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Файл:Ординатура / Хирургия / Библиотека им академика М.И. Перельмана / Книга_5511_Библиотеки_им_академика_М_И_Перельмана.pdf
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- •CONTENTS
- •Contributors
- •Lichen Sclerosus
- •Preface
- •Introduction
- •Normal Anatomy and Histology
- •Clinical Identification of Early Vulvar Neoplasms
- •Processing of a Surgical Specimen for Pathologic Evaluation
- •Non-Neoplastic Epithelial Disorders
- •Vulvar Dermatoses
- •Squamous Hyperplasia/Lichen Simplex Chronicus
- •Condylomata Acuminata
- •Pre-Malignant Squamous Epithelial Lesions
- •Invasive Carcinoma
- •Squamous Cell Carcinoma
- •Epidemiology, Etiology and Pathogenesis
- •Histologic Subtypes
- •Staging
- •Sentinel Lymph Nodes
- •Grading
- •Adenocarcinoma
- •Paget Disease
- •Bartholin Gland Carcinoma
- •Skene Gland Carcinoma
- •Malignant Melanoma
- •Mesenchymal Tumors
- •Other Malignant Tumors of the Vulva
- •Ancillary Studies
- •Identification of HPV associated lesions
- •Identification of superficial stromal invasion
- •Paget disease and its differential diagnosis
- •Metastatic tumors
- •REFERENCES
- •Introduction
- •Normal Anatomy, Histology and Physiologic Changes
- •Clinical Identification of Early Vaginal and Cervical Neoplasms
- •Processing of a Surgical Specimen for Pathologic Evaluation
- •Benign Disorders
- •Hyperkeratosis and Parakeratosis
- •Polyps
- •Endometriosis
- •Cysts
- •Condylomata
- •Diethylstilbestrol
- •Human Papilloma Virus (HPV): Life Cycle and Role in Tumorigenesis
- •Premalignant Epithelial Lesions
- •Squamous Lesions
- •Terminology
- •Epidemiology
- •Histomorphology
- •Preinvasive Glandular Lesions
- •Terminology, Epidemiology and Clinical Aspects
- •Histomorphology
- •Invasive Carcinoma of the Cervix
- •Squamous Cell Carcinoma
- •Microinvasive Carcinoma
- •FIGO Stage IA2 and Up
- •Carcinoma During Pregnancy
- •Histologic Subtypes
- •Grading
- •Adenocarcinoma
- •Epidemiology and Clinical Aspects
- •Microinvasive Adenocarcinoma
- •Histologic Subtypes
- •Grading
- •Other Epithelial Tumors
- •Staging
- •Sentinel Lymph Nodes
- •Pathology Report
- •Carcinoma of the Vagina
- •DES-Associated Clear Cell Carcinoma
- •Embryonal Rhabdomyosarcoma
- •Malignant Melanoma
- •Other Malignant Tumors of the Vagina and Cervix
- •Ancillary Studies
- •Dysplastic Squamous Epithelium versus Atrophic Squamous Epithelium, Immature Squamous Metaplasia, Transitional Cell Metaplasia or Inflammatory Atypia
- •AIS versus Benign Mimickers
- •AIS versus Microinvasive Endocervical Adenocarcinoma
- •Endocervical Microglandular Hyperplasia versus Endometrioid Adenocarcinoma
- •Endometrial versus Endocervical Adenocarcinoma
- •Müllerian Endometrioid Carcinoma versus Colon Carcinoma
- •Müllerian Clear Cell Carcinoma versus Renal Clear Cell Carcinoma
- •Pregnancy-related Changes
- •Small Round Blue Cell Tumors
- •Ectopic Prostatic Tissue
- •HPV-Vaccine
- •References
- •Cervical Cancer
- •General Considerations
- •Screening for Cervical Neoplasia Precursors
- •HPV Testing
- •Screening Older Women (Age 60 and Over)
- •Cervical Neoplasms
- •Diagnosis and Management
- •The 2006 Consensus Guidelines
- •Discussion
