Добавил:
kiopkiopkiop18@yandex.ru t.me/Prokururor I Вовсе не секретарь, но почту проверяю Опубликованный материал нарушает ваши авторские права? Сообщите нам.
Вуз: Предмет: Файл:
Ординатура / Хирургия / Библиотека им академика М.И. Перельмана / Книга_5192_Библиотеки_им_академика_М_И_Перельмана.pdf
Скачиваний:
0
Добавлен:
30.08.2026
Размер:
67 Мб
Скачать
Any screen. Any time. Anywhere.
Activate the eBook version of this title at no additional charge.
Elsevier eBooks+ gives you the power to browse, search, and customize your content, make notes and highlights, and have content read aloud.
Unlock your eBook today.
1. Visit http://ebooks.health.elsev ier.com/
2. Log in or Sign up
3. Scratch box below to reveal your code
4. Type your access code into the “Redeem
Access Code” box
5. Click “Redeem”
It’s that easy!
For technical assistance: email textbookscom.support@elsevier.com call 1-800-545-2522 (inside the US) call +44 1 865 844 640 (outside the US)
Place Peel Off
Sticker Here
Use of the current edition of the electronic version of this book (eBook) is subject to the terms of the nontransferable, limited license granted on http://ebooks.health.elsevier.com/. Access to the eBook is limited to the first individual who redeems the PIN, located on the inside cover of this book, at http://ebooks.health.elsevier.com/ and may not be transferred to another party by resale, lending, or other means.
2022v1.0
Review of
Dermatology
This page intentionally left blank
Ali Alikhan, MD
Dermatologist Department of Dermatology Sutter Medical Foundation Sacramento, CA, USA
Thomas L.H. Hocker, MD, PCEO
Mohs Surgeon Dermatopathologist and Dermatologist Surgical Director Department of Dermatology University of Missouri Kansas City Overland Park, KS, USA
Review of
Dermatology
SE CO ND ED IT IO N
Section Editors
Monisha N. Dandekar, MD Linda T. Doan, MD, PhD Nada Elbuluk, MD, MSc Ronda S. Farah, MD Phillip C. Hochwalt, MD, FACMS Julia S. Lehman, MD Alexander Maley, MD Roberto A. Novoa, MD Brea Prindaville, MD Anand Rajpara, MD Christopher Sayed, MD Tiffany C. Scharschmidt, MD Jennifer J. Schoch, MD Jonathan I. Silverberg, MD, PhD, MPH Olayemi Sokumbi, MD
Elsevier 1600 John F. Kennedy Blvd. Ste 1800 Philadelphia, PA 19103-2899
REVIEW OF DERMATOLOGY, SECOND EDITION ISBN: 978-0-323-65386-2
Copyright © 2024 by Elsevier, Inc. All rights reserved.
No part of this publication may be reproduced or transmitted in any form or by any means, electronic or mechanical, including photocopying, recording, or any information storage and retrieval system, without permission in writing from the publisher. Details on how to seek permission, further information about the Publisher’s permissions policies and our arrangements with organizations such as the Copyright Clearance Center and the Copyright Licensing Agency, can be found at our website: www.elsevier.com/permissions
This book and the individual contributions contained in it are protected under copyright by the Publisher (other than as may be noted herein).
Notice
Practitioners and researchers must always rely on their own experience and knowledge in evaluating and using any information, methods, compounds or experiments described herein. Because of rapid advances in the medical sciences, in particular, independent verication of diagnoses and drug dosages should be made. To the fullest extent of the law, no responsibility is assumed by Elsevier, authors, editors or contributors for any injury and/or damage to persons or property as a matter of products liability, negligence or otherwise, or from any use or operation of any methods, products, instructions, or ideas contained in the material herein.
Previous edition copyrighted 2017.
Senior Content Strategist: Charlotta Kryhl Senior Content Development Specialist: Rae L. Robertson Publishing Services Manager: Shereen Jameel Project Manager: Vishnu T. Jiji Senior Designer: Renee Duenow
Printed in India
Last digit is the print number: 9 8 7 6 5 4 3 2 1

Dedications

To my wife, for her unwavering and unconditional love and support
To my grandmother (Amma), who taught me the meaning of sacrice
To my parents, who have always been the best role models
To my son, whose curiosity and determination continue to amaze me
Ali Alikhan, MD
To Anjali, Avani, and Akari, and Jeevan: daddy loves you un­conditionally, and I am inspired constantly by your curiosity, intelligence, relentless drive, and kind hearts. God blessed me with the most amazing kids I could hope for, and blessed you with the unique abilities and talents to achieve anything you set your mind to! Be a force for good.
