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170 Direct contrast venography
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(b)
Figure 15.1 (a) Tourniquet is applied for the first part of
the (arrow) study in order to direct the contrast mixed blood into the deep veins. Note that the anterior tibial vein is hardly filled. (b) The tourniquet has now been released. Superficial vein do now fill (arrow) and the ante­rior tibial veins are also filled (arrow heads).
Typically, a tourniquet is tightly placed around the ankle at the beginning of the examination (Figure 15.1). e pur- pose of the maneuver is to direct the contrast into the deep venous system. is enables examination of the deep veins of the calf. Because of how supercial the anterior tibial vein is at the ankle level, it may not ll with the tourniquet applied. When the deep veins have been evaluated, the tourniquet is released; the supercial veins will ll with further contrast injection, as will the anterior tibial vein and the muscular branches, if they have not lled already (Figure 15.1).
Typically, a second tourniquet is placed around the upper or lower part of the knee. e purpose of this is to delay the contrast ow to the thigh veins, allowing time to adequately evaluate the lower leg veins. is tourniquet is released, typically aer the ankle tourniquet is released, and then a larger bolus of contrast-enhanced blood will enter the thigh veins and ow towards the pelvic veins (Figure
Figure 15.2 Before (a) and after (b) release of the tourni-
quet (arrow) at the knee. Note the normal looking dupli-
after the release (arrow head). Contrast will now fill the thigh veins and by squeezing the calf contrast bolus can be pressed up into the thigh veins.
15.2). Up to this time, the table has been kept tilted with the
head end at 40–60°. When the thigh veins have been evalu­ated, the head end of the table can be lowered to horizontal level or even to a head down (Trendelenburg) position, and the contrast-enhanced blood can be observed owing into the pelvic veins and up to the inferior vena cava.
During the venogram, the examiner can turn the leg inwards and outwards and take X-rays in dierent obliq­uities in order to better understand the anatomy and any possible pathology.
By pressing on the sole of the foot, contrast lling the plantar venous plexus (Figure 15.3) can be ejected up into the calf, which will increase the visualization of the calf veins. A similar technique can be applied to the higher leg segment, when manual compression of the calf forces con­trast into the thigh veins, increasing the opacication of these veins.
e contrast of choice is non-ionic contrast medium, typically with 300 mg/mL of iodine. For good lling of the venous system, 100–150 mL of contrast should be injected rmly. It is best to have an assistant injecting the contrast while the person performing the study rotates the leg medi­ally and laterally under uoroscopic visualization and takes images (X-rays) intermittently for review and documenta­tion (Figure 15.4). Dierent positions of the limb help with three-dimensional understanding and clarify the anatomy and possible pathology.
15.2 Lower extremity ascending venography 171
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Figure 15.3 The plantar veins are nicely filled (arrow).
By compressing the sole, a bolus of contrast can be “squeezed” into the calf veins increasing the visibility of the calf veins.
15.2.2 Indications
Diagnosis of DVT was the main indication for ascending venography until ultrasound took its place. Ascending venography still has its place in a select group of patients where ultrasound has either been negative or inconclusive, but with high suspicion of DVT, as well as in instances where ultrasound cannot be relied upon or cannot be per­formed for some reasons (e.g., presence of a cast, severe swelling, scar tissue, etc.). e American College of Chest Physicians recommendations for the diagnosis of DVT pub­lished in 2012 stated that: “In patients with suspected rst lower extremity DVT in whom [ultrasound] is impractical (e.g. when leg casting or excessive subcutaneous tissue or uid prevent adequate assessment of compressibility) or nondiagnostic, we suggest [computed tomography] scan venography or magnetic resonance (MR) venography, or MR direct thrombus imaging could be used as an alterna­tive to venography.” when high-quality venography is available, patients who are not averse to the discomfort of venography, are less con­cerned about the complications of venography, and place a high value on avoiding treatment of false-positive results are likely to choose conrmatory venography if ndings
6
ey also add that: “In circumstances
Figure 15.4 (a) Lateral view from a right lower extremity
venogram. clarifies the anatomy which is normal but the anterior tibial vein is not filled well, probably due to the tourniquet compressing the vein at the ankle.
(b) Front view (PA). Comparing the two views
for DVT are less certain (e.g. a short segment of venous no compressibility).” e new problem is related to the lack of experience of some physicians/institutions. Indeed, the per­formance of this study demands an understanding of the technical aspects, as well as extensive training in the prac­tice and interpretation of the results/images.
