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104 Essentials of neuromodulation
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it is recommended that the product be utilized within 6–24 h. It is necessary to read the package insert frequently on each product to keep current on best practice. However, it is common practice to reconstitute the neuromodu­lator products with bacteriostatic saline. When the product is reconstituted with bacteriostatic saline, the shelf life will increase from 24 h (with normal saline) to 6 weeks (with bacteriostatic saline). However, once the injector has strayed from the on-label guidelines, it is no longer on the FDA approved use of the product.
Novice areas and advanced areas for neuromodulation
Commonly treated areas
Lateral Canthal lines Frontalis Muscle Glabellar region Procerus Orbicularis Oculi
Advanced areas
Vertical Rhytids above the lips Bunny Lines DOA Mentalis (Peau d’ orange) Lower orbicularis oculi Platysmal Bands Masseter Depressor Supercili
Novice (N) areas and advanced areas (A)
(N) Forhead wrinkles—Frontalis muscle to treat the transverse rhytids on the forehead (N) Frown Lines—Glabeller Complex Injections (N) Eyebrow Shaping—Lateral and Medial Arch (N) Crows Feet—Lateral Canthal Rhytids (A) Bunny lines (A) Gummy Smile—Gingival display (A) Nasal tip ptosis
Injection preparation
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(A) Marionette lines (A) Depressor Anguli Oris Injection (A) Neck bands—Platsymal bands (A) Dimpled Chin: Hypertrophic Mentalis Injections (A) Hyperhidrosis: Axillae (A) Dental Application
References
The Aesthetic Society. (2019). Aesthetic plastic surgery national databank. https://www.surgery.
org/sites/default/files/Aesthetic-Society_Stats2019Book_FINAL.pdf. (Accessed May
2020).
Further reading
Allergan. (2020). Botox cosmetic history. https://www.botoxcosmetic.com/what-is-botox-
cosmetic/botox-cosmetic-history. (Accessed March 2020).
Dysport. (2020). For health care professionals. https://www.dysportusa.com/healthcare-
professionals#importantsafetyinformation. (Accessed March 2020).
Jeuveau. (2020). Ready for a modern-made tox?. https://jeuveau.evolus.com. (Accessed July
2020).
Xeomin. (2020). A uniquely purified choice for frown lines. https://www.xeominaesthetic.com/
professionals/. (Accessed March 2020).
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CHAPTER 11
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Neuromodulation injection technique procedural steps
1. Treatment area
2. Indications with area defined
3. Emotions expressed with animation
4. Muscles in the treatment area
5. Muscles to be treated in the targeted zone
6. Special consideration
7. Complimentary locations to increase the efficacy
8. Treatment goals
9. Documentation
10. Equipment
11. Assessment
12. Pre-procedure steps
13. Technique
14. Results
15. Duration
16. Follow up
17. Complications
Areas for injection
1. Glabellar complex
2. Frontalis
3. Eyebrow shaping—lateral and medial arch
4. Crows feet-lateral canthal rhytids
5. Bunny lines
6. Gummy smile-gingival display
7. Smokers lines
8. Nasal tip ptosis
9. Marionette lines
10. Depressor Anguli Oris Injection
11. Neckbands—Platsymal bands
Essentials of Neuromodulation Copyright © 2021 Elsevier Inc.
https://doi.org/10.1016/B978-0-323-89920-8.00011-4 All rights reserved.
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Essentials of neuromodulation
12. Dimpled chin: hypertrophic mentalis injections
13. Hyperhidrosis: Axillae
14. Dental application
Fig. 11.1 Elevator and depressor muscle diagram. Neuromodulation will cause the opposite effect once placed in the muscle. Depressors become elevated and elevators become depressed.
Neuromodulation for frown linesGlabellar complex injections
Static and dynamic frown lines occur due to the active use of the complex depressor muscles, which consist of the procerus and the medial and lateral
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corrugators. This was the most commonly treated area for neuromodula­tion, but with the recent additional FDA approval Botox, has acquired for additional areas such as the forehead lines and the crows feet, these sta­tistics will be rapidly changing (Fig. 11.1).
Indications for treatment
Neuromodulation for injection is indicated for the temporary improvement in the appearance of moderate to severe glabellar lines associated with cor­rugator and procerus muscle activity in adult patients.
1. Frown lines
2. Medial eyebrow elevation
Emotion
Disapproving, angry, squint due to bright lights, irritation, disdain, disgrun­tled, frustrated, concentration.
Muscles in treatment area
Proceurus Corrugator Frontalis Depressor Supercilli Orbicularis oculli Levator palbebrae
Muscles to be treated in the targeted zone
Procerus Corrugator medial and lateral portions Depressor Supercilli Lateral tail of the orbicularis oculi
Special considerations
If the patient has a deep-set crease across the bridge of the nose, the injector will want to inject a bit lower at the procerus insertion point on the nasal bridge. Alternatively, provide two injection points into the procures to help remedy the horizontal crease. It is common to find patients that use their frontalis muscle to frown. If this is the case, it is advised that the injector edu­cate the patient on the need for concomitant treatment of the frontalis.
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Complimentary locations to increase efficacy
Frontalis Lateral canthal lines
Treatment goals
Inhibit the procerus and corrugators’ activation to minimize the patient’s ability to frown or furrow. Preventing muscle activity in this area will help to prevent deep-set at rest rhytids from developing. This treatment can be both preventative and restorative.
