutures are placed at the mid-point of each side of the mesh. Points of reference on the mesh and corresponding points
5 mm
5 mm
5 mm
on the abdominal wall are marked to aid in orienting the mesh after its introduction into the abdomen. The mesh is rolled up and pushed or pulled into the abdomen through an additional 12 or 15-mm trocar. This port is placed near the her­nia defect so that the mesh covers the site, negat­ing the need for fascial closure and minimizing the risks of trocar-site hernia (Fig. 21.4 ). Alternatively, (and less desirable in our opinion), any of the lateral trocars could be up-sized to allow for mesh introduction.
The mesh is rolled from both edges to facili­tate the unfolding step. If the defect size requires a very large prosthetic, it is usually introduced in the abdominal cavity by pulling with the grasper passed through the contralateral trocar (Fig. 21.5 ). It is important to maintain the appro- priate mesh orientation during the insertion and unfolding of the mesh. Modern positioning devices have signifi cantly facilitated this step, allowing for rapid and accurate mesh placement. After the mesh is oriented intra-corporeally, the sutures are pulled through the abdominal wall with a suture passer (Fig. 21.6 ). Adequate mesh/ defect overlap is once again confi rmed using spi­nal needles, similarly to that described above.
226
Fig. 21.3 Intra-corporeal (direct) measurement of a hernia defect. Spinal needles allow for more precise identifi cation of the edges of the defect. Additional spinal needles may be used for defects larger than the length of a ruler
Fig. 21.4 Instead of enlarging a 5-mm lateral port, the additional 12-mm port, used for mesh introduction, is placed close to the edge of the hernia to allow for subsequent mesh coverage of the trocar site
D.M. Krpata and Y.W. Novitsky
12 mm
5 mm
5 mm
The top or bottom suture is pulled fi rst. We rec­ommend beginning with the point closest to the bony margin (xiphoid, pubis, iliac crest, costal margin, etc.). We subsequently pull the suture that is opposite to the fi rst one. Once suffi cient overlap is confi rmed, we tie both sutures with the knots buried in the subcutaneous tissues. The other two lateral sutures are then pulled trans­abdominally and tied ensuring that the overlap is suffi cient. We recommend starting with the lat­eral stitch ipsilateral to the camera (#3 in
21.6 ). To facilitate this step, we move the
Fig.
5 mm
5 mm
5 mm
camera to the superior-most trocar. We routinely reduce pneumoperitoneum to 7–8 mmHg to ensure the mesh is taut and doesn’t wrinkle after desufl ation. Once again, having at least two tro­cars on each side of the abdomen allows for easy and precise mesh positioning. After correct posi­tioning is confi rmed, the fourth stitch is pulled through and all stitches are tied.
The perimeter of the mesh is then attached to the peritoneum with tacks, at approximately 1 cm intervals to prevent intestinal herniation. Placing the tacks is facilitated by the external manual
21 Laparoscopic Ventral Hernia Repair
Fig. 21.5 The mesh could be introduced by “pulling” it in to the abdomen through a trocar
227
Fig. 21.6 Mesh fi xation. Inferior and superior sutures are pulled fi rst, followed by the lateral sutures
228
D.M. Krpata and Y.W. Novitsky
palpation of the tacker’s tip (Fig. 21.7 ). Tactile feedback is particularly important for tacking the mesh in the lower abdomen to ensure that the tacks are placed superiorly to the inguinal ligament. Similarly, for upper abdominal hernias, manual counter palpation is paramount to ensure that the tacks are placed below the costal margin. Failure to do so may lead to pulmonary and peri­cardial injuries. If the mesh extends cephalad to the costal margin and xiphoid process, that por­tion of the mesh should not be tacked and should be affi xed to the peritoneum with sutures or glue.
Although some investigators have advocated a “double-crown” technique of mesh fi xation, we strongly believe additional suture fi xation is criti­cal to ensure the long-term durability of the repair. Additional full-thickness stitches are placed circumferentially every 5–8 cm by using the suture passer (Fig. 21.8 ). This trans- abdominal fi xation is crucial to ensure that the mesh will not be displaced over time. The knots are tied in the subcutaneous tissues. The skin is released to avoid dimpling.

