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Herbs forAutoimmune Diseases
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inammation and oxidative stress, a deciency of neurotransmitters mainly acetylcholine, and synaptic dysfunction, all of which ultimately result in neuronal death [213,
218].
N-methyl--Aspartate (NMDA)-receptor antagonist and
cholinesterase inhibitors are two drug classes currently used
as medication for symptomatic relief in Alzheimer’s disease
[219]. Some of the herbs used in management of ALD are
discussed below.
3.4.3.1 Herbs Used forManagement ofAlzheimer’s
Disease
Acorus calamus
Acorus calamus rhizomes contain the phenylpropanoids
α-asarone and β-asarone, which indicate anti-cancer, antiinammatory, anti-apoptotic, antioxidant and neuroprotective activities [220]. Various fractions of A. calamus extract
have been studied for preventing memory loss, anxiety and
oxidative stress in LPS-induced neuroinammation rat models by Esfandiari et al. [221]. Administration of aqueous
extract of A. calamus via oral route reduces inammation
and oxidative stress and prevents memory loss. In another
study, invitro effects of A. calamus extract and α-asarone on
oxidative stress-induced and ER stress-induced cell death in
hippocampal HT22 cells was investigated by Mikami etal.
[222]. It was found that A. calamus extract and α-asarone
greatly prevent cell death caused by ER stress inducer, tunicamycin, and oxidative stress inducer, -glutamate. Asarone
and A. calamus extract both inhibit the production of ROS,
indicating that they both may be efcient therapeutic options
for treating neurodegenerative disorders like ALD.
Crocus sativus
Crocus sativus has three major components—crocin (source
of colouring pigment), the glycoside picrocrocin (a precursor
of safranal) and safranal (the deglycosylated form of picrocrocin)—with great antioxidant potential. It has a wide spectrum of biological activities including antioxidant and
anti-inammatory activity [223]. Extensive literature was
reviewed by D’Onofrio etal. [224] in which 17 invitro and
invivo preclinical and 4 clinical studies have been reported
for evaluating the effectiveness of saffron on cognitive deformity in animal models of ALD.Crocin reduces oxidative
stress, modulates A tau protein aggregation and regulates
glutamate levels. Saffron had a superior safety prole and its
effects on cognitive impairment were similar to those brought
on by donepezil and memantine.
3.4.4 Parkinson’s Disease
PD is a chronic neurodegenerative disease that generally
affects elderly people. Pathologically, PD is categorised by
loss of dopaminergic neurons in the substantia nigra, with
appearance of cytoplasmic inclusions known as Lewy bod-
ies. Postural instability, muscle rigidity, slowness or loss of
mobility and resting tremor all are common manifestations
of PD.The aetiology of PD is unclear; however, it is believed
to be multifactorial including both genetic and environmental variables that trigger growth of disorder [225].
Pathogenesis of PD occurs in three phases; in the rst phase,
the disease development is initiated by triggers (viral infections or environmental toxins), followed by spread of disease
to the CNS via facilitators (genetic factors) causing systemic
inammation and mitochondrial damage. In the third phase,
the aggravators (α synuclein pathology) promote inammation leading to neurodegeneration [226]. Environmental risk
factors associated with PD include pesticides (insecticiderotenone and herbicide-paraquat), heavy metals (trafcrelated air pollution as well as industrial airborne heavy
metal pollution) and chlorinated solvents (drinking water)
[29].
Familial forms of PD are associated with mutations in ve
genes that code for α-synuclein, PARKIN, ubiquitin
carboxyl- terminal hydrolase L1 (UCH-L1), PTEN induced
putative kinase 1 (PINK1) and Protein deglycase (DJ-1)
through pathogenic pathways that may frequently evolve in
imbalances in mitochondrial and ubiquitin-proteasome system (UPS) function. Oxidative stress, protein misfolding and
oxidation of cytosolic dopamine (DA) contribute to the
brillisation and aggregation of α-synuclein which impairs
UPS function and may cause destruction of mitochondria.
Variations in mitochondrial function trigger oxidative stress,
deciencies in ATP synthesis and α-synuclein aggregation,
which may promote UPS dysfunction. Antioxidant function
of DJ-1 that promotes oxidation of DA through S-nitrosylation
may be affected by oxidative and nitrosative stress. Excess
DA metabolism may further promote oxidative stress. DA
neurons in PD eventually die due to mitochondrial and UPS
malfunction, oxidative stress and synuclein aggregation
[227].
3.4.4.1 Herbs Used forManagement ofParkinson’s
Disease
Panax ginseng
The ginsenosides in P. ginseng possess antioxidative and
immunomodulatory activities that have therapeutic action on
neurodegenerative diseases [30]. Liu etal. [228] evaluated
the neuroprotective effects of P. ginseng extract on 1-methyl-
4-phenylpyridinium ion (MPPþ)-induced apoptosis in
SH-SY5Y cells and reported that ginsenosides possess antioxidant properties which have protective impact on 1-methyl4-phenylpyridinium (MPP+) and MPTP-induced
experimental PD models [228]. In another study, Zhou etal.
reported neuroprotective effects of ginsenosides in both
invivo (C57BL/6J mice) and invitro (PC12 cells) models of
PD by activating the Wnt/β-catenin signalling pathway
[229].
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Astragalus membranaceus
One of the major constituents of Astragalus membranaceus
aqueous extract is astragaloside IV (AS-IV), a triterpene glycoside belonging to the cycloartane category. AS-IV is
known to possess anti-inammatory, antioxidant and neuroprotective action [230]. Xu etal. [231] evaluated the neuroprotective effect of AS-IV in 6-OHDA SH-SY5Y cell model
of PD through activation of JAK2/STAT3 pathways [231].
4 Conclusion
Human health has been one of the major casualties of the
fast-paced modern lifestyle; autoimmune diseases form a
major chunk of the difcult-to-treat and manage ailments
that continue to afict increasing numbers of populations
globally. At best, what the new-age therapeutics can offer is
mild-to-moderate relief in the spectrum of symptoms; not
without the attendant toxicity associated with long term,
chronic use of these agents. Traditional systems of medicine
including Ayurveda have documented use of herbs in effectively managing the ubiquitous challenges typically associated with the poor prognosis prole in patients with
autoimmune diseases. The chemically complex mix of phytomolecules in these herbs help restore the homeostasis by
tempering the micromilieu within the host cells, tissues and
interstitia via modulation of key signalling pathways involved
in inammation, cell necrosis and apoptosis. In vitro biochemical and cell-based assays and preliminary invivo biological assays are being reported that provide evidence-based
bioactivity validation of these herbs. The pressing need is to
design clinical study protocols that can establish efcacy of
phytotherapies for effective management of autoimmune
diseases.
References
1. Ahsan H.Origins and history of autoimmunity—a brief review.
Rheumatol Autoimmun. 2023;3:9–14.
2. Wang L, Wang FS, Gershwin ME.Human autoimmune diseases: a
comprehensive update. J Intern Med. 2015;278(4):369–95.
3. Miller FW. The increasing prevalence of autoimmunity and
autoimmune diseases: an urgent call to action for improved
understanding, diagnosis, treatment, and prevention. Curr Opin
Immunol. 2023;80:102266.
4. Muñiz-Castrillo S, Vogrig A, Honnorat J.Associations between
HLA and autoimmune neurological diseases with autoantibodies.
Autoimmun Highlights. 2020;11(1):1–13.
5. Matzaraki V, Kumar V, Wijmenga C, Zhernakova A.The MHC
locus and genetic susceptibility to autoimmune and infectious diseases. Genome Biol. 2017;18(1):1–21.
6. Ramos-Casals M, Diaz-Lagares C, Cuadrado MJ, Khamashta MA,
Group BS.Autoimmune diseases induced by biological agents: a
double-edged sword? Autoimmun Rev. 2010;9(3):188–93.
7. Barber MR, Drenkard C, Falasinnu T, Hoi A, Mak A, Kow NY,
etal. Global epidemiology of systemic lupus erythematosus. Nat
Rev Rheumatol. 2021;17(9):515–32.
8. Fava A, Petri M. Systemic lupus erythematosus: diagnosis and
clinical management. J Autoimmun. 2019;96:1–13.
9. Balkrishna A, Thakur P, Singh S, Chandra Dev SN, Varshney
A. Mechanistic paradigms of natural plant metabolites as
remedial candidates for systemic lupus erythematosus. Cells.
