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Файл:Ординатура / Хирургия / Библиотека им академика М.И. Перельмана / Книга_706_Библиотеки_им_академика_М_И_Перельмана.pdf
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- •Contents
- •Editors and Contributors
- •Editor in Chief
- •Compile Secretary
- •Review Experts
- •Case Providers
- •1.1.2.2 Physical Examination
- •1.1.2.3 Auxiliary Examination
- •1.1.3 Therapy
- •1.1.3.1 Case Analysis
- •1.1.3.2 Treatment
- •1.1.4 Prognosis
- •1.2.1 Introduction
- •1.2.2 Case Background
- •1.2.2.2 Physical Examination
- •1.2.2.3 Auxiliary Examination
- •1.2.3 Therapy
- •1.2.3.1 Case Analysis
- •1.2.3.2 Treatment
- •1.2.4 Prognosis
- •1.3 Expert Comments
- •References
- •2.1.1 Introduction
- •2.1.2 Case Background
- •Translators
- •1.1.1 Introduction
- •1.1.2 Case Background
- •2.1.2.2 Physical Examination
- •2.1.2.3 Auxiliary Examination
- •2.1.3 Therapy
- •2.1.3.1 Case Analysis
- •2.1.3.2 Treatment
- •2.1.4 Prognosis
- •2.2.1 Case Background
- •2.2.1.2 Physical Examination
- •2.2.1.3 Auxiliary Examination
- •2.2.2 Therapy
- •2.2.2.1 Case Analysis
- •2.2.2.2 Treatment
- •2.2.3 Prognosis
- •2.3 Expert Comments
- •References
- •3.1.1 Introduction
- •3.1.2 Case Background
- •3.1.2.2 Physical Examination
- •3.1.2.3 Auxiliary Examination
- •3.1.3 Therapy
- •3.1.3.1 Case Analysis
- •3.1.3.2 Treatment
- •3.1.4 Prognosis
- •3.2 Expert Comments
- •References
- •4.1.1 Introduction
- •4.1.2 Case Background
- •4.1.2.2 Physical Examination
- •4.1.2.3 Auxiliary Examination
- •4.1.2.4 Primary Diagnosis
- •4.1.3 Therapy
- •4.1.3.1 Case Analysis
- •4.1.3.2 Treatment
- •4.1.4 Prognosis
- •4.2.1 Introduction
- •4.2.2 Case Background
- •4.2.2.2 Physical Examination
- •4.2.2.3 Auxiliary Examination
- •4.2.2.4 Primary Diagnosis
- •4.2.3 Therapy
- •4.2.3.1 Case Analysis
- •4.2.3.2 Treatment
- •4.2.4 Prognosis
- •4.3 Expert Comments
- •References
- •5.1.1 Introduction
- •5.1.2 Case Background
- •5.1.2.2 Physical Examination
- •5.1.2.3 Auxiliary Examination
- •5.1.3 Therapy
- •5.1.3.1 Case Analysis
- •5.1.3.2 Treatment
- •7.1.1 Introduction
- •7.1.2 Case Background
- •7.1.2.2 Physical Examination
- •5.1.4 Prognosis
- •5.2.1 Case Background
- •5.2.1.2 Physical Examination
- •5.2.1.3 Auxiliary Examination
- •5.2.2 Therapy
- •5.2.2.1 Case Analysis
- •5.2.2.2 Treatment
- •5.2.3 Prognosis
- •5.3 Expert Comments
- •References
- •6.1.1 Introduction
- •6.1.2 Case Background
- •6.1.2.2 Physical Examination
- •6.1.2.3 Auxiliary Examination
- •6.1.3 Therapy
- •6.1.3.1 Case Analysis
- •6.1.3.2 Treatment
- •6.1.4 Prognosis
- •6.2 Expert Comments
- •References
- •7.1.2.3 Auxiliary Examination
- •7.1.2.4 Primary Diagnosis
- •7.1.3 Therapy
- •7.1.3.1 Case Analysis
- •7.1.3.2 Treatment
- •7.1.4 Prognosis
- •7.2 Expert Comments
- •References
- •8.1.1 Introduction
- •8.1.2 Case Background
- •8.1.2.2 Physical Examination
- •8.1.2.3 Auxiliary Examination
- •8.1.2.4 Preliminary Diagnosis
- •8.1.3 Therapy
- •8.1.3.1 Case Analysis
- •8.1.3.2 Therapy
- •8.1.4 Prognosis
- •8.1.5.2 Close Assessment Is Key during Preoperative Therapy
- •8.2 Expert Comments
- •References
- •9.1.1 Introduction
- •9.1.2 Case Background
- •9.1.2.2 Physical Examination
- •9.1.2.3 Auxiliary Inspection
- •9.1.3 Therapy
- •9.1.3.1 Case Analysis
- •9.1.3.2 Treatment
- •9.1.3.4 Prognosis