To my family: your love and support is the light that brightens even the darkest of nights.
To my mentors at Harvard (Dr. Harley Haynes and Hensin Tsao), Mayo (esp. Drs. Pittelkow, Camilleri, and Roenigk), and the entire University of Michigan Dermpath group: thank you for your immense personal support and for shaping my dermatologic world view!
Thomas L. H. Hocker, MD, PCEO
v

Contributors

Ali Alikhan, MD
Dermatologist Department of Dermatology Sutter Medical Foundation Sacramento, CA, USA
Section Editor for Section 2, Dermatopharmacology
2.1 Antihistamines
2.2 Retinoids
2.3 Corticosteroids
2.4 Immunomodulatory Agents
2.5 Oncologic Agents in Dermatology
2.6 Antimicrobial Agents
2.7 Phototherapy
2.8 Miscellaneous Agents
2.9 Drug Interactions and the Cytochrome P-450 System
2.10 Drug Reactions
Section Editor for Section 3, General Dermatology
3.1 Papulosquamous Dermatoses
3.2 Eczematous Dermatoses
3.3 Interface Dermatitis
3.4 Blistering Diseases
3.5 Connective Tissue Diseases (CTDs) and Sclerosing Dermopathies
3.6 Granulomatous/Histiocytic Disorders
3.7 Monoclonal Gammopathies of Dermatologic Interest
3.8 Xanthomas
3.9 Urticaria and Angioedema
3.10 Neutrophilic Dermatoses
3.11 Eosinophilic Disorders
3.12 Figurate Erythemas
3.13 Follicular and Eccrine/Apocrine Disorders
3.14 Drug Reactions
3.15 Photodermatoses and Other Physical Dermatoses
3.16 Amyloidoses
3.17 Neurodermatology and Psychodermatology
3.18 Palmoplantar Keratodermas
3.19 Nutritional Disorders in Dermatology
3.20 Depositional and Calcication Disorders Not Discussed Elsewhere
3.21 Ulcers
3.22 Vasculitides, Vasculopathies, and Other Vascular Disorders
3.23 Panniculitides and Lipodystrophies
3.24 Dermatoses of Pregnancy
3.25 Hair, Nail, and Mucosal Disorders
3.26 Pigmentary Disorders
Section Editor for Section 5, Infectious Diseases
5.1 Viral Diseases
5.2 HIV/AIDS Dermatology
5.3 Bacterial Infections
5.4 Fungal Diseases
5.5 Parasites and Other Creatures
Monisha N. Dandekar, MD
Dermatopathologist MAWD Pathology Lenexa, KS, USA
Section Editor for Section 6, Neoplastic Dermatology
6.1 Keratinocytic Neoplasms
6.2 Cysts
6.3 Melanocytic Neoplasms
6.4 Adnexal Neoplasms and Hamartomas
6.5 Hair Follicle Neoplasms/Hamartomas
6.6 Sebaceous Proliferations
6.7 Neural Neoplasms
6.8 Smooth Muscle Neoplasms
6.9 Hematolymphoid Neoplasms
6.10 Fibrohistiocytic Neoplasms
6.11 Vascular Proliferations
6.12 Neoplasms of Adipocytic Lineage
6.13 Dermoscopy
Linda T. Doan, MD, PhD
Assistant Professor of Dermatology and Pathology University of California, Irvine Irvine, CA, USA
Section Editor for Section 1, Basic Science
1.1 Structure and Function of the Skin
1.2 Embryology
1.3 Wound Healing
1.4 Genetics
1.5 Ultraviolet Light
1.6 Immunology
1.6.1 Innate Versus Adaptive Immunity
1.6.2 Immunologic Mediators
1.6.3 Cells of Signicance
1.6.4 Major Histocompatibility Complex
1.7 Laboratory Techniques
Nada Elbuluk, MD, MSc
Associate Professor of Dermatology University of Southern California Los Angeles, CA, USA
Section Editor for Section 10, Cutaneous Manifestations of Internal Disease and Metastases
10.1 Cardiovascular/Cardiopulmonary
10.2 Endocrine
10.3 Gastroenterology
10.4 Neurology
10.5 Renal
10.6 Paraneoplastic Syndromes
vi
Contributors
Ronda S. Farah, MD