- •Endocervical Preneoplastic and Neoplastic Changes
- •Diagnosis
- •Management of VAIN
- •Vaginal Squamous Cell Carcinoma
- •Other Vaginal Malignancies
- •Verrucous Carcinoma of Vagina
- •Adenocarcinoma of Vagina
- •Primary Sarcoma of the Vagina
- •Malignant Melanoma of the Vagina
- •Vulvar Intraepithelial Neoplasia (VIN)
- •Diagnosis
- •Management
- •Discussion
- •Conclusion
- •Vaginal and Vulvar Cancer
- •General Considerations
- •Vulvar Cancer
- •Practical Clinical Evaluation
- •References
- •Introduction
- •Precursors of Endometrial Carcinoma
- •Pathology
- •Classification of Endometrial Carcinoma
- •Early Endometrial Carcinoma
- •Pathology of Endometrial Carcinoma
- •Endometrioid Adenocarcinomas Histologic Variants
- •Non-Endometrioid EC
- •Molecular Biology of Endometrial Carcinoma
- •Conclusions
- •References
- •Introduction
- •Risk Factors, Genetic Risk
- •Non-Hereditary Risk
- •Hereditary Risk
- •Ovarian Dysplasia
- •Prophylactic Oophorectemy and the Ovary at Risk
- •Stage I Ovarian Carcinoma
- •Conclusions
- •References
- •Ovarian Cancer
- •Risk Factors
- •Early Detection
- •Screening
- •Symptoms
- •When to Operate
- •New Ideas
- •Endometrial Cancer
- •Types of Endometrial Carcinoma
- •Who is at Risk for Endometrial Cancer?
- •Endometrial Sampling
- •Reliability of Endometrial Biopsy
- •Hazards of Endometrial Biopsy
- •Adequate Specimen
- •Technology
- •References
- •Introduction
- •Cervical, Vaginal and Vulvar Neoplasms
- •Cytology and Liquid Based New Technology
- •Elements in a Normal Pap
- •Epithelial Abnormality
- •Human Papilloma Virus (HPV)
- •Molecular Studies
- •Endometrial Neoplasia
- •Endometrial Cytology
- •Updated Endometrial Carcinogenesis and Molecular Studies
- •Ovarian Neoplasia
- •Ovarian and Peritoneal Cytology
- •Updated Ovarian Carcinogenesis and Molecular Studies
- •Summary
- •References
- •Ovarian Cancer
- •Serum and Urine Biomarkers
- •Ca 125 and Transvaginal Sonography (TVS)
- •Mathematical Models
- •Genomic Approaches
- •Loss of Heterozygosity Analysis (LOH)
- •Comparative Genomic Hybridization Analysis (CGH)
- •Transcription Profiling (cDNA Arrays)
- •Proteomics
- •Conclusions
- •Cervical Cancer
- •New Markers in Cervical Cancer Screening
- •HPV Testing
- •Hybrid Capture
- •Tissue Based Assays: In situ Hybridization Kits
- •Surrogate Markers
- •HPV Persistence
- •Could HPV Testing Replace PAP Test?
- •What is the Indication of ISH?
- •Endometrial Cancer
- •Conclusion
- •References
- •Index
vaginal intraepithelial neoplasia
(VAIN), 66, 129–132, 135,
139
verrucous, 132, 135, 140
virus-like particle, 107
visual inspection of the cervix with
acetic acid, 117
vulva
assessment of margins, 6
excisional biopsy, 5
incisional biopsy, 5
self-examination, 3
vulvar cancer
epidemiology, 18
etiology, 18
precursor lesion, 13
risk factor, 3
sentinel lymph node, 24
staging, 21, 22, 29, 30, 37
superficially invasive, 21
survival rate, 23
warty (condylomatous), 13,
14, 20, 85
vulvar dermatoses, 6
vulvar intraepithelial neoplasia
(VIN), 8, 11
basaloid, 39
bowenoid, 13
classic, 13
differentiated, 13, 15
grading, 17, 24
pagetoid, 27, 41
simplex, 13, 15, 19
type, 18
undifferentiated, 13
usual, 13
Xq11.2–q12, 271
298 Index
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