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Kaixiong Tao Hui Cao
Editors
Clinical Management of Gastrointestinal Stromal Tumor
123
Clinical Management of Gastrointestinal Stromal Tumor
Kaixiong Tao • Hui Cao
Editors
Clinical Management of Gastrointestinal Stromal Tumor
Editors
Kaixiong Tao Gastrointestinal Surgery Wuhan Union Hospital Wuhan, China
Hui Cao Gastrointestinal Surgery Renji Hospital Shanghai, China
ISBN 978-981-99-9391-8 ISBN 978-981-99-9392-5 (eBook)
https://doi.org/10.1007/978-981-99-9392-5
© People's Medical Publishing House, PR of China 2024 Jointly published with People's Medical Publishing House, PR of China This work is subject to copyright. All rights are solely and exclusively licensed by the Publisher, whether the whole or part of the material is concerned, specically the rights of reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microlms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specic statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publishers, the authors, and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publishers nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. The publishers remain neutral with regard to jurisdictional claims in published maps and institutional afliations.
This Springer imprint is published by the registered company Springer Nature Singapore Pte Ltd. The registered company address is: 152 Beach Road, #21-01/04 Gateway East, Singapore 189721, Singapore
If disposing of this product, please recycle the paper.

Contents

Part I Surgical Management of Gastrointestinal Stromal Tumors
1 Laparoscopic Management of Gastrointestinal Stromal Tumors . . . . . . . . . . . . . 3
Tao Wang, Ming Wang, Gan Mao, Jie Jia, and Hui Cao
2 Laparoscopic Combined with Endoscopic Management
of Gastrointestinal Stromal Tumors . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 9
Xinyu Zeng, Ming Wang, Qian Shen, Huikuan Chu, and Gang Zhao
3 Da Vinci Robotic Management of Gastrointestinal Stromal Tumors. . . . . . . . . . . 17
Tao Wang, Ming Cai, and Yanbing Zhou
4 Endoscopic Management of Gastrointestinal Stromal Tumors . . . . . . . . . . . . . . . 21
Qi Jiang, Zhen Ding, Jiaxian Yu, Lei Tu, and Yingjiang Ye
Part II Preoperative Treatment of Gastrointestinal Stromal Tumors
5 Rectal Gastrointestinal Stromal Tumors with Preoperative Treatment . . . . . . . . 31
Yao Lin, Youwei Kou, Chengguo Li, Xing Liu, and Jiren Yu
6 Giant Abdominal Gastrointestinal Stromal Tumors
with Preoperative Treatment . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 39
Lei Yang, Xiaodong Gao, and Kuntang Shen
7 Preoperative Treatment of Duodenal Gastrointestinal Stromal Tumors . . . . . . . . 43
Yongzhou Huang, Yuan Yin, and Zhiqiang Ma
8 Avapritinib Therapy for Preoperative Treatment of Gastrointestinal
Stromal Tumors with PDGFRA Mutation . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 47
Bo Ni, Linxi Yang, and Kaixiong Tao
9 Preoperative Treatment of Rectal- Vaginal Septum Gastrointestinal
Stromal Tumors . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 53
Wenchang Yang, Zhidong Gao, and Yingjiang Ye
Part III Uncommon Pathological Types of Gastrointestinal Stromal Tumors
10 Small Hypermitotic Gastrointestinal Stromal Tumors . . . . . . . . . . . . . . . . . . . . . . 63
Jianbo Lyu, Xin Chen, and Yong Li
11 Mitotic Extremely High Gastrointestinal Stromal Tumors . . . . . . . . . . . . . . . . . . . 69
Pei Zhou, Zhen Xiong, and Kaixiong Tao
12 Neurofibromatosis Type 1 Associated Gastrointestinal Stromal Tumors . . . . . . . 75
Yao Lin, Xiangyu Zeng, Chengguo Li, Zhidong Gao, and Jian Li
v
vi
13 Succinate Dehydrogenase Deficient GIST . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 83
Peng Zhang, Weizhen Liu, Yuqiang Du, and Bo Zhang
14 KIT Mutant Gastrointestinal Stromal Tumors with Lymphatic
Metastasis . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 93
