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References
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C H A P T E R
Noninvasive Examination of the Patient Before Sclerotherapy
Before sclerotherapy is performed, the examiner must obtain a focused history and perform a meticulous physical exami­nation including inspection and palpation (level 1). This combination places the patient into a proper clinical classifica­tion and this, in turn, will dictate therapy. For example, primary venous insufficiency is characterized by telangiecta­sias, reticular varicosities, and varicose veins without the stigmata of chronic venous disease. The latter has charac­teristic hyperpigmentation, edema, ulceration, or scarring from healed ulcers. The presence of chronic disease findings aids the examiner to be more insistent regarding further evaluation.
Confirmatory diagnostic testing is performed after the history is taken and the physical examination performed. The handheld continuous-wave Doppler historically was a routine part of the physical examination but is slowly being replaced by compact, portable duplex ultrasound visualization. At present, the vascular laboratory (level 2) provides a reliable tool for acquiring anatomic and functional information that not only confirms the diagnosis but also formulates treatment. Elements of the diagnostic vascular laboratory are slowly becoming part of a routine physical examination. examination of the venous system is becoming a more impor­tant diagnostic tool. This approach has been confirmed in the guidelines of the American Venous Forum.
Invasive testing such as phlebography and ambulatory venous pressure (level 3) measurements, while of historical significance, have been relegated to a secondary role as large amounts of data are obtained from duplex ultrasound. The level of diagnostic testing is dictated by the severity of the clinical condition.
2
1
A duplex
Medical History
A focused history is the beginning of every evaluation for any patient with a suspected vascular disorder. A clear understand­ing and detailed description of the symptoms is the first step. Recording of the patient’s concerns and reasons for seeking treatment should also be done at this time since patients concerned by pain at first interrogation may focus on esthetics in subsequent sessions following treatment of primary sources of reflux. Symptoms of venous insufficiency have been termed nonspecific. However, patients with clear symptoms of venous insufficiency typically do not ascribe these to varicose veins. Symptoms include aching tiredness and far ranging discom­fort in the legs, relieved by sitting and leg elevation. Such discomfort increases as the day progresses with increased vein stretching. In women symptoms are exacerbated on the first days of a menstrual period, since elevated progesterone levels cause increase vein swelling. Symptoms may also begin in pregnancy. It has been said that for males with varicose veins the lack of progesterone or estrogen results in fewer symptoms.
The magnitude of symptoms is not dependent on the size of the varicosities. Telangiectasias and reticular varicosities may cause symptoms identical to those of gross varicose veins. Since symptoms are due to pressure of dilated veins on somatic nerves, it is not surprising that some patients experience burning near varices. This is thought to be ischemic neuropa­thy, but may be capillary pressure related. A disabling bursting pain that develops on standing or sitting with legs dependent and that is relieved by muscular activity is paradoxically called venous claudication, although incorrectly.
A family history of varicose veins is common. A personal and family history of a diagnosis of venous thrombosis should be requested. If present, it is important to clarify the way in which this diagnosis was confirmed (phlebography, venous duplex, or simply clinically). The patient should be prompted to recall specific aspects of their medical history, such as trau­matic fractures, leg swelling, need for systemic anticoagulation, illness requiring bed rest, or major surgical intervention.
CEAP classification
An international ad hoc committee of the American Venous Forum developed the CEAP classification for chronic venous disease in 1994 (Table 5.1; see also Chapter 2) with the goal of stratifying clinical levels of venous insufficiency. The four categories and descriptors selected for classification were clini­cal state (C), etiology (E), anatomy (A), and pathophysiology (P). The CEAP classification has been endorsed worldwide, despite its acknowledged deficiencies. It has been adopted as a standard in many clinics in Europe, Asia, South America, and the United States it is considered the only modern method for reporting data. It’s weakness is the inability to distinguish between levels of smaller superficial veins. The CEAP classifica­tion was revised in 2004,
4
CEAP.
It includes:
Clinical assessment:
C1 is presence of telangiectatic and reticular veins (see
definitions in Chapter 2)
C2 is presence of varicose veins
C3 is presence of venous edema
C4 is presence of skin changes (C4a for pigmentation
and/or eczema, C4b for lipodermatosclerosis and/or atrophie blanche)
C5 is presence of healed ulcer
C6 of an active ulcer.
The descriptor (a) is added for asymptomatic patients and (s) in case of symptoms.
