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Contents
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xiii
21 Moving Your Results from Bench to Bedside: Protecting
Scientific Findings . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 221
Dominik Thor
22 The Regulatory Landscape of Cell- and Tissue-Based
Regenerative Medicine: Current Challenges
and Emerging Issues . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 229
Sarah Khalid Alageel, Martin Hildebrandt,
and Ana Valéria Gouveia de Andrade
23 Translational Challenges in Soft Tissue Regeneration . . . . . . . . 245
Juan Liu, Jennifer Ernst, Eric Klingelhoefer, Dominik Saul,
Wolfgang Lehmann, Gunter Felmerer, and Arndt F. Schilling
24 Bone Tissue Engineering Challenges in Craniofacial
Reconstructive Surgeries . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 283
Seyed Mohammad Zargar and Nima Jamshidi
25 Translational Challenges: Lymph Node Tissue Engineering . . . 293
Philipp Neßbach and Matthias M. Aitzetmüller
26 Implementing Tissue Engineering and Regenerative
Medicine Solutions in Silicone Implants . . . . . . . . . . . . . . . . . . . . 303
Jae Chul Lee and Chan Yeong Heo
Part V Regenerative Plastic Surgery
27 Microdeformational Wound Therapy . . . . . . . . . . . . . . . . . . . . . . 321
Douglas Helm and Dennis P. Orgill
28 Clinical Treatment of Hypertrophic Scars . . . . . . . . . . . . . . . . . . 329
Rei Ogawa
29 Tissue Engineering and Regenerative Medicine in Oral
and Maxillofacial Surgery: The Most Important Clinical
Applications of Mesenchymal Stem Cells . . . . . . . . . . . . . . . . . . . 337
Marco Tatullo, Massimo Marrelli, Francesco Paduano,
Francesca Palmieri, Sandro Rengo, Carlo Rengo,
Gianrico Spagnuolo, and Bruna Codispoti
30 Reconstruction of Post-Traumatic Maxillary Ridges Using
a Radial Forearm Free Flap and Allogeneic
Tissue-Engineered Bone Grafts . . . . . . . . . . . . . . . . . . . . . . . . . . . 349
James C. Melville, Huy Q. Tran, Jonathan W. Shum,
Ramzey Tursun, and Robert E. Marx
31 Postoperative Complications of Mandibular Fracture
Management . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 357
Giuseppe Spinelli, Francesco Arcuri, Domenico Valente,
and Tommaso Agostini
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32 Use of Porcine Urinary Bladder Matrix (UBM-ECM) in the
Head and Neck Region . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 365
Bruce A. Kraemer and Amanda Gryniewicz Rowe
33 Advances in Facial Nerve Paralysis: Surgical Innovation,
Tissue Engineering, and Emerging Technology . . . . . . . . . . . . . . 395
Julia R. Brennan, Matthew E. Spector, Jennifer C. Kim,
and Michael J. Brenner
34 Management of Capsular Contracture: Non-surgical
and Surgical Options . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 411
Jacob Haiavy and Whitney Florin
35 Soft Tissue Reconstruction of the Lower Limb . . . . . . . . . . . . . . 429
Mahmoud Kazem Nassar, Daniel J. Jordan,
and Sandip Hindocha
Index . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 459
Contents
Contributors
https://t.me/medicina_free
Tommaso Agostini, MD Department of Maxillo Facial Surgery, Azienda
Ospedaliero-Universitaria Careggi, Florence, Italy
MatthiasM.Aitzetmüller, MD Department of Plastic and Hand Surgery,
Klinikum rechts der Isar, Technical University of Munich, Munich, Germany
Section of Plastic and Reconstructive Surgery, Department of Trauma, Hand
and Reconstructive Surgery, Westfaelische Wilhelms, University of Muenster,
Muenster, Germany
Sarah Khalid Alageel, MSc Department for Plastic Surgery and Hand
Surgery, TUM School of Medicine, Technical University of Munich,
München, Germany
TUM Cells Interdisciplinary Center for Cellular Therapies, TUM School of