- •9.2 Expert Comments
- •References
- •10: Small Hypermitotic Gastrointestinal Stromal Tumors
- •10.1.1 Introduction
- •10.1.2 Case Background
- •10.1.2.2 Physical Examination
- •10.1.2.3 Auxiliary Examination
- •10.1.3 Therapy
- •10.1.3.1 Case Analysis
- •10.1.3.2 Treatment
- •10.1.4 Prognosis
- •10.2 Expert Comments
- •References
- •11: Mitotic Extremely High Gastrointestinal Stromal Tumors
- •11.1.1 Introduction
- •11.1.2 Case Background
- •11.1.2.2 Physical Examination
- •11.1.2.3 Auxiliary Examination
- •11.1.2.4 Primary Diagnosis
- •11.1.3 Therapy
- •11.1.3.1 Case Analysis
- •11.1.3.2 Treatment
- •11.1.4 Prognosis
- •11.2 Expert Comments
- •References
- •12: Neurofibromatosis Type 1 Associated Gastrointestinal Stromal Tumors
- •12.1.1 Introduction
- •12.1.2 Case Background
- •12.1.2.2 Physical Examination
- •12.1.2.3 Auxiliary Examination
- •12.1.2.4 Preliminary Diagnosis
- •12.1.3 Therapy
- •12.1.3.1 Case Analysis
- •12.1.3.2 Treatment
- •12.1.4 Prognosis
- •12.2.1 Case Background
- •12.2.1.2 Physical Examination
- •12.2.1.3 Auxiliary Examination
- •12.2.1.4 Preliminary Diagnosis
- •12.2.2 Therapy
- •12.2.2.1 Case Analysis
- •12.2.2.2 Treatment
- •12.2.3 Prognosis
- •12.3 Expert Comments
- •References
- •13: Succinate Dehydrogenase Deficient GIST
- •13.1.1 Introduction
- •13.1.2 Case Background
- •13.1.2.2 Physical Examination
- •13.1.2.3 Auxiliary Examination
- •13.1.2.4 Preliminary Diagnosis
- •13.1.3 Therapy
- •13.1.3.1 Case Analysis
- •13.1.3.2 Treatment
- •13.1.4 Prognosis
- •13.2.1 Case Background
- •13.2.1.2 Physical Examination
- •13.2.1.3 Auxiliary Examination
- •13.2.2 Primary Diagnosis
- •13.2.3 Therapy
- •13.2.3.1 Case Analysis
- •13.2.3.2 Treatment
- •13.2.4 Prognosis
- •13.3 Expert Comments
- •References
- •14.1.1 Introduction
- •14.1.2 Case Background
- •14.1.2.2 Physical Examination
- •14.1.2.3 Auxiliary Examination
- •14.1.3 Primary Diagnosis
- •14.1.4 Therapy
- •14.1.4.1 Case Analysis
- •14.1.4.2 Treatment
- •14.1.5 Prognosis
- •14.2 Expert Comments
- •References
- •15.1.1 Introduction
- •15.1.2 Case Background
- •15.1.2.2 Physical Examination
- •15.1.2.3 Auxiliary Examination
- •15.1.2.4 Preliminary Diagnosis
- •15.1.3 Therapy
- •15.1.3.1 Case Analysis
- •15.1.3.2 Treatment
- •15.1.4 Prognosis
- •15.2 Expert Comments
- •References
- •16: Multiple Gastrointestinal Stromal Tumors
- •16.1.1 Introduction
- •16.1.2 Case Background
- •16.1.2.2 Physical Examination
- •16.1.2.3 Auxiliary Examination
- •16.1.2.4 Preliminary Diagnosis
- •16.1.3 Therapy
- •16.1.3.1 Case Analysis
- •16.1.3.2 Treatment
- •16.1.4 Prognosis
- •16.2.1 Case Background
- •16.2.1.2 Physical Examination
- •16.2.1.3 Auxiliary Examination
- •16.2.1.4 Preliminary Diagnosis
- •16.2.2 Therapy
- •16.2.2.1 Case Analysis
- •16.2.2.2 Treatment
- •16.2.3 Prognosis
- •16.3 Expert Comments
- •References
- •17: Hereditary Gastrointestinal Stromal Tumors
- •17.1.1 Introduction
- •17.1.2 Case Background
- •17.1.2.2 Physical Examination
- •17.1.2.3 Auxiliary Examination
- •17.1.2.4 Preliminary Diagnosis
- •17.1.3 Therapy
- •17.1.3.1 Case Analysis
- •17.1.3.2 Treatment
- •17.1.4 Prognosis
- •17.2 Expert Comments
- •References
- •18.1.1 Introduction
- •18.1.2 Case Background
- •18.1.2.2 Physical Examination
- •18.1.2.3 Auxiliary Examination
- •18.1.2.4 Preliminary Diagnosis
- •18.1.3 Therapy