In many cases, acute DVT causes occlusion of the vein, which will then be seen on the venography as an abrupt termination of the contrast-lled vein (Figure 15.5a). Frequently, there is slight ow around the thrombus— between the vein wall and the thrombus—giving an impres­sion of lines up along the vein, referred to as the “tram track
5, 7,8
sign” (Figure 15.5b).
Abrupt occlusion and the tram track sign are oen regarded as the diagnostic signs of acute DVT. e thrombus may not be occlusive, but rather rmly adherent to the wall of the vessel on one side, but allow­ing contrast to ow around the thrombus (the lling defect sign) (Figure 15.5c).
Chronic post-thrombotic changes are easily documented on an ascending venogram. Use of an ankle tourniquet is very important to direct the contrast into the deep vein sys­tem. If there are chronic thrombotic changes in the deep veins, the pressure in the deep veins is typically high and
172 Direct contrast venography
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Figure 15.5 (a) Occlusion (arrow head) of one of the two peroneal vein branches with a filling defect (arrow). (b) Tra m
tracks are faintly seen as contrast is traveling between the thrombus and the vessel wall (arrows) and the density is most when seen “tangential.” (c) Thrombus adherent to the vein on one side but allowing flow around it (arrows) on the oppo­site side. Sometimes it is only held in place by the thrombus caudal and then it is referred to as a free floating thrombus or thrombus tail.
ow is diverted into the supercial system. e degree of post-thrombotic changes varies from a patent vein with possible smaller-than-expected diameter and lack of valves (Figure 15.6a) to complete occlusion with no lling of the vein lumen. In-between ndings, corresponding to septa­tions or webs from the thrombus recanalization process, involve small strands of contrast tracking along the pre­viously healthy veins, looking like a “water lter” (Figure
15.6b).
Venography of patients with Klippel–Trenaunay syn-
drome presents a logistical problem. e indication for a venogram in this case is to demonstrate the patency and size of the deep venous system, the extent of the super­cial veins, and the communication from the supercial system to the deep system. e deep system can oen be small (hypoplastic); therefore, it is important to have tight tourniquets around the ankle in order to divert the con­trast into the deep system (Figure 15.7). In dicult cases, Alomari9 recommended identifying the perforating veins initially using ultrasound. Tourniquets could then be placed at the level of the identied perforators, trying to prevent early lling of the perforators,9 so that the deep system can be better evaluated. In other instances, it may be the marginal (lateral veins) and other congenital por­tions of the system that are of interest for pre-operative evaluation. In such cases, large volumes of contrast may
9
be needed to ll the veins adequately
; therefore, Alomari9 recommended using diluted contrast and subtractions imaging.
Figure 15.6 (a) Right lower leg ascending venogram.
Note normal valve sinuses in the anterior tibial vein (arrow) indicative of normal vein. The peroneal vein is smooth with “wave” outlines and no valves, indicative of chronic postthrombotic changes (arrow head). Note varicosity of the small saphenous vein with filling of the vasa vasorum (hollow arrow head) possible indicating recent superficial thrombophlebitis. (b) Typical postthrombotic changes with a “water filter” appearance from the recanalization’s process with webs (arrow).
15.3 Lower extremity descending venography 173
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Left
Figure 15.7 Klippel Trenaunay syndrome left side. (a) Prominent greater saphenous vein appearing to communicate with
the deep vein (arrow head). saphenous vein drains prepubic into the contralateral greater saphenous vein (arrow head).
Currently, perforators are localized and evaluated for
incompetence using ultrasound and Doppler, but the
(b) Small femoral vein (arrow). No filling of the common femoral vein (arrow) and the greater
15.3 LOWER EXTREMITY DESCENDING VENOGRAPHY
technique of identifying and marking perforators with ascending venography can be helpful. When looking for an incompetent perforator, a tourniquet should be placed around the ankle to force the contrast into the deep venous system and prevent contrast ow directly into the super­cial system. On ascending venogram, an incompetent
Ultrasound with Doppler can give accurate indications of the location of the venous valvular incompetence. In the 1980s, descending venography was popularized, mainly for evaluating valvular competence in the central lower extremity veins as workup for valvular surgery.
14
perforating vein can be seen lling from the deep venous system towards the supercial system (Figure 15.8).10 It helps to have a measuring device (radiopaque ruler) next to the examined leg at the same time, so that the perfo­rators can be identied on the leg using bone landmarks such as the malleoli.