2020;9(4):1049.
10. Shin J.Epidemiology of atopic dermatitis. In: Practical insights
into atopic dermatitis. Berlin: Springer; 2021. p.11–20.
11. Na K, Lkhagva-Yondon E, Kim M, Lim YR, Shin E, Lee CK, etal.
Oral treatment with Aloe polysaccharide ameliorates ovalbumininduced atopic dermatitis by restoring tight junctions in skin.
Scand J Immunol. 2020;91(3):e12856.
12. Tsang MS, Jiao D, Chan BC, Hon KL, Leung PC, Lau CB, etal.
Anti-inammatory activities of pentaherbs formula, berberine,
gallic acid and chlorogenic acid in atopic dermatitis-like skin
inammation. Molecules. 2016;21(4):519.
13. Bergqvist C, Ezzedine K.Vitiligo: a focus on pathogenesis and its
therapeutic implications. J Dermatol. 2021;48(3):252–70.
14. Mihăilă B, Dinică RM, Tatu AL, Buzia OD.New insights in vitiligo treatments using bioactive compounds from Piper nigrum.
Exp Ther Med. 2019;17(2):1039–44.
15. Stojanović-Radić Z, Pejčić M, Dimitrijević M, Aleksić A,
Anil Kumar NV, Salehi B, et al. Piperine—a major principle of
black pepper: a review of its bioactivity and studies. Appl Sci.
2019;9(20):4270.
16. Thakur S, Kaurav H, Chaudhary G. Nigella sativa (Kalonji): a
black seed of miracle. Int J Res Rev. 2021;8(4):342–57.
17. Sarac G, Kapicioglu Y, Sener S, Mantar I, Yologlu S, Dundar C,
etal. Effectiveness of topical Nigella sativa for vitiligo treatment.
Dermatol Ther. 2019;32(4):e12949.
18. Yamanaka K, Yamamoto O, Honda T. Pathophysiology of
Psoriasis: a review. J Dermatol. 2021;48(6):722–31.
19. Ampawong S, Kengkoom K, Sukphopetch P, Aramwit P,
Muangkaew W, Kanjanapruthipong T, etal. Evaluating the effect of
rice (Oryza sativa L.: SRNC05053-6-2) crude extract on Psoriasis
using invitro and invivo models. Sci Rep. 2020;10(1):1–14.
20. Bahraini P, Rajabi M, Mansouri P, Saraan G, Chalangari R,
Azizian Z. Turmeric tonic as a treatment in scalp Psoriasis: a
randomized placebo-control clinical trial. J Cosmet Dermatol.
2018;17(3):461–6.
21. Antiga E, Bonciolini V, Volpi W, Del Bianco E, Caproni M.Oral
curcumin (Meriva) is effective as an adjuvant treatment and is able
to reduce IL-22 serum levels in patients with Psoriasis vulgaris.
Biomed Res Int. 2015;2015:283634.
22. Saverino S, Falorni A.Autoimmune Addison’s disease. Best Pract
Res Clin Endocrinol Metab. 2020;34(1):101379.
23. Stansbury J, Saunders P, Winston D, Zampieron ER. Treating
adrenal insufciency and hypotension with glycyrrhiza. J Restor
Med. 2012;1(1):102–6.
24. Pastorino G, Cornara L, Soares S, Rodrigues F,
Oliveira MB. Liquorice (Glycyrrhiza glabra): a phytochemical and pharmacological review. Phytother Res.
2018;32(12):2323–39.
25. Walton C, King R, Rechtman L, Kaye W, Leray E, Marrie RA,
etal. Rising prevalence of multiple sclerosis worldwide: insights
from the Atlas of MS.Mult Scler J. 2020;26(14):1816–21.
26. Ekiert H, Świątkowska J, Knut E, Klin P, Rzepiela A, Tomczyk
M, etal. Artemisia dracunculus (Tarragon): a review of its traditional uses, phytochemistry and pharmacology. Front Pharmacol.
2021;12:653993.
27. Dumurgier J, Sabia S.Epidemiology of Alzheimer’s disease: latest trends. Rev Prat. 2020;70(2):149–51.
Herbs forAutoimmune Diseases
https://t.me/medicina_free
383
28. Saleem S, Muhammad G, Hussain MA, Altaf M, Bukhari SNA.
Withania somnifera L.: insights into the phytochemical prole,
therapeutic potential, clinical trials, and future prospective. Iran J
Basic Med Sci. 2020;23(12):1501.
29. Ball N, Teo WP, Chandra S, Chapman J.Parkinson’s disease and
the environment. Front Neurol. 2019;10:218.
30. Liu H, Lu X, Hu Y, Fan X.Chemical constituents of Panax gin-
seng and Panax notoginseng explain why they differ in therapeutic
efcacy. Pharmacol Res. 2020;161:105263.
31. Horwitz DA, Fahmy TM, Piccirillo CA, La Cava A.Rebalancing
immune homeostasis to treat autoimmune diseases. Trends
Immunol. 2019;40(10):888–908.
32. Frizinsky S, Haj-Yahia S, Machnes Maayan D, Lifshitz Y, MaozSegal R, Offengenden I, Kidon M, Agmon-Levin N.The innate
immune perspective of autoimmune and autoinammatory conditions. Rheumatology. 2019;58(Suppl 6):vi1–8.
33. Langan D, Rose NR, Moudgil KD.Common innate pathways to
autoimmune disease. Clin Immunol. 2020;212:108361.
34. Maddur MS, Vani J, Lacroix-Desmazes S, Kaveri S, Bayry
J.Autoimmunity as a predisposition for infectious diseases. PLoS
Pathog. 2010;6(11):e1001077.
35. Kamali AN, Noorbakhsh SM, Hamedifar H, Jadidi-Niaragh F,
Yazdani R, Bautista JM, etal. A role for Th1-like Th17 cells in
the pathogenesis of inammatory and autoimmune disorders. Mol
Immunol. 2019;105:107–15.
36. El-Zayat SR, Sibaii H, Mannaa FA. Toll-like receptors activation, signaling, and targeting: an overview. Bull Natl Res Centre.
2019;43(1):1–2.
37. Xing Y, Hogquist KA. T-cell tolerance: central and peripheral.
Cold Spring Harb Perspect Biol. 2012;4(6):a006957.
38. Yang L, Wang G, Xia H. Molecular mechanism for impaired
suppressive function of Tregs in autoimmune diseases: a summary of cell-intrinsic and cell-extrinsic factors. J Cell Mol Med.
2020;24(19):11056–63.
39. Sehrawat S, Rouse BT.Interplay of regulatory T cell and Th17
cells during infectious diseases in humans and animals. Front
Immunol. 2017;8:341.
40. Takaba H, Takayanagi H.The mechanisms of T cell selection in
the thymus. Trends Immunol. 2017;38(11):805–16.
41. Khan U, Ghazanfar H.T lymphocytes and autoimmunity. Int Rev
Cell Mol Biol. 2018;341:125–68.
42. Anaya JM, Restrepo Jimenez P, Rojas M, Pacheco Nieva Y,
Monsalve DM, Ramirez-Santana C. Molecular mimicry and
autoimmunity.
43. Rojas M, Restrepo-Jiménez P, Monsalve DM, Pacheco Y, AcostaAmpudia Y, Ramírez-Santana C, et al. Molecular mimicry and
autoimmunity. J Autoimmun. 2018;95:100–23.
44. Cunningham MW.Molecular mimicry, autoimmunity, and infection: the cross-reactive antigens of group A streptococci and their
sequelae. Microbiol Spectr. 2019;7(4):7–4.
45. Cornaby C, Gibbons L, Mayhew V, Sloan CS, Welling
A, Poole BD. B cell epitope spreading: mechanisms and
contribution to autoimmune diseases. Immunol Lett.
2015;163(1):56–68.
46. Didona D, Di Zenzo G. Humoral epitope spreading in autoimmune bullous diseases. Front Immunol. 2018;9:779.
47. Venkatesha SH, Durai M, Moudgil KD.Epitope spreading in autoimmune diseases. In: Infection and autoimmunity. Amsterdam:
Elsevier; 2015. p.45–68.
48. Sundaresan B, Shirafkan F, Ripperger K, Rattay K.The role of
viral infections in the onset of autoimmune diseases. Viruses.
2023;15(3):782.