All clinical features must be reported in the advanced CEAP; for example a patient with telangiectasias, varicose veins, edema, pigmentation, active ulcer and pain is classified C6s in the basic (classical) CEAP but will be C1,2,3,4a,6,s in the advanced (revised) CEAP. This approach carries much more information but stratifies the patients’ samples.
3
and is now referred to as ‘advanced’
Table 5.1 CEAP classification
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CLINICAL CLASSIFICATION
C0 No visible or palpable signs of venous disease
C1 Telangiectasias or reticular veins
C2 Varicose veins – separated from reticular veins by a diameter of 3 mm as the upper limit of size of a reticular vein
C3 Edema
C4 Changes in the skin and subcutaneous tissue secondary to chronic venous disease are divided into two subclasses to better define the
differing severity of venous disease: C4a Pigmentation and eczema C4b Lipodermatosclerosis and atrophie blanche
C5 Healed venous ulcer
C6 Active venous ulcer
Each clinical class is further characterized by a subscript for the presence of symptoms (S, symptomatic) or their absence (A, asymptomatic). Symptoms include aching, pain, tightness, skin irritation, heaviness, and muscle cramps, as well as other complaints attributable to venous dysfunction.
ETIOLOGIC CLASSIFICATION
Ec Congenital
Ep Primary
Es Secondary (postthrombotic)
En No venous etiology identified
ANATOMIC CLASSIFICATION
As Superficial veins
Ap Perforator veins
Ad Deep veins
An No venous location identified
PATHOPHYSIOLOGIC CLASSIFICATION
Basic CEAP
Pr Reflux
Po Obstruction
Pro Reflux and obstruction
Pn No venous pathophysiology identifiable
Advanced CEAP
Same as Basic with the addition that any of 18 named venous segments (below) can be utilized as locators for venous pathology.
All items listed in C should be repeated.
VENOUS SEGMENTS
Superficial veins
1 Telangiectasias/reticular veins
2 GSV above knee
3 GSV below knee
4 SSV
5 Nonsaphenous veins
Deep veins
6 IVC
7 Common iliac vein
8 Internal iliac vein
9 External iliac vein
10 Pelvic: gonadal, broad ligament veins, other
11 Common femoral vein
12 Deep femoral vein
13 Femoral vein
14 Popliteal vein
15 Crural: anterior tibial, posterior tibial, fibular veins (all paired)
16 Muscular: gastrocnemial, soleal veins, other
Perforating veins
17 Thigh
18 Calf
Medical History
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Noninvasive Examination of the Patient Before Sclerotherapy
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Etiology is reported by descriptor E: Ec is congenital
(usually present at birth), Ep is primary (degenerative, typically varicose veins), Es is secondary (like in post-thrombotic syndrome), En is for no venous etiology identified.
Anatomy is described by the A: As for superficial
(venous network involvement), Ap for perforators, Ad for deep, An when no venous location has been identified. Involved venous segments are recorded with a number (see Table 5.1).
Pathophysiology is reported by the P descriptor: Pr for
reflux, Po for obstruction, Pro for association of both and Pn if pathophysiology has not been recognized. Here again, involved venous segments must be recorded by numbers (see Table 5.1).
Date of patient’s evaluation
Level of examination: L1 (level 1) is clinical plus
continuous wave Doppler, L2 is noninvasive (duplex ultrasound, plethysmography), L3 includes complex imaging such as computed tomography (CT) and magnetic resonance imaging (MRI) and invasive investigations such as venograms, intravenous ultrasound and blood pressure measurement.
Diagnostic approach
The first step in evaluating a patient with venous disease is to establish his or her clinical class, which rapidly progresses from cosmetic to chronic venous insufficiency. The next is to correlate the symptoms, which place the limb being examined into one of the classes shown in Table 5.1. The patient’s clini­cal class will dictate the need for further evaluation. In patients with telangiectasias (class 1 or 2), the evaluation can be limited to a physical examination and evaluation of the superficial venous system with a handheld continuous-wave Doppler. Imaging of 83 limbs with clinical evidence of only telangiectatic vessels demonstrated that nearly 25% had insuf­ficiency of the great saphenous vein (GSV) or small saphenous veins (SSV), which was not apparent on physical examina-
5
tion.