11
How good is ascending venography at detecting acute DVT? Ascending venography served as the reference study (gold standard) when evaluating new technology for the diagnosis of DVT. Hull et al.12 followed patients who had negative venography for DVT and found that two out of 160 (1.3%) patients who were not treated based on negative ascending venography presented within 8 days with veri­able DVT. is was felt to be a strong indication that patients with symptoms that are suggestive of DVT but with nega­tive ascending venograms could safely forgo treatment.12 Ascending venography requires expertise and training, and one study found that 10%–15% of ascending venography examinations were inadequate for diagnostic purposes due to insucient contrast.
13
15.3.1 Technique
Descending venography requires placement of a catheter at the common femoral vein level (junction of the external iliac and common femoral vein), or at the popliteal vein level in the case of competent common femoral and femoral valves but suspicion of popliteal and calf incompetence (this may require popliteal vein puncture).15 Access can be gained from any accessible vein where a catheter can be advanced to the common femoral veins, such as the internal jugular veins, arm veins, contralateral common femoral vein, and even the ipsilateral common femoral vein. is performed on a tilt-table with the head end elevated to approximately 60°. A footrest is in place and a block placed under the contralateral foot such that the studied leg is free. Contrast is then injected at 7 mL/second, with a total volume of 70 mL, and the patient is asked to perform the Valsalva maneuver during the injection. Care has to be taken that the X-ray equipment is positioned such that the contrast can be
14,16
e procedure
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grade 3 indicates incompetence of the popliteal vein but not beyond that, not opacifying the deep veins of the calf; and nally, grade 4 reux includes the deep veins of the calf down to the ankle level. is grading is for the deep veins only, but by positioning the catheter close to the ostium of the greater saphenous vein, reux in that vein can also be evaluated in a similar manner. It is important to note that the test will not give any indication of the competency of the valve beyond the most cephalic competent valve unless a catheter is placed below that level, either with direct punc­ture or by advancing a catheter distal to that level.
15.3.2 Indications
Figure 15.8 A perforating vein (arrow) from the poste-
rior tibial vein to superficial varicosities. Note tourniquet around the ankle (arrow head).
followed below the knee and up to the inferior vena cava dur­ing and immediately following the injection.
Using uoroscopy, the examiner observes contrast ow down the leg and images are taken, typically consisting of spot images, but the uoroscopic evaluation can also be stored as a “video recording.”17 e reux is then graded based on how far down the leg along the axial deep veins the contrast descends during the injection.
14,18
Grade 0 indicates no contrast beyond the common femoral vein conuence; grade 1 indicates reux into the femoral vein down to, but not beyond, the mid-thigh (Figure 15.9); grade 2 indicates reux beyond the mid-thigh but not into the popliteal vein;
is study is mostly used to map for valve surgery.
17
Descending venography is invasive and ultrasound with Doppler has very much replaced it for patient workup. One of the challenges of the interpretation of the examination is that contrast may “leak” through the valves. It is oen dicult to decide whether this is true reux or clinically unimportant “leaky valves.”
15.4 UPPER EXTREMITY VENOGRAPHY
Venography of the upper extremity is, in many regards, akin to what was described for the lower extremity.
Venography is rarely used for the diagnosis of DVT of the upper extremity, but occasionally ultrasound is not con­vincing or uncertain, and in those cases, venography pro­vides the answer.
15.4.1 Technique
e venogram is carried out in a similar way to lower extremity venogram. An 18–20-gauge Angiocath is placed into a dorsal hand vein and 20–30 mL of non-ionic contrast with 300 mg/mL of iodine is injected. A tourniquet can be placed at the elbow level or just above in order to force the contrast into the deep vein system. e same criteria are used to diagnose thrombus as for lower extremity DVT.8 Sometimes, the venogram is performed with injection into a dorsal hand vein. is is done for the purposes of delin­eating the venous anatomy, such as before the creation of a dialysis stula. In such a case, it is best to place the access needle peripherally in order to achieve dispersal of the con­trast into the supercial veins as well as the deep veins.
Venous thoracic outlet syndrome is caused by compres­sion of the subclavian vein as it passes out of the chest in front of the anterior scalene muscle, behind the costocla­vicular muscle and between the collarbone and the rst rib. Venography was the most-used test for its diagnosis, but now computed tomography and MR imaging have replaced venography for the most part, onstrates whether there is occlusion or not, without identi­fying the structures around the vein.
