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Chapter 2. Pathophysiology andHypermetabolic…
113. Gebhard F, Pfetsch H, Steinbach G, Strecker W, Kinzl L,
Brückner UB. Is interleukin 6 an early marker of injury
severity following major trauma in humans? Arch Surg.
2000;135(3):291–5. https://doi.org/10.1001/archsurg.135.3.291.
114. Yeh FL, Lin WL, Shen HD, Fang RH.Changes in circulating levels of interleukin 6in burned patients. Burns. 1999;25(2):131–6.
https://doi.org/10.1016/s0305- 4179(98)00150- 8.
115. Finnerty CC, Mabvuure NT, Ali A, Kozar RA, Herndon DN.The
Surgically Induced Stress Response. JPEN. 2013;37:21S–9S.
https://doi.org/10.1177/0148607113496117.
116. Gore DC, Jahoor F, Wolfe RR, Herndon DN. Acute response
of human muscle protein to catabolic hormones. Ann Surg.
1993;218(5):679–84.
1 17. Raju R. Immune and metabolic alterations following trauma
and sepsis—an overview. Biochim Biophys Acta. 2017;1863(10):
2523–5. https://doi.org/10.1016/j.bbadis.2017.08.008.
118. Perlman RL, Chalfie M.Catecholamine release from the adrenal medulla. Clin Endocrinol Metab. 1977;6(3):551–76. https://
doi.org/10.1016/s0300- 595x(77)80071- 6.
119. Ballard-Croft C, Maass DL, Sikes P, White J, Horton
J.Activation of stress-responsive pathways by the sympathetic
nervous system in burn trauma. Shock. 2002;18:38–45. https://
doi.org/10.1097/00024382- 200207000- 00008.
120. Bakhtyar N, Sivayoganathan T, Jeschke MG. Therapeutic
approaches to combatting hypermetabolism in severe
burn injuries. J Crit Care. 2015;1(16):1–12. https://doi.
org/10.21767/2471- 8505.10006.
121. Cartwright MM. The metabolic response to stress: a case
of complex nutrition support management. Crit Care Nurs
Clin North Am. 2004;16(4):467–87. https://doi.org/10.1016/j.
ccell.2004.07.001.
122. Wilmore DW, Curreri PW, Spitzer KW, Spitzer ME, Pruitt
BA. Supranormal dietary intake in thermally injured hypermetabolic patients. Surg Gynecol Obstet. 1971;132(5):881–6.
123. Curreri PW. Assessing nutritional needs for the burned
patient. J Trauma. 1990;30(12):S20–3. https://doi.
org/10.1097/00005373- 199012001- 00007.
124. Machado NM, Gragnani A, Ferreira LM. Burns, metabolism
and nutritional requirements. Nutr Hosp. 2011;26(4):692–700.
https://doi.org/10.3305/nh.2011.26.4.5217.
125. Hall KL, Shahrokhi S, Jeschke MG.Enteral nutrition support in
burn care: a review of current recommendations as instituted in
75

76
Данная книга находится в списке для перевода на русский язык сайта https://meduniver.com/
R. Vinaik et al.
the Ross Tilley Burn Centre. Nutrients. 2012;4:1554–65. https://
doi.org/10.3390/nu4111554.
126. Rodriquez NA, Jeschke MG, Williams FN, Kamolz LP, Herndon
DN. Nutrition in burns: Galveston contributions. JPEN.
2011;35(6):704–14. https://doi.org/10.1177/0148607111417446.
127. Williams FN, Branski LK, Jeschke MG, Herndon DN. What,
how, and how much should patients with burns be fed? Surg
Clin North Am 2011;9(3)1:609-629. doi: https://doi.org/10.1016/j.
suc.2011.03.002.
128. Gore DC, Chinkes D, Sanford A, Hart DW, Wolfe SE, Herndon
DN.Influence of fever on the hypermetabolic response in burninjured children. Arch Surg. 2003;138(2):169–74. https://doi.
org/10.1001/archsurg.138.2.169.
