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Ординатура / Хирургия / Библиотека им академика М.И. Перельмана / Книга_5850_Библиотеки_им_академика_М_И_Перельмана

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AmalKumarDhara SubhashC.Mandal
Editors
Role ofHerbal Medicines
Management ofLifestyle Diseases
123
Role of Herbal Medicines
Amal Kumar Dhara • Subhash C. Mandal
Editors
Role of Herbal Medicines
Management ofLifestyle Diseases
Editors
Amal Kumar Dhara Department of Pharmacy Contai Polytechnic, Government of West Bengal Kolkatta, West Bengal, India
Subhash C. Mandal Department of Pharmaceutical Technology Jadavpur University Kolkata, West Bengal, India
ISBN 978-981-99-7702-4 ISBN 978-981-99-7703-1 (eBook)
https://doi.org/10.1007/978-981-99-7703-1
© The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Singapore Pte Ltd. 2023 This work is subject to copyright. All rights are solely and exclusively licensed by the Publisher, whether the whole or part of the material is concerned, specically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microlms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specic statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors, and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, expressed or implied, with respect to the material contained herein or for any errors or omissions that may have been made. The publisher remains neutral with regard to jurisdictional claims in published maps and institutional afliations.
This Springer imprint is published by the registered company Springer Nature Singapore Pte Ltd. The registered company address is: 152 Beach Road, #21-01/04 Gateway East, Singapore 189721, Singapore
Paper in this product is recyclable
Preface
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Modern drifts towards the utilization of herbal medicines in different healthcare aspects neces­sitate the replacement of synthetic molecules with phytoconstituents because of their biocom­patibility, biodegradability, economic extraction process, and ready availability from natural sources. The emergence of lifestyle diseases, e.g. type II diabetes, cancers, obesity, cardiovas­cular disorders, and liver cirrhosis, is exponentially increasing day by day. The major causes of modern lifestyle diseases are a lack of physical activity, consumption of imbalanced diet and junk foods, unhealthy habits like alcoholic beverages consumption, tobacco smoking, late­night sleep, and so on.
Despite signicant developments in the eld of science and technology, the majority of the population relies on phytomedicines in both Third World and developed countries for their healthcare. Considering the valuable ancient approaches for the utilization of herbal constitu­ents and the application of modern scientic knowledge for evaluating (both therapeutic and toxicological) and standardizing phytoconstituents can help to nd a better way for the man­agement of lifestyle diseases.
The book Role of Herbal Medicines: Management of Lifestyle Diseases provides a system­atic insight into the inclusive herbal medicines’ chemistry, extraction, purication, toxicity studies, characterization, standardization, bioactivity, and applications in the management of lifestyle diseases. This volume is a collection of four different sections (namely introduction; extraction and chemical characterization; bioactivity and applications; pharmacovigilance, clinical trial, and regulatory) containing 31 chapters contributed by academicians and research­ers from across the globe. A concise overview of the contents of each chapter has been pro­vided to give readers a glimpse of the book’s contents.
Chapter ‘Introduction to Lifestyle Diseases and Role of Herbal Medicines’ describes differ­ent types of lifestyle diseases such as diabetes, obesity, COPD, and liver cirrhosis and the role of herbal medicines in the management of these diseases.
Chapter ‘The Importance and Scope of Medicinal Plants Suggested in Traditional Medicine in the Holistic Care of Occupational Lifestyle Disorders with Special Mention to Insulin Resistance Associated Clinical Syndromes’ focuses on lifestyle disorders (LsD), the pathology of insulin resistance in LsD, and a few medicinal plants extensively used in traditional medi­cine practices to treat lifestyle diseases and the associated IR states.
Chapter ‘Extraction of Phytoconstituents for Lifestyle Diseases’ provides an overview of traditional and modern extraction techniques that are used for the extraction of herbal drugs.
Chapter ‘Chemical Characterization of Phytoconstituents for Lifestyle Diseases’ provides an overview of different phytoconstituents frequently involved in the management of lifestyle diseases and the various chemical techniques used for their characterization, namely mass spectrometry, UV-visible spectroscopy, infrared spectroscopy, nuclear magnetic resonance spectroscopy, X-ray crystallography, and so forth.