49. Pacheco Y, Acosta-Ampudia Y, Monsalve DM, Chang C,
Gershwin ME, Anaya JM.Bystander activation and autoimmunity. J Autoimmun. 2019;103:102301.
50. Lee H, Jeong S, Shin EC.Signicance of bystander T cell activation in microbial infection. Nat Immunol. 2022;23(1):13–22.
51. Shim CH, Cho S, Shin YM, Choi JM. Emerging role of
bystander T cell activation in autoimmune diseases. BMB Rep.
2022;55(2):57.
52. Bruserud Ø, Oftedal BE, Wolff AB, Husebye ES.AIRE-mutations
and autoimmune disease. Curr Opin Immunol. 2016;43:8–15.
53. Zhao B, Chang L, Fu H, Sun G, Yang W. The role of autoimmune regulator (AIRE) in peripheral tolerance. J Immunol Res.
2018;2018:2018.
54. Dominguez-Villar M, Haer DA.Regulatory T cells in autoimmune disease. Nat Immunol. 2018;19(7):665–73.
55. Hosseini A, Gharibi T, Maro F, Babaloo Z, Baradaran B.CTLA4: from mechanism to autoimmune therapy. Int Immunopharmacol.
2020;80:106221.
56. Surace AE, Hedrich CM.The role of epigenetics in autoimmune/
inammatory disease. Front Immunol. 2019;10:1525.
57. Aslani S, Mahmoudi M, Karami J, Jamshidi AR, Malekshahi Z,
Nicknam MH.Epigenetic alterations underlying autoimmune diseases. Autoimmunity. 2016;49(2):69–83.
58. Ilchmann-Diounou H, Menard S.Psychological stress, intestinal
barrier dysfunctions, and autoimmune disorders: an overview.
Front Immunol. 2020;11:1823.
59. Ilchmann-Diounou H, Ménard S.Psychological stress, intestinal
barrier dysfunctions, and autoimmune disorders: an overview.
Front Immunol. 2020;11:1823.
60. Ortona E, Pierdominici M, Maselli A, Veroni C, Aloisi F,
Shoenfeld Y.Sex-based differences in autoimmune diseases. Ann
Ist Super Sanita. 2016;52(2):205–12.
61. Mazzucca CB, Raineri D, Cappellano G, Chiocchetti A.How to
tackle the relationship between autoimmune diseases and diet:
well begun is half-done. Nutrients. 2021;13(11):3956.
62. Lerner A, Matthias T. Changes in intestinal tight junction permeability associated with industrial food additives explain
the rising incidence of autoimmune disease. Autoimmun Rev.
2015;14(6):479–89.
63. Ferrari SM, Fallahi P, Antonelli A, Benvenga S.Environmental
issues in thyroid diseases. Front Endocrinol. 2017;8:50.
64. Winston D.Adaptogens: herbs for strength, stamina, and stress
relief. NewYork: Simon and Schuster; 2019.
65. Santos AL, Junior CP, Neto RN, Santos MH, Santos VF, Rocha
BA, et al. Machaerium acutifolium lectin inhibits inammatory responses through cytokine modulation. Process Biochem.
2020;97:149–57.
66. Lin Y, Wu S. Vegetable soybean (Glycine max (L.) Merr.)
leaf extracts: functional components and antioxidant and
anti- inammatory activities. J Food Sci. 2021;86(6):
2468–80.
67. Burgos RA, Alarcón P, Quiroga J, Manosalva C, Hancke J.
Andrographolide, an anti-inammatory multitarget drug: all roads
lead to cellular metabolism. Molecules. 2020;26(1):5.
68. Beg S, Swain S, Hasan H, Barkat MA, Hussain MS.Systematic
review of herbals as potential anti-inammatory agents: recent
advances, current clinical status and future perspectives.
Pharmacogn Rev. 2011;5(10):120.
69. Sahoo BM, Banik BK.Medicinal plants: source for immunosuppressive agents. Immunol Curr Res. 2018;2:106.
70. Batiha GES, Magdy Beshbishy A, Wasef L, Elewa YH, Abd
El-Hack ME, Taha AE, et al. Uncaria tomentosa (Willd. ex
Schult.) DC.: a review on chemical constituents and biological
activities. Appl Sci. 2020;10(8):2668.
71. Montserrat-de la Paz S, Fernandez-Arche A, De La Puerta R,
Quilez AM, Muriana FJ, Garcia-Gimenez MD, etal. Mitraphylline
inhibits lipopolysaccharide-mediated activation of primary human
neutrophils. Phytomedicine. 2016;23(2):141–8.
384
https://t.me/medicina_free
A. Mukne et al.
72. Batiha GE, Magdy Beshbishy A, Wasef L, Elewa YH, Abd
El-Hack ME, Taha AE, Al-Sagheer AA, Devkota HP, Tufarelli V.
Uncaria tomentosa (Willd. ex Schult.) DC.: a review on chemical
constituents and biological activities. Appl Sci. 2020;10(8):2668.
73. Wang HMD, Fu L, Cheng CC, Gao R, Lin MY, Su HL, et al.
Inhibition of LPS-induced oxidative damages and potential
anti-inammatory effects of Phyllanthus emblica extract via
down-regulating NF-κB, COX-2, and iNOS in RAW 264.7 cells.
Antioxidants. 2019;8(8):270.
74. Guazelli CF, Fattori V, Ferraz CR, Borghi SM, Casagrande R,
Baracat MM, et al. Antioxidant and anti-inammatory effects
of hesperidin methyl chalcone in experimental ulcerative colitis.
Chem Biol Interact. 2021;333:109315.
75. de Oliveira ALB, Monteiro VVS, Navegantes-Lima KC, Reis JF,
Gomes RdS, Rodrigues DVS, etal. Resveratrol role in autoimmune disease—a mini-review. Nutrients. 2017;9(12):1306.
76. Bai J, Zhang Y, Tang C, Hou Y, Ai X, Chen X, etal. Gallic acid:
pharmacological activities and molecular mechanisms involved
in inammation-related diseases. Biomed Pharmacother.
2021;133:110985.
77. Rahayu RP, Prasetyo RA, Purwanto DA, Kresnoadi U, Iskandar
RPD, Rubianto M. The immunomodulatory effect of green tea
(Camellia sinensis) leaves extract on immunocompromised Wistar
rats infected by Candida albicans. Vet World. 2018;11(6):765–70.
78. Yuan K, Li X, Lu Q, Zhu Q, Jiang H, Wang T, etal. Application
and mechanisms of triptolide in the treatment of inammatory
diseases—a review. Front Pharmacol. 2019;10:1469.
79. Song J, Hu Y, Wang L, Ao C. Ethanol extract of Artemisia
Annua prevents LPS-induced inammation and blood–milk barrier disruption in bovine mammary epithelial cells. Animals.
2022;12(10):1228.
80. Vetvicka V, Vannucci L.Biological properties of andrographolide,
an active ingredient of Andrographis Paniculata: a narrative
review. Ann Transl Med. 2021;9(14):1186.
81. Peng Y, Ao M, Dong B, Jiang Y, Yu L, Chen Z, et al. Antiinammatory effects of curcumin in the inammatory diseases:
status, limitations and countermeasures. Drug Des Devel Ther.
2021:4503–25.
82. Batiha GE, Beshbishy AM, Wasef LG, Elewa YH, Al-Sagan
AA, El-Hack MEA, Taha AE, Abd-Elhakim YM, Devkota
HP.Chemical constituents and pharmacological activities of garlic
(Allium sativum L.): a review. Nutrients. 2020;12(3):872.
83. Zhu L, Myhill LJ, Andersen-Civil AI, Thamsborg SM, Blanchard
A, Williams AR. Garlic-derived organosulfur compounds regulate metabolic and immune pathways in macrophages and
attenuate intestinal inammation in mice. Mol Nutr Food Res.
2022;66(7):2101004.
84. Zamani Taghizadeh Rabe S, Ghazanfari T, Siadat Z, Rastin M,
Zamani Taghizadeh Rabe S, Mahmoudi M. Anti-inammatory
effect of garlic 14-kDa protein on LPS-stimulated-J774A.1 macrophages. Immunopharmacol Immunotoxicol. 2015;37(2):158–64.
85. Alanazi HH, Elfaki E.The immunomodulatory role of Withania
somnifera (L.) dunal in inammatory diseases. Front Pharmacol.
2023;14:430.