129. Mochizuki H, Trocki O, Dominioni L, Brackett KA, Joffe
SN, Alexander JW. Mechanism of prevention of postburn hypermetabolism and catabolism by early enteral
feeding. Ann Surg. 1984;200(3):297–310. https://doi.
org/10.1097/00000658- 198409000- 00007.
130. Saffle JR, Graves C, Herndon DN. Nutritional support of the
burned patient. Total burn care. 2007, 3rd ed. London Saunders
Elsevier:389-419.
131. Gore DC, Rutan RL, Hildreth M, Desai MH, Herndon
DN. Comparison of resting energy expenditures
and caloric intake in children with severe burns. J
Burn Care Rehabil. 1990;11(5):400–4. https://doi.
org/10.1097/00004630- 1999009000- 00005.
132. Suman OE, Mlcak RP, Chinkes DL, Herndon DN. Resting
energy expenditure in severely burned children: analysis
of agreement between indirect calorimetry and prediction equations using the Bland-Altman method. Burns.
2006;32(3):335–42.
133. Clark A, Imran J, Madni T, Wolf SE. Nutrition and metabolism in burn patients. Burns Trauma. 2017;5:11. https://doi.
org/10.1186/s41038- 017- 0076- x.
134. Gottschlich MM, Jenkins ME, Mayes T, Khoury J, Kagan RJ,
Warden GD.The 2002 Clinical Research Award. An evaluation
of the safety of early vs. delayed enteral support and effects
on clinical, nutritional, and endocrine outcomes after severe
burns. J Burn Care Rehabil. 2002;23(6):401–15. https://doi.
org/10.1097/01.BCR.0000036588.09166.F1.
135. Peck MD, Kessler M, Cairns BA, Chang YH, Ivanova A,
Schooler W.Early enteral nutrition does not decrease hyperme-

Chapter 2. Pathophysiology andHypermetabolic…
tabolism with burn injury. J Trauma. 2004;57(6):1143–8. https://
doi.org/10.1097/01.ta.0000145826.84657.38.
136. Graf S, Pichard C, Genton L, Oshima T, Heidegger CP.Energy
expenditure in mechanically ventilated patients: the weight
of body weight! Clin Nutr. 2017;36(1):224–8. https://doi.
org/10.1016/j.clnu.2015.11.007.
137. Hart DW, Wolf SE, Beauford RB, Lal SO, Chinkes DL,
Herndon DN.Determinants of blood loss during primary burn
excision. Surgery. 2001;130(2):396–402. https://doi.org/10.1067/
msy.2001.116916.
138. Burke JF, Wolfe RR, Mullany CJ, Mathews DE, Bier
DM. Glucose requirements following burn injury.
Parameters of optimal glucose infusion and possible
hepatic and respiratory abnormalities following excessive
glucose intake. Ann Surg. 1979;190(3):274–85. https://doi.
org/10.1097/00000658- 197909000- 00002.
139. Wolfe RR.Metabolic response to burn injury: nutritional implications. Semin Nephrol. 1993;13(4):382–90.
140. Patterson BW, Nguyen T, Pierre E, Herndon DN, Wolfe
RR. Urea and protein metabolism in burned children: effect
of dietary protein intake. Metabolism. 1997;46(5):573–8. https://
doi.org/10.1016/S0026- 0495(97)90196- 7.
141. Gore DC, Jahoor F. Glutamine kinetics in burn patients.
Comparison with hormonally induced stress in volunteers.
Arch Surg. 1994;129(12):1318–23. https://doi.org/10.1001/
archsurg.1994.01420360108015.
142. Windle EM.Glutamine supplementation in critical illness: evidence, recommendations, and implications for clinical practice
in burn care. J Burn Care Res. 2006;27(6):764–72. https://doi.
org/10.1097/01.BCR.0000245417.47510.9C.
143. Heyland DK, Samis A. Does immunonutrition in patients
with sepsis do more harm than good? Intensive Care Med.
2003;29(5):669–71. https://doi.org/10.1007/s00134- 003- 1719- 6.