Assistant Professor of Dermatology University of Minnesota Minneapolis, MN, USA
Section Editor for Section 9, Cosmetic Dermatology
9.1 Lasers
9.2 Botulinum Toxin
9.3 Dermal Fillers
9.4 Liposuction and Fat Reduction
9.5 Sclerotherapy
9.6 Cosmeceuticals, Nutraceuticals, and Other Supplements
9.7 Hair Transplantation
9.8 Chemical Peels
9.9 Other Esthetic Procedures and Scales
Phillip C. Hochwalt, MD, FACMS
Mohs and Reconstructive Surgeon Department of Dermatology Conuence Health Wenatchee, WA, USA
Section Editor for Section 6, Neoplastic Dermatology
6.1 Keratinocytic Neoplasms
6.2 Cysts
6.3 Melanocytic Neoplasms
6.4 Adnexal Neoplasms and Hamartomas
6.5 Hair Follicle Neoplasms/Hamartomas
6.6 Sebaceous Proliferations
6.7 Neural Neoplasms
6.8 Smooth Muscle Neoplasms
6.9 Hematolymphoid Neoplasms
6.10 Fibrohistiocytic Neoplasms
6.11 Vascular Proliferations
6.12 Neoplasms of Adipocytic Lineage
6.13 Dermoscopy
Section Editor for Section 8, Dermatologic Surgery
8.1 Surgical Anatomy
8.2 Local Anesthetics and Perioperative Pain Control
8.3 Surgical Instruments and Needles
8.4 Suture Techniques
8.5 Wound Closure Materials
8.6 Antisepsis and Sterilization
8.7 Electrosurgery
8.8 Cryosurgery
8.9 Excisions
8.10 Mohs Surgery
8.11 Flaps
8.12 Grafts
8.13 Surgical Complications and Measures to Avoid Them
8.14 Scar Improvement
8.15 Nail Surgery
8.16 Wound Dressings
Thomas L.H. Hocker, MD, PCEO
Mohs Surgeon Dermatopathologist and Dermatologist Surgical Director Department of Dermatology University of Missouri Kansas City Overland Park, KS, USA
Section Editor for Section 5, Infectious Diseases
5.1 Viral Diseases
5.2 HIV/AIDS Dermatology
5.3 Bacterial Infections
5.4 Fungal Diseases
5.5 Parasites and Other Creatures
Section Editor for Section 8, Dermatologic Surgery
8.1 Surgical Anatomy
8.2 Local Anesthetics and Perioperative Pain Control
8.3 Surgical Instruments and Needles
8.4 Suture Techniques
8.5 Wound Closure Materials
8.6 Antisepsis and Sterilization
8.7 Electrosurgery
8.8 Cryosurgery
8.9 Excisions
8.10 Mohs Surgery
8.11 Flaps
8.12 Grafts
8.13 Surgical Complications and Measures to Avoid Them
8.14 Scar Improvement
8.15 Nail Surgery
8.16 Wound Dressings
Julia S. Lehman, MD
Professor of Dermatology, Laboratory Medicine, and Pathology Laboratory Director, Immunodermatology Mayo Clinic Rochester, MN, USA
Section Editor for Section 3, General Dermatology
3.4 Blistering Diseases
Section Editor for Section 7, Dermatopathology
7.1 Essential Concepts in Dermatopathology
7.2 High-Yield Dermatopathology Diagnoses at a Glance
7.3 High-Yield Dermatopathology Differential Diagnoses
Alexander Maley, MD
Dermatologist Aurora Healthcare Milwaukee, WI, USA
Section Editor for Section 2, Dermatopharmacology
2.1 Antihistamines
2.2 Retinoids
2.3 Corticosteroids
2.4 Immunomodulatory Agents
2.5 Oncologic Agents in Dermatology
2.6 Antimicrobial Agents
2.7 Phototherapy
2.8 Miscellaneous Agents
2.9 Drug Interactions and the Cytochrome P-450 System
2.10 Drug Reactions
Section Editor for Section 11, Epidemiology, Statistics, Study Design, Public Health Principles, and Billing
11.6 Billing
Roberto A. Novoa, MD
Clinical Associate Professor of Pathology and Dermatology Stanford University Stanford, CA, USA
Section Editor for Section 6, Neoplastic Dermatology