Dosing
Women 12–30 units Botox, Jeuveau, and Xeomin Women 30–70 units Dsyport Men 24–40 units Botox, Jeuveau and Xeomin Men 50–70 units Dsyport
Documentation
Medical history including allergies Medication Dose Lot number Expiration date Provider Equipment used Treatment area and specific dose per injection point How the patient tolerated Treatment plan
Equipment
Medication Botox Jeuveau Xeomin Dysport Bacteriostatic saline or preservative-free saline 3 mL luer lock syringe 27 Gauge luer lock 1 1/2 in. needle 2 2 non-woven gauze
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Alcohol Ice Bottle opener Marking pencil BD insulin Syringe 31 gauge ultra thin
Non-sterile gloves Hemostat, if needed, to assist in the removal of tight needles from luer lock or removing the metal portion of the bottle of neuromodulator.
Assessment
The patient should be assessed in animation and at rest. They should further be assessed from all angles. Even if only the glabellar complex is being trea­ted, the forehead should still be assessed at rest and with animation. It is essential to understand the relationship between the brows and the treatment area. It is also necessary to have the patient smile as well to assess how the smile can interfere with the lateral tail of the eyebrow, which is most often a part of the treatment zone for the glabellar complex.
Pre-procedure steps
1. Consultation
2. Have patient sign consent and pre and post-procedure guidelines
3. Photographs at three angles at rest and animated
50 degrees both left and right 45 degrees both left and right Straight on
4. Have the patient comfortably seated in an upright position
5. Ensure adequate overhead lighting
6. Mark out danger zones
7. Additionally, mark out treatment areas with a marking pencil. Be sure
not to inject through the marking pencil as this can create a permanent tattoo.
8. Calculate dosing according to the desired look, anatomy, and area being treated.
9. Draw up the medication, being sure not to dull the needle by touching the sides of the glass bottle, or going through the rubber stopper with the intended injection needle.
10. Cleanse the face thoroughly with a double cleanse and then chlorhex­idine or alcohol (allow to dry) (Fig. 11.2).
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Fig. 11.2 SAFE ZONE for injection into the glabellar complex.
Technique
1. Identify the treatment danger zones.
2. Mark out the treatment zone paying close attention to the lateral edges of
the corrugators. This area can be elicited by having the patient frown. Often, a bit of a divot is seen where the corrugator ends, and the levator palpebrae inserts onto the forehead above the mid pupillary line.
3. Be sure that the patient is still cleansed and has not touched the treatment area since proper cleansing performed in the pre-procedural steps.
4. Have the patient activate the muscles to be treated and begin at the pro­cerus muscle. Inject in the middle of the procerus belly. The needle will be inserted about halfway into the skin if using a 31 gauge 5/16 needle. Inject 4 units of Botox, Jeaveau, Xeominor 10 units of Dysport to the belly of the procerus. Do not hit the periosteum. If the periosteum is struck, back the needle out before pushing the product into the muscle. When the periosteum is struck, change the needle or the syringe as it will be lead to an increase in the sheering of the skin and vessels, leading to an increased risk of bruising. Should a two-point injection be necessary to the procerus, place one injection toward the bottom of the procerus and one at the top of the procerus muscle. If the patient has a deep crease that runs straight to the insertion at the nasal bridge, it will be necessary to split the injection and do half on either side of the split. So this time inject 2 units of Botox, Jeuveau, Xeomin or 5 units of Dysport bilaterally into both bellies of the procerus (Fig. 11.2).
00
(8 mm)
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5. The next injection point will be placed into the corrugator muscle about 1 cm inferiorly to the previous injection of the procerus muscle. Angle the needle toward the procerus muscle. The needle depth will be about 1/2 way into the skin. Slowly inject 4 units of Botox, Jeuveau, Xeomin or 10 units of Dysport at this insertion point.
6. Now move to the lateral corrugator. Have the patient contract the tar­geted muscles for the best visualization of the area. Insert the needle about 1–2 cm above the supraorbital ridge at the lateral margin of the corrugator muscle. It is essential that the injector angle the needle toward the procerus muscle and insert the needle 1/4–1/2 in. (depth depends on individual patient anatomy) way in and deliver 2–4 units of Botox, Jeuveau, Xeomin or 5–10 units of Dysport depending on the desired dose. Be sure to push slowly with the bevel down. The reason for inject­ing toward the procerus muscle is to avoid inadvertent spread or diffusion to the frontalis or levator palpebrae muscle.
7. Repeat steps five and six on the opposite side.
8. Do not press or rub on the injection sites. If the patient happens to bleed,
apply gentle pressure to stop the bleeding. GENTLE!!! It is not advised that manual force and manipulation occur in the area post-injection. Manual manipulation can force the product from the intended site, and the patient may suffer from an adverse event.
Results
Within 3–10 days, patients will start to see gradual improvement of the trea­ted area’s dynamic wrinkles. At no time during the 2 weeks should more neuromodulator be injected in the same area. It takes a full 2 weeks for the product to take effect. All good things come to those who wait. At 2 weeks’ time, it is strongly advised that the patient come back in for a follow-up evaluation. Discuss how the patient feels, how they like their results. Take after photos in the exact positions as the before photos.
Duration
Neuromodulators last anywhere from 2 to 4 months. The average length is about 3 months. It is essential to the clients to let them know they will not be completely frozen the entire treatment duration. It will take about 2 weeks to become fully effective, and then at about 6–8 weeks, the neuromodula­tion will start to “break.” Break, meaning a little bit of expression or