Medicine, Technical University of Munich, München, Germany
Francesco Arcuri, MD, PhD Department of Maxillo Facial Surgery,
Azienda Ospedaliero-Universitaria Careggi, Florence, Italy
Tugba Sezgin Arslan, MSc Regenerative Biomaterials Laboratory,
Department of Bioengineering, Engineering Faculty, Canakkale Onsekiz
Mart University, Canakkale, Turkey
Yavuz Emre Arslan, PhD, MSc Regenerative Biomaterials Laboratory,
Department of Bioengineering, Engineering Faculty, Canakkale Onsekiz
Mart University, Canakkale, Turkey
OskarC. Aszmann, MD Division of Plastic and Reconstructive Surgery,
Department of Surgery, Medical University of Vienna, Vienna, Austria
Christian Doppler Laboratory for Restoration of Extremity Function, Medical
University of Vienna, Vienna, Austria
Patrick C. Baer, MD Division of Nephrology, Department of Internal
Medicine III, Goethe-University, Frankfurt am Main, Germany
MimiR.Borrelli, MBBS, MSc, BSc Division of Plastic and Reconstructive
Surgery, Department of Surgery, Stanford University School of Medicine,
Stanford, CA, USA
JuliaR.Brennan Department of Otolaryngology—Head and Neck Surgery,
University of Michigan, Ann Arbor, MI, USA
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MichaelJ.Brenner, MD Department of Otolaryngology—Head and Neck
Surgery, University of Michigan, Ann Arbor, MI, USA
Elizabeth A. Brett, MSc Experimental Plastic Surgery, Department of
Plastic and Hand Surgery, Klinikum rechts der Isar, Technical University of
Munich, Munich, Germany
Kelly Bridgham, BS Department of Plastic and Reconstructive Surgery,
Johns Hopkins School of Medicine, Baltimore, MD, USA
Akash Chandawarkar, MD Department of Plastic and Reconstructive
Surgery, Johns Hopkins School of Medicine, Baltimore, MD, USA
Laura Cipolla, PhD Department of Biotechnology and Biosciences,
University of Milano-Bicocca, Milano, Italy
BrunaCodispoti, BBSc, PhD Tecnologica Research Institute, Biomedical
Section, Crotone, Italy
AlexandraCondé-Green, MD Division of Plastic Surgery, Department of
General Surgery, Rutgers New Jersey Medical School, Newark, NJ, USA
Halley Darrach, BS Department of Plastic and Reconstructive Surgery,
Johns Hopkins School of Medicine, Baltimore, MD, USA
AnaValériaGouveiade Andrade, MD TUM Cells Interdisciplinary Center
for Cellular Therapies, TUM School of Medicine, Klinikum rechts der Isar,
Technical University of Munich, Munich, Germany
Contributors
BurakDerkus, PhD Department of Biomedical Engineering, Engineering
Faculty, Eskisehir Osmangazi University, Eskisehir, Turkey
Neelima Deshpande, MD Healthpoint Polyclinic, Kothrud, Pune, MH,
India
DominikDuscher, MD Department for Plastic Surgery and Hand Surgery,
Division of Experimental Plastic Surgery, Technical University of Munich,
Munich, Germany
Steffen U. Eisenhardt, MD Division of Reconstructive Microsurgery,
Department of Plastic and Hand Surgery, Medical Center—University of
Freiburg Faculty of Medicine, University of Freiburg, Freiburg, Germany
Emel Emregul, PhD Bioelectrochemistry Laboratory, Department of
Chemistry, Ankara University, Tandogan, Ankara, Turkey
Kaan C. Emregul, PhD Bioelectrochemistry Laboratory, Department of
Chemistry, Ankara University, Tandogan, Ankara, Turkey
Jennifer Ernst, MD Clinic for Trauma Surgery, Orthopedics and Plastic
Surgery, University Medical Center Goettingen, Goettingen, Germany
AngelaFaga, MD Advanced Technologies for Regenerative Medicine and
Inductive Surgery Research Center (T.A.Me.Ri.C.I.), University of Pavia,
Pavia, Pavia, Italy
Contributors
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xvii
GunterFelmerer, MD Clinic for Trauma Surgery, Orthopedics and Plastic
Surgery, University Medical Center Goettingen, Goettingen, Germany
WhitneyFlorin, MD, DDS Inland Cosmetic Surgery, Rancho Cucamonga,