- •18.1.3.1 Case Analysis
- •18.1.3.2 Treatment
- •18.1.3.3 Postoperative Pathology
- •18.1.4 Prognosis
- •18.1.5.3 Adjuvant Therapy
- •18.2 Expert Comments
- •References
- •19.1.1 Introduction
- •19.1.2 Case Background
- •19.1.2.2 Physical Examination
- •19.1.2.3 Preliminary Diagnosis
- •19.1.3 Therapy
- •19.1.3.1 Case Analysis
- •19.1.3.2 Treatment
- •19.1.4 Prognosis
- •19.2 Expert Comments
- •References
- •20: Gastrointestinal Stromal Tumors Progression During Adjuvant Therapy
- •20.1.1 Introduction
- •20.1.2 Case Background
- •20.1.2.2 Physical Examination
- •20.1.2.3 Auxiliary Examination
- •20.1.2.4 Preliminary Diagnosis
- •20.1.3 Therapy
- •20.1.3.1 Case Analysis
- •20.1.3.2 Treatment
- •20.1.4 Prognosis
- •20.2 Expert Comments
- •References
- •21: Gastrointestinal Stromal Tumors Recurrence After Stopping Adjuvant Therapy
- •21.1.1 Introduction
- •21.1.2 Case Background
- •21.1.2.2 Physical Examination
- •21.1.2.3 Auxiliary Examination
- •21.1.2.4 Preliminary Diagnosis
- •21.1.3 Therapy
- •21.1.3.1 Case Analysis
- •21.1.3.2 Treatment
- •21.1.3.3 Postoperative Pathology
- •21.1.4 Prognosis
- •21.2 Expert Comments
- •References
- •22: Low Risk Rectal Gastrointestinal Stromal Tumors Recurrence 12 Years After Surgery
- •22.1.1 Introduction
- •22.1.2 Case Background
- •22.1.2.2 Physical Examination
- •22.1.2.3 Auxiliary Examination
- •22.1.2.4 Preliminary Diagnosis
- •22.1.3 Therapy
- •22.1.3.1 Case Analysis
- •22.1.3.2 Treatment
- •22.1.3.3 Postoperative Pathology
- •22.1.4 Prognosis
- •22.2 Expert Comments
- •References
- •23.1.1 Introduction
- •23.1.2 Case Background
- •23.1.2.2 Physical Examination
- •23.1.2.3 Auxiliary Examination
- •23.1.2.4 Preliminary Diagnosis
- •23.1.3 Therapy
- •23.1.3.1 Case Analysis
- •23.1.3.2 Treatment
- •23.1.4 Prognosis
- •23.2.1 Case Background
- •23.2.1.2 Physical Examination
- •23.2.1.3 Auxiliary Examination
- •23.2.1.4 Preliminary Diagnosis
- •23.2.2 Therapy
- •23.2.2.1 Case Analysis
- •23.2.2.2 Treatment
- •September 2010
- •November 2013
- •December 2015
- •23.2.3 Prognosis
- •23.3 Expert Comments
- •References
- •24.1.1 Introduction
- •24.1.2 Case Background
- •24.1.2.2 Physical Examination
- •24.1.2.3 Preliminary Diagnosis
- •24.1.3 Therapy
- •24.1.3.1 Auxiliary Examination
- •24.1.3.2 Case Analysis
- •24.1.4 Prognosis
- •24.2 Case Review
- •References
- •25.1.1 Introduction
- •25.1.2 Case Background
- •25.1.2.2 Physical Examination
- •25.1.2.3 Auxiliary Examination
- •25.1.2.4 Preliminary Diagnosis
- •25.1.3 Therapy
- •25.1.3.1 Case Analysis
- •25.1.3.2 Treatment
- •25.1.4 Prognosis
- •25.2 Expert Comments
- •25.3.1 Introduction
- •25.3.2 Case Background
- •25.3.2.2 Physical Examination
- •25.3.2.3 Preliminary Diagnosis
- •25.3.3 Therapy
- •25.3.3.1 Case Analysis
- •25.3.3.2 Treatment
- •25.3.4 Prognosis
- •25.4.1 Case Background
- •25.4.1.2 Physical Examination
- •25.4.1.3 Auxiliary Examination
- •25.4.2 Therapy
- •25.4.2.1 Case Analysis
- •25.4.2.2 Treatment
- •25.4.3 Prognosis
- •25.5 Expert Comments
- •References
- •26.1.1 Introduction
- •26.1.2 Case Background
- •26.1.2.2 Physical Examination
- •26.1.2.3 Auxiliary Examination
- •26.1.2.4 Preliminary Diagnosis
- •26.1.3 Therapy
- •26.1.3.1 Case Analysis
- •26.1.3.2 Treatment
- •26.1.4 Prognosis
- •26.2 Expert Comments
- •References
- •27.1.1 Introduction