144. Garrel DR, Razi M, Larivière F, Jobin N, Naman N, EmpotozBonneton A, Pugeat MM. Improved clinical status and length
of care with low-fat nutrition support in burn patients. JPEN.
1995;19(6):482–91. https://doi.org/10.1177/0148607195019006482.
145. Alexander JW, Gottschlich MM. Nutritional immunomodulation in burn patients. Crit Care Med. 1990;18(2S):S149–53.
146. Alexander JW, Saito T, Trocki O, Ogle CK.The importance of
lipid type in the diet after burn injury. Ann Surg. 1986;204(1):1–
8. https://doi.org/10.1097/00000658- 198607000- 00001.
77

78
Данная книга находится в списке для перевода на русский язык сайта https://meduniver.com/
R. Vinaik et al.
1 4 7. Gamliel Z, DeBiasse MA, Demling RH.Essential micromin-
erals and their response to burn injury. J Burn Care Rehabil.
1996;17(3):264–72.
148. Rock CL, Dechert RE, Khilnani R, Parker PS, Rodriguez
JL. Carotenoids and antioxidant vitamins in patients after
burn injury. J Burn Care Rehabil. 1997;18(3):269–78. https://doi.
org/10.1097/00004630- 199705000- 00018.
149. Klein GL. Burns: where has all the calcium (and vitamin
D) gone? Adv Nutr. 2011;2(6):457–62. https://doi.org/10.3945/
an.111.000745.
150. Berger MM, Shenkin A.Trace element requirements in critically ill burned patients. J Trace Elem Mol Biol. 2007;21(S1):44–
8. https://doi.org/10.1016/j.jtemb.2007.09.013.
151. Berger MM, Binnert C, Chiolero RL, Taylor W, Raffoul W,
Cayeux M-C, Benethan M, Shenkin A, Tappy L.Trace elements
supplementation after major burns increases burned skin trace
element concentrations and modulates local protein metabolism but not whole-body substrate metabolism. Am J Clin Nutr.
2007;85(5):1301–6.
152. Gottschlich MM, Mayes T, Khoury J, Warden
GD. Hypovitaminosis D in acutely injured pediatric burn
patients. J Am Diet Assoc. 2004;104(6):931–41. https://doi.
org/10.1016/j.jada.2004.03.020.
153. Berger MM. Antioxidant micronutrients in major trauma and
burns: evidence and practice. Nutr Clin Pract. 2006;21(5):438–
49. https://doi.org/10.1177/0115426506021005438.
154. Sampson B, Constantinescu MA, Chandarana I, Cussons
PD. Severe hypocupraemia in a patient with extensive burn
injuries. Ann Clin Biochem. 1996;33(Pt 5):462–4. https://doi.
org/10.1177/000456329603300513.
155. Cunningham JJ, Lydon MK, Emerson R, Harmatz
PR. Low ceruloplasmin levels during recovery from
major burn injury: Influence of open wound size and copper supplementation. Nutrition. 1996;12(2):83–8. https://doi.
org/10.1016/0899- 9007(96)90704- 2.
156. Huang Z, Rose AH, Hoffman PR. The role of selenium
in inflammation and immunity: from molecular mechanisms to therapeutic opportunities. Antioxid Redox Signal.
2012;16(7):705–43. https://doi.org/10.1089/ars.2011.4145.
1 5 7. Wilmore DW, Mason AD, Johnson DW, Pruitt BA. Effect
of ambient temperature on heat production and heat loss in

Chapter 2. Pathophysiology andHypermetabolic…
burn patients. J Appl Physiol. 1975;38(4):593–7. https://doi.
org/10.1152/jappl.1975.38.4.593.
158. Herndon DN, Hawkins HK, Nguyen TT, Pierre E, Cox
R, Barrow RE. Characterization of growth hormone
enhanced donor site healing in patients with large cutaneous burns. Ann Surg. 1995;221(6):649–56. https://doi.
org/10.1097/00000658- 199506000- 00004.