Venography for thoracic outlet syndrome is typically done with the patient lying at on the examination table.
19,20
as venography only dem-
15.4 Upper extremity venography 175
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Left
Figure 15.9 Bilateral lower extremity descending venogram. Puncture was made into the right common femoral vein and
a catheter then advanced over the bifurcation into the left common femoral vein and the left extremity was examined. The catheter was then pulled back into the right external iliac vein just above the puncture and the right veins evaluated.
(a) Right leg venogram demonstrates grade 1 reflux into the profunda femoral and femoral veins (arrows) with reflux into
a large and incompetent greater saphenous vein (arrow head). thigh vessels. See competent valves (arrows). Also note postthrombotic changes in the greater saphenous vein which is incompetent (arrow head).
An 18–20-gauge Angiocath is placed in an antecubital vein and 20 mL of non-ionic contrast and 300 mg/mL of iodine are injected rmly. ree separate studies are typically done: the rst one has the arm lying neutral by the patient’s
(b) Left leg venogram shows Grade 1 reflux into the mid-
the third injection, one can usually see impression at the thoracic outlet in the case of compression. e diagnosis is made by the imaging of collaterals with an obstruction, typically at the inner border of the rst rib (Figure 15.10).
side; the second has the arm reaching out at 90° holding a weight, such as a 1 L saline bag, and the same injection
15.4.2 Indication
is repeated; and the nal injection is then performed with the arm stretched above the head. On the second injection, impression at the pectoralis minor muscle is visible, and on
(a) (b) (c)
Left
Direct venography is a dying imaging technique, giving way to more advanced cross-sectional imaging, such as MR imaging,
Figure 15.10 Left upper extremity venogram with maneuvers directed at the diagnosis of thoracic outlet syndrome. (a)
Neutral position. The subclavian vein is narrow (arrow) at the medial vein and there are collaterals bridging (arrow head).
(b) With the arm at 90° the central subclavian vein is obstructed (arrow) and the collaterals are still seen (arrow head). (c)
With the arm stretched above the head the subclavian vein is narrowed (arrow) but the collaterals do not fill (arrow head) probably as they are compressed.
Left
Left
176 Direct contrast venography
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computed tomography, and, not least, ultrasound. e abil­ity to visualize surrounding structures and obtain three­dimensional correlations make these studies very valuable.
e addition of ow evaluation by ultrasound is signicant. However, direct contrast venography still has a place in the evaluation of the patient with complex venous abnormalities.
Guidelines 2.5.0 of the American Venous Forum on direct contrast venography
Grade of
recommendation
No. Guideline
(1:strong; 2: weak)
2.5.1 We recommend contrast venography before performing endovenous reconstructions for acute or chronic venous disease.
2.5.2 We suggest contrast venography for patients suspected of having acute deep vein thrombosis only if other imaging modalities are inconclusive.
REFERENCES
10. Hach W. [Varicose veins of the deep perforating veins—A typical phlebologic disease picture]. Vasa
●     
= Key primary papers
★ 
= Major Review articles
◆ 
= Guidelines
1985;14(2):155 –7.
11. Massell TB and Ettinger J. Phlebography in the local­ization of incompetent communicating veins in patients with varicose veins. Ann Surg 1948;127(6):1217–25.
1. Rabinov K and Paulin S. Roentgen diagnosis of venous thrombosis in the leg. Arch Surg 1972;104(2):134–44.
2. Cronan JJ. Venous thromboembolic disease: The role of US. Radiology 1993;186(3):619–30.
3. Haeger K and Sjukhuset A. Problems of acute deep venous thrombosis: I. The interpretation of signs and symptoms. Angiology 1969;20(4):219–23.
4. Dos Santos J. La phlebographie directe. Conception, technique, premiers resultats. J Int Chir 1938;3:625–69.
5. Nicolaides AN, Kakkar VV, Field ES, and Renney JT. The origin of deep vein thrombosis: A venographic study. Br J Radiol 1971;44(525):653–63.
6. Bates SM, Jaeschke R, Stevens SM etal.; American College of Chest Physicians. Diagnosis of DVT: Antithrombotic therapy and prevention of throm­bosis, 9th ed: American College of Chest Physicians evidence-based clinical practice guidelines. Chest 2012;141(2 Suppl.):e351S – 418S.