86. Bashir A, Nabi M, Tabassum N, Afzal S, Ayoub M.An updated
review on phytochemistry and molecular targets of Withania som-
nifera (L.) dunal (Ashwagandha). Front Pharmacol. 2023;14:643.
87. Kunnumakkara AB, Bordoloi D, Padmavathi G, Monisha J,
Roy NK, Prasad S, et al. Curcumin, the golden nutraceutical:
multitargeting for multiple chronic diseases. Br J Pharmacol.
2017;174(11):1325–48.
88. Ghanaatian N, Lashgari NA, Abdolghaffari AH, Rajaee SM,
Panahi Y, Barreto GE, etal. Curcumin as a therapeutic candidate
for multiple sclerosis: molecular mechanisms and targets. J Cell
Physiol. 2019;234(8):12237–48.
89. Kang D, Li B, Luo L, Jiang W, Lu Q, Rong M, et al. Curcumin
shows excellent therapeutic effect on psoriasis in mouse model.
Biochimie. 2016;123:73–80.
90. Zhang S, Wang J, Liu L, Sun X, Zhou Y, Chen S, Lu Y, Cai X, Hu
M, Yan G, Miao X.Efcacy and safety of curcumin in psoriasis:
preclinical and clinical evidence and possible mechanisms. Front
Pharmacol. 2022;13:903160.
91. Chopra H, Dey PS, Das D, Bhattacharya T, Shah M, Mubin S,
etal. Curcumin nanoparticles as promising therapeutic agents for
drug targets. Molecules. 2021;26(16):4998.
92. Bulboacă AE, Porre AS, Tefas LR, Boarescu PM, Bolboacă SD,
Stănescu IC, etal. Liposomal curcumin is better than curcumin
to alleviate complications in experimental diabetic mellitus.
Molecules. 2019;24(5):846.
93. Recinella L, Gorica E, Chiavaroli A, Fraschetti C, Filippi A, Cesa
S, et al. Anti-inammatory and antioxidant effects induced by
Allium sativum L. extracts on an ex vivo experimental model of
ulcerative colitis. Foods. 2022;11(22):3559.
94. Ezzat SM, Ezzat MI, Okba MM, Menze ET, Abdel-Naim AB.The
hidden mechanism beyond ginger (Zingiber ofcinale R.) potent
invivo and invitro anti-inammatory activity. J Ethnopharmacol.
2018;214:113–23.
95. Habib SH, Makpol S, Hamid NA, Das S, Ngah WZ, Yusof
YA.Ginger extract (Zingiber ofcinale) has anti-cancer and antiinammatory effects on ethionine-induced hepatoma rats. Clinics.
2008;63(6):807–13.
96. Hwang JH, Jung HW, Oh SY, Kang JS, Kim JP, Park YK.Effects
of Zingiber ofcinale extract on collagen-induced arthritis in mice
and IL-1β-induced inammation in human synovial broblasts.
Eur J Inamm. 2017;15(3):168–78.
97. Karthikeyan V, Balakrishnan BR, Senniappan P, Janarthanan L,
Venkateswarlu BS, Anandharaj G. Berbris aristata DC: pharmacognostical standardization and phytochemical studies of its
leaves. J Drug Deliv Ther. 2019;9(4-A):229–36.
98. Ehteshamfar SM, Akhbari M, Afshari JT, Seyedi M, Nikfar
B, Shapouri-Moghaddam A, et al. Anti-inammatory and
immune-modulatory impacts of berberine on activation of autoreactive T cells in autoimmune inammation. J Cell Mol Med.
2020;24(23):13573–88.
99. Yue M, Xia Y, Shi C, Guan C, Li Y, Liu R, et al. Berberine
ameliorates collagen-induced arthritis in rats by suppressing
Th17 cell responses via inducing cortistatin in the gut. FEBS J.
2017;284(17):2786–801.
100. Shari-Rad J, Quispe C, Ayatollahi SA, Kobarfard F, Staniak
M, Stępień A, Czopek K, Sen S, Acharya K, Matthews KR,
Sener B. Chemical composition, biological activity, and healthpromoting effects of Withania somnifera for pharma-food indus-
try applications. J Food Qual. 2021;2021:8985179.
101. Fry CH, Fluck D, Han TS. Adrenal hypofunction associated
with ashwagandha (Withania somnifera) supplementation: a case
report. Toxicol Environ Health Sci. 2022;14(2):141–5.
102. Khan N, Swami DH, Gourav P, Kushwah M, Raj P.Phytochemical
investigation and evaluation of anti-inammatory activity of
Camellia sinensis (Green Tea) leaves in experimental animals. 8(2).
103. Oliveira AP, Guimarães AL, de Oliveira-Júnior RG, Quintans
JD, de Medeiros FA, Barbosa-Filho JM, Quintans-Júnior LJ,
da Silva Almeida JR. Camellia sinensis (L.) Kuntze: a review
of chemical and nutraceutical properties. Nat Prod Res Rev.
2016;4:21–62.
104. Kim J, Choi H, Choi DH, Park K, Kim HJ, Park M.Application
of green tea catechins, polysaccharides, and avonol prevent ne
dust induced bronchial damage by modulating inammation and
airway cilia. Sci Rep. 2021;11(1):2232.
105. Huang SS, Su SY, Chang JS, Lin HJ, Wu WT, Deng JS, et al.
Antioxidants, anti-inammatory, and antidiabetic effects of the
Herbs forAutoimmune Diseases
https://t.me/medicina_free
385
aqueous extracts from glycine species and its bioactive compounds. Bot Stud. 2016;57(1):1–11.
106. Hancke JL, Srivastav S, Cáceres DD, Burgos RA.A double-blind,
randomized, placebo-controlled study to assess the efcacy of
Andrographis paniculata standardized extract (ParActin®) on
pain reduction in subjects with knee osteoarthritis. Phytother Res.
2019;33(5):1469–79.
107. Suriyo T, Pholphana N, Ungtrakul T, Rangkadilok N, Panomvana
D, Thiantanawat A, Pongpun W, Satayavivad J.Clinical parameters following multiple oral dose administration of a standardized
Andrographis paniculata capsule in healthy Thai subjects. Planta
Medica. 2017;83(9):778–89.
108. Ciampi E, Uribe-San-Martin R, Cárcamo C, Cruz JP, Reyes A,
Reyes D, Pinto C, Vásquez M, Burgos RA, Hancke J. Efcacy
of andrographolide in not active progressive multiple sclerosis: a
prospective exploratory double-blind, parallel-group, randomized,
placebo-controlled trial. BMC Neurol. 2020;20:173.
109. Lu J, Ma Y, Wu J, Huang H, Wang X, Chen Z, etal. A review for
the neuroprotective effects of andrographolide in the central nervous system. Biomed Pharmacother. 2019;117:109078.
110. Borges RS, Ortiz BLS, Pereira ACM, Keita H, Carvalho JCT.
Rosmarinus ofcinalis essential oil: a review of its phytochemistry, anti-inammatory activity, and mechanisms of action
involved. J Ethnopharmacol. 2019;229:29–45.
111. Andrade JM, Faustino C, Garcia C, Ladeiras D, Reis CP, Rijo P.
Rosmarinus ofcinalis L.: an update review of its phytochemistry
and biological activity. Future Sci OA. 2018;4(4):FSO283.
112. Yuan R, Liu Z, Zhao J, Wang QQ, Zuo A, Huang L, etal. Novel
compounds in fruits of coriander (Coşkuner & Karababa) with
anti-inammatory activity. J Funct Foods. 2020;73:104145.
113. Chahal KK, Singh R, Kumar A, Bhardwaj U.Chemical composition and biological activity of Coriandrum sativum L.: a review.
Indian J Nat Prod Resour. 2018;8:193–203.
114. Foudah AI, Alqarni MH, Alam A, Salkini MA, Ahmed EOI,
Yusufoglu HS.Evaluation of the composition and invitro antimicrobial, antioxidant, and anti-inammatory activities of Cilantro
(Coriandrum sativum L. leaves) cultivated in Saudi Arabia
(Al-Kharj). Saudi J Biol Sci. 2021;28(6):3461–8.
115. Jahurul MHA, Patricia M, Shihabul A, Norazlina MR, George
MR, Noorakmar AW, etal. A review on functional and nutritional
properties of noni fruit seed (Morinda citrifolia L.) and its oil.
Food Biosci. 2021;41:101000.