159. Solomon JR. Early surgical excision and grafting of burns
including tangential excision. Prog Pediatr Surg. 1981;14:133–49.
160. Kraemer WJ, Deschenes MR, Fleck SJ. Physiological adaptations to resistance exercise. Implications for athletic
conditioning. Sports Med. 1988;6(4):246–56. https://doi.
org/10.2165/00007256- 198806040- 00006.
161. Suman OE, Spies RJ, Celis MM, Mlcak RP, Herndon
DN.Effects of a 12-wk resistance exercise program on skeletal
muscle strength in children with burn injuries. J Appl Physiol.
2001;91(3):1168–75. https://doi.org/10.1152/jappl.2001.91.3.1168.
162. Breitenstein E, Chioléro RL, Jéquier E, Dayer P, Krupp
S, Schutz Y. Effects of beta-blockade on energy metabolism following burns. Burns. 1990;16(4):259–64. https://doi.
org/10.1016/0305- 4179(90)900136- K.
163. Mohammadi AA, Bakhshaeekia A, Alibeigi P, Hasheminasab
MJ, Tolide-ei HR, Tavakkolian AR, Mohammadi MK.Efficacy
of propranolol in wound healing for hospitalized burn patients.
J Burn Care Res. 2009;30(6):1013–7. https://doi.org/10.1097/
BCR.0b013e3181b48600.
164. Jeschke MG, Finnerty CC, Kulp GA, Przkora R, Mlcak RP,
Herndon DN. Combination of recombinant human growth
hormone and propranolol decreases hypermetabolism
and inflammation in severely burned children. Pediatr
Crit Care Med. 2008;9(2):209–16. https://doi.org/10.1097/
PCC.0b013e318166d414.
165. Martinez R, Rogers A, Numanoglu A, Rode H. Fatal nonocclusive mesenteric ischemia and the use of propranolol in pediatric burns. Burns. 2016;42(4):e70–3. https://doi.
org/10.1016/j.burns.2015.08.015.
166. Arbabi S, Ahrns KS, Wahl WL. Beta-blocker use is associated with improved outcomes in adult burn patients. J
Trauma. 2004;56(2):265–9. https://doi.org/10.1097/01.
TA.0000109859.91202.C8.
1 6 7. Flores O, Stockton K, Robers JA. The efficacy and safety of
adrenergic blockade after burn injury: a systematic review and
79

80
Данная книга находится в списке для перевода на русский язык сайта https://meduniver.com/
R. Vinaik et al.
meta-analysis. J Trauma Acute Care Surg. 2016;80(1):146–55.
https://doi.org/10.1097/TA.0000000000000887.
168. Kim JB, Cho YS, Jang KU, Joo SY, Choi JS, Soo CH.Effects of
sustained release growth hormone treatment during the rehabilitation of adult severe burn survivors. Growth Horm IGF
Res. 2016;27:1–6. https://doi.org/10.1016/j.ghir.2015/12.009.
169. Hart DW, Wolf SE, Chinkes DL, Lal SO, Ramzy
PI, Herndon DN. β-Blockade and growth hormone
after burn. Ann Surg. 2002;236(4):450–7. https://doi.
org/10.1097/00000658- 200210000- 00007.
170. Connolly CM, Barrow RE, Chinkes DL, Martinez JA, Herndon
DN. Recombinant human growth hormone increases thyroid hormone-binding sites in recovering severely burned
children. Shock. 2003;19(5):399–403. https://doi.org/10.1097/01.
shk.0000051758.08171.bc.
171. Branski LK, Herndon DN, Barrow RE, Kulp GA, Klein GL,
Suman OE, Przkora R, Meyer W 3rd, Huang T, Lee JO, Chinkes
DL, Mlcak RP, Jeschke MG. Randomized controlled trial to
determine the efficacy of long-term growth hormone treatment
in severely burned children. Ann Surg. 2009;250(4):514–23.
https://doi.org/10.1097/SLA.0b013e3181b8f9ca.