Patients with symptomatic class 2 varicosities and class 4, 5, and 6 skin changes require a duplex venous reflux exami­nation because surgical intervention is indicated. trant cases may require more extensive imaging studies to detect venous occlusive disease. Physiologic testing can be relegated to documentation rather than to diagnosis, and phlebography should be performed only when venous recon­struction is contemplated.
Prior treatment
The physician should discuss prior treatment for venous disease. However, he or she must realize that although proper ligation, with or without stripping of the main saphenous trunks, implies that reflux through the saphenofemoral junc­tion (SFJ) and saphenopopliteal junction (SPJ) has been pre­vented, this is not always the case. Some have proposed that in up to 27% of patients there is a duplication of the GSV; thus, the removal of the GSV may be followed by the develop­ment of varicosity in the remaining GSV, although this is not universally accepted.
In 20% to 40% the SSV has a variable termination is not in the popliteal vein at or above the popliteal fossa. Therefore, the actual SPJ must be correctly diagnosed other­wise it will lead to an apparent rapid recurrence with varicose changes occurring in the remaining segment of the SSV and its tributaries. Finally, in a number of patients, a recurrence of varicose veins in the upper thigh may be the result of incom­plete ligation and division of the other tributaries arising at the level of the SFJ or failure to accomplish the ligation flush with the femoral vein. In fact, in a review of 341 extremities that underwent repeat operations for varicose veins, Lofgren
6–10
Recalci-
14–17
11–13
that
et al17 found that 61% had inadequate ligation. These facts make it imperative that, even in the patient with a history of ligation, division, and stripping, an examination for reflux through the SFJ and SPJ be performed.
The physician should consider responses to and complica­tions from all treatment modalities (sclerotherapy, laser, etc.). Certain complications, such as ischemic ulceration caused by injection into an arteriovenous malformation, can be avoided more easily if their prior diagnosis is made. Given the predi­lection for these to occur in a particular anatomic distribution(s), the physician might avoid treating that area or use greater caution in the previously affected region. A history of prior hyperpigmentation, blushing, or poor response to a particular sclerosing agent may support a variety of changes in treatment protocol, such as altering the sclerosant concentration, increas­ing the strength or duration of compression, and paying greater attention to post-treatment thrombectomy.
Symptoms
It is not well known that presence and severity of symptoms has no correlation with the size or severity of varicose veins present. Symptoms usually attributable to varicose veins include feelings of heaviness, tiredness, aching, burning, throbbing, itching, and cramping in the legs (Box 5.1). These symptoms are generally worse with prolonged sitting or standing and are improved with leg elevation or walking. A premenstrual exacerbation of symptoms is also common. Patients typically find relief with the use of compression in the form of either support hose or an elastic bandage if they are compliant. Compliance can be a challenge. Weight loss or the commencement of a regular program of lower extremity exercise may also lead to a diminution in the sever­ity of varicose vein symptoms. Clearly, these symptoms are not specific, as they may also be indicative of a variety of rheumatologic or orthopedic problems. However, their rela­tionship to lower extremity movement and compression is usually helpful in establishing a venous origin for the symp­toms. Significant symptoms suggestive of chronic venous disease should prompt further evaluation for valvular insuf­ficiency and calf muscle pump dysfunction. If a venous etio­logy is suspected but all examinations are negative, repeat examination during a symptomatic period is warranted and often fruitful.
The recent development of an extremely painful area on the lower leg associated with an overlying area of erythema and warmth may be indicative of lipodermatosclerosis, which may be associated with insufficiency of underlying perforator veins or reflux from a proximal point. Examination for under­lying perforator vein reflux should be performed. Lipoderma­tosclerosis may precede ulceration and has been shown to be improved by stiff compression and certain pharmacologic interventions.
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Rarely, patients with a history of iliofemoral thrombophle­bitis who describe ‘bursting’ pain with walking may be suffer­ing from ‘venous claudication’. In these patients, an evaluation for persistent hemodynamically significant obstruction, pos­sibly treatable with venous bypass surgery, is appropriate.
Box 5.1
Symptoms attributable to varicose veins
• Aching
• Heaviness, tiredness
• Pain (throbbing, burning, sharp, tingling)
• Itching
• Cramping
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Complications of varicose vein disease
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Complications such as ulceration and hemorrhage should be discussed with the patient because this provides additional insight into both the severity and the probable locations of abnormality within the venous system. A history of ulceration of the medial aspect of the lower leg should prompt further examination of the GSV trunk,
6
whereas involvement of the lateral aspect of the lower leg suggests an abnormality in the SSV, in addition to the deep and perforating vein systems. A history of hemorrhage from telangiectasias in a particular area suggests further examination for underlying incompetent perforators and is an indication to treat all suspicious telangiectasias.