- •27.1.2 Case Background
- •27.1.2.2 Physical Examination
- •27.1.2.3 Auxiliary Examination
- •27.1.2.4 Preliminary Diagnosis
- •27.1.3 Therapy
- •27.1.3.1 Case Analysis
- •27.1.3.2 Treatment
- •27.1.4 Prognosis
- •27.2 Expert Comments
- •References
- •28.1.1 Introduction
- •28.1.2 Case Background
- •28.1.2.2 Physical Examination
- •28.1.2.3 Auxiliary Examination
- •28.1.2.4 Preliminary Diagnosis
- •28.1.3 Therapy
- •28.1.3.1 Case Analysis
- •28.1.3.2 Treatment
- •28.1.3.3 Postoperative Pathology
- •28.1.4 Prognosis
- •28.2 Expert Comments
- •References
- •29.1.1 Introduction
- •29.1.2 Case Background
- •29.1.2.2 Physical Examination
- •29.1.2.3 Auxiliary Examination
- •29.1.2.4 Preliminary Diagnosis
- •29.1.3 Therapy
- •29.1.3.1 Case Analysis
- •29.1.3.2 Treatment
- •29.1.4 Prognosis
- •29.2 Expert Comments
- •References
- •30.1.1 Introduction
- •30.1.2 Case Background
- •30.1.2.2 Physical Examination
- •30.1.2.3 Auxiliary Examination
- •30.1.3 Therapy
- •30.1.3.1 Case Analysis
- •30.1.3.2 Treatment
- •30.1.4 Prognosis
- •30.2 Expert Comments
- •References
- •31.1.1 Introduction
- •31.1.2 Case Background
- •31.1.2.2 Physical Examination
- •31.1.2.3 Auxiliary Examination
- •31.1.2.4 Preliminary Diagnosis
- •31.1.3 Therapy
- •31.1.3.1 Case Analysis
- •31.1.3.2 Treatment
- •31.1.4 Prognosis
- •31.2 Expert Comments
- •References
- •32.1.1 Introduction
- •32.1.2 Case Background
- •32.1.2.2 Physical Examination
- •32.1.2.3 Auxiliary Examination
- •32.1.2.4 Preliminary Diagnosis
- •32.1.3 Therapy
- •32.1.3.1 Case Analysis
- •32.1.3.2 Treatment
- •32.1.4 Prognosis
- •32.2 Expert Comments
- •References
- •33.1.1 Introduction
- •33.1.2 Case Background
- •33.1.2.2 Physical Examination
- •33.1.2.3 Auxiliary Examination
- •33.1.2.4 Preliminary Diagnosis
- •33.1.3 Therapy
- •33.1.3.1 Case Analysis
- •33.1.3.2 Therapy
- •33.1.4 Prognosis
- •33.2.1 Case Background
- •33.2.1.2 Physical Examination
- •33.2.1.3 Auxiliary Examination
- •33.2.1.4 Preliminary Diagnosis
- •33.2.2 Therapy
- •33.2.2.1 Case Analysis
- •33.2.2.2 Treatment
- •33.2.3 Prognosis
- •33.3.1 Case Background
- •33.3.1.2 Physical Examination
- •33.3.1.3 Auxiliary Examination
- •33.3.1.4 Primary Diagnosis
- •33.3.2 Therapy
- •33.3.2.1 Case Analysis
- •33.3.2.2 Treatment
- •33.3.2.3 Postoperative Pathology
- •33.3.3 Prognosis
- •33.3.4.4 Rhabdomyosarcoma
- •33.4 Expert Comments
- •References

Kaixiong Tao
Hui Cao
Editors
Clinical Management of
Gastrointestinal
Stromal Tumor
123

Clinical Management of Gastrointestinal
Stromal Tumor

Kaixiong Tao • Hui Cao
Editors
Clinical Management of
Gastrointestinal Stromal
Tumor

Editors
Kaixiong Tao
Gastrointestinal Surgery
Wuhan Union Hospital
Wuhan, China
Hui Cao
Gastrointestinal Surgery
Renji Hospital
Shanghai, China
ISBN 978-981-99-9391-8 ISBN 978-981-99-9392-5 (eBook)
https://doi.org/10.1007/978-981-99-9392-5
© People's Medical Publishing House, PR of China 2024
Jointly published with People's Medical Publishing House, PR of China
This work is subject to copyright. All rights are solely and exclusively licensed by the Publisher, whether the whole or
part of the material is concerned, specically the rights of reprinting, reuse of illustrations, recitation, broadcasting,
reproduction on microlms or in any other physical way, and transmission or information storage and retrieval,
electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed.
The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not
imply, even in the absence of a specic statement, that such names are exempt from the relevant protective laws and
regulations and therefore free for general use.
The publishers, the authors, and the editors are safe to assume that the advice and information in this book are believed
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If disposing of this product, please recycle the paper.

Contents
Part I Surgical Management of Gastrointestinal Stromal Tumors
1 Laparoscopic Management of Gastrointestinal Stromal Tumors . . . . . . . . . . . . . 3
Tao Wang, Ming Wang, Gan Mao, Jie Jia, and Hui Cao
2 Laparoscopic Combined with Endoscopic Management
of Gastrointestinal Stromal Tumors . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 9
Xinyu Zeng, Ming Wang, Qian Shen, Huikuan Chu, and Gang Zhao
3 Da Vinci Robotic Management of Gastrointestinal Stromal Tumors. . . . . . . . . . . 17
Tao Wang, Ming Cai, and Yanbing Zhou
4 Endoscopic Management of Gastrointestinal Stromal Tumors . . . . . . . . . . . . . . . 21
Qi Jiang, Zhen Ding, Jiaxian Yu, Lei Tu, and Yingjiang Ye
Part II Preoperative Treatment of Gastrointestinal Stromal Tumors
5 Rectal Gastrointestinal Stromal Tumors with Preoperative Treatment . . . . . . . . 31
Yao Lin, Youwei Kou, Chengguo Li, Xing Liu, and Jiren Yu
6 Giant Abdominal Gastrointestinal Stromal Tumors
with Preoperative Treatment . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 39
Lei Yang, Xiaodong Gao, and Kuntang Shen
7 Preoperative Treatment of Duodenal Gastrointestinal Stromal Tumors . . . . . . . . 43
Yongzhou Huang, Yuan Yin, and Zhiqiang Ma
8 Avapritinib Therapy for Preoperative Treatment of Gastrointestinal
Stromal Tumors with PDGFRA Mutation . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 47
Bo Ni, Linxi Yang, and Kaixiong Tao
9 Preoperative Treatment of Rectal- Vaginal Septum Gastrointestinal
Stromal Tumors . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 53
Wenchang Yang, Zhidong Gao, and Yingjiang Ye
Part III Uncommon Pathological Types of Gastrointestinal Stromal Tumors
10 Small Hypermitotic Gastrointestinal Stromal Tumors . . . . . . . . . . . . . . . . . . . . . . 63
Jianbo Lyu, Xin Chen, and Yong Li
11 Mitotic Extremely High Gastrointestinal Stromal Tumors . . . . . . . . . . . . . . . . . . . 69
Pei Zhou, Zhen Xiong, and Kaixiong Tao
12 Neurofibromatosis Type 1 Associated Gastrointestinal Stromal Tumors . . . . . . . 75
Yao Lin, Xiangyu Zeng, Chengguo Li, Zhidong Gao, and Jian Li
v

vi
13 Succinate Dehydrogenase Deficient GIST . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 83
Peng Zhang, Weizhen Liu, Yuqiang Du, and Bo Zhang
14 KIT Mutant Gastrointestinal Stromal Tumors with Lymphatic
Metastasis . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 93
Yongzhou Huang, Xiangyu Zeng, and Ye Zhou
15 Gastrointestinal Stromal Tumors with PDGFRA Exon 18 D842V
Mutation . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 99
Liwu Zeng, Peng Zhang, and Kailin Cai
16 Multiple Gastrointestinal Stromal Tumors . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 105
Peng Zhang, Yuan Yin, Xinyu Zeng, Qun Zhao, and Jun Zhang
17 Hereditary Gastrointestinal Stromal Tumors . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 113