Yongzhou Huang, Xiangyu Zeng, and Ye Zhou
15 Gastrointestinal Stromal Tumors with PDGFRA Exon 18 D842V
Mutation . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 99
Liwu Zeng, Peng Zhang, and Kailin Cai
16 Multiple Gastrointestinal Stromal Tumors . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 105
Peng Zhang, Yuan Yin, Xinyu Zeng, Qun Zhao, and Jun Zhang
17 Hereditary Gastrointestinal Stromal Tumors . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 113
Xiaoqi Li, Linxi Yang, and Gang Zhao
Part IV Gastrointestinal Stromal Tumors with Other Malignant Tumors
18 Intermediate-Risk Gastrointestinal Stromal Tumor
with Advanced Gastric Cancer
. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 119
Tianlong Ling, Haibo Qiu, and Leping Li
19 Gastrointestinal Stromal Tumors with Kidney Cancer . . . . . . . . . . . . . . . . . . . . . . 125
Chen Huang, Ruizhi Zhang, and Yong Li
Contents
Part V Targeted Therapy for Gastrointestinal Stromal Tumors
20 Gastrointestinal Stromal Tumors Progression During Adjuvant
Therapy . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 133
Tianlong Ling, Ming Wang, and Xianfa Wang
21 Gastrointestinal Stromal Tumors Recurrence After Stopping
Adjuvant Therapy . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 139
Xiaoqi Li, Wenze Wan, and Han Liang
22 Low Risk Rectal Gastrointestinal Stromal Tumors Recurrence
12 Years After Surgery . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 145
Xiaoqi Li, Cong Li, and Zekuan Xu
23 Surgery Combined with Targeted Therapy in Advanced
Gastrointestinal Stromal Tumors . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 149
Chun Zhuang, Ming Wang, Haibo Qiu, and Ye Zhou
24 Avapritinib Therapy in Advanced Gastrointestinal Stromal
Tumor with PDGFRA Mutation . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .161
Xiaoqi Li, Xinli Ma, and Gang Zhao
25 Therapy for Advanced Gastrointestinal Stromal Tumors . . . . . . . . . . . . . . . . . . . . 165
Xinli Ma, Ming Wang, Kuntang Shen, Xinhua Zhang, Bo Ni, Linxi Yang, and Hui Cao
26 Management of Targeted Drug Adverse Reaction . . . . . . . . . . . . . . . . . . . . . . . . . . 179
Bo Ni, Jian Li, and Lin Shen
Contents
vii
Part VI Management of Patients with Special Gastrointestinal Stromal Tumors
27 Senile Gastrointestinal Stromal Tumors with Coronary Heart Disease . . . . . . . . 185
Chun Zhuang, Tianlong Ling, and Guoqing Liao
28 Gastric Gastrointestinal Stromal Tumors with Gastroparesis
After Surgery . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 191
Lin Tu, Peng Zhang, and Junbo Hu
29 Gastrointestinal Stromal Tumors with Brain Metastases . . . . . . . . . . . . . . . . . . . .197
Lin Tu, Tao Chen, and Zhigang Jie
30 Gastrointestinal Stromal Tumors with Giant Liver Metastases . . . . . . . . . . . . . . . 203
Linxi Yang, Tianlong Ling, and Kaixiong Tao
Part VII Management of Misdiagnosed Gastrointestinal Stromal Tumors
31 Small Intestine Gastrointestinal Stromal Tumor Misdiagnosed
as Gynecological Tumor . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 209
Lin Tu, Youwei Kou, and Jinbo Gao
32 Castleman Disease Misdiagnosed as Gastrointestinal Stromal Tumor . . . . . . . . . 215
Chen Huang, Chun Zhuang, and Yulong He
33 Other Primary Malignant Tumors Misdiagnosed as Recurrent
Gastrointestinal Stromal Tumor . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 219
Bo Ni, Lin Tu, Chen Huang, Xin Wu, Wenchang Yang, Weizhen Liu, and Hui Cao

Editors and Contributors

Editor in Chief

Kaixiong Tao Department of Gastrointestinal Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
Hui Cao Department of Gastrointestinal Surgery, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China

Compile Secretary

Peng Zhang Department of Gastrointestinal Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
Ming Wang Department of Gastrointestinal Surgery, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China