116. Tanikawa T, Kitamura M, Hayashi Y, Tomida N, Uwaya A, Isami
F, et al. Anti-inammatory effects of Morinda citrifolia extract
against lipopolysaccharide-induced inammation in RAW264
Cells. Medicines. 2021;8(8):43.
117. Lee D, Yu JS, Huang P, Qader M, Manavalan A, Wu X,
et al. Identication of anti-inammatory compounds from
Hawaiian noni (Morinda citrifolia L.) fruit juice. Molecules.
2020;25(21):4968.
118. Salaria D, Rolta R, Sharma N, Dev K, Sourirajan A, Kumar V. In
silico and in vitro evaluation of the anti-inammatory and anti-
oxidant potential of Cymbopogon citratus from North-western
Himalayas. BioRxiv. 2020;2020.05.31.124982.
119. Ekpenyong CE, Akpan E, Nyoh A. Ethnopharmacology, phytochemistry, and biological activities of Cymbopogon citratus (DC.)
Stapf extracts. Chinese J Nat Med. 2015;13(5):321–37.
120. Borges PH, Pedreiro S, Baptista SJ, Geraldes CF, Batista
MT, Silva MM, et al. Inhibition of α-glucosidase by avonoids of Cymbopogon citratus (DC) Stapf. J Ethnopharmacol.
2021;280:114470.
121. Ajayi AM, Ologe MO, Ben-Azu B, Okhale SE, Adzu B, Ademowo
OG, Ocimum gratissimum Linn. Leaf extract inhibits free radical
generation and suppressed inammation in carrageenan-induced
inammation models in rats. J Basic Clin Physiol Pharmacol.
2017;28(6):531–41.
122. Tiwari P, Nayak P, Prusty SK, Sahu PK. Phytochemistry and
pharmacology of Tinospora cordifolia: a review. Syst Rev Pharm.
2018;9(1):70–8.
123. Nandan A, Sharma V, Banerjee P, Sadasivam K, Venkatesan S,
Prasher B. Deciphering the mechanism of Tinospora cordifolia
extract on Th17 cells through in-depth transcriptomic proling
and in silico analysis. Front Pharmacol. 2022;13:1056677.
124. Maidhof W, Hilas O.Lupus: an overview of the disease and management options. Pharm Ther. 2012;37(4):240–9.
125. Balkrishna A, Thakur P, Singh S, Chandra Dev SN, Varshney
A. Mechanistic paradigms of natural plant metabolites as
remedial candidates for systemic lupus erythromatosus. Cells.
2020;9(4):1049.
126. Pan L, Lu MP, Wang JH, Xu M, Yang SR.Immunological pathogenesis and treatment of systemic lupus erythematosus. World J
Pediatr. 2020;16:19–30.
127. Dörner T, Furie R.Novel paradigms in systemic lupus erythematosus. Lancet. 2019;393(10188):2344–58.
128. Song CY, Xu YG, Lu YQ.Use of Tripterygium wilfordii Hook F
for immune-mediated inammatory diseases: progress and future
prospects. J Zhejiang Univ Sci B. 2020;21(4):280–90.
129. Sun Q, Liu Y, Lu D, Ji L, Wang W, Wang X, et al. Therapeutic
effects of triptolide on the balance of Th17/Treg cells via AKT/
mTOR/p70S6k signaling pathway in lupus-like mic. 2022 [cited
2022 Dec 18]. https://doi.org/10.21203/rs.3.rs- 1354719/v1.
130. Zhang LY, Li H, Wu YW, Cheng L, Yan YX, Yang XQ, Zhu FH, He
SJ, Tang W, Zuo JP. (5R)-5-hydroxytriptolide ameliorates lupus
nephritis in MRL/lpr mice by preventing inltration of immune
cells. Am J Physiol Renal Physiol. 2017;312(4):F769–77.
131. Zhang Y, Zhang F, Gao Y, Wang M, Li H, Sun J, Wen C, Xie
Z. Triptolide in the treatment of systemic lupus erythematosusregulatory effects on miR-146a in B cell TLR7 signaling pathway
in mice. Front Pharmacol. 2022;13:952775.
132. Liu W, Yan L, Zhu Q, Shao FM.Therapeutic effect of Tripterygium
glycosides plus prednisone on moderate active systemic lupus erythematosus. J Chin Pract Diagn Ther. 2014;28(12):1234–5.
133. Wang YJ, Li YX, Li S, He W, Wang ZR, Zhan TP, etal. Progress
in traditional Chinese medicine and natural extracts for the treatment of lupus nephritis. Biomed Pharmacother. 2022;149:112799.
134. Zamani S, Emami SA, Iranshahi M, Rabe SZ, Mahmoudi
M.Sesquiterpene fractions of Artemisia plants as potent inhibitors
of inducible nitric oxide synthase and cyclooxygenase-2 expression. Iran J Basic Med Sci. 2019;22(7):774.
135. Chebbac K, Benziane Ouaritini Z, El Moussaoui A, Chalkha M,
Lafraxo S, Bin Jardan YA, Nadi HA, Bourhia M, Guemmouh
R. Antimicrobial and antioxidant properties of chemically analyzed essential oil of Artemisia annua L. (Asteraceae) native to
Mediterranean Area. Life. 2023;13(3):807.
136. Avena-Woods C. Overview of atopic dermatitis. Am J Manag
Care. 2017;23(8 Suppl):S115–23.
137. Otsuka A, Nomura T, Rerknimitr P, Seidel JA, Honda T,
Kabashima K.The interplay between genetic and environmental
factors in the pathogenesis of atopic dermatitis. Immunol Rev.
2017;278(1):246–62.
138. David Boothe W, Tarbox JA, Tarbox MB. Atopic dermatitis:
pathophysiology. In: Management of atopic dermatitis: methods
and challenges. Berlin: Springer; 2017. p.21–37.
139. Sroka-Tomaszewska J, Trzeciak M. Molecular mechanisms of
atopic dermatitis pathogenesis. Int J Mol Sci. 2021;22(8):4130.
140. Peng W, Novak N. Pathogenesis of atopic dermatitis. Clin Exp
Allergy. 2015;45(3):566–74.
141. Kim J, Kim BE, Leung DY.Pathophysiology of atopic dermatitis:
clinical implications. In: Allergy and asthma proceedings. East
Providence: OceanSide Publications; 2019. p.84.
142. Kwatra SG, Misery L, Clibborn C, Steinhoff M. Molecular
and cellular mechanisms of itch and pain in atopic dermatitis
386
https://t.me/medicina_free
A. Mukne et al.
and implications for novel therapeutics. Clin Transl Immunol.
2022;11(5):e1390.
143. Fania L, Moretta G, Antonelli F, Scala E, Abeni D, Albanesi C,
etal. Multiple roles for cytokines in atopic dermatitis: from pathogenic mediators to endotype-specic biomarkers to therapeutic
targets. Int J Mol Sci. 2022;23(5):2684.
144. Dattola A, Bennardo L, Silvestri M, Nisticò SP.What’s new in the
treatment of atopic dermatitis? Dermatol Ther. 2019;32(2):e12787.
145. Maliehe TS, Nqotheni MI, Shandu JS, Selepe TN, Masoko P,
Pooe OJ. Chemical prole, antioxidant and antibacterial activities, mechanisms of action of the leaf extract of Aloe arborescens
Mill. Plants. 2023;12(4):869.
146. Rodrigues M, Ezzedine K, Hamzavi I, Pandya AG, Harris JE,
Group VW.New discoveries in the pathogenesis and classication
of Vitiligo. J Am Acad Dermatol. 2017;77(1):1–13.
147. Spritz RA, Santorico SA.The genetic basis of Vitiligo. J Investig
Dermatol. 2021;141(2):265–73.
148. Bergqvist C, Ezzedine K. Vitiligo: a review. Dermatology.
2020;236(6):571–92.
149. Harris JE. Chemical-induced Vitiligo. Dermatol Clin.
2017;35(2):151–61.
150. Manga P, Choudhury N.The unfolded protein and integrated stress
response in melanoma and Vitiligo. Pigment Cell Melanoma Res.
2021;34(2):204–11.
151. Seneschal J, Boniface K, D’Arino A, Picardo M. An update
on Vitiligo pathogenesis. Pigment Cell Melanoma Res.
2021;34(2):236–43.
152. Stojanović-Radić Z, Pejčić M, Dimitrijević M, Aleksić A, Anil
Kumar NV, Salehi B, Cho CW, Shari-Rad J.Piperine—a major
principle of black pepper: a review of its bioactivity and studies.