Chapter ‘Role of Medicinal Plants in the Management of Diabetes Mellitus’ describes the signicance of bioactive phytoconstituents from various plant sources in exhibiting antidia­betic activity and also explains how herbal medicines act through different pathways and their multifaceted mechanisms of action.
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Chapter ‘Herbal Medicines for the Management of Obesity’ addresses how lifestyle causes obesity and its potential role in generating various diseases and disorders, such as atheroscle­rosis, diabetes mellitus, cardiovascular problems, metabolic syndrome, lung diseases, neuro­logical disorders, arthritis, osteoarthritis, kidney disease, sleep disorders, obstructive sleep apnoea, asthma, blood lipid disorders, insulin resistance, depression, anxiety, infertility, uri­nary incontinence, stroke, and cancer. This chapter also covers some recent studies on plants, plant products, and plant-originated compounds having anti-obesity activity with a focus on their anti-obesity-related activities.
Chapter ‘Herbal Medicines for the Management of Diseases in the Heart, Circulation, and Blood’ gives an insight into the cardio-protective potential of various medicinal plants such as Emblica ofcinalis, Rauwola serpentina, Terminalia arjuna, and Ziziphus oxyphylla. It also encompasses the therapeutic potential of many phytomolecules such as taxifolin, caffeic acid, quercetin, rosmarinic acid, arjunolic acid, andrographolide, and others against cardiovascular disorders.
Chapter ‘Role of Lifestyle Modication and Diet in the Prevention of Cancer’ describes different natural mechanisms that can lower the risk of developing different types of cancer and how lifestyle modications as well as changes in nutritional diet can modulate different regulatory players associated with cancer signalling axes. This chapter also highlights the miti­gating roles of low bre, omega-3 and omega-6 fatty acids, red meat, ax seeds, fruits, and vegetables in protecting different cancer types ranging from breast to lung to prostrate carcinoma.
Chapter ‘Herbal Medicine for the Treatment of COPD’ presents a brief review on molecular mechanisms involved in chronic obstructive pulmonary disease (COPD), the natural history of herbal medicine, novel and marketed herbal medicine available for the treatment of COPD, and secondary metabolites involved in the inhibition of COPD.
Chapter ‘Herbal Medicines for the Treatment of Liver Cirrhosis’ focuses on several natural compounds implicated in reversing the development of liver cirrhosis via numerous molecular pathways. In-depth descriptions of various phytochemicals in preclinical stages are provided. The successful therapeutic regimens of herbal compounds imparting to multiple cell lines, and well-established animal models are discussed in detail.
Chapter ‘Plants Affecting Serotonergic Neurotransmission’ provides a general overview of the serotonergic system, associated disorders, and natural compounds involved in the modula­tion of the serotonergic system with potential therapeutic applications.
Chapter ‘Herbal Medicines for Management of Alzheimer’s Disease’ reviews some of the important and widely studied plants and their constituents against Alzheimer’s disease.
Chapter ‘Herbal Medicine for the Management of Anxiety, Depression, and Insomnia’ intends to provide a comprehensive view of mechanisms of herbs used in the management of anxiety, depression, and insomnia.
Chapter ‘Role of Herbal Medicines for the Treatment of Arthritis’ gives an insight into the promising anti-arthritis effects of varieties of phytoconstituents, different animal models and clinical studies of rheumatoid arthritis and osteoarthritis, and the important mechanisms responsible for the anti-arthritis properties of these herbal medicines.
Chapter ‘Role of Herbal Medicines for the Treatment of Chronic Kidney Disease’ focuses on the promising anti-chronic kidney disease effects of different herbal medicines.
Chapter ‘Herbal Medicines for the Management of Irritable Bowel Syndrome and Constipation Problem’ addresses the aetiopathogenesis of IBS and constipation, gut microbi­ota dysbiosis in IBS and related disorders, diet-microbiota interaction in IBS and related dis­orders, and efcacy of herbal medicines in the management of irritable bowel syndrome, constipation, and related disorders.