172. Breederveld RS, Tuinebreijer WE.Recombinant human growth
hormone for treating burns and donor sites (Cochrane Systematic
Review). Cochrane Database Syst Rev. 2014;(9):CD008990.
173. Takala J, Ruokonen E, Webster NR, Nielsen MS, Zandstra
DF, Vundelinckx G, Hinds CJ. Increased mortality associated with growth hormone treatment in critically ill
adults. NEJM. 1999;341:785–92. https://doi.org/10.1056/
NEJM199909093411102.
174. Lang CH, Frost RA. Role of growth hormone, insulin-like
growth factor-I, and insulin-like growth factor binding proteins in the catabolic response to injury and infection. Curr
Opin Clin Nutr Metab Care. 2002;5(3):271–9. https://doi.
org/10.1097/00075197- 2000205000- 00006.
175. Cioffi WG, Gore DC, Rue LW 3rd, Carrougher G, Guler
HP, McManus WF, Pruitt BA Jr. Insulin-like growth factor- 1 lower protein oxidation in patients with thermal injury. Ann Surg. 1994;220(3):310–6. https://doi.
org/10.1097/00000658- 199409000- 00007.
176. Jeschke MG, Barrow RE, Herndon DN. Recombinant
human growth hormone treatment in pediatric burn
patients and its role during the hepatic acute phase

Chapter 2. Pathophysiology andHypermetabolic…
response. Crit Care Med. 2000;28(5):1578–84. https://doi.
org/10.1097/00003246- 200005000- 00053.
1 7 7. Spies M, Wolf SE, Barrow RE. Modulation of types I and II
acute phase reactants with insulin-like growth factor-1/binding
protein-3 complex in severely burned children. Crit Care Med.
2002;30(1):83–8.
178. Wolf SE, Woodside KJ, Ramirez RJ, Kobayashi M, Suzuki F,
Herndon DN. Insulin-like growth factor-1/insulin-like growth
factor binding protein-3 alters lymphocyte responsiveness following severe burn. J Surg Res. 2004;117(2):255–61. https://doi.
org/10.1016/S0022- 4804(03)00305- 6.
179. Jeschke MG, Barrow RE, Herndon DN. Insulin-like growth
factor I plus insulin-like growth factor binding protein 3 attenuates the proinflammatory acute phase response in severely
burned children. Ann Surg. 2000;231(2):246–52. https://doi.
org/10.1097/00000658- 200002000- 00014.
180. Jeschke MG, Barrow RE, Suzuki F, Rai J, Benjamin D,
Herndon DN. IGF-1/IGFBP-3 equilibrates ratios of pro- to
anti- inflammatory cytokines, which are predictors for organ
function in severely burned pediatric patients. Mol Med.
2002;8(5):238–46.
181. Hasselbren PO. Burns and metabolism. J Am Coll Surg.
1999;188(2):98–103.
182. Van den Berghe G.On the neuroendocrinopathy of critical illness. Am J Respir Crit Care Med. 2016;194(11):1337–48.
183. Debroy MA, Wolf SE, Zhang XJ, Chinkes DL, Ferrando
AA, Wolfe RR, Herndon DN. Anabolic effects of insulinlike growth factor in combination with insulin-like growth
factor binding protein-3 in severely burned adults. J Trauma.
1999;47(5):904–10.
184. Gore DC, Wolfe SE, Herndon DN, Wolfe RR.Relative influence of glucose and insulin on peripheral amino acid metabolism in severely burned patients. JPEN. 2002;26(5):272–7.
https://doi.org/10.1177/0148607102026005271.
185. Pham TN, Warren AJ, Phan HH.Impact of tight glycemic control in severely burned children. J Trauma. 2005;59:1148–54.
https://doi.org/10.1097/01.ta.0000188933.16637.68.
186. Pidcoke HF, Baer LA, Wu X, Wolf SE, Aden JK, Wade
CE. Insulin effects on glucose tolerance, hypermetabolic
response, and circadian-metabolic protein expression in
a rat burn and disuse model. Am J Physiol Regul Integr
81

82
Данная книга находится в списке для перевода на русский язык сайта https://meduniver.com/
R. Vinaik et al.
Comp Physiol. 2014;307(1):R1–R10. https://doi.org/10.1152/
ajpregu.00312.2013.