Postoperative Ca re

While some patients may be suited for LVHR on an outpatient basis, most patients with moderate defects require at least a 1–2 day hospitalization.
This is done to ensure adequate pain control and resolution of ileus. Factors infl uencing longer recovery include extensive adhesiolysis, large incarcerated defects, and multiple trans­abdominal sutures. We advocate a clear or soft diet for the fi rst 3–5 days following the repair to provide for adequate return of normal bowel function. The abdominal binders are encouraged, especially in the fi rst 2 weeks. Activities are not restricted and are guided by patients’ discomfort.

Complications and Outcomes

While LVHR has its benefi ts with relation to wound morbidity compared to open techniques, it is not without potential complications. In gen­eral, these complications can be categorized into intra-operative, postoperative, and long-term. Some complications are associated with laparos­copy and some with ventral hernia repair; the fol­lowing discussion focuses on complications that are somewhat unique to LVHR.
Wound and mesh infections are known com­plications of any hernia repair. Many investigators have shown that laparoscopy is associated with an extremely low rate of wound infections and very rare mesh infections [ 57 ]. Modern meshes with- out an ePTFE component have reduced infectious complications of LVHR even further. However,
Fig. 21.7 Placement of tack is done circumferentially along the whole length of the mesh to avoid bowel incar­ceration. External palpation of the abdominal wall facili-
tates placement of the tacks and helps to avoid tacking the mesh below the inguinal ligament and above costal margins
21 Laparoscopic Ventral Hernia Repair
Fig. 21.8 Trans-abdominal suture fi xation of the mesh
229
any persistent cellulitis and/or persistent fl uid col­lection around the intra- peritoneal mesh should be a point of concern for acute or chronic prosthetic infection, especially if ePTFE-based mesh was used. Open exploration, mesh removal, primary hernia repair, and delayed formal reconstruction are the best and safest ways to approach infected mesh after LVHR.
Intra-operative complications such as bleeding or injury to surrounding intra-abdominal structures are rare. Nonetheless, an enterotomy or missed enterotomy will signifi cantly impact the outcome of surgery. An enterotomy identifi ed during surgery with spillage of enteric content within the abdomen should cause the surgeon to re-evaluate the opera­tive plan. The enterotomy can be repaired laparo­scopically if it is well visualized and ports are optimally placed. If there is any question about the integrity of laparoscopic repair of the enterotomy, conversion to a laparotomy is mandatory. With gross spillage of enteric content, a formal hernia repair should be delayed. Missed enterotomy or a delayed bowel injury from electrocautery resulting in intra- abdominal sepsis and mesh infection would require laparotomy, repair of the bowel injury, and complete excision of the mesh. Failure to com­pletely remove the mesh would almost certainly lead to persistent intra-abdominal infection.
Seroma formation is one of the most common complications after LVHR [ 6 ]. Failure to obliter- ate the potential space within the hernia sac fre­quently leads to fl uid accumulation in the hernia sac. The seroma may present as a bulge which patients may commonly perceive as a hernia recurrence. Careful physical exam should easily
differentiate between the two. If the diagnosis is in question, ultrasound or CT scan evaluation can be used to differentiate between diagnoses. Management of a seroma should follow a conser­vative pathway as it will typically resolve with­out intervention. For persistent seromas, sterile aspiration can be performed in the offi ce. However, fl uid may re-accumulate in the poten­tial space after aspiration necessitating additional aspirations. It is important to realize that any aspiration and subsequent aspirations put a patient at risk for converting a sterile seroma into an abscess. Closing the defect during LVHR with the “shoelace” technique (Chapter 22 ) can sig- nifi cantly reduce or even eliminate the risk of seroma formation.
In the early postoperative period, patients may complain of pain at the trans-abdominal suture sites. Conservative management with NSAIDs may resolve the patient’s pain; however, persis­tent pain may require injection with local anes­thetics. The use of slowly absorbable sutures for mesh fi xation could be associated with reduced postoperative pain, but that has not been proven in prospective trials. While the use of absorbable tacks has been proposed to reduce chronic pain, their utilization has been shown to have no effect on postoperative pain.
Arguably, the most important complication from an LVHR is a hernia recurrence , as this is the primary outcome measure of long-term suc­cess of the surgery. Recurrence rates in the litera­ture vary from 2 to 20% with the largest series demonstrating recurrence rates around 5% [ 6 , 7 ]. Long-term, the best chance for a successful