6.1 Keratinocytic Neoplasms
6.2 Cysts
6.3 Melanocytic Neoplasms
6.4 Adnexal Neoplasms and Hamartomas
6.5 Hair follicle Neoplasms/Hamartomas
6.6 Sebaceous Proliferations
6.7 Neural Neoplasms
6.8 Smooth Muscle Neoplasms
6.9 Hematolymphoid Neoplasms
6.10 Fibrohistiocytic Neoplasms
6.11 Vascular Proliferations
6.12 Neoplasms of Adipocytic Lineage
6.13 Dermoscopy
Section Editor for Section 7, Dermatopathology
7.1 Essential Concepts in Dermatopathology
7.2 High-Yield Dermatopathology Diagnoses at a Glance
7.3 High-Yield Dermatopathology Differential Diagnoses
Brea Prindaville, MD
Assistant Professor of Dermatology Pediatric Dermatologist Brown University Providence, RI, USA
Section Editor for Section 4, Pediatric Dermatology
4.1 Neonatal Dermatology
4.2 Viral Exanthems and Select Infectious Disorders of Childhood
4.3 Inherited Pigmentary Disorders
4.4 Epidermolysis Bullosa
4.5 Tumor Syndromes
4.6 Vascular Tumors, Malformations, and Related Vascular Disorders
4.7 Disorders of Hair and Nails
4.8 Inherited Metabolic and Nutritional Disorders
4.9 Inherited Connective Tissue Disorders
4.10 Autoinammatory Disorders (Periodic Fever Syndromes)
4.11 Neurocutaneous Syndromes
vii
Contributors
4.12 Premature Aging Syndromes and DNA Repair Disorders
4.13 Primary Immunodeciency Disorders with Cutaneous Manifestations
4.14 Disorders of Cornication
4.15 Miscellaneous Pediatric Dermatologic Disorders
Anand Rajpara, MD
Residency Program Director and Associate Professor Department of Dermatology Kansas University Medical Center Kansas City, KS, USA
Section Editor for Section 3, General Dermatology
3.1 Papulosquamous Dermatoses
3.2 Eczematous Dermatoses
3.3 Interface Dermatitis
3.4 Blistering Diseases
3.5 Connective Tissue Diseases (CTDs) and Sclerosing Dermopathies
3.6 Granulomatous/Histiocytic Disorders
3.7 Monoclonal Gammopathies of Dermatologic Interest
3.8 Xanthomas
3.9 Urticaria and Angioedema
3.10 Neutrophilic Dermatoses
3.11 Eosinophilic Disorders
3.12 Figurate Erythemas
3.13 Follicular and Eccrine/Apocrine Disorders
3.14 Drug Reactions
3.15 Photodermatoses and Other Physical Dermatoses
3.16 Amyloidoses
3.17 Neurodermatology and Psychodermatology
3.18 Palmoplantar Keratodermas
3.19 Nutritional Disorders in Dermatology
3.20 Depositional and Calcication Disorders Not Discussed Elsewhere
3.21 Ulcers
3.22 Vasculitides, Vasculopathies, and Other Vascular Disorders
3.23 Panniculitides and Lipodystrophies
3.24 Dermatoses of Pregnancy
3.25 Hair, Nail, and Mucosal Disorders
3.26 Pigmentary Disorders
Christopher Sayed, MD
Professor of Dermatology University of North Carolina Chapel Hill, NC, USA
Section Editor for Section 3, General Dermatology
3.1 Papulosquamous Dermatoses
3.2 Eczematous Dermatoses
3.3 Interface Dermatitis
3.4 Blistering Diseases
3.5 Connective Tissue Diseases (CTDs) and Sclerosing Dermopathies
3.6 Granulomatous/Histiocytic Disorders
3.7 Monoclonal Gammopathies of Dermatologic Interest
3.8 Xanthomas
3.9 Urticaria and Angioedema
3.10 Neutrophilic Dermatoses
3.11 Eosinophilic Disorders
3.12 Figurate Erythemas
3.13 Follicular and Eccrine/Apocrine Disorders
3.14 Drug Reactions
3.15 Photodermatoses and Other Physical Dermatoses
3.16 Amyloidoses
3.17 Neurodermatology and Psychodermatology
3.18 Palmoplantar Keratodermas