Review Experts

Hui Cao Department of Gastrointestinal Surgery, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China
Gang Zhao Department of Gastrointestinal Surgery, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China
YanbingZhou Department of Gastrointestinal Surgery, The Afliated Hospital of Qingdao University, Qingdao, China
YingjiangYe Department of Gastrointestinal Surgery, Peking University People’s Hospital, Beijing, China
JirenYu Department of Gastrointestinal Surgery, The First Afliated Hospital of Zhejiang University School of Medicine, Hangzhou, China
Kuntang Shen Department of Gastrointestinal Surgery, Zhongshan Hospital, Fudan University, Shanghai, China
ZhiqiangMa Department of Gastrointestinal Cancer, Arion Cancer Center, Beijing, China
Kaixiong Tao Department of Gastrointestinal Surgery, Union Hospital, Tongji Medical
College, Huazhong University of Science and Technology, Wuhan, China
Yong Li Department of Gastrointestinal Surgery, Guangdong Provincial People’s Hospital, Guangzhou, China
ix
x
Jian Li Department of Gastrointestinal Oncology, Peking University Cancer Hospital & Institute, Beijing, China
Bo Zhang Department of Gastrointestinal Surgery, Huaxi Hospital, Sichuan University, Chengdu, China
YeZhou Department of Gastric Surgery, Fudan University Cancer Hospital, Shanghai, China
KailinCai Department of Gastrointestinal Surgery, Union Hospital, Tongji Medical College
of Huazhong University of Science and Technology, Wuhan, China
JunZhang Department of Gastrointestinal Surgery, The First Afliated Hospital of Chongqing Medical University, Chongqing, China
Leping Li Department of Gastrointestinal Surgery, Shandong Provincial Hospital, Jinan, China
YongLi Department of General Surgery, The Fourth Hospital of Hebei Medical University, Shijiazhuang, China
XianfaWang Department of General Surgery, Sir Run Run Shaw Hospital, afliated with the Zhejiang University School of Medicine, Hangzhou, China
HanLiang Department of Gastric Surgery, Tianjin Medical University Cancer Institute & Hospital, Tianjin, China
Editors and Contributors
Zekuan Xu Department of Gastric Surgery, The First Afliated Hospital with Nanjing Medical University, Nanjing, China
Lin Shen Department of Gastrointestinal Oncology, Peking University Cancer Hospital & Institute, Beijing, China
Guoqing Liao Department of Gastrointestinal Surgery, Xiangya Hospital, Central South University, Changsha, China
JunboHu Department of Gastrointestinal Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
Zhigang Jie Department of General Surgery, The First Afliated Hospital of Nanchang University, Nanchang, China
JinboGao Department of Gastrointestinal Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology University, Wuhan, China
Yulong He Digestive Diseases Center, The Seventh Afliated Hospital of Sun Yat⁃sen University, Shenzhen, China

Case Providers

Ming Wang Department of Gastrointestinal Surgery, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China
Jie Jia Department of Gastrointestinal Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
Huikuan Chu Department of Gastroenterology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
MingCai Department of Gastrointestinal Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
Editors and Contributors
xi
Zhen Ding Department of Gastroenterology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
LeiTu Department of Gastroenterology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
YouweiKou Department of Gastrointestinal Surgery, Shengjing Hospital of China Medical University, Shenyang, China
Xing Liu Department of Colorectal Surgery, Fujian Medical University Union Hospital, Fuzhou, China
Xiaodong Gao Department of General Surgery, Zhongshan Hospital, Fudan University, Shanghai, China
YuanYin Department of Gastrointestinal Surgery, West China Hospital, Sichuan University, Chengdu, China
Linxi Yang Department of Gastrointestinal Surgery, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China
ZhidongGao Department of Gastrointestinal Surgery, Peking University People’s Hospital, Beijing, China
XinChen Department of Gastrointestinal Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
ZhenXiong Department of Gastrointestinal Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
Xiangyu Zeng Department of Gastrointestinal Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
Weizhen Liu Department of Gastrointestinal Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
Peng Zhang Department of Gastrointestinal Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
QunZhao Department of General Surgery, The Fourth Hospital of Hebei Medical University, Shijiazhuang, China
HaiboQiu Department of Gastric Surgery, Sun Yat-sen University Cancer Center, Guangzhou, China
Ruizhi Zhang Department of Gastrointestinal Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
WenzeWan Department of Gastrointestinal Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
CongLi Department of Colorectal Surgery, Sun Yat-sen University Cancer Center, Guangzhou, China
Xinli Ma Department of Gastrointestinal Surgery, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China
XinhuaZhang Department of Gastrointestinal Surgery, The First Afliated Hospital of Sun Yat-sen University, Guangzhou, China
Jian Li Department of Gastrointestinal Oncology, Peking University Cancer Hospital & Institute, Beijing, China