CA, USA
MarkS.Granick, MD Division of Plastic Surgery, Department of General
Surgery, Rutgers New Jersey Medical School, Newark, NJ, USA
AmandaGryniewiczRowe, MS Division of Plastic Surgery, Department of
Surgery, St. Louis University School of Medicine, St. Louis, MO, USA
Christina Irene Günter, MD Department for Plastic Surgery and Hand
Surgery, Klinikum rechts der Isar, Technical University of Munich, Germany
GeoffreyC.Gurtner, MD Division of Plastic and Reconstructive Surgery,
Department of Surgery, Stanford University School of Medicine, Stanford,
CA, USA
Jacob Haiavy, MD Inland Cosmetic Surgery, Rancho Cucamonga, CA,
USA
DouglasHelm, MD Brigham and Women’s Hospital Wound Care Center,
Division of Plastic and Reconstructive Surgery, Brigham and Women’s
Hospital, Boston, MA, USA
Chan Yeong Heo, MD, PhD Department of Plastic and Reconstructive
Surgery, Seoul National University Bundang Hospital, Seongnam-si,
Gyeonggi-do, Republic of Korea
Department of Plastic Surgery, College of Medicine, Interdisciplinary
Program in Bioengineering, College of Engineering, Seoul National
University, Seoul, Republic of Korea
MartinHildebrandt, MD TUM Cells Interdisciplinary Center for Cellular
Therapies, TUM School of Medicine, Klinikum rechts der Isar, Technical
University of Munich, Munich, Germany
Institute of Clinical Chemistry and Pathobiochemistry, Klinikum rechts der
Isar, Technical University of Munich, Munich, Germany
Sandip Hindocha, MD, MP, MBChB, MRCS Plastic Surgery & Laser
Centre, Bedford Hospital NHS Trust, Bedford, UK
Khosrow Siamak Houschyar, MD Department of Plastic Surgery, BG
University Hospital Bergmannsheil, Ruhr University Bochum, Bochum,
Germany
Nima Jamshidi, PhD Department of Biomedical Engineering, Faculty of
Engineering, University of Isfahan, Isfahan, Iran
Daniel J. Jordan, MBChB, MRCS, BSc, MSc Plastic Surgery and
Reconstruction Department, Ninewells Hospital and Medical School, Tayside
NHS Trust, Dundee, UK
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ShilpaDeshpandeKaistha, PhD Department of Microbiology, Institute of
Biosciences & Biotechnology, Chhatrapati Shahu Ji Maharaj University,
Kanpur, UP, India
Reba Kanungo, MD Department of Clinical Microbiology, Pondicherry
Institute of Medical Sciences, Kalapet, Puducherry, India
Ravish Katiyar, PhD Department of Microbiology, Sanjay Gandhi Post
Graduate Institute of Medical Sciences, Lucknow, UP, India
JenniferC.Kim Department of Otolaryngology—Head and Neck Surgery,
University of Michigan, Ann Arbor, MI, USA
EricKlingelhoefer, MD Clinic for Trauma Surgery, Orthopedics and Plastic
Surgery, University Medical Center Goettingen, Goettingen, Germany
Benjamin Koch, MD Division of Nephrology, Department of Internal
Medicine III, Goethe-University, Frankfurt am Main, Germany
Bruce A. Kraemer, M.D. Division of Plastic Surgery, Department of
Surgery, St. Louis University School of Medicine, St. Louis, MO, USA
Jae Chul Lee, PhD Department of Plastic and Reconstructive Surgery,
Seoul National University Bundang Hospital, Seongnam-si, Gyeonggi-do,
Republic of Korea
Contributors
Wolfgang Lehmann, MD Clinic for Trauma Surgery, Orthopedics and
Plastic Surgery, University Medical Center Goettingen, Goettingen, Germany
JuanLiu, MD Department of Hand Surgery, Wuhan Union Hospital, Tongji
Medical College, Huazhong University of Science and Technology, Wuhan,
China
Zeshaan N. Maan, MD Division of Plastic and Reconstructive Surgery,
Department of Surgery, Stanford University School of Medicine, Stanford,
CA, USA
Hans-GüntherMachens, MD Clinic for Plastic Surgery and Hand Surgery,
Klinikum Rechts der Isar, Technical University Munich, Munich, Germany
Division for Experimental Plastic Surgery, Department of Plastic and Hand
