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FIGURE 4.11 Computed tomographic angiography for
deep inferior epigastric perforator planning. A. Sectioning of axial images for muscle and vessels; B and C. Construction of 3D model with separated structures.
Indocyanine green angiography has revolutionized our ability to
intraoperatively evaluate the perfusion of skin flaps.
27,28
By selectively clamping certain vessels, the surgeon can see in real time the area that is perfused by a blood vessel of their choice (Figure 4.12). This tool can help with flap design as well as in blood supply selection.
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FIGURE 4.12 Indocyanine green angiography for flap
evaluation.
TROUBLESHOOTING
Even perfectly planned and elevated flaps can develop issues. Venous outflow problems are more common than arterial inflow. Veins are lower pressure systems and more susceptible to kinking or compression. A venously congested skin flap will appear darker than normal and will bleed brisk dark blood upon scratching the epidermis. One of the first actions that can be taken is to release some of the sutures to alleviate pressure. If this is ineffective, it must be decided whether the problem can be fixed by urgently returning to the operating room. Flaps with large named vessels can be reopened and checked for pedicle kinking, and free flaps can be checked for anastomotic issues. If all vessels and anastomoses are patent, the venous drainage of the remaining blood supply may be inadequate. There are a few ways to augment venous drainage. The flap can be venously supercharged by hooking up another vein to drain the flap. Alternatively, the flap can be simply allowed to bleed until inosculation and neovascularization of the flap occur. Deepithelialization and application of heparin-soaked dressings will promote continued bleeding. The use of medicinal leeches or Hirudo
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medicinalis will also promote outflow of blood by interrupting the clotting cascade.29 Arterial system problems are typically recognized quickly, as lack of inflow of oxygenated blood rapidly becomes evident. These problems may be a result of poor flap planning; however, for free flaps, arterial issues are almost always a result of issues with the new anastomosis and should prompt examination of said anastomosis.
30
CONCLUSION
Flaps are a backbone of reconstructive surgery, and a careful consideration of the recipient and donor site can help guide the surgeon to the best option for any given defect. Consideration of blood supply is always important; however, with improvements in technological adjuncts and surgical technique, flaps are only as limited as the surgeon’s creativity.
QUESTIONS
1. A 26-year-old man has a degloving injury of the dorsum of his right hand. A pedicled radial forearm flap is designed to cover this defect. Which of the following best describes the blood supply to this flap?
a. Random b. Free
c. Anterograde
d. Retrograde
2. An 18-year-old man is diagnosed with ameloblastoma of the mandible. Segmental resection of the mandible is planned from angle to contralateral parasymphysis with resection of a portion of the intraoral mucosa. Which of the following is the best option for reconstruction for this patient?
a. Free fibula osteocutaneous flap b. Nonvascularized rib Graft
c. Free iliac crest bone flap
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d. Free anterolateral thigh flap
3. A 53-year-old woman with left breast cancer undergoes left mastectomy and immediate reconstruction with deep inferior epigastric perforator flap. While in the recovery room, the skin paddle of the flap looks pale and has no capillary refill. What is the best next step in management of this patient?
a. Observation b. Initiation of leech therapy
c. Return to operating room
d. Release of sutures
ANSWERS AND EXPLANATIONS
1. Answer: d.  Radial forearm flaps are axial flaps based on the
radial artery. For a pedicled radial forearm to reach the dorsum of the hand, it must be distally based on the retrograde flow from across the palmar arch through the radial artery.16 It would not be considered a free or random pattern flap.
2. Answer: a.  The best option for this patient is a flap that contains both bone and skin, as these are the elements being resected during extirpation. Free fibula osteocutaneous flap would provide both skin and good vascularized bone for reconstruction. Nonvascularized rib graft is not ideal for a bony defect of this size, nor does it provide skin. A free iliac crest bone flap only reconstructs bone without skin. A free anterolateral thigh flap provides skin without bone.
3. Answer: c.  A pale flap without capillary refill implies that there is an issue with the arterial inflow of the flap. Leech therapy and release of sutures can assist with venous congestion but not arterial problems. The first item in the differential for arterial issues should be a problem with the new anastomosis and should prompt urgent return to the operating
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room for examination and salvage. Observation would not be correct given the time sensitivity of flap salvage and could potentially jeopardize the ability to correct the arterial problem.