Appl Sci. 2019;9(20):4270.
153. Shaee A, Hoormand M, Shahidi-Dadras M, Abadi A.The effect
of topical piperine combined with narrowband UVB on Vitiligo
treatment: a clinical trial study. Phytother Res. 2018;32(9):1812–7.
154. Hwang JR, Cartron AM, Khachemoune A. A review of Nigella
sativa plant-based therapy in dermatology. Int J Dermatol.
2021;60(12):e493–9.
155. Hugh JM, Weinberg JM.Update on the pathophysiology of psoriasis. Cutis. 2018;102(5S):6–12.
156. Sarac G, Koca TT, Baglan T.A brief summary of clinical types of
psoriasis. North Clin Istanb. 2016;3(1):79.
157. Yan BX, Chen XY, Ye LR, Chen JQ, Zheng M, Man XY.Cutaneous
and systemic psoriasis: classications and classication for the
distinction. Front Med. 2021;8:649408.
158. Zhou X, Chen Y, Cui L, Shi Y, Guo C.Advances in the pathogenesis of psoriasis: from keratinocyte perspective. Cell Death Dis.
2022;13(1):81.
159. Herman A, Herman AP. Topically used herbal products for the
treatment of psoriasis—mechanism of action, drug delivery, clinical studies. Planta Med. 2016;82(17):1447–55.
160. Rout SK, Tripathy BC, Kar BR. Natural green alternatives
to psoriasis treatment—a review. Glob J Pharm Pharm Sci.
2017;4(1):1–7.
161. Aghmiuni AI, Khiavi AA.Medicinal plants to calm and treat psoriasis disease. In: Aromatic and medicinal plants—back to nature,
vol. 2016. London: IntechOpen; 2017. p.1–28.
162. Thepthanee C, Liu CC, Yu HS, Huang HS, Yen CH, Li YH, etal.
Evaluation of phytochemical contents and invitro antioxidant, antiinammatory, and anticancer activities of black rice leaf (Oryza
sativa L.) extract and its fractions. Foods. 2021;10(12):2987.
163. Xu Y, Shi Y, Huang J, Gu H, Li C, Zhang L, etal. The essential oil
derived from Perilla frutescens (L.) Britt. attenuates imiquimod-
induced psoriasis-like skin lesions in BALB/c mice. Molecules.
2022;27(9):2996.
164. Hellesen A, Bratland E, Husebye ES.Autoimmune Addison’s disease—an update on pathogenesis. In: Annales d’endocrinologie.
Amsterdam: Elsevier; 2018. p.157–63.
165. Bancos I, Hahner S, Tomlinson J, Arlt W.Diagnosis and management of adrenal insufciency. Lancet Diabetes Endocrinol.
2015;3(3):216–26.
166. Perniola R, Fierabracci A, Falorni A. Autoimmune Addison’s
disease as part of the autoimmune polyglandular syndrome type
1: historical overview and current evidence. Front Immunol.
2021;12:606860.
167. Husebye ES, Pearce SH, Krone NP, Kämpe O.Adrenal insufciency. Lancet. 2021;397(10274):613–29.
168. Pignatti E, Flück CE. Adrenal cortex development and related
disorders leading to adrenal insufciency. Mol Cell Endocrinol.
2021;527:111206.
169. Hellesen A, Bratland E, Husebye ES.Autoimmune Addison’s disease—an update on pathogenesis. In: Annales d’endocrinologie,
vol. 79, no. 3. Paris: Elsevier Masson; 2018. p.157–63.
170. Betterle C, Presotto F, Furmaniak J.Epidemiology, pathogenesis,
and diagnosis of Addison’s disease in adults. J Endocrinol Invest.
2019;42(12):1407–33.
171. Methlie P, Husebye EE, Hustad S, Lien EA, Løvås K.Grapefruit
juice and licorice increase cortisol availability in patients with
Addison’s disease. Eur J Endocrinol. 2011;165(5):761–9.
172. Kumari A, Kumar R, Sulabh G, Singh P, Kumar J, Singh VK,
Ojha KK. In silico ADMET, molecular docking and molecular
simulation-based study of glabridin’s natural and semisynthetic
derivatives as potential tyrosinase inhibitors. Adv Tradit Med.
2023;23:733–51.
173. Morsy MA, Patel SS, El-Sheikh AA, Savjani JK, Nair AB, Shah
JN, Venugopala KN. Computational and biological comparisons of plant steroids as modulators of inammation through
interacting with glucocorticoid receptor. Mediators Inamm.
2019;2019:3041438.
174. Boswellia Serrata, a potential antiinammatory agent: an overview—PMC. [cited 2023 Mar 3]. https://www.ncbi.nlm.nih.gov/
pmc/articles/PMC3309643/.
175. Zameer S, Najmi AK, Vohora D, Akhtar M.A review on therapeutic potentials of Trigonella foenum graecum (fenugreek) and its
chemical constituents in neurological disorders: complementary
roles to its hypolipidemic, hypoglycemic, and antioxidant potential. Nutr Neurosci. 2018;21(8):539–45.
176. Aylanc V, Eskin B, Zengin G, Dursun M, Cakmak YS. In
vitro studies on different extracts of fenugreek (Trigonella
spruneriana BOISS.): phytochemical prole, antioxidant
activity, and enzyme inhibition potential. J Food Biochem.
2020;44(11):e13463.
177. Prema A, Thenmozhi AJ, Manivasagam T, Essa MM, Akbar MD,
Akbar M. Fenugreek seed powder nullied aluminium chloride
induced memory loss, biochemical changes, Aβ burden and apoptosis via regulating Akt/GSK3β signaling pathway. PLoS One.
2016;11(11):e0165955.
178. Ratheesh G, Tian L, Venugopal JR, Ezhilarasu H, Sadiq A, Fan
TP, etal. Role of medicinal plants in neurodegenerative diseases.
Biomanuf Rev. 2017;2(1):2.
179. Rai K, Gupta N, Dharamdasani L, Nair P, Bodhankar P. Bacopa
monnieri: a wonder drug changing fortune of people. Int J Appl
Sci Biotechnol. 2017;5(2):127–32.
180. Fatima U, Roy S, Ahmad S, Ali S, Elkady WM, Khan I, Alsaffar
RM, Adnan M, Islam A, Hassan MI.Pharmacological attributes of
Bacopa monnieri extract: current updates and clinical manifestation. Front Nutr. 2022;9:972379.
181. Kishore D, Babu RS, Begum A, Noor A, Farheen S, Kauser SM,
Yaser AA.Evaluation of nootropic activity of two marketed drugs
Herbs forAutoimmune Diseases
https://t.me/medicina_free
387
of Bacopa monnieri in scopolamine induced amnesic models.
Indian J Res Pharm Biotechnol. 2018;6:84–90.
182. Nowak A, Kojder K, Zielonka-Brzezicka J, Wróbel J, Bosiacki
M, Fabiańska M, etal. The use of Ginkgo Biloba L. as a neuroprotective agent in the Alzheimer’s Disease. Front Pharmacol.
2021;12:775034. https://www.frontiersin.org/articles/10.3389/
fphar.2021.775034.
183. Das R, Lami MS, Chakraborty AJ, Mitra S, Tallei TE, Idroes R,
Mohamed AA, Hossain M, Dhama K, Mostafa-Hedeab G, Emran
TB. Ginkgo biloba: a treasure of functional phytochemicals with
multimedicinal applications. Evid Based Complement Alternat
Med. 2022;2022:8288818.
184. Yu D, Zhang P, Li J, Liu T, Zhang Y, Wang Q, Zhang J, Lu X,
Fan X.Neuroprotective effects of Ginkgo biloba dropping pills in
Parkinson’s disease. J Pharm Anal. 2021;11(2):220–31.
185. Rapp M, Burkart M, Kohlmann T, Bohlken J. Similar treatment
outcomes with Ginkgo biloba extract EGb 761 and donepezil in
Alzheimer’s dementia in very old age: a retrospective observational study. Int J Clin Pharmacol Ther. 2018;56(3):130.
186. Sun B, Wu L, Wu Y, Zhang C, Qin L, Hayashi M, etal. Therapeutic
potential of Centella asiatica and its triterpenes: a review. Front
Pharmacol. 2020;11:568032.