Surgery, Klinikum Rechts der Isar, Technical University of Munich, Munich,
Germany
MassimoMarrelli, MD Marrelli Health, Clinical Research Unit, Crotone,
Italy
RobertE. Marx, DDS University of Miami, Jackson Memorial Hospital,
Miami, FL, USA
StephenK.Mathew, MD Department of Microbiology, Believers Church
Medical College, Thiruvalla, Kerala, India
Contributors
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xix
Department of Microbiology, Pondicherry Institute of Medical Sciences,
Kalapet, Puducherry, India
JohannesA.Mayer, MD Christian Doppler Laboratory for Restoration of
Extremity Function, Medical University of Vienna, Vienna, Austria
James C. Melville, DDS Department of Oral and Maxillofacial Surgery,
University of Texas Health Sciences Center at Houston, Houston, TX, USA
Department of Oral and Head and Neck Oncology and Microvascular Surgery,
School of Dentistry, University of Texas Health Sciences Center at Houston,
Houston, TX, USA
SilviaMihalceanu Division for Experimental Plastic Surgery, Department
of Plastic and Hand Surgery, Klinikum rechts der Isar, Technical University
of Munich, Munich, Germany
CaitlynA.Moore, ME Division of Plastic Surgery, Department of General
Surgery, Rutgers New Jersey Medical School, Newark, NJ, USA
Mahmoud Kazem Nassar, MBChB, MRCS Plastic Surgery and
Reconstruction Department, Ninewells Hospital and Medical School, Tayside
NHS Trust, Dundee, UK
PhilippNeßbach, MSc Department for Plastic and Hand Surgery, Klinkum
rechts der Isar, Technical University of Munich, Munich, Germany
GiovanniNicoletti, MD Advanced Technologies for Regenerative Medicine
and Inductive Surgery Research Center (T.A.Me.Ri.C.I.), University of Pavia,
Pavia, Italy
Plastic Surgery Unit, Department of Clinical-Surgical, Diagnostic and
Pediatric Sciences, University of Pavia, Pavia, Italy
ReiOgawa, MD, PhD Department of Plastic, Reconstructive and Aesthetic
Surgery, Nippon Medical School, Tokyo, Japan
DennisP. Orgill, MD, PhD Brigham and Women’s Hospital Wound Care
Center, Division of Plastic and Reconstructive Surgery, Brigham and
Women’s Hospital, Boston, MA, USA
ErenOzudogru, MSc Regenerative Biomaterials Laboratory, Department
of Bioengineering, Engineering Faculty, Canakkale Onsekiz Mart University,
Canakkale, Turkey
FrancescoPaduano, BBSc, PhD Marrelli Health, Clinical Research Unit,
Crotone, Italy
AndreaPagani Department of Plastic and Hand Surgery, Klinikum rechts
der Isar, Technical University of Munich, Munich, Germany
FrancescaPalmieri, Biol. Lab.Technician Tecnologica Research Institute,
Biomedical Section, Crotone, Italy
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Pranela Rameshwar, PhD Division of Plastic Surgery, Department of
General Surgery, Rutgers New Jersey Medical School, Newark, NJ, USA
CarloRengo, DDS, PhD University of Naples “Federico II”, Naples, Italy
SandroRengo, MD, DDS, PhD University of Naples “Federico II”, Naples,
Italy
Roberto Guizzardi Department of Biotechnology and Biosciences,
University of Milano-Bicocca, Milan, Italy
Justin M. Sacks, MD, MBA Department of Plastic and Reconstructive
Surgery, Johns Hopkins School of Medicine, Baltimore, MD, USA
StefanSalminger, MD, PhD Division of Plastic and Reconstructive Surgery,
Department of Surgery, Medical University of Vienna, Vienna, Austria
Christian Doppler Laboratory for Restoration of Extremity Function, Medical
University of Vienna, Vienna, Austria
MihaiSăndulescu, DDS, PhD Department of Implant Prosthetic Therapy,
Carol Davila University of Medicine and Pharmacy, Bucharest, Romania
OanaSăndulescu, MD, PhD Department of Infectious Diseases I, National
Institute for Infectious Diseases “Prof. Dr. Matei Bals”, Carol Davila
University of Medicine and Pharmacy, Bucharest, Romania