1 8 7. Gore DC, Wolf SE, Sanford AP. Extremity hyperinsulinemia
stimulates muscle protein synthesis in severely injured patients.
Am J Physiol Endocrinol Metab. 2004;286(4):E529–34. https://
doi.org/10.1152/ajpendo.00258.2003.
188. Jeschke MG, Boehning DF, Finnerty CC, Herndon DN.Effect
of insulin on the inflammatory and acute phase response after
burn injury. Crit Care Med. 2007;35(9S):S519–23.
189. Van den Berghe G.How does blood glucose control with insulin
save lives in intensive care? J Clin Invest. 2004;114(9):1187–225.
https://doi.org/10.1172/JCI23506.
190. Codère-Maruyama T, Schricker T, Shum-Tim D, Wykes
L, Nitschmann E, Guichon C, Kristof AS, Hatzakorzian
R. Hyperinsulinemic-normoglycemic clamp administered together with amino acids induces anabolism
after cardiac surgery. Am J Physiol Regul Integr Comp
Physiol. 2016;311(6):1085–92. https://doi.org/10.1152/
ajpregu.000334.2016.
191. Ferrando AA, Chinkes DL, Wolfe SE, Matin S, Herndon
DN, Wolfe RR. A submaximal dose of insulin promotes
net skeletal muscle protein synthesis in patients with
severe burns. Ann Surg. 1999;229(1):11–8. https://doi.
org/10.1097/00000658- 199901000- 00002.
192. Gore DC, Wolf SE, Sanford A, Herndon DN, Wolfe RR.Influence
of metformin on glucose intolerance and muscle catabolism
following severe burn injury. Ann Surg. 2005;241(2):334–42.
https://doi.org/10.1097/01.sla.0000152013.23032.d1.
193. Miller RA, Chu Q, Xie J, Foretz M, Viollet B, Birnbaum
MJ. Biguanides suppress hepatic glucagon signaling by decreasing production of cyclic AMP. Nature.
2013;494(7436):256–60. https://doi.org/10.1038/nature11808.
194. Gore DC, Herndon DN, Wolfe RR. Comparison of peripheral metabolic effects of insulin and metformin following
severe burn injury. J Trauma. 2005;59(2):316–23. https://doi.
org/10.1097/01.ta.0000180387.34057.5a.
195. Auger C, Samadi O, Jeschke MG. The biochemical alterations underlying post-burn hypermetabolism. Biochim
Biophys Acta. 2017;1863(10):2633–44. https://doi.org/10.1016/j.
bbadis.2017.02.019.
196. Salpeter SR, Greyber E, Pasternak GA, Salpeter EE.Risk of
fatal and nonfatal lactic acidosis with metformin use in type 2

Chapter 2. Pathophysiology andHypermetabolic…
diabetes mellitus: a systematic review and meta-analysis. Arch
Intern Med. 2003;163(21):2594–602.
1 9 7. Riesenman PJ, Braithwaite SS, Cairns BA.Metformin-associated
lactic acidosis in a burn patient. J Burn Care Res. 2007;28(2):342–
7. https://doi.org/10.1097/BCR.0B013E318031A1FE.
198. Sears B, Perry M. The role of fatty acids in insulin resistance. Lipids Health Dis. 2015;14:121. https://doi.org/10.1186/
s12944- 015- 0123- 1.
199. Di Girolamo FG, Situlin R, Biolo G.What factors influence
protein synthesis and degradation in critical illness? Curr Opin
Clin Nutr Metab Care. 2017;20(2):124–30.
200. Barrow RE, Dasu MR, Ferando AA, Spies M, Thomas SJ,
Perez-Polo JR, Herndon DN.Gene expression patterns in skeletal muscle of thermally injured children treated with oxandrolone. Ann Surg. 2003;237(3):422–8. https://doi.org/10.1097/01.