187. Wong JH, Barron AM, Abdullah JM. Mitoprotective effects of
Centella asiatica (L.) Urb.: anti-inammatory and neuroprotective opportunities in neurodegenerative disease. Front Pharmacol.
2021;12:687935.
188. Haz ZZ, Amin MAM, Johari James RM, Teh LK, Salleh
MZ, Adenan MI. Inhibitory effects of raw-extract Centella
asiatica (RECA) on acetylcholinesterase, inammations, and
oxidative stress activities viain vitro and in vivo. Molecules.
2020;25(4):892.
189. Fujimori H, Ohba T, Mikami M, Nakamura S, Ito K, Kojima H,
Takahashi T, Iddamalgoda A, Shimazawa M, Hara H.The protective effect of Centella asiatica and its constituent, araliadiol on
neuronal cell damage and cognitive impairment. J Pharmacol Sci.
2022;148(1):162–71.
190. Gray NE, Zweig JA, Murchison C, Caruso M, Matthews DG,
Kawamoto C, Harris CJ, Quinn JF, Soumyanath A. Centella asi-
atica attenuates Aβ-induced neurodegenerative spine loss and
dendritic simplication. Neurosci Lett. 2017;646:24–9.
191. Nakoti SS, Juyal D, Josh AK.A review on pharmacognostic and
phytochemical study of a plant Nardostachys Jatamansi. Pharma
Innov. 2017;6(7, Part G):936.
192. Liu QF, Jeon Y, Sung Y-W, Lee JH, Jeong H, Kim YM, et al.
Nardostachys jatamansi ethanol extract ameliorates Aβ42 cyto-
toxicity. Biol Pharm Bull. 2018;41(4):470–7.
193. Kaur N, Sarkar B, Gill I, Kaur S, Mittal S, Dhiman M, etal. Indian
herbs and their therapeutic potential against Alzheimer’s disease
and other neurological disorders. In: Neuroprotective effects of
phytochemicals in neurological disorders. New York: Wiley;
2017. p.79–112.
194. Devi P. An updated review on Shankhpushpi—As Medhya
Rasayana. J Ayurvedic Herb Med. 2021;7(2):119–23.
195. Sethiya NK, Nahata A, Singh PK, Mishra
SH. Neuropharmacological evaluation on four traditional herbs
used as nervine tonic and commonly available as Shankhpushpi in
India. J Ayurveda Integr Med. 2019;10(1):25–31.
196. Suryavanshi SV, Barve K, Addepalli V, Utpat SV, Kulkarni
YA. Triphala Churna—a traditional formulation in ayurveda
mitigates diabetic neuropathy in rats. Front Pharmacol.
2021;12:662000.
197. Ning W, Li S, Tsering J, Ma Y, Li H, Ma Y, etal. Protective effect
of Triphala against oxidative stress-induced neurotoxicity. Biomed
Res Int. 2021;2021:6674988.
198. Tarlinton RE, Khaibullin T, Granatov E, Martynova E, Rizvanov
A, Khaiboullina S.The interaction between viral and environmental risk factors in the pathogenesis of multiple sclerosis. Int J Mol
Sci. 2019;20(2):303.
199. Guan Y, Jakimovski D, Ramanathan M, Weinstock-Guttman B,
Zivadinov R.The role of Epstein-Barr virus in multiple sclerosis: from molecular pathophysiology to invivo imaging. Neural
Regen Res. 2019;14(3):373.
200. Zéphir H.Progress in understanding the pathophysiology of multiple sclerosis. Rev Neurol (Paris). 2018;174(6):358–63.
201. Dighriri IM, Aldalbahi AA, Albeladi F, Tahiri AA, Kinani EM,
Almohsen RA, Alamoudi NH, Alanazi AA, Alkhamshi SJ,
Althomali NA, Alrubaiei SN.An overview of the history, pathophysiology, and pharmacological interventions of multiple sclerosis. Cureus. 2023;15(1):e33242.
202. Kaskow BJ, Baecher-Allan C.Effector T cells in multiple sclerosis. Cold Spring Harb Perspect Med. 2018;8(4):a029025.
203. Huang WJ, Chen WW, Zhang X. Multiple sclerosis: pathology, diagnosis and treatments. Exp Ther Med. 2017;13(6):
3163–6.
204. Moser T, Akgün K, Proschmann U, Sellner J, Ziemssen T. The
role of TH17 cells in multiple sclerosis: therapeutic implications.
Autoimmun Rev. 2020;19(10):102647.
205. Qureshi M, Al-Suhaimi E, Shehzad A.Curcumin impact on multiple sclerosis. In: Curcumin for neurological and psychiatric disorders. Amsterdam: Elsevier; 2019. p.365–80.
206. Balasa R, Barcutean L, Balasa A, Motataianu A, Roman-Filip C,
Manu D.The action of TH17 cells on blood brain barrier in multiple sclerosis and experimental autoimmune encephalomyelitis.
Hum Immunol. 2020;81(5):237–43.
207. Kimura K. Regulatory T cells in multiple sclerosis. Clin Exp
Neuroimmunol. 2020;11(3):148–55.
208. Barcelos IP, Troxell RM, Graves JS.Mitochondrial dysfunction
and multiple sclerosis. Biology. 2019;8(2):37.
209. Bayat P, Farshchi M, Yousean M, Mahmoudi M, Yazdian-Robati
R.Flavonoids, the compounds with anti-inammatory and immunomodulatory properties, as promising tools in multiple sclerosis (MS) therapy: a systematic review of preclinical evidence. Int
Immunopharmacol. 2021;95:107562.
210. Safari H, Anani Sarab G, Naseri M.Artemisia dracunculus L.
modulates the immune system in a multiple sclerosis mouse
model. Nutr Neurosci. 2021;24(11):843–9.
211. Adetuyi BO, Omolabi FK, Olajide PA, Oloke JK.Pharmacological,
biochemical and therapeutic potential of milk thistle (silymarin): a
review. World News Nat Sci. 2021;37:75–91.
212. Shariati M, Shaygannejad V, Abbasirad F, Hosseininasab F,
Kazemi M, Mirmosayyeb O, etal. Silymarin restores regulatory T
cells (tregs) function in multiple sclerosis (MS) patients invitro.
Inammation. 2019;42:1203–14.
213. Eratne D, Loi SM, Farrand S, Kelso W, Velakoulis D, Looi
JC. Alzheimer’s disease: clinical update on epidemiology, pathophysiology and diagnosis. Australas Psychiatry.
2018;26(4):347–57.
214. Twohig D, Nielsen HM. α-Synuclein in the pathophysiology of
Alzheimer’s disease. Mol Neurodegener. 2019;14(1):1–19.
215. Scheltens P, Blennow K, Breteler MM, De Strooper B,
Frisoni GB, Salloway S, et al. Alzheimer’s disease. Lancet.
2016;388(10043):505–17.
216. Masters CL, Bateman R, Blennow K, Rowe CC, Sperling
RA, Cummings JL. Alzheimer’s disease. Nat Rev Dis Primer.
2015;1(1):1–18.
217. Wan W, Cao L, Kalionis B, Murthi P, Xia S, Guan Y.Iron deposition leads to hyperphosphorylation of tau and disruption of insulin
signaling. Front Neurol. 2019;10:607.
388
https://t.me/medicina_free
A. Mukne et al.
218. Kumar A, Singh A. A review on Alzheimer’s disease pathophysiology and its management: an update. Pharmacol Rep.
2015;67(2):195–203.
219. Khoury R, Rajamanickam J, Grossberg GT. An update on the
safety of current therapies for Alzheimer’s disease: focus on rivastigmine. Ther Adv Drug Saf. 2018;9(3):171–8.
220. Balakrishnan R, Cho DY, Kim IS, Seol SH, Choi DK.Molecular
mechanisms and therapeutic potential of α- and β-asarone in the
treatment of neurological disorders. Antioxidants. 2022;11(2):281.
221. Esfandiari E, Ghanadian M, Rashidi B, Mokhtarian A, Vatankhah
AM.The effects of Acorus calamus L. in preventing memory loss,
anxiety, and oxidative stress on lipopolysaccharide-induced neuroinammation rat models. Int J Prev Med. 2018;9:85.
222. Mikami M, Takuya O, Yoshino Y, Nakamura S, Ito K, Kojima
H, et al. Acorus calamus extract and its component α-asarone
attenuate murine hippocampal neuronal cell death induced
by l-glutamate and tunicamycin. Biosci Biotechnol Biochem.