Xiaoqi Li, Linxi Yang, and Gang Zhao
Part IV Gastrointestinal Stromal Tumors with Other Malignant Tumors
18 Intermediate-Risk Gastrointestinal Stromal Tumor
with Advanced Gastric Cancer
. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 119
Tianlong Ling, Haibo Qiu, and Leping Li
19 Gastrointestinal Stromal Tumors with Kidney Cancer . . . . . . . . . . . . . . . . . . . . . . 125
Chen Huang, Ruizhi Zhang, and Yong Li
Contents
Part V Targeted Therapy for Gastrointestinal Stromal Tumors
20 Gastrointestinal Stromal Tumors Progression During Adjuvant
Therapy . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 133
Tianlong Ling, Ming Wang, and Xianfa Wang
21 Gastrointestinal Stromal Tumors Recurrence After Stopping
Adjuvant Therapy . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 139
Xiaoqi Li, Wenze Wan, and Han Liang
22 Low Risk Rectal Gastrointestinal Stromal Tumors Recurrence
12 Years After Surgery . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 145
Xiaoqi Li, Cong Li, and Zekuan Xu
23 Surgery Combined with Targeted Therapy in Advanced
Gastrointestinal Stromal Tumors . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 149
Chun Zhuang, Ming Wang, Haibo Qiu, and Ye Zhou
24 Avapritinib Therapy in Advanced Gastrointestinal Stromal
Tumor with PDGFRA Mutation . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .161
Xiaoqi Li, Xinli Ma, and Gang Zhao
25 Therapy for Advanced Gastrointestinal Stromal Tumors . . . . . . . . . . . . . . . . . . . . 165
Xinli Ma, Ming Wang, Kuntang Shen, Xinhua Zhang, Bo Ni,
Linxi Yang, and Hui Cao
26 Management of Targeted Drug Adverse Reaction . . . . . . . . . . . . . . . . . . . . . . . . . . 179
Bo Ni, Jian Li, and Lin Shen

Contents
vii
Part VI Management of Patients with Special Gastrointestinal Stromal Tumors
27 Senile Gastrointestinal Stromal Tumors with Coronary Heart Disease . . . . . . . . 185
Chun Zhuang, Tianlong Ling, and Guoqing Liao
28 Gastric Gastrointestinal Stromal Tumors with Gastroparesis
After Surgery . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 191
Lin Tu, Peng Zhang, and Junbo Hu
29 Gastrointestinal Stromal Tumors with Brain Metastases . . . . . . . . . . . . . . . . . . . .197
Lin Tu, Tao Chen, and Zhigang Jie
30 Gastrointestinal Stromal Tumors with Giant Liver Metastases . . . . . . . . . . . . . . . 203
Linxi Yang, Tianlong Ling, and Kaixiong Tao
Part VII Management of Misdiagnosed Gastrointestinal Stromal Tumors
31 Small Intestine Gastrointestinal Stromal Tumor Misdiagnosed
as Gynecological Tumor . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 209
Lin Tu, Youwei Kou, and Jinbo Gao
32 Castleman Disease Misdiagnosed as Gastrointestinal Stromal Tumor . . . . . . . . . 215
Chen Huang, Chun Zhuang, and Yulong He
33 Other Primary Malignant Tumors Misdiagnosed as Recurrent
Gastrointestinal Stromal Tumor . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 219
Bo Ni, Lin Tu, Chen Huang, Xin Wu, Wenchang Yang, Weizhen Liu,
and Hui Cao

Editors and Contributors
Editor in Chief
Kaixiong Tao Department of Gastrointestinal Surgery, Union Hospital, Tongji Medical
College, Huazhong University of Science and Technology, Wuhan, China
Hui Cao Department of Gastrointestinal Surgery, Renji Hospital, Shanghai Jiaotong
University School of Medicine, Shanghai, China
