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FIGURE 4.11 Computed tomographic angiography for
deep inferior epigastric perforator planning. A. Sectioning
of axial images for muscle and vessels; B and C.
Construction of 3D model with separated structures.
Indocyanine green angiography has revolutionized our ability to
intraoperatively evaluate the perfusion of skin flaps.
27,28
By
selectively clamping certain vessels, the surgeon can see in real
time the area that is perfused by a blood vessel of their choice
(Figure 4.12). This tool can help with flap design as well as in blood
supply selection.
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FIGURE 4.12 Indocyanine green angiography for flap
evaluation.
TROUBLESHOOTING
Even perfectly planned and elevated flaps can develop issues.
Venous outflow problems are more common than arterial inflow.
Veins are lower pressure systems and more susceptible to kinking or
compression. A venously congested skin flap will appear darker than
normal and will bleed brisk dark blood upon scratching the
epidermis. One of the first actions that can be taken is to release
some of the sutures to alleviate pressure. If this is ineffective, it must
be decided whether the problem can be fixed by urgently returning to
the operating room. Flaps with large named vessels can be
reopened and checked for pedicle kinking, and free flaps can be
checked for anastomotic issues. If all vessels and anastomoses are
patent, the venous drainage of the remaining blood supply may be
inadequate. There are a few ways to augment venous drainage. The
flap can be venously supercharged by hooking up another vein to
drain the flap. Alternatively, the flap can be simply allowed to bleed
until inosculation and neovascularization of the flap occur.
Deepithelialization and application of heparin-soaked dressings will
promote continued bleeding. The use of medicinal leeches or Hirudo
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medicinalis will also promote outflow of blood by interrupting the
clotting cascade.29 Arterial system problems are typically recognized
quickly, as lack of inflow of oxygenated blood rapidly becomes
evident. These problems may be a result of poor flap planning;
however, for free flaps, arterial issues are almost always a result of
issues with the new anastomosis and should prompt examination of
said anastomosis.
30
CONCLUSION
Flaps are a backbone of reconstructive surgery, and a careful
consideration of the recipient and donor site can help guide the
surgeon to the best option for any given defect. Consideration of
blood supply is always important; however, with improvements in
technological adjuncts and surgical technique, flaps are only as
limited as the surgeon’s creativity.
QUESTIONS
1. A 26-year-old man has a degloving injury of the dorsum of his
right hand. A pedicled radial forearm flap is designed to cover
this defect. Which of the following best describes the blood
supply to this flap?
a. Random
b. Free
c. Anterograde
d. Retrograde
2. An 18-year-old man is diagnosed with ameloblastoma of the
mandible. Segmental resection of the mandible is planned
from angle to contralateral parasymphysis with resection of a
portion of the intraoral mucosa. Which of the following is the
best option for reconstruction for this patient?
a. Free fibula osteocutaneous flap
b. Nonvascularized rib Graft
c. Free iliac crest bone flap
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d. Free anterolateral thigh flap
3. A 53-year-old woman with left breast cancer undergoes left
mastectomy and immediate reconstruction with deep inferior
epigastric perforator flap. While in the recovery room, the skin
paddle of the flap looks pale and has no capillary refill. What
is the best next step in management of this patient?
a. Observation
b. Initiation of leech therapy
c. Return to operating room
d. Release of sutures
ANSWERS AND EXPLANATIONS
1. Answer: d. Radial forearm flaps are axial flaps based on the
radial artery. For a pedicled radial forearm to reach the dorsum
of the hand, it must be distally based on the retrograde flow from
across the palmar arch through the radial artery.16 It would not
be considered a free or random pattern flap.
2. Answer: a. The best option for this patient is a flap that
contains both bone and skin, as these are the elements being
resected during extirpation. Free fibula osteocutaneous flap
would provide both skin and good vascularized bone for
reconstruction. Nonvascularized rib graft is not ideal for a bony
defect of this size, nor does it provide skin. A free iliac crest
bone flap only reconstructs bone without skin. A free
anterolateral thigh flap provides skin without bone.
3. Answer: c. A pale flap without capillary refill implies that
there is an issue with the arterial inflow of the flap. Leech
therapy and release of sutures can assist with venous
congestion but not arterial problems. The first item in the
differential for arterial issues should be a problem with the new
anastomosis and should prompt urgent return to the operating
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room for examination and salvage. Observation would not be
correct given the time sensitivity of flap salvage and could
potentially jeopardize the ability to correct the arterial problem.