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Purpose of Venous Evaluation
More extensive evaluation can provide essential information regarding both venous anatomy and function. Abnormalities of the superficial, perforating, or deep systems can be diag­nosed, and the exact sites of valvular insufficiency within the various systems (and therefore the sites where treatment must be directed) can be determined. The hemodynamic signifi­cance of each of these abnormalities may be defined, and the effect of correcting each site of reflux may be assessed. Insuf­ficiency at a particular site within the venous system may be found to have no importance in the patient’s pathologic venous hypertension or symptoms. This site may or may not be incorporated into the treatment plan to minimize the number of treatments. With the examination techniques dis­cussed in the following sections, the result of sclerotherapy may be documented in a more accurate and sensitive manner than with simple observation and palpation. Treatment success may be enhanced significantly with the goal being restoration of normal venous flow. If the presence of deep venous thrombosis (DVT) and/or deep venous valvular insuf­ficiency are detected, these are absolute and relative contrain­dications to sclerotherapy. Once properly diagnosed, serious
complications in these non-candidates for sclerotherapy can be avoided.
Physical Examination
The best way to approach examination of the venous system before sclerotherapy is to be methodical. Although the exact method is a matter of personal preference, a systematic approach is advisable.
Using skills of clinical practice, the practitioner can obtain a degree of information regarding overall venous outflow from the leg, the sites of valvular insufficiency, the presence of primary versus secondary varicose veins, and the presence of DVT.
The screening physical examination consists of careful observation of the legs. Any patient with the following condi­tions should be examined more fully: large varicose veins; bulges in the thigh, calf, or the inguinal region representative of incompetent perforating veins (IPVs) or a saphena varix; signs of superficial venous hypertension, such as an accumula­tion of telangiectasias in the ankle region (corona phlebec­tatica); or any finding suggestive of venous dermatitis (pigmentation, induration, eczema). This includes patients with obvious cutaneous signs of venous disease, such as venous ulceration, atrophie blanche, or lipodermatosclerosis. An obvious but often forgotten point is the necessity of observ­ing the entire leg and not confining the examination simply to the area that the patient feels is abnormal. The importance of this is demonstrated in Figure 5.1. This patient came for treatment of an obviously dilated anterior thigh vein, but further inspection revealed a saphena varix, with incompe­tence at the level of the SFJ; thus defining the first step in her treatment. Similarly, patients often seek treatment of specific clusters of telangiectasia and do not notice the underlying reticular veins that should be treated before or at the same time (see Chapter 12).
Finally, because the veins of the leg empty into the pelvic and abdominal veins, inspection of the abdomen is very
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Physical Examination
A
Figure 5.1 A, This patient sought treatment because of an obviously enlarged vein in her thigh. B, Further inspection revealed a saphena varix (arrow)
indicative of saphenofemoral junction insufficiency.
B
(Courtesy Anton Butie, MD)
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important, since dilation of veins on the abdominal wall or across the pubic region suggests an old iliofemoral thrombus or, rarely, a developmental anomaly of the venous system.
22
23
Dilated veins along the medial or posterior aspect of the proxi­mal thigh or buttocks most often arise from varicosities involving the pudendal or other pelvic vessels. These can be associated with vulvar varices that may remain symptomatic after the completion of the pregnancy during which they formed. The enlarged veins in the thigh or buttocks may also be quite symptomatic and respond well to treatment.
Cough test
One hand is placed gently over the GSV or SFJ and the patient is asked to cough or perform a Valsalva maneuver (Fig. 5.3). Simply palpating an impulse over the vein being examined may be indicative of insufficiency of the valve at the SFJ and below to the level of the palpating hand. This test, however, is not applicable to the examination of the SSV and SPJ (see following section). ver is generally more diagnostic. One study found a low sen­sitivity of 0.59 and low specificity of 0.67 with this test.