Compile Secretary
Peng Zhang Department of Gastrointestinal Surgery, Union Hospital, Tongji Medical
College, Huazhong University of Science and Technology, Wuhan, China
Ming Wang Department of Gastrointestinal Surgery, Renji Hospital, Shanghai Jiaotong
University School of Medicine, Shanghai, China
Review Experts
Hui Cao Department of Gastrointestinal Surgery, Renji Hospital, Shanghai Jiaotong
University School of Medicine, Shanghai, China
Gang Zhao Department of Gastrointestinal Surgery, Renji Hospital, Shanghai Jiaotong
University School of Medicine, Shanghai, China
YanbingZhou Department of Gastrointestinal Surgery, The Afliated Hospital of Qingdao
University, Qingdao, China
YingjiangYe Department of Gastrointestinal Surgery, Peking University People’s Hospital,
Beijing, China
JirenYu Department of Gastrointestinal Surgery, The First Afliated Hospital of Zhejiang
University School of Medicine, Hangzhou, China
Kuntang Shen Department of Gastrointestinal Surgery, Zhongshan Hospital, Fudan
University, Shanghai, China
ZhiqiangMa Department of Gastrointestinal Cancer, Arion Cancer Center, Beijing, China
Kaixiong Tao Department of Gastrointestinal Surgery, Union Hospital, Tongji Medical
College, Huazhong University of Science and Technology, Wuhan, China
Yong Li Department of Gastrointestinal Surgery, Guangdong Provincial People’s Hospital,
Guangzhou, China
ix

x
Jian Li Department of Gastrointestinal Oncology, Peking University Cancer Hospital &
Institute, Beijing, China
Bo Zhang Department of Gastrointestinal Surgery, Huaxi Hospital, Sichuan University,
Chengdu, China
YeZhou Department of Gastric Surgery, Fudan University Cancer Hospital, Shanghai, China
KailinCai Department of Gastrointestinal Surgery, Union Hospital, Tongji Medical College
of Huazhong University of Science and Technology, Wuhan, China
JunZhang Department of Gastrointestinal Surgery, The First Afliated Hospital of Chongqing
Medical University, Chongqing, China
Leping Li Department of Gastrointestinal Surgery, Shandong Provincial Hospital, Jinan,
China
YongLi Department of General Surgery, The Fourth Hospital of Hebei Medical University,
Shijiazhuang, China
XianfaWang Department of General Surgery, Sir Run Run Shaw Hospital, afliated with the
Zhejiang University School of Medicine, Hangzhou, China
HanLiang Department of Gastric Surgery, Tianjin Medical University Cancer Institute &
Hospital, Tianjin, China
Editors and Contributors
Zekuan Xu Department of Gastric Surgery, The First Afliated Hospital with Nanjing
Medical University, Nanjing, China
Lin Shen Department of Gastrointestinal Oncology, Peking University Cancer Hospital &
Institute, Beijing, China
Guoqing Liao Department of Gastrointestinal Surgery, Xiangya Hospital, Central South
University, Changsha, China
JunboHu Department of Gastrointestinal Surgery, Tongji Hospital, Tongji Medical College,
Huazhong University of Science and Technology, Wuhan, China
Zhigang Jie Department of General Surgery, The First Afliated Hospital of Nanchang
University, Nanchang, China
JinboGao Department of Gastrointestinal Surgery, Union Hospital, Tongji Medical College,
Huazhong University of Science and Technology University, Wuhan, China
Yulong He Digestive Diseases Center, The Seventh Afliated Hospital of Sun Yat⁃sen
University, Shenzhen, China