Chapter ‘Herbal Medicines for the Management of Diseases on Vitamin Deciency’ describes the dietary sources of vitamins, deciency disorders of vitamins and their herbal remedies, the qualitative and quantitative procedures of vitamin analysis as well as different analytical approaches for the analysis.
Preface
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Chapter ‘Herbs for Autoimmune Diseases’ focuses on providing an update on herbs reported in the management and treatment of autoimmune diseases, with detailed, in-depth understand­ing of their molecular level mechanism of action and modulation of various cell signalling pathways.
Chapter ‘Role of Herbal Medicine in Boosting Immune System’ reviews the use of herbal medicines in boosting the immune system. The chapter covers why people prefer herbal medi­cines, role of some herbal plants in enhancing the immune system, and role of some individual natural products in boosting the immune system.
Chapter ‘Medicinal Plants, Antioxidant Potential, and Applications to Aging’ highlights some important plant material and isolated compounds that are reported to have the ability to slow down the rate of ageing and are used worldwide. Majority of them exhibited anti-ageing effects through their antioxidant potential.
Chapter ‘Role of Natural Polysaccharides in the Management of Lifestyle Diseases’ out­lines numerous attributes and cellular mechanisms of several plant polysaccharides (PPS) in metabolic disorders and also elucidates the interaction of PPS with various genes and proteins involved in molecular signalling pathways.
Chapter ‘Role of Antioxidant Vitamins and Minerals from Herbal Source in the Management of Lifestyle Diseases’ highlights the oxidative stress, its generation in different pathological condition of diseases, and their mechanism in promoting lifestyle diseases. It also describes remedies and lists antioxidant vitamins and minerals, along with their modes of antioxidant action, which are essential to alleviate lifestyle diseases and lead a disease-free life.
Chapter ‘Role of Nutraceuticals in the Management of Lifestyle Diseases’ discusses differ­ent types of nutraceuticals and their signicance in the management of various lifestyle disorders.
Chapter ‘Eating and Healing: Traditional Food as Medicine’ highlights the traditional sys­tems of medicines, food, spices, condiments, and herbs with medicinal value and probiotics and prebiotics.
Chapter ‘Nanotechnology in Delivery and Targeting of Phytochemicals for Lifestyle Diseases’ provides an overview of main problems connected with the delivery of phytophar­maceuticals, main properties of different types of plant drugs, and properties and limitations connected to the application of numerous lipid, polymer, and inorganic nanoparticles as phyto­drug carriers. It also provides information about up-to-date investigated combinations of phy­topharmaceuticals and nanocarriers.
Chapter ‘Pharmacovigilance of Herbal Medicines for Lifestyle Diseases’ reviews basic knowledge of pharmacovigilance and adverse drug reactions, along with the safe dosage range of phytochemicals in lifestyle diseases, viz. obesity, diabetes, and atherosclerosis.
Chapter ‘Standardization of Herbal Medicines for Lifestyle Diseases’ highlights the signi­cance of herbal medicine standardization in ensuring consistent quality, safety, and efcacy of herbal products. Also it describes qualitative and quantitative methods, along with ngerprint proling for the characterization of herbal samples and bioactive compounds.
Chapter ‘Intellectual Property Rights, Naturally Derived Bioactive Compounds, and Resource Conservation’ describes recent scientic advancements and comprehends the inter­relationship between IPR, bioactivity of natural origin, and conservation of resources in order to establish a smooth avenue for traditional drugs and medicine thereof.
Chapter ‘Clinical Trial on and Regulatory Considerations for Herbal Medicines for Lifestyle Diseases’ highlights regulations by the FDA and its mechanisms and also describes several ongoing clinical trials aimed at generating precise evidence for their acceptance and greater acceptability.
Chapter ‘Market Overview of Herbal Medicines for Lifestyle Diseases’ focuses on the mar­ket analysis of herbal medicines used in lifestyle diseases, which demonstrates a rising trend in the adoption of herbal medicines, with signicant potential for continued growth in the foreseeable future.