14
Palpation of a thrill during this maneu-
25
Clinical testing
Historically, tests of venous function have been part of the physical examination of venous insufficiency. These tests have been slowly abandoned due to lack of specificity and sensitiv­ity. As the ‘stethoscope’ of the venous examination, the continuous-wave Doppler examination has replaced most of these tests, while confirmatory duplex testing has supplanted all. With that being said, an educated physician who treats venous insufficiency must have knowledge of these tests and their physiologic background.
Knowledge of the Trendelenburg test (or Brodie­Trendelenburg test) is important for understanding venous physiology and is of historical significance.
Noninvasive Examination of the Patient Before Sclerotherapy
Trendelenburg test
For the Trendelenburg test, a tourniquet may be placed around the patient’s proximal thigh while the patient is standing. The patient then assumes the supine position with the affected leg elevated 45 degrees. The tourniquet is removed and the time required for the leg veins to empty, which is indicative of the adequacy of venous drainage, is recorded.
When compared with the contralateral leg, the method just described may demonstrate a degree of venous obstructive disease. Another approach is to elevate the leg while the patient is supine and to observe the height of the heel in rela­tion to the level of the heart that is required for the prominent veins to collapse (Fig. 5.2). Unfortunately, neither procedure is sufficiently sensitive or accurate, or able to differentiate acute from chronic obstruction, which means neither of them is much assistance in current medical practice. This empha­sizes the important role of duplex ultrasound in modern evaluation of the superficial venous system. One study found that pneumatic tourniquets only occluded 27% of saphenous
24
trunks. described below, can provide information on the competence of the venous valves.
Several other physical examination maneuvers,
Percussion/Schwartz test
One hand is placed over the SFJ or SPJ while the other hand is used to tap very lightly on a distal segment of the GSV or SSV (Fig. 5.4). The production of an impulse in this manner implies insufficiency of the valves in the segment between the two hands. Confirmation of valvular insufficiency can be achieved by tapping proximally while palpating distally. This test can also be used to detect whether an enlarged tributary is in direct connection with the GSV or SSV by palpating over the main trunk and tapping lightly on the dilated tributary, or vice versa. The presence of a direct connection results in a palpable impulse being transmitted from the percussing to the palpating hand. As might be expected, these tests are far from infallible. In a study of 105 limbs, Chan et al these clinical examination techniques correctly identified SFJ incompetence in only 82% of limbs. False negatives were believed to be caused primarily by previous groin surgery with resultant scarring and by obesity. However, false positives were the result of variations in venous anatomy, such as a dilated tributary emptying into the common femoral vein (CFV) adjacent to the GSV or the absence of valves in an oth­erwise normal CFV and external iliac vein (seen in 5% to 30% of patients).
0.59 with a high specificity of 0.92.
27,28
Another study showed a low sensitivity of
25
A further source of error with the cough and/or percussion test is simply a misinterpre­tation of the muscle contraction that occurs with coughing as a reflux impulse.
26
found that
Figure 5.2 Venous outflow may also be assessed by elevating the leg until
the superficial veins collapse and then measuring the distance (X) from the heart to the heel and comparing this measurement with the other leg.
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X
Figure 5.3 Cough test. The saphenofemoral junction (SFJ) is palpated
while the patient coughs. Palpation of an impulse is indicative of SFJ insufficiency.
Figure 5.4 Percussion test. The saphenopopliteal junction (SPJ) is palpated
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while the small saphenous vein is gently percussed. Palpation of an impulse is indicative of SPJ insufficiency.
Brodie-Trendelenburg test
The Brodie-Trendelenburg test traditionally involves the manual obstruction of the proximal end of the GSV (or SSV) while the patient lies supine with the leg elevated, after strok­ing the vein in a cephalad direction to empty it of blood. The patient then assumes the standing position, and the leg is observed for 30 seconds (Fig. 5.5). In a ‘nil’ test there is slow filling of the veins from below, and the release of the compres­sion does not result in rapid filling from above, indicating competence of valves in deep and perforating veins and at the SFJ (Fig. 5.6A). Rapid filling of the GSV or more distal tributar­ies that occurs only after release of the compression consti­tutes a ‘positive’ test, indicating the presence of an insufficient valve at the SFJ (Fig. 5.6B). In the ‘double-positive’ test, some distension of the veins occurs within the initial 30 seconds while the compression is maintained, as well as additional filling once the compression is released (Fig. 5.6C). This is taken as evidence of incompetent deep and perforating veins as well as reflux through the SFJ. A ‘negative’ test occurs when the veins fill within the initial 30 seconds with no increased filling after the compression is released, implying only deep and perforating valvular insufficiency (Fig. 5.6D). The reverse may not be true; that is, filling in longer than 30 seconds does not imply competence of perforating veins. In a study of 901 extremities, Sherman
33
found that 95% had a nil Trendelen­burg test, but surgical exploration later showed incompetent perforators in 90% of these patients. Another study showed a high sensitivity of 0.91 with a low specificity of 0.15.
