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Vascular and Intravascular
Imaging Trends, Analysis, and
Challenges, Volume 1
Stent applications

https://t.me/medicina_free

Vascular and Intravascular
https://t.me/medicina_free
Imaging Trends, Analysis, and
Challenges, Volume 1
Stent applications
Petia Radeva
Universitat de Barcelona, Barcelona, Spain
and
Computer Vision Center, Bellaterra (Barcelona), Spain
Jasjit S Suri
ATHEROPOINT, California, USA
IOP Publishing, Bristol, UK

ª IOP Publishing Ltd 2019
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All rights reserved. No part of this publication may be reproduced, stored in a retrieval system
or transmitted in any form or by any means, electronic, mechanical, photocopying, recording
or otherwise, without the prior permission of the publisher, or as expressly permitted by law or
under terms agreed with the appropriate rights organization. Multiple copying is permitted in
accordance with the terms of licences issued by the Copyright Licensing Agency, the Copyright
Clearance Centre and other reproduction rights organizations.
Permission to make use of IOP Publishing content other than as set out above may be sought
at permissions@ioppublishing.org.
Petia Radeva and Jasjit S Suri have asserted their right to be identified as the authors of this work
in accordance with sections 77 and 78 of the Copyright, Designs and Patents Act 1988.
ISBN 978-0-7503-1997-3 (ebook)
ISBN 978-0-7503-1995-9 (print)
ISBN 978-0-7503-1996-6 (mobi)
DOI 10.1088/2053-2563/ab01fa
Version: 20190801
IOP Expanding Physics
ISSN 2053-2563 (online)
ISSN 2054-7315 (print)
British Library Cataloguing-in-Publication Data: A catalogue record for this book is available
from the British Library.
Published by IOP Publishing, wholly owned by The Institute of Physics, London
IOP Publishing, Temple Circus, Temple Way, Bristol, BS1 6HG, UK
US Office: IOP Publishing, Inc., 190 North Independence Mall West, Suite 601, Philadelphia,
PA 19106, USA

To our families and friends for their infinite patience, love and support.
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Contents
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Preface xvii
Editor biographies xix
List of contributors xx
Section I Vascular and intravascular clinical analysis
1 OCT in the evaluation of late stent pathology: restenosis,
1-1
neoatherosclerosis and late malapposition
1.1 Stent evolution and late stent pathology 1-1
1.2 OCT characterization of late stent pathology 1-2
1.2.1 Stent coverage: re-endothelialization 1-2
1.2.2 Restenosis 1-7
1.2.3 Neoatherosclerosis 1-11
1.2.4 Incomplete stent apposition (malapposition) 1-14
1.2.5 Stent thrombosis 1-20
1.3 OCT evaluation of bioresorbable vascular scaffolds 1-24
1.3.1 OCT in the evaluation of long-term BVS performance 1-25
1.3.2 Current pitfalls of BVSs 1-26
1.4 Future perspectives 1-26
References 1-27
2 Bioresorbable eluting scaffolds in the era of optical coherence
2-1
tomography: real-world clinical practice
2.1 Introduction 2-2
2.2 Historical background and the search for the ideal bioresorbable
scaffold
2.3 Bioresorbable scaffolds: current clinical evidence 2-4
®
2.3.1 The Absorb
2.3.2 Metallic magnesium BRSs 2-8
2.3.3 Other resorbable scaffolds 2-9
2.4 The clinical utility of optical coherence tomography in the
optimization of bioresorbable scaffolds
2.5 Bioresorbable scaffolds in real-world clinical settings 2-12
scaffold 2-5
2-3
2-10
vii

Vascular and Intravascular Imaging Trends, Analysis, and Challenges, Volume 1
https://t.me/medicina_free
2.5.1 Case 1—the need for state-of-the-art peri-procedural
intravascular imaging
2.5.2 Case 2—a careful OCT interpretation 2-14
2.5.3 Case 3—BRS in calcified vessels. Does OCT have a role? 2-18
2.5.4 Case 4—BRS in ST-elevation myocardial infarction and
long-term evaluation by OCT
2.5.5 Case 5—different devices for different lesions 2-21
2.6 Conclusions 2-22
References 2-24
2-12
2-20
Section II Computer modeling and computational fluid
hemodynamics
3 Computer modeling of blood flow and plaque progression
3-1
in the stented coronary artery
3.1 Introduction 3-2
3.2 Methods 3-5
3.2.1 Geometrical stent modeling 3-5
3.2.2 Blood flow simulation 3-8
3.2.3 Modeling the deformation of blood vessels 3-10
3.2.4 Plaque formation and progression modeling—continuum
approach
3.2.5 Discrete approach 3-13
3.2.6 DPD modeling of oxidized LDL particle adhesion to the wall 3-14
3.3 Results 3-14
3.3.1 Coupled method for modeling of atherosclerosis 3-14
3.3.2 Stent deployment modeling 3-15
3.3.3 Deformable artery wall 3-16
3.3.4 Nitinol material model 3-18
3.3.5 Stress analysis for stent deployment 3-19
3.3.6 Plaque concentration for stented arteries 3-20
3.4 Discussion and conclusions 3-21
References 3-23
3-11
viii

Vascular and Intravascular Imaging Trends, Analysis, and Challenges, Volume 1
https://t.me/medicina_free
4 Current status of computational fluid dynamics for modeling
4-1
of diseased vessels
4.1 Introduction 4-1
4.1.1 Disease vessel classification 4-1
4.2 Constitutive equation of blood flow in a diseased vessel 4-4
4.2.1 Mass conservation equation 4-4
4.2.2 Momentum conservation equations 4-5
4.3 Viscoelastic models of diseased blood 4-6
4.3.1 Carreau model 4-6
4.3.2 Power-law model 4-7
4.3.3 Quemada model 4-7
4.4 CFD modeling of blood flow in a diseased vessel 4-8
4.4.1 Laminar flow model 4-8
4.5 Evaluation of the shear index on the vascular wall 4-11
4.5.1 Oscillatory shear index 4-14
4.5.2 Relative residual time 4-17
4.6 Conclusion 4-17
References 4-19
5 Fast virtual endovascular stenting: technique, validation and
5-1
applications in computational haemodynamics
5.1 Motivation 5-1
5.2 Virtual stenting 5-2
5.3 The fast virtual stenting method 5-3
5.4 Validation—how accurate is accurate enough? 5-5
5.4.1 FVS versus FEM—mechanics 5-5
5.4.2 FVS versus FEM—fluid dynamics 5-8
5.4.3 FVS—real versus virtual angiographies 5-10
5.5 Discussion and future work 5-10
5.5.1 Comparison of steady-state and transient blood flow
simulations of intracranial aneurysms
5.5.2 Haemodynamic alterations of intracranial aneurysms
induced by virtual stent deployment
5.5.3 Reproducibility of virtual angiographies by computational
haemodynamics simulations in a stented aneurysm model
5.5.4 Effect of vascular morphology on haemodynamics after flow
diverter placement in intracranial aneurysms
ix
5-11
5-12
5-13
5-14
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