REFERENCES
1. Bath K, Aggarwal S, Sharma V. Sushruta: father of plastic surgery
in Benares. J Med Biogr. 2019;27(1):2-3.
doi:10.1177/0967772016643463
2. Champaneria MC, Workman AD, Gupta SC. Sushruta: father of
plastic surgery. Ann Plast Surg. 2014;73(1):2-7.
doi:10.1097/SAP.0b013e31827ae9f5
3. Milton SH. Pedicled skin-flaps: the fallacy of the length—width
ratio. Br J Surg. 1970;57(7):502-508. doi:10.1002/bjs.1800570705
4. McGregor IA, Jackson IT. The groin flap. Br J Plast Surg.
1972;25(1):3-16. doi:10.1016/s0007-1226(72)80003-1
5. Sinna R, Boloorchi A, Mahajan AL, Qassemyar Q, Robbe M. What
should define a “perforator flap”? Plast Reconstr Surg.
2010;126(6):2258-2263. doi:10.1097/PRS.0b013e3181f61824
6. Blondeel PN, Van Landuyt KHI, Monstrey SJM , et al. The “Gent”
consensus on perforator flap terminology: preliminary definitions.
Plast Reconstr Surg. 2003;112(5):1378-1383. quiz 1383, 1516;
discussion 1384-1387. doi:10.1097/01.PRS.0000081071.83805.B6
7. Hashimoto I, Abe Y, Ishida S , et al. Development of skin flaps for
reconstructive surgery: random paern flap to perforator flap. J
Med Invest. 2016;63(3-4):159-162. doi:10.2152/jmi.63.159
8. Schaverien MV, Badash I, Patel KM, Selber JC, Cheng MH.
Vascularized lymph node transfer for lymphedema. Semin Plast
Surg. 2018;32(1):28-35. doi:10.1055/s-0038-1632401
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9. Abdulrauf BMI. Our field, and the two-edge sword. Plast Reconstr
Surg Glob Open. 2023;11(1):e4763.
doi:10.1097/GOX.0000000000004763
(angiosome) and clinical territories of cutaneous perforating
arteries: development of the concept and designing safe flaps. Plast
Reconstr Surg. 2011;127(4):1447-1459.
doi:10.1097/PRS.0b013e318208d21b
perforasome theory: vascular anatomy and clinical implications.
Plast Reconstr Surg. 2009;124(5):1529-1544.
doi:10.1097/PRS.0b013e3181b98a6c
the lower leg. Br J Plast Surg. 1981;34(2):215-220. doi:10.1016/s00071226(81)80097-5
flaps according to their paerns of vascularisation. Br J Plast Surg.
1984;37(1):80-87. doi:10.1016/0007-1226(84)90049-3
to the skin and classification of skin flaps according to their
vascularization. Ann Plast Surg. 1986;16(1):1-19.
doi:10.1097/00000637-198601000-00001
muscles: experimental and clinical correlation. Plast Reconstr Surg.
1981;67(2):177-187.
radial forearm fascial flap for soft tissue coverage of hand and
forearm wounds. J Hand Surg Br. 2000;25(4):385-389.
doi:10.1054/jhsb.2000.0410
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vascular delay for high-risk breast reconstruction. Plast Reconstr
Surg. 1995;96(7):1615-1622. doi:10.1097/00006534-199512000-00015
transplantation: supercharging and turbocharging. Arch Plast
Surg. 2017;44(3):238-242. doi:10.5999/aps.2017.44.3.238
2004;24(3):157-161. doi:10.1002/micr.20035
Tagliacozzi, pioneer of plastic surgery and the spread of his
technique throughout Europe in “De Curtorum Chirurgia per
Insitionem.” Eur Rev Med Pharmacol Sci. 2014;18(4):445-450.
patients. Clin Plast Surg. 2005;32(1):35-44. viii.
doi:10.1016/j.cps.2004.08.001
flap. Plast Reconstr Surg. 1982;69(3):568. doi:10.1097/00006534198203000-00051
neck: a 10-year experience. Plast Reconstr Surg. 1999;103(3):808-
820. doi:10.1097/00006534-199903000-00006
grafts for free tissue transfer. Vasc Endovascular Surg.