SLA.0000055276.10357.FB.
20 1. Wolf SE, Thomas SJ, Dasu MR, Ferrando AA, Chinkes DL,
Wolfe RR, Herndon DN.Improved net protein balance, lean
mass, and gene expression changes with oxandrolone treatment
in the severely burned. Ann Surg. 2003;237(6):801–11. https://
doi.org/10.1097/01.SLA.0000071562.12637.3E.
202. Cochran A, Thuet W, Holt B, Faraklas I, Smout RJ, Horn
SD. The impact of oxandrolone on length of stay following major burn injury: a clinical practice evaluation. Burns.
2013;39(7):1374–9. https://doi.org/10.1016/j.burns.2013.04.002.
203. Jeschke MG, Norbury WB, Finnerty CC, Branski LK,
Herndon DN. Propranolol does not increase inflammation, sepsis, or infections episodes in severely burned children. J Trauma. 2007;62(3):676–81. https://doi.org/10.1097/
TA/0b013e318031afd3.
204. Pham TN, Klein MB, Gibran NS, Arnolod BD, Camelli RL,
Silver GM, Jeschke MG, Finnerty CC, Tompkins RG, Herndon
DN.Impact of oxandrolone treatment on acute outcomes after
severe burn injury. J Burn Care Res. 2008;29(6):902–6. https://
doi.org/10.1097/BCR.0b013e31818ba14d.
205. Porro LJ, Herndon DN, Rodriguez NA. Five-year outcomes
after oxandrolone administration in severely burned children: a randomized clinical trial of safety and efficacy. J
Am Coll Surg. 2012;214(4):489–502. https://doi.org/10.1016/j.
jamcollsurg.2011.12.038.
206. Demling RH.The role of anabolic hormones for wound healing
in catabolic states. J Burns Wounds. 2005;4:46–62.
83

84
Данная книга находится в списке для перевода на русский язык сайта https://meduniver.com/
R. Vinaik et al.
207. Jeschke M, Finnerty CC, Suman OE. The effect of oxandrolone on the endocrinologic, inflammatory, and hypermetabolic responses during the acute phase postburn.
Ann Surg. 2007;246(3):351–62. https://doi.org/10.1097/
SLA.0b013e318146980e.
208. Miller JT, Btaiche IF. Oxandrolone treatment in adults with
severe thermal injury. Pharmacotherapy. 2009;29(2):213–26.
https://doi.org/10.1592/phco.29.2.213.
209. McCullough MC, Namias N, Schulman C, Gomez E, Manning
R, Goldberg S, Pizano L, Ward GC.Incidence of hepatic dysfunction is equivalent in burn patients receiving oxandrolone
and controls. J Burn Care Res. 2007;28(3):412–20. https://doi.
org/10.1087/BCR.0B013E318053D257.
210. Ferrando AA, Sheffield-Moore M, Wolfe SE,
Herndon DN, Wolfe RR. Testosterone administration in severe burn patients ameliorates muscle catabolism. Crit Care Med. 2001;29(10):1936–42. https://doi.
org/10.1097/00003246- 200110000- 00015.
211. Ferrando AA. Anabolic hormones in critically ill patients.
Curr Opin Clin Nutr Metab Care. 1999;2(2):171–5. https://doi.
org/10.1097/00075197- 199903000- 00014.
212. Ferrando AA, Wolfe RR.Restoration of hormonal action and
muscle protein. Crit Care Med. 2007;35(9S):S630–4. https://doi.
org/10.1097/01.CCM.0000278529.44899.57.
213. Spratt DI.Altered gonadal steroidogenesis in critical illness: is
treatment with anabolic steroids indicated? Best Pract Res Clin
Endocrinol Metab. 2001;15(4):479–94. https://doi.org/10.1053/
beem.2001.0165.
214. Basaria S, Coviello AD, Travison TG, et al. Adverse events
associated with testosterone administration. N Engl J Med.
2010;363(2):109–22. https://doi.org/10.1056/NEJMoa1000485.
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