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Chapter
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8
Complications and Adverse Sequelae of Sclerotherapy
Migraine
Triggering of migraine headaches, in patients who have an underlying history of recurrent migraines, has occurred after sclerotherapy. foamed sclerotherapy but most likely is more common with foamed sclerosing solutions. may occur in patients with a migraine diathesis. In such a case, the patient’s history is helpful, and the outcome is usually benign. A complete ophthalmologic examination is recom­mended in these patients to rule out other, more serious and treatable causative factors. Künzlberger et al describe a 23-year­old female who abruptly developed homonymous hemiano­pia and paresthesia in the hands and feet followed by a headache shortly after sclerotherapy with POL 1% liquid. This patient subsequently underwent an ophthalmologic as well as a neurologic examination, both of which were other­wise normal. A PFO was ruled out, and the patient’s constel­lation of symptoms completely resolved within 2 hours after its acute onset. In this case, an acute thrombosis of the cerebral artery, showing spontaneous and rapid resolution in an oth­erwise healthy, young patient seemed highly unlikely. The lack of an underlying PFO disfavored a paradoxical embolism caused by the intravenous injection of POL. Thus, the authors concluded that this patient’s homonymous hemianopia was caused by a vascular spasm in the contralateral cerebral hemi­sphere. This case demonstrates a phenomenon described as ‘migraine ophthalmique,’ which is characterized by homony­mous hemianopia without macular involvement, often accompanied by migraine, dizziness, and nausea. Whether or not certain patients have cortical regions more susceptible to systemically administered triggers (e.g. sclerotherapy at a distant site) is unclear. However, this case does demonstrate that this rare complication of sclerotherapy can occur inde­pendent of an air embolism, as liquid as opposed to foam POL was used as the sclerosant.
In patients having symptoms of a migraine or visual distur­bance after sclerotherapy, the practitioner should search for a PFO. If positive and future sclerotherapy sessions are desired, the practitioner should consider using liquid rather than foam, though the former can also occasionally, albeit less frequently, cause neurologic sequelae in susceptible patients. Coleridge Smith sclerotherapy patients experience visual or chest symptoms after sclerotherapy and that these typically last less than 1 hour. He recommends that patients who have had previous visual disturbances following sclerotherapy remain supine for
8,608
This can occur with and without the use of
608
Monocular retinal migraine
610
estimates that approximately 2% of his
609
10 to 30 minutes after treatment, as well as that they prevent performing inadvertent Valsalva maneuvers in the immediate post-treatment period. Strejcek
611
notes that he has been regu­larly performing foam sclerotherapy for more than 6 years, with an estimated 35,400 treatments over that period, and that he has not noted any complications in any case. He attributes this lack of complications to the fact that he always injects foam into an elevated leg, and subsequently has the patient remain supine for 10 minutes following the proce­dure. Our experience is similar to Strejcek. We rarely observe migraines in our patients and we treat reticular veins with foam sclerotherapy routinely. We do not treat truncal varicose veins with foam, except in segmental recanalization following endovenous saphenous ablative procedures.
Membranous fat necrosis
A single patient with multiple tender erythematous subcuta­neous nodules that occurred after sclerotherapy with HS solution has been reported.
612
This rare dermatologic entity is the result of subcutaneous inflammation with alteration and necrosis of adipose tissue. It also may be caused by trauma, thromboangiitis obliterans, arteriosclerosis, or sclero­derma. Essentially, it is a diagnosis of exclusion made on the basis of the biopsy result. In the reported patient, extrava­sation of HS solution or vessel rupture with subsequent exposure of HS to subcutaneous tissues was the probable causative event.
Summary
In summary, sclerotherapy of varicose and telangiectatic leg veins may be associated with a number of complications and adverse sequelae, which may occur despite expert and optimal treatment. Some adverse sequelae are preventable to a limited degree, but given a large enough number of procedures, these adverse sequelae will occur in any practice. Complications can be minimized with adherence to principles of slow injection, minimal sclerosant concentration, low injection pressures and watchful technique. As with any procedure, sclerotherapy has inherent risks, although with low incidence considering the millions of procedures performed worldwide. Each patient should be evaluated and informed accordingly before initiat­ing treatment. A summary of the common complications that can occur with the commonly used sclerosing agents is pre­sented in Table 8.3.
Table 8.3 Summary of complications of sclerosing agents
Solution Pigmentation Allergic Reaction Necrosis Pain
Sodium morrhuate
Sodium tetradecyl sulfate
Ethanolamine oleate
Polidocanol
Hypertonic saline
Sclerodex (10% saline + 25% dextrose) +
Chromated glycerin 0
Glycerin 0 0 0
Polyiodinated iodine
+, Minimal; ++, moderate; +++, significant. *Concentration dependent.
224
++ ++ +++* +++
++ + ++* +
+ ++ ++* ++
+ + +*
+
++ + +++* +++
0
0
+
+++* +++
+ ++
0
0
++
+
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