2012;46(1):30-33. doi:10.1177/1538574411418843
muscle perfusion. Herz. 2004;29(1):32-46. doi:10.1007/s00059-0042532-1
SJ. Anastomotic technique and preoperative imaging in
microsurgical lower-extremity reconstruction: a single-surgeon
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experience. Ann Plast Surg. 2020;84(4):425-430.
doi:10.1097/SAP.0000000000002227
postmastectomy breast reconstruction patients: preventative or
overly conservative? Plast Reconstr Surg. 2016;138(1):15e-21e.
doi:10.1097/PRS.0000000000002266
flap surgery: a systematic review. J Reconstr Microsurg.
2018;34(2):77-86. doi:10.1055/s-0037-1606536
of flap salvage with medicinal leech therapy. Microsurgery.
2012;32(5):351-357. doi:10.1002/micr.21960
systematic approach to emergent breast free flap takeback: clinical
outcomes, algorithm, and review of the literature. Microsurgery.
2013;33(7):505-513. doi:10.1002/micr.22151
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CHAPTER 5 Principles of Microsurgery
Saïd C. Azoury and L. Scott Levin
KEY POINTS
Microsurgical techniques are used in plastic surgery,
orthopedic surgery, urology, neurosurgery, and
ophthalmology. Within plastic surgery, these techniques
are employed for limb salvage, gender-affirming surgery,
nerve surgery, replantation, vascularized composite
transplantation, head and neck surgery, and other
traumatic and oncologic indications.
The key elements of successful free tissue transfer
include meticulous recipient vessel/site preparation, flap
dissection, and microvascular anastomoses.
The venous coupler has been one of the greatest
advancements in technique, resulting in improved
efficiency, shorter anastomotic times, and at least
equivalent patency rates compared to hand-sewn
anastomoses.
End-to-end arterial anastomoses are used in most
anatomic locations; end-to-side arterial anastomoses are
useful in extremity reconstruction to preserve distal blood
flow.
Monitoring is most often performed by visual inspection of
a skin paddle as well as an internal or external doppler
monitoring. While rare, compromise is more common in
the first 24 to 48 hours. Early failure is often technical in
nature.
INTRODUCTION
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Current-day reconstructive microsurgery is a culmination of decades
of countless and innovative advancements in preoperative
planning/imaging, instrumentation, technique, as well as
postoperative monitoring and rehabilitation. The introduction of the
dual-surgeon operating microscope, fine microsutures, clamps, and
instruments has promoted for the widespread adoption of
reconstructive microsurgical techniques. Microsurgical techniques
have allowed for innovative approaches to upper and lower extremity
limb salvage, gender-affirming surgery, nerve surgery, lymphatic
surgery, vascularized composite allotransplantation (VCA), head and
neck (H&N) surgery, and other traumatic and oncologic indications.
HISTORY
While it is impossible to recount all the historical milestones in
microsurgery in one text, there are several developments that are
particularly noteworthy. Microsurgery finds its roots in vascular
surgery principles and techniques that date back over a century.
Alexis Carrel, a French general surgeon and biologist working in the
lab of Charles Guthrie, studied various techniques in vascular
surgery in the late 19th and early 20th centuries.1 In 1902, he
reported the first end-to-end vascular anastomosis and introduced
the concept of triangulation for vessel repair. He was awarded the
Nobel Prize in 1912 for his work. Alongside Carrell in advancing the
field of vascular and transplantation surgery, Edmund Höpfner of
Germany described the first successful extremity replantation in
dogs.2 Fast forward several decades, and clinical transplantation in
humans became a reality when Joseph E. Murray performed the first
kidney transplant in 1954 between identical twins.3 He was later
awarded the Nobel Prize in Medicine or Physiology for his work on
solid organ transplantation in 1990.
Julius Jacobson is considered the father of vascular microsurgery
and was using an eye/ear surgery microscope as early as the 1940s
to perform small blood vessel anastomoses. Recognizing the
limitations of a single-operator microscope, he built and introduced
the double-headed operating microscope for arterial anastomoses of
less than 3 mm.4 The ability to use the microscope for anastomosing
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