Contributors
Dominik Saul, MD Clinic for Trauma Surgery, Orthopedics and Plastic
Surgery, University Medical Center Goettingen, Goettingen, Germany
Matthias A. Sauter, MD Experimental Plastic Surgery, Department of
Plastic and Hand Surgery, Klinikum rechts der Isar, Technical University of
Munich, München, Germany
Richard Schäfer, MD Institute for Transfusion Medicine and
Immunohematology, German Red Cross Blood Donor Service BadenWürttemberg-Hessen gGmbH, Goethe University Hospital, Frankfurt am
Main, Germany
Arndt F. Schilling Clinic for Trauma Surgery, Orthopedics and Plastic
Surgery, University Medical Center Goettingen, Goettingen, Germany
Jonathan W. Shum, DDS, MD Department of Oral and Maxillofacial
Surgery, University of Texas Health Sciences Center at Houston, Houston,
TX, USA
Department of Oral and Head and Neck Oncology and Microvascular Surgery,
School of Dentistry, University of Texas Health Sciences Center at Houston,
Houston, TX, USA
Gianrico Spagnuolo, DDS, PhD University of Naples “Federico II”,
Naples, Italy
Matthew E. Spector Department of Otolaryngology—Head and Neck
Surgery, University of Michigan, Ann ArborMI, USA
Contributors
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xxi
Giuseppe Spinelli, MD Department of Maxillo Facial Surgery, Azienda
Ospedaliero-Universitaria Careggi, Florence, Italy
Adrian Streinu-Cercel, MD, PhD Department of Infectious Diseases I,
National Institute for Infectious Diseases “Prof. Dr. Matei Bals”, Carol Davila
University of Medicine and Pharmacy, Bucharest, Romania
Anca Streinu-Cercel, MD, PhD Department of Infectious Diseases I,
National Institute for Infectious Diseases “Prof. Dr. Matei Bals”, Carol Davila
University of Medicine and Pharmacy, Bucharest, Romania
MarcoTatullo, MD, DS, PhD Tecnologica Research Institute, Biomedical
Section, Crotone, Italy
DominikThor, PhD Vienna University of Economics and Business, Institute
for Small Business Management and Entrepreneurship, Vienna, Austria
Huy Q. Tran, DDS Department of Oral and Maxillofacial Surgery,
University of Texas Health Sciences Center at Houston, Houston, TX, USA
Department of Oral and Head and Neck Oncology and Microvascular Surgery,
School of Dentistry, University of Texas Health Sciences Center at Houston,
Houston, TX, USA
MarcoMarioTresoldi, MD Plastic Surgery Unit, Department of ClinicalSurgical, Diagnostic and Pediatric Sciences, University of Pavia, Pavia, Italy
I.C.S. Maugeri Research and Care Institute, Pavia, Italy
Ramzey Tursun, DDS Department of Oral and Maxillofacial Surgery,
University of Texas Health Sciences Center at Houston, Houston, TX, USA
Department of Oral and Head and Neck Oncology and Microvascular Surgery,
School of Dentistry, University of Texas Health Sciences Center at Houston,
Houston, TX, USA
University of Miami, Jackson Memorial Hospital, Miami, FL, USA
PramilaDeviUmrao, MSc, PhD Department of Microbiology, Institute of
Biosciences & Biotechnology, Chhatrapati Shahu Ji Maharaj University,
Kanpur, UP, India
MattiaVacchini Department of Biotechnology and Biosciences, University
of Milano-Bicocca, Milan, Italy
Domenico Valente, MD Department of Maxillo Facial Surgery, Azienda
Ospedaliero-Universitaria Careggi, Florence, Italy
Maximilian Zaussinger, MD Department of Plastic and Hand Surgery,
Klinikum rechts der Isar, Technical University of Munich, Munich, Germany
Johannes Zeller, EMDM, MD Division of Reconstructive Microsurgery,
Department of Plastic and Hand Surgery, Medical Center—University of
Freiburg Faculty of Medicine, University of Freiburg, Freiburg, Germany
Part I
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Elements of Regenerative Medicine
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