2021;85(3):493–501.
223. Talebi M, Talebi M, Samarghandian S.Association of Crocus sativus with cognitive dysfunctions and Alzheimer’s disease: a systematic review. Biointerface Res Appl Chem. 2021;11(1):7468–92.
224. D’Onofrio G, Nabavi SM, Sancarlo D, Greco A, Pieretti S,
Crocus sativus L. (Saffron) in Alzheimer’s disease treatment:
bioactive effects on cognitive impairment. Curr Neuropharmacol.
2021;19(9):1606.
225. Bloem BR, Okun MS, Klein C. Parkinson’s disease. Lancet.
2021;397(10291):2284–303.
226. Johnson ME, Stecher B, Labrie V, Brundin L, Brundin P.Triggers,
facilitators, and aggravators: redening Parkinson’s disease pathogenesis. Trends Neurosci. 2019;42(1):4–13.
227. Maiti P, Manna J, Dunbar GL. Current understanding of the
molecular mechanisms in Parkinson’s disease: targets for potential treatments. Transl Neurodegener. 2017;6:1–35.
228. Liu Y, Zhang RY, Zhao J, Dong Z, Feng DY, Wu R, etal. Ginsenoside
Rd protects SH-SY5Y cells against 1-methyl-4-phenylpyridinium
induced injury. Int J Mol Sci. 2015;16(7):14395–408.
229. Zhou T, Zu G, Zhang X, Wang X, Li S, Gong X, et al.
Neuroprotective effects of ginsenoside Rg1 through the Wnt/β- -
catenin signaling pathway in both invivo and invitro models of
Parkinson’s disease. Neuropharmacology. 2016;101:480–9.
230. Zhang J, Wu C, Gao L, Du G, Qin X.Astragaloside IV derived
from Astragalus membranaceus: a research review on the pharma-
cological effects. Adv Pharmacol. 2020;87:89–112.
231. Xu Z, Yang D, Huang X, Huang H. Astragaloside IV protects
6-hydroxydopamine-induced SH-SY5Y cell model of Parkinson’s
disease via activating the JAK2/STAT3 pathway. Front Neurosci.
2021;15:631501.
Role ofHerbal Medicine inBoosting
https://t.me/medicina_free
Immune System
AnchalDabas, ParulYadav, Geetanjali, andRamSingh
Abstract
Herbal medicines are the medicines obtained from plant
sources. This is an alternate type of treatment based on
traditional knowledge and scientic evidences in many
cases. The utility of plants as whole or their parts like
fruits, owers, leaves, stem, and roots have been established for the treatment of many diseases. The active
ingredients present in the plants either alone or in combination have improved the immune system if taken with
proper care. Many studies have shown that these are better in comparison to conventional modern treatment with
respect to less or no side effects. This chapter focused on
the use of herbal medicines in boosting the immune system. This chapter covers why people prefer herbal medicines, role of some herbal plants in enhancing the immune
system, and role of some individual natural products in
boosting the immune system.
Keywords
Herbal medicine · Natural products · Secondary metabolites · Flavonoids · Polyphenols · Immunity ·
Immunomodulators
1 Introduction
Mother Nature has provided us with numerous ways to
maintain our health. Herbal drugs are one of them that are
used to treat various diseases. As per World Health
Organization (WHO), herbal medicines include herbs or
herbal materials that contain active ingredients present in
A. Dabas · P. Yadav · R. Singh (*)
Department of Applied Chemistry, Delhi Technological University,
Delhi, India
e-mail: ramsingh@dtu.ac.in
Geetanjali
Department of Chemistry, Kirori Mal College, University of Delhi,
Delhi, India
plants. Herbal materials are plant materials taken from plants
as a whole or its parts like owers, fruits, leaves, stems,
roots, and leaves. Herbal plants used to boost the immune
system is a centuries-old practice (Fig.1). These plants contain bioactive compounds that have the potential to improve
the body’s defense mechanism [1]. These plants are used to
cure various diseases like diseases caused by bacteria,
viruses, fungi, etc. [2]. Plants high in avonoids, vitamin C,
or carotenoids have been shown to improve immune function. This can stimulate interferon production, lymphocyte
activity, and increase phagocytosis [3]. Traditional medicine
systems around the world have relied on the therapeutic
properties of various plants to boost the immune system.
Scientic research has started throwing light on the potential
benets of these herbal remedies for immune support, as
interest in natural remedies and holistic health has grown in
recent years [2]. Naturally, there is a wide range of herbs
with medicinal properties that are used to make herbal medicines. This is an excellent alternative to allopathic drugs.
Allopathic drugs are available to cure diseases and thus
improve immunity, but the prohibitive cost and side effects
of these allopathic drugs demand the search for an alternative. The Ayurvedic medical system which utilizes herbal
materials not only provides that alternative, but it also outperforms allopathic medicine in terms of the limitations that
it possesses [4].
Herbal medicine is an alternative treatment that involves
the therapeutic use of various plants and plant extracts [5].
Many drugs, including morphine (derived from the opium
poppy), aspirin (derived from willow bark), quinine (derived
from cinchona bark), and digitoxin (derived from foxglove),
have herbal sources [6]. Few other examples of herbs used in
the medicinal eld are Aloe barbadensis, Ocimum tenuio-
rum, Echinacea purpurea, Tinospora cordifolia, Panax ginseng, Withania somnifera, Allium sativum, Emblica
ofcinalis, Curcuma longa, Azadirachta indica, Zingiber
ofcinale, and many more. Around 80% of the population
uses herbal remedies for primary health care in developing
countries, owing to the widespread belief that herbal drugs
© The Author(s), under exclusive license to Springer Nature Singapore Pte Ltd. 2023
A. K. Dhara, S. C. Mandal (eds.), Role of Herbal Medicines, https://doi.org/10.1007/978-981-99-7703-1_19
389
390
https://t.me/medicina_free
Fig. 1 Examples of herbal
plants used to boost the
immune system
Ashwagandha
Turmeric
A. Dabas et al.
Tulsi
Ginger
Some Ayurvedic
herbstoboost
immunity
Neem
are inexpensive, without side effects, and readily available.
The earliest records of its use date back to writings written in
Indian, Egyptian, Syrian, Chinese, Roman, and Greek languages. Classical Indian literature that explains the herbal
medicinal system includes the Sushruta Samhita,
Atharvaveda, Charak Samhita, Rigveda, and others. As a
result, the traditional medicines and herbal remedies are a
result of the rich cultural traditions and scientic history of
earlier civilizations [7, 8]. According to a report by Spherical
Insights, the Global herbal medicine market is expected to
reach USD 430.05 billion in 2030. This huge market is selfexplanatory toward rise in demand of herbal medicines.
Throughout the range of global public health, the immune
system plays an important role to keep human healthy. As
multiple-component agent, the herbal medicines control the
complex immune process and did not allow infections by
pathogens. These herbal medicines are excellent immunomodulators, and they are gaining popularity in today’s world
[9]. Furthermore, micronutrients and bioactive compounds
found in functional foods, herbal remedies, and dietary supplements can help boost the immune system [9, 10, 11]. In
this chapter, we will discuss about the use of herbal plants in
boosting the immunity. From anti-inammatory and antioxidant to antimicrobial and immune-modulating effects, these
herbs have provided us with different ways to enhance the
immunity.
Amla
2 Why People Use Herbal Medicines?
Since ancient times, the human usage of plants for healing
purposes is well known [12]. People have been using herbal
medication for many diseases without understanding their
mechanistic pathways. This has been stated that using herbs
gives one a “sense of control and a mental comfort.” Also,
patients seek home remedies for acute, frequently selflimiting diseases like colds, sore throats, or bee stings
because its access is easy than the professional care which
is uncomfortable, expensive, or sometime takes too much
time [12].
Usually, people from rural places use herbal medicines.
This is because they are well acquainted with traditional
knowledge about the herbal medicines which they have
inherited from their ancestors. This is advantageous to them
because the rural area lacks access to modern medical care
[13–15]. Additionally, reports of herbal toxicities are signicantly less common than reports of unfavorable side effects
of modern allopathic drugs. The inclusion of herbal medicines in daily routine supports a strong immune system, general health, and well-being. The likes of brewed herbal teas,
soups, tinctures, or nutraceuticals enhances the immune system. In recent times, even the urban people have started
using the herbal medicines and supplements to keep themselves healthy.
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