The Brodie-Trendelenburg test thus can be an important method of localizing the most proximal site of reflux in most dilated superficial veins by obstructing the GSV, SSV, or whichever vein is suspected of refluxing into a more distal vein. The physician can also place the examining finger over palpable fascial defects in the leg while the patient is supine and then release the obstructions one by one after the patient is standing. This allows the sites of insufficient perforators, or ‘points of control’ (considered so crucial in Fegan’s technique of sclerotherapy), to be defined, because the superficial veins distal to the insufficient perforator fill rapidly once the obstructing fingers are removed (see Chapter 9).
22,29–32
25
34,35
With this technique, described well in many papers, the practitioner first marks on the leg the sites of all dilated varicosities. The patient then assumes the supine position with the leg elevated to approximately 60 degrees to empty the veins. After at least 20 seconds, or when the distended veins are flattened, the leg is gently and rapidly palpated to detect any defects in the fascia. With experience, these can be detected easily as places that allow the entrance of the examining finger without the use of any pressure. Fascial defects can be caused by many abnormalities other than perforating veins, thus the practitioner continues the examination by compressing the individual fascial defects with his or her fingers and then having the patient stand. The fingers are then released one by one, starting with the most distal defect, and rapid filling of more distal varicosities is noted (Fig. 5.7). Those defects that cause distal filling when released are assumed to correspond to sites of IPVs. In the presence of a dilated GSV or SSV, these points of reflux first must be controlled with either digital compression or a tourniquet to evaluate the lower volume reflux through the perforators. For the evaluation to be helpful, compression of the defects must first cause sustained flatten­ing of the varicosities when the patient initially stands. If the veins fill before any of the fingers are released, the test must be restarted and other sites compressed until the sites respon­sible for the reflux are located. This examination is associated with a 50% to 70% accuracy
36–39
compared with findings at surgical exploration. Repeated examination at different times and improvement of edema allows the detection of increased numbers of perforators.
Bracey Variation
A clever variation of the Brodie-Trendelenburg technique was proposed by Bracey cm-wide, rubber tourniquet and two rubber rings covered with latex, with inside diameters of 7 cm and 8.2 cm. The smaller ring is used between the ankle and knee and may also be used for the thigh if the patient is thin. If not, the larger ring is used for the thigh. With the patient standing, the small ring is rolled over the foot to just above the ankle, and the rubber tourniquet is then placed below the ring to obstruct any upward flow of blood through the superficial veins. The small ring is then slowly rolled upward, emptying the super­ficial veins as it moves. As soon as it passes an IPV, the blood enters the superficial vein that connects with it, causing a dila­tion of the vein. The exit site of the perforating vein may then be marked. This reflux of blood can be accentuated by asking the patient to repetitively dorsiflex the foot. When the ring reaches the knee, the tourniquet is moved up to the knee, just below the ring. Either the smaller or larger ring is then used similarly to examine the thigh.
40
in 1958 (Fig. 5.8). He used a flat, 3.8-
Perthes’ test
The Perthes’ test ing between venous valvular insufficiency in the deep, perfora­tor, and superficial systems and screening for DVT (Table 5.2). To localize the site of valvular disease, the physician places a tourniquet around the proximal thigh with the patient stand­ing. When the patient ambulates, a decrease in the distension of varicose veins suggests a primary process without underly­ing deep venous disease because the calf muscle pump effec­tively removes blood from the leg and empties the varicose veins. Secondary varicose veins do not change caliber (if there is patency of the deep venous system) because of the inability to empty blood out of the veins as a result of impairment of the calf muscle pump. In the setting of a concurrent DVT, they may increase in size. If there is significant chronic or acute obstructive disease in the iliofemoral segment, the patient may note pain (venous claudication) obstruction to outflow through both the deep and superficial
22,32,41
has several uses, including distinguish-
42–44
as a result of the
21,34–37
Physical Examination
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