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Chapter ‘Future Prospective of Herbal Medicines for Lifestyle Diseases’ addresses the role of some herbal medicines in the treatment of major non-communicable diseases (NCDs), cur­rent challenges, and some future perspectives for herbal medicines.
At the end, we the editors convey our sincere thanks to all the distinguished authors for contributing signicant chapters in a timely manner, which facilitated to bring out this volume on time. We specially thank the entire team at Springer Nature for the invaluable support in organizing the intelligent editing of the book. We also would put on record our special thanks to Dr. Naren Aggarwal (Editorial Director—Books, Asia, Medicine and Life Sciences), Dr. Emmy Lee (Editor, Biomedicine & Life Science Books), Dr. Sudha Ramachandran (Project coordinator—Books), and Dr. Chaitra Jawalkoti (Editorial Advisor) for their priceless support right from the beginning to the completion of this book. We gratefully acknowledge all the permissions we received for reproducing the copyright materials from different sources. Finally, we cannot overlook the sacrices and support from our family members during the preparation of the book. All our friends, colleagues, and students who have helped in the pro­cess of editing of this book deserve our great appreciations. Contributing authors, the publish­ers, and we the editors will be extremely pleased if our endeavour fulls the needs of academicians, researchers, students, pharmaceutical experts, biomedicine experts, and herbal drug formulators.
Kolkata, West Bengal, India AmalKumarDhara Kolkata, West Bengal, India SubhashC.Mandal
Preface
Contents
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Introduction to Lifestyle Diseases and Role of Herbal Medicines . . . . . . . . . . . . . . . . . 1
Amal Kumar Dhara and Amit Kumar Nayak
The Importance and Scope of Medicinal Plants Suggested in Traditional Medicine in the Holistic Care of Occupational Lifestyle Disorders with
Special Mention to Insulin Resistance Associated Clinical Syndromes . . . . . . . . . . . . . 13
Parvathy G. Nair, Pratibha P. Nair, and Amit Kumar Dixit
Extraction of Phytoconstituents for Lifestyle Diseases . . . . . . . . . . . . . . . . . . . . . . . . . . 33
Joseph Tchamgoue, Yvan Anderson T. Ngandjui, Rostan M. Talla, Bruno Dupon A. Ambamba, Jean Claude Tchouankeu, and Simeon F. Kouam
Chemical Characterization of Phytoconstituents for Lifestyle Diseases . . . . . . . . . . . . 59
Yvan Anderson T. Ngandjui, Joseph Tchamgoue, Donald Ulrich K. Kagho, Titus Alfred M. Msagati, Bathelemy Ngameni, and Simeon F. Kouam
Role of Medicinal Plants in the Management of Diabetes Mellitus . . . . . . . . . . . . . . . . 89
Saroj Singhmura, Souvik Basak, and Nilanjan Ghosh
Herbal Medicines for the Management of Obesity . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 105
Ceyda Sibel Kılıç
Herbal Medicines for the Management of Diseases in the Heart, Circulation,
and Blood . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 129
Jagdish S. Bankar, Kajal N. Bondre, Pratiksha P. Wagh, Surbhi S. Bhope, Jayesh S. Pande, Prakash R. Itankar, Satyendra K. Prasad, and Shailendra S. Gurav
Role of Lifestyle Modification and Diet in the Prevention of Cancer . . . . . . . . . . . . . . 145
Moumita Chatterjee, Sharmistha Ganguly, and Subhajit Dutta
Herbal Medicines for the Treatment of COPD . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 167
Samir Ranjan Panda, Siddhi Jain, N. P. Syamprasad, Priyanka Adhikari, Meenakshi Singh, Alok Ranjan, A. Parthiban, and V. G. M. Naidu
Herbal Medicines for the Treatment of Liver Cirrhosis . . . . . . . . . . . . . . . . . . . . . . . . . 185
