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1 Clinical Diagnostic Nasopharyngolaryngoscopy