REFERENCES
1. Bath K, Aggarwal S, Sharma V. Sushruta: father of plastic surgery in Benares. J Med Biogr. 2019;27(1):2-3. doi:10.1177/0967772016643463
2. Champaneria MC, Workman AD, Gupta SC. Sushruta: father of plastic surgery. Ann Plast Surg. 2014;73(1):2-7. doi:10.1097/SAP.0b013e31827ae9f5
3. Milton SH. Pedicled skin-flaps: the fallacy of the length—width ratio. Br J Surg. 1970;57(7):502-508. doi:10.1002/bjs.1800570705
4. McGregor IA, Jackson IT. The groin flap. Br J Plast Surg. 1972;25(1):3-16. doi:10.1016/s0007-1226(72)80003-1
5. Sinna R, Boloorchi A, Mahajan AL, Qassemyar Q, Robbe M. What should define a “perforator flap”? Plast Reconstr Surg. 2010;126(6):2258-2263. doi:10.1097/PRS.0b013e3181f61824
6. Blondeel PN, Van Landuyt KHI, Monstrey SJM , et al. The “Gent” consensus on perforator flap terminology: preliminary definitions. Plast Reconstr Surg. 2003;112(5):1378-1383. quiz 1383, 1516; discussion 1384-1387. doi:10.1097/01.PRS.0000081071.83805.B6
7. Hashimoto I, Abe Y, Ishida S , et al. Development of skin flaps for reconstructive surgery: random paern flap to perforator flap. J Med Invest. 2016;63(3-4):159-162. doi:10.2152/jmi.63.159
8. Schaverien MV, Badash I, Patel KM, Selber JC, Cheng MH. Vascularized lymph node transfer for lymphedema. Semin Plast Surg. 2018;32(1):28-35. doi:10.1055/s-0038-1632401
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9. Abdulrauf BMI. Our field, and the two-edge sword. Plast Reconstr Surg Glob Open. 2023;11(1):e4763. doi:10.1097/GOX.0000000000004763
(angiosome) and clinical territories of cutaneous perforating arteries: development of the concept and designing safe flaps. Plast Reconstr Surg. 2011;127(4):1447-1459. doi:10.1097/PRS.0b013e318208d21b
perforasome theory: vascular anatomy and clinical implications. Plast Reconstr Surg. 2009;124(5):1529-1544. doi:10.1097/PRS.0b013e3181b98a6c
the lower leg. Br J Plast Surg. 1981;34(2):215-220. doi:10.1016/s0007­1226(81)80097-5
flaps according to their paerns of vascularisation. Br J Plast Surg. 1984;37(1):80-87. doi:10.1016/0007-1226(84)90049-3
to the skin and classification of skin flaps according to their vascularization. Ann Plast Surg. 1986;16(1):1-19. doi:10.1097/00000637-198601000-00001
muscles: experimental and clinical correlation. Plast Reconstr Surg. 1981;67(2):177-187.
radial forearm fascial flap for soft tissue coverage of hand and forearm wounds. J Hand Surg Br. 2000;25(4):385-389. doi:10.1054/jhsb.2000.0410
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vascular delay for high-risk breast reconstruction. Plast Reconstr Surg. 1995;96(7):1615-1622. doi:10.1097/00006534-199512000-00015
transplantation: supercharging and turbocharging. Arch Plast Surg. 2017;44(3):238-242. doi:10.5999/aps.2017.44.3.238
2004;24(3):157-161. doi:10.1002/micr.20035
Tagliacozzi, pioneer of plastic surgery and the spread of his technique throughout Europe in “De Curtorum Chirurgia per Insitionem.” Eur Rev Med Pharmacol Sci. 2014;18(4):445-450.