Case Providers
Ming Wang Department of Gastrointestinal Surgery, Renji Hospital, Shanghai Jiaotong
University School of Medicine, Shanghai, China
Jie Jia Department of Gastrointestinal Surgery, Union Hospital, Tongji Medical College,
Huazhong University of Science and Technology, Wuhan, China
Huikuan Chu Department of Gastroenterology, Union Hospital, Tongji Medical College,
Huazhong University of Science and Technology, Wuhan, China
MingCai Department of Gastrointestinal Surgery, Union Hospital, Tongji Medical College,
Huazhong University of Science and Technology, Wuhan, China

Editors and Contributors
xi
Zhen Ding Department of Gastroenterology, Union Hospital, Tongji Medical College,
Huazhong University of Science and Technology, Wuhan, China
LeiTu Department of Gastroenterology, Union Hospital, Tongji Medical College, Huazhong
University of Science and Technology, Wuhan, China
YouweiKou Department of Gastrointestinal Surgery, Shengjing Hospital of China Medical
University, Shenyang, China
Xing Liu Department of Colorectal Surgery, Fujian Medical University Union Hospital,
Fuzhou, China
Xiaodong Gao Department of General Surgery, Zhongshan Hospital, Fudan University,
Shanghai, China
YuanYin Department of Gastrointestinal Surgery, West China Hospital, Sichuan University,
Chengdu, China
Linxi Yang Department of Gastrointestinal Surgery, Renji Hospital, Shanghai Jiaotong
University School of Medicine, Shanghai, China
ZhidongGao Department of Gastrointestinal Surgery, Peking University People’s Hospital,
Beijing, China
XinChen Department of Gastrointestinal Surgery, Union Hospital, Tongji Medical College,
Huazhong University of Science and Technology, Wuhan, China
ZhenXiong Department of Gastrointestinal Surgery, Union Hospital, Tongji Medical College,
Huazhong University of Science and Technology, Wuhan, China
Xiangyu Zeng Department of Gastrointestinal Surgery, Union Hospital, Tongji Medical
College, Huazhong University of Science and Technology, Wuhan, China
Weizhen Liu Department of Gastrointestinal Surgery, Union Hospital, Tongji Medical
College, Huazhong University of Science and Technology, Wuhan, China
Peng Zhang Department of Gastrointestinal Surgery, Union Hospital, Tongji Medical
College, Huazhong University of Science and Technology, Wuhan, China
QunZhao Department of General Surgery, The Fourth Hospital of Hebei Medical University,
Shijiazhuang, China
HaiboQiu Department of Gastric Surgery, Sun Yat-sen University Cancer Center, Guangzhou,
China
Ruizhi Zhang Department of Gastrointestinal Surgery, Union Hospital, Tongji Medical
College, Huazhong University of Science and Technology, Wuhan, China
WenzeWan Department of Gastrointestinal Surgery, Union Hospital, Tongji Medical College,
Huazhong University of Science and Technology, Wuhan, China
CongLi Department of Colorectal Surgery, Sun Yat-sen University Cancer Center, Guangzhou,
China
Xinli Ma Department of Gastrointestinal Surgery, Renji Hospital, Shanghai Jiaotong
University School of Medicine, Shanghai, China
XinhuaZhang Department of Gastrointestinal Surgery, The First Afliated Hospital of Sun
Yat-sen University, Guangzhou, China
Jian Li Department of Gastrointestinal Oncology, Peking University Cancer Hospital &
Institute, Beijing, China
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