3.19 Nutritional Disorders in Dermatology
3.20 Depositional and Calcication Disorders not Discussed Elsewhere
3.21 Ulcers
3.22 Vasculitides, Vasculopathies, and Other Vascular Disorders
3.23 Panniculitides and Lipodystrophies
3.24 Dermatoses of Pregnancy
3.25 Hair, Nail, and Mucosal Disorders
3.26 Pigmentary Disorders
Tiffany C. Scharschmidt, MD
Associate Professor of Dermatology University of California San Francisco, CA, USA
Section Editor for Section 1, Basic Science
1.1 Structure and Function of the Skin
1.2 Embryology
1.3 Wound Healing
1.4 Genetics
1.5 Ultraviolet Light
1.6 Immunology
1.6.1 Innate Versus Adaptive Immunity
1.6.2 Immunologic Mediators
1.6.3 Cells of Signicance
1.6.4 Major Histocompatibility Complex
1.7 Laboratory Techniques
Jennifer J. Schoch, MD
Associate Professor of Dermatology University of Florida Gainesville, FL, USA
Section Editor for Section 4, Pediatric Dermatology
4.1 Neonatal Dermatology
4.2 Viral Exanthems and Select Infectious Disorders of Childhood
4.3 Inherited Pigmentary Disorders
4.4 Epidermolysis Bullosa
4.5 Tumor Syndromes
4.6 Vascular Tumors, Malformations, and Related Vascular Disorders
4.7 Disorders of Hair and Nails
4.8 Inherited Metabolic and Nutritional Disorders
4.9 Inherited Connective Tissue Disorders
4.10 Autoinammatory Disorders (Periodic Fever Syndromes)
4.11 Neurocutaneous Syndromes
4.12 Premature Aging Syndromes and DNA Repair Disorders
4.13 Primary Immunodeciency Disorders with Cutaneous Manifestations
4.14 Disorders of Cornication
4.15 Miscellaneous Pediatric Dermatologic Disorders
Jonathan I. Silverberg, MD, PhD, MPH
Professor of Dermatology George Washington University School of Medicine and Health Sciences Baltimore, MD, USA Director, Clinical Research and Contact Dermatitis Washington, DC, USA
Section Editor for Section 11, Epidemiology, Statistics, Study Design, Public Health Principles, and Billing
11.1 Epidemiological Denitions
11.2 Epidemiologic Principles
11.3 Types of Studies and Their Limitations
11.4 Types of Bias
11.5 Maintenance of Certication for the American Board of Dermatology
Olayemi Sokumbi, MD
Associate Professor of Dermatology and Laboratory Medicine & Pathology Mayo Clinic Jacksonville, FL, USA
Section Editor for Section 3, General Dermatology
3.1 Papulosquamous Dermatoses
3.2 Eczematous Dermatoses
3.3 Interface Dermatitis
3.4 Blistering Diseases
3.5 Connective Tissue Diseases (CTDs) and Sclerosing Dermopathies
3.6 Granulomatous/Histiocytic Disorders
3.7 Monoclonal Gammopathies of Dermatologic Interest
3.8 Xanthomas
3.9 Urticaria and Angioedema
3.10 Neutrophilic Dermatoses
3.11 Eosinophilic Disorders
3.12 Figurate Erythemas
3.13 Follicular and Eccrine/Apocrine Disorders
3.14 Drug Reactions
3.15 Photodermatoses and Other Physical Dermatoses
3.16 Amyloidoses
3.17 Neurodermatology and Psychodermatology
3.18 Palmoplantar Keratodermas
3.19 Nutritional Disorders in Dermatology
3.20 Depositional and Calcication Disorders Not Discussed Elsewhere
3.21 Ulcers
3.22 Vasculitides, Vasculopathies, and Other Vascular Disorders
3.23 Panniculitides and Lipodystrophies
3.24 Dermatoses of Pregnancy
3.25 Hair, Nail, and Mucosal Disorders
3.26 Pigmentary Disorders
viii
Соседние файлы в папке Библиотека им академика М.И. Перельмана