7. Andrews RT. Contrast peripheral phlebography and pulmonary angiography for diagnosis of thromboembolism. Circulation 2004;109(12 Suppl.
1):I-22–I-27.
8. Deweese JA and Rogoff SM. Phlebographic patterns of acute deep venous thrombosis of the leg. Surgery 1963;53:99–108.
9. Alomari AI. Diversion venography—A modified tech­nique in Klippel–Trenaunay syndrome: Initial experi­ence. J Vasc Interv Radiol 2010;21(5):685–9.
12. Hull R, Hirsh J, Sackett DL etal. Clinical valid­ity of a negative venogram in patients with clini­cally suspected venous thrombosis. Circulation 1981;64 (3):622–5.
13. Leizorovicz A, Kassai B, Becker F, and Cucherat M. The assessment of deep vein thromboses for thera­peutic trials. Angiology 2003;54(1):19–24.
14. Kistner RL, Ferris EB, Randhawa G, and Kamida C. A method of performing descending venography. JVasc Surg 1986;4(5):464–8.
15. Perrin M, Bolot JE, Genevois A, and Hiltband B. Dynamic popliteal phlebography. Phlebology 1988;3(4):227–35.
★ 
16. Kistner RL and Kamida CB. Update on phlebography and varicography. Dermatol Surg 1994;21(1):71– 6.
17. Rosales A. Valve reconstructions. Phlebology 2015;30(1 Suppl.):50–8.
18. Herman RJ, Neiman HL, Yao JS, Egan TJ, Bergan JJ, and Malave SR. Descending venography: A method of evaluating lower extremity venous valvular func­tion. Radiology 1980;137(1):63–9.
19. Demondion X, Herbinet P, Van Sint Jan S, Boutry N, Chantelot C, and Cotten A. Imaging assess­ment of thoracic outlet syndrome. Radiographics 2006;26(6):1735–50.
20. Moriarty JM, Bandyk DF, Broderick DF etal. ACR appropriateness criteria imaging in the diagno­sis of thoracic outlet syndrome. J Am Coll Radiol 2015;12(5):438–43.
Grade of evidence (A: high
quality; B: moderate quality
C: low or very low quality
1 B
2 B
Computed tomography and magnetic
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resonance imaging in venous disease
TERRI J. VRTISKA AND JAMES F. GLOCKNER
16
16.1 Introduction 177
16.2 Imaging technologies: CTofvenous disease 177
16.3 Imaging technologies: MRI of venous disease 185
16.1 INTRODUCTION
Current diagnostic evaluation of disorders of the venous system have beneted from advances in state-of-the­art computed tomography (CT) and magnetic resonance imaging (MRI) applications. An understanding of the fundamentals and the appropriate utilization of each tech­nology will provide useful information for medical man­agement and decisions regarding surgical interventions for venous disease.
16.2 IMAGING TECHNOLOGIES: CTOFVENOUS DISEASE
During the past decade, CT has become a standard non­invasive imaging modality for the depiction of a wide variety of vascular anatomies and pathologies. Modern CT acquisi­tions have evolved from single-detector spiral scanners to multichannel helical CT examinations. More recently, 256­slice, 320-slice, and dual-energy CT systems have become available in many practices, and have replaced catheter­directed vascular imaging for many diagnostic studies. e proper application of modern CT techniques provides an extremely accurate, time-ecient, and cost-eective diag­nostic evaluation prior to surgical intervention.
e two dominant advantages of CT are the speed and resolution of image acquisition. Modern CT acqui­sitions can be acquired in less than a minute during a single breath-hold. In addition, submillimeter resolution details are available for accurate depiction of the imaging details communicated to clinicians using advanced post­processing techniques and 3D displays (Figure 16.1). One
additional distinct advantage of CT compared with MRI is the ability to demonstrate calcied densities such as
16.4 Summary 201 References 201
calcied granulomatous lymph nodes as a cause of superior vena cava (SVC) obstruction on pre-contrast acquisitions.
e two primary disadvantages of CT imaging of the venous system include radiation exposure and the necessity for administration of iodinated contrast material. Atypical abdominal and pelvic CT evaluation includes a radiation exposure of approximately 5–10 mSv. Ongoing eorts within the CT physics community are focused on optimiz­ing the necessary radiation required for CT acquisitions by tailoring the dose to the individual patient size via modu­lation of the radiation beam.1 Administration of iodinated contrast material is necessary for accurate evaluation of the venous system and, therefore, patients with a signicant allergic reaction to iodinated contrast material or decreased renal function should be evaluated with alternative imag­ing techniques, including ultrasound or MRI.
