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Файл:Ординатура / Хирургия / Библиотека им академика М.И. Перельмана / Книга_5511_Библиотеки_им_академика_М_И_Перельмана.pdf
Early Pathologic Diagnosis
of Gynecologic Cancer
Including a Clinician’s View
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HONG KONG
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of Gynecologic Cancer
ncluding a Clinician’s View
Editor
Liane Deligdisch
Mount Sinai School of Medicine, USA
Co-editor
Albert Altchek
Mount Sinai School of Medicine & Lenox Hill Hospital, USA
Co-authors
Peter Schlosshauer
Maoxin Wu
Mount Sinai School of Medicine, USA
Frédérique Penault-Llorca
Clermont-Ferrand Medical School, France
World Scientifi c
LONDON
SINGAPORE
BEIJING
SHANGHAI
TAIPEI
CHENNAI
Published by
World Scientific Publishing Co. Pte. Ltd.
5 Toh Tuck Link, Singapore 596224
USA office: 27 Warren Street, Suite 401-402, Hackensack, NJ 07601
UK office: 57 Shelton Street, Covent Garden, London WC2H 9HE
British Library Cataloguing-in-Publication Data
A catalogue record for this book is available from the British Library.
EARLY PATHOLOGIC DIAGNOSIS OF GYNECOLOGIC CANCER
INCLUDING A CLINICIAN’S VIEW
Copyright © 2009 by World Scientific Publishing Co. Pte. Ltd.
All rights reserved. This book, or parts thereof, may not be reproduced in any form or by any means,
electronic or mechanical, including photocopying, recording or any information storage and retrieval
system now known or to be invented, without written permission from the Publisher.
For photocopying of material in this volume, please pay a copying fee through the Copyright
Clearance Center, Inc., 222 Rosewood Drive, Danvers, MA 01923, USA. In this case permission to
photocopy is not required from the publisher.
ISBN-13 978-981-281-895-9
ISBN-10 981-281-895-2
Typeset by Stallion Press
Email: enquiries@stallionpress.com
Printed in Singapore.
CON TEN T S
Contributors ix
Preface xi
Chapter 1 EARLY DIAGNOSIS OF VULVAR 1
CANCER
Peter Schlosshauer
Introduction 1
Normal Anatomy and Histology 2
Clinical Identification of Early Vulvar Neoplasms 3
Processing of a Surgical Specimen 4
for Pathologic Evaluation
Non-Neoplastic Epithelial Disorders 6
Pre-Malignant Squamous Epithelial Lesions 11
Invasive Carcinoma 18
References 43
Chapter 2 EARLY DIAGNOSIS OF CERVICAL 47
AND VAGINAL CANCER
Peter Schlosshauer
Introduction 47
v
Normal Anatomy, Histology and Physiologic 48
Changes
Clinical Identification of Early Vaginal 52
and Cervical Neoplasms
Processing of a Surgical Specimen for 54
Pathologic Evaluation
Benign Disorders 56
Human Papilloma Virus (HPV): Life Cycle 62
and Role in Tumorigenesis
Premalignant Epithelial Lesions 65
Invasive Carcinoma of the Cervix 79
Carcinoma of the Vagina 97
Other Malignant Tumors of the Vagina 101
and Cervix
Ancillary Studies 101
HPV-Vaccine 107
References 109
Chapter 3 EARLY DIAGNOSIS OF CERVICAL, 115
VAGINAL AND VULVAR CANCER:
A CLINICIAN’S VIEW
Albert Altchek
Cervical Cancer 115
Vaginal and Vulvar Cancer 129
References 144
Chapter 4 EARLY DIAGNOSIS OF ENDOMETRIAL 149
CANCER
Liane Deligdisch
Introduction 149
Precursors of Endometrial Carcinoma 150
Classification of Endometrial Carcinoma 157
Early Endometrial Carcinoma 160
Pathology of Endometrial Carcinoma 163
vi Contents
Histologic Patterns of Endometrial 165
Carcinomas
Molecular Biology of Endometrial Carcinoma 168
Conclusions 170
References 172
Chapter 5 EARLY DIAGNOSIS OF 175
OVARIAN CANCER
Liane Deligdisch
Introduction 175
Risk Factors, Genetic Risk 176
Ovarian Dysplasia 177
Prophylactic Oophorectemy and the Ovary at Risk 183
Stage I Ovarian Carcinoma 188
Conclusions 195
References 195
Chapter 6 EARLY DIAGNOSIS OF OVARIAN 199
AND ENDOMETRIAL CANCER:
A CLINICIAN’S VIEW
Albert Altchek
Ovarian Cancer 199
Endometrial Cancer 212
References 224
Chapter 7 CYTOLOGY FOR EARLY DIAGNOSIS 229
OF GYNECOLOGIC CANCER
Maoxin Wu
Introduction 229
Cervical, Vaginal and Vulvar Neoplasms 234
Endometrial Neoplasia 253
Ovarian Neoplasia 256
Summary 261
References 261
Contents vii
Chapter 8 MOLECULAR AND BIOLOGICAL 267
DIAGNOSIS OF EARLY
GYNECOLOGIC CANCERS
Frederique Penault-Llorca
Ovarian Cancer 267
Cervical Cancer 274
Endometrial Cancer 280
References 282
Index 285
viii Contents
ix
CONTRI BU TORS
Albert Altchek, MD, FACOG, FACS
Clinical Professor with Tenure of Obstetrics
Gynecology and Reproductive Science
Attending Obstetrician-Gynecologist
Chief of Pediatric and Adolescent Gynecology
The Mount Sinai School of Medicine and Hospital
One Gustave L. Levy Place
New York, NY 10029, USA
Attending Obstetrician-Gynecologist Lenox Hill Hospital
Liane Deligdisch, MD, FCAP
Professor of Pathology
Professor of Obstetrics-Gynecology and Reproductive Science
Attending Pathologist and Obstetrician-Gynecologist
The Mount Sinai School of Medicine and Hospital
One Gustave L. Levy Place
New York, NY 10029, USA
Member of the French National Academy of Medicine, Paris, France
Frederique Penault-Llorca, MD, PhD
Professor of Pathology
Medical School Clermont-Ferrand
Director of Pathology
Institute Jean Perrin, Clermont-Ferrand, France