patients. Clin Plast Surg. 2005;32(1):35-44. viii. doi:10.1016/j.cps.2004.08.001
flap. Plast Reconstr Surg. 1982;69(3):568. doi:10.1097/00006534­198203000-00051
neck: a 10-year experience. Plast Reconstr Surg. 1999;103(3):808-
820. doi:10.1097/00006534-199903000-00006
grafts for free tissue transfer. Vasc Endovascular Surg. 2012;46(1):30-33. doi:10.1177/1538574411418843
muscle perfusion. Herz. 2004;29(1):32-46. doi:10.1007/s00059-004­2532-1
SJ. Anastomotic technique and preoperative imaging in microsurgical lower-extremity reconstruction: a single-surgeon
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experience. Ann Plast Surg. 2020;84(4):425-430. doi:10.1097/SAP.0000000000002227
postmastectomy breast reconstruction patients: preventative or overly conservative? Plast Reconstr Surg. 2016;138(1):15e-21e. doi:10.1097/PRS.0000000000002266
flap surgery: a systematic review. J Reconstr Microsurg. 2018;34(2):77-86. doi:10.1055/s-0037-1606536
of flap salvage with medicinal leech therapy. Microsurgery. 2012;32(5):351-357. doi:10.1002/micr.21960
systematic approach to emergent breast free flap takeback: clinical outcomes, algorithm, and review of the literature. Microsurgery. 2013;33(7):505-513. doi:10.1002/micr.22151
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CHAPTER 5 Principles of Microsurgery
Saïd C. Azoury and L. Scott Levin
KEY POINTS
Microsurgical techniques are used in plastic surgery, orthopedic surgery, urology, neurosurgery, and ophthalmology. Within plastic surgery, these techniques are employed for limb salvage, gender-affirming surgery, nerve surgery, replantation, vascularized composite transplantation, head and neck surgery, and other traumatic and oncologic indications.
The key elements of successful free tissue transfer include meticulous recipient vessel/site preparation, flap dissection, and microvascular anastomoses.
The venous coupler has been one of the greatest advancements in technique, resulting in improved efficiency, shorter anastomotic times, and at least equivalent patency rates compared to hand-sewn anastomoses.
End-to-end arterial anastomoses are used in most anatomic locations; end-to-side arterial anastomoses are useful in extremity reconstruction to preserve distal blood flow.
Monitoring is most often performed by visual inspection of a skin paddle as well as an internal or external doppler monitoring. While rare, compromise is more common in the first 24 to 48 hours. Early failure is often technical in nature.
INTRODUCTION
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Current-day reconstructive microsurgery is a culmination of decades of countless and innovative advancements in preoperative planning/imaging, instrumentation, technique, as well as postoperative monitoring and rehabilitation. The introduction of the dual-surgeon operating microscope, fine microsutures, clamps, and instruments has promoted for the widespread adoption of reconstructive microsurgical techniques. Microsurgical techniques have allowed for innovative approaches to upper and lower extremity limb salvage, gender-affirming surgery, nerve surgery, lymphatic surgery, vascularized composite allotransplantation (VCA), head and neck (H&N) surgery, and other traumatic and oncologic indications.
HISTORY
While it is impossible to recount all the historical milestones in microsurgery in one text, there are several developments that are particularly noteworthy. Microsurgery finds its roots in vascular surgery principles and techniques that date back over a century. Alexis Carrel, a French general surgeon and biologist working in the lab of Charles Guthrie, studied various techniques in vascular surgery in the late 19th and early 20th centuries.1 In 1902, he reported the first end-to-end vascular anastomosis and introduced the concept of triangulation for vessel repair. He was awarded the Nobel Prize in 1912 for his work. Alongside Carrell in advancing the field of vascular and transplantation surgery, Edmund Höpfner of Germany described the first successful extremity replantation in dogs.2 Fast forward several decades, and clinical transplantation in humans became a reality when Joseph E. Murray performed the first kidney transplant in 1954 between identical twins.3 He was later awarded the Nobel Prize in Medicine or Physiology for his work on solid organ transplantation in 1990.
Julius Jacobson is considered the father of vascular microsurgery
and was using an eye/ear surgery microscope as early as the 1940s to perform small blood vessel anastomoses. Recognizing the limitations of a single-operator microscope, he built and introduced the double-headed operating microscope for arterial anastomoses of less than 3 mm.4 The ability to use the microscope for anastomosing
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