Tanmoy Banerjee, Shuvam Sar, Saptapadi Saha, Arun Baidya, Arnab Sarkar, Sanmoy Karmakar, Amit Kumar Halder, and Nilanjan Ghosh
Plants Affecting Serotonergic Neurotransmission . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 211
Keya Mallick and Sugato Banerjee
Herbal Medicines for Management of Alzheimer’s Disease . . . . . . . . . . . . . . . . . . . . . . 231
Jai Malik, Subhash C. Mandal, Sunayna Choudhary, Shweta Parihar, and Mohamed Rahamathulla
Herbal Medicine for the Management of Anxiety, Depression, and Insomnia . . . . . . . 251
Sunday Oritsetimenyin Otimenyin
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Role of Herbal Medicines for the Treatment of Arthritis . . . . . . . . . . . . . . . . . . . . . . . . 271
Vafa Baradaran Rahimi and Vahid Reza Askari
Role of Herbal Medicines for the Treatment of Chronic Kidney Disease . . . . . . . . . . . 293
Vafa Baradaran Rahimi and Vahid Reza Askari
Herbal Medicines for the Management of Irritable Bowel Syndrome
and Constipation Problem . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 313
Eswara Rao Puppala, Neethu Prasad, Meenakshi Singh, Arun N. Prakash, Md Abubakar, Priyanka Adhikari, and V. G. M. Naidu
Herbal Medicines for the Management of Diseases on Vitamin Deficiency . . . . . . . . . 343
Sathi Sarkar, Anish Kumar Das, and Satheesh Kumar Nanjappan
Herbs for Autoimmune Diseases . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 361
A. Mukne, S. Dangat, P. Shirodkar, and K. Sawate
Role of Herbal Medicine in Boosting Immune System . . . . . . . . . . . . . . . . . . . . . . . . . . 389
Anchal Dabas, Parul Yadav, Geetanjali, and Ram Singh
Medicinal Plants, Antioxidant Potential, and Applications to Aging . . . . . . . . . . . . . . . 403
Aabir Pramanik, Sonali Maheshwari, and Niyati Acharya
Role of Natural Polysaccharides in the Management of Lifestyle Diseases. . . . . . . . . . 415
Shuvam Sar, Tanmoy Banerjee, Ankit Kumar, Arun Baidya, Saptapadi Saha, Jayashree Mondal, Rituparna Chaki, Amit Kumar Halder, and Nilanjan Ghosh
Contents
Role of Antioxidant Vitamins and Minerals from Herbal Source
in the Management of Lifestyle Diseases . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 443
S. Ganguly and J. Kumar
Role of Nutraceuticals in the Management of Lifestyle Diseases . . . . . . . . . . . . . . . . . . 461
Vimalavathini Ramesh, Kayalvizhie Subbarayan, Sittarthan Viswanathan, and Kavimani Subramanian
Eating and Healing: Traditional Food as Medicine . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 479
Sparsha Suresh Bandekar and Ajay Gajanan Namdeo
Nanotechnology in Delivery and Targeting of Phytochemicals
for Lifestyle Diseases . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 497
Milan Milivojević, Ivana Pajic-Lijaković, Zora Dajić, Amal Kumar Dhara, Amit Kumar Nayak, and Md Saquib Hasnain
Pharmacovigilance of Herbal Medicines for Lifestyle Diseases . . . . . . . . . . . . . . . . . . . 525
Shuvam Sar, Tanmoy Banerjee, Arun Baidya, Saptapadi Saha, Ankit Kumar, Amit Kumar Halder, Madhurima Ghosh, Vilas D. Nasare, and Nilanjan Ghosh
Standardization of Herbal Medicines for Lifestyle Diseases . . . . . . . . . . . . . . . . . . . . .545
Tiyasa Paul and K. Jayaram Kumar
Intellectual Property Rights, Naturally Derived Bioactive Compounds,
and Resource Conservation . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 559
Raju Wadekar, Subhash C. Mandal, and Kalpana Patil
Clinical Trial on and Regulatory Considerations for Herbal Medicines
for Lifestyle Diseases . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 573
Samir Bhargava, Amal Kumar Dhara, Manmohan Singhal, Neeraj Kr. Sethiya, Bhavna, Satish Shilpi, Vijay Singh Rana, Amit Kr. Dubey, Ashok Behera, and Anuj Nautiyal