16.2.1 Clinical applications
16.2.1.1 SVC AND BRACHIOCEPHALIC VEINS
CT evaluation of the SVC is most commonly performed for the evaluation of acute or chronic occlusive changes, and has been shown to be a useful noninvasive imaging technique for the diagnosis of SVC and central venous disorders. Evaluation of post-procedural changes, including endovas­cular stent patency or post-operative changes of surgically placed bypass gras, can also be performed. Regardless of the indication, CT acquisitions are optimally performed by the simultaneous injection of the antecubital veins using 90–100 mL of dilute contrast material in each extremity at an injection rate of 2–3 mL/second. e bilateral arm injec­tions provide homogeneous opacication of the innominate veins and SVC, and avoid potential artifacts from unopaci­ed blood within the central venous structures (Figure 16.2).
2–5
177
178 Computed tomography and magnetic resonance imaging in venous disease
(a)
(b)
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Figure 16.1 Current computed tomography technology combined with tailored acquisition techniques and post-process-
ing applications provide accurate depiction of
(a) the thoracic and (b) abdominal venous vasculature.
(a)
(c)
(b)
Figure 16.2 (a, b) Contrast-enhanced axial and (c) coronal computed tomography of the chest demonstrate artifactual low
density filling defects because of unopacified blood flow from the right jugular vein and unopacified blood from the left brachiocephalic vein entering the opacified right brachiocephalic vein (a and c, arrows) and the superior vena cava (b and
c, arrowheads).
16.2 Imaging technologies: CTofvenous disease 179
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Subsequent injection of 20–30 cm3 of saline is helpful for ushing the contrast material from the brachial and axillary veins into the central venous system. CT acquisition using thin collimation (1–2 mm) is useful in order to provide both traditional axial images and appropriate reconstructions that can be analyzed in the coronal, sagittal, or tailored o­axis planes. Careful review of the axial images and dedi­cated reconstructions are useful for optimal visualization of venous patency, obstructed venous segments, intraluminal thrombus, and collateral venous pathways.
On contrast-enhanced (CE) CT images, acute thrombus within the SVC or central venous structures is character­ized by a low-attenuation lling defect within the lumen of the vessel (Figure 16.3). e involved venous segment may be normal caliber or expanded. Chronic occlusive changes are most commonly visualized as small, non-opacied, brotic-appearing linear densities. Extensive upper chest wall and azygous collaterals can be precisely depicted by 3D images (Figure 16.4).
An advantage of evaluation of the SVC and central venous structures by CT rather than catheter venography is the ability of CT to accurately depict the pathology resulting from venous occlusive changes. e most common cause
(a)
of obstruction of the SVC and upper venous structures is malignancy, most commonly pulmonary neoplasm. e obstruction may result from extrinsic compression due to primary or metastatic neoplasm, or from direct invasive changes. Other common causes of SVC obstruction include granulomatous disease and iatrogenic occlusive changes (transvenous cardiac pacers, central venous catheters, and post-radiation changes). Anatomic variants of the SVC can also be accurately visualized by CT evaluation, such as a le-sided SVC.
16.2.1.2 INFERIOR VENA CAVA
Accurate evaluation of the inferior vena cava (IVC) requires knowledge of potential ow artifacts that are especially prominent due to the rapid acquisitions provided by mod­ern CT scanning (Figure 16.5). In addition, knowledge of
anatomic variation of the IVC is important for determin­ing the accurate evaluation of ndings due to anatomic variation rather than pathology (Figures 16.6 and 16.7).
6–9
e ow artifacts visualized with the IVC are due to the unopacied blood from the lower extremities entering the infrarenal IVC, whereas the suprarenal IVC receives an admixture of opacied blood, due to the rapid transit of the
(b)
(c)
Figure 16.3 Thrombotic occlusion of the superior vena cava. (a) Unenhanced axial image of the chest demonstrates the
location of a tunneled central venous catheter (arrows). (b) Coronal CT image acquired with iodinated contrast material injected simultaneously via bilateral antecubital iv access shows low attenuation thrombus in the right and left brachio­cephalic veins (arrows). (c) Subsequent post-lysis catheter venogram with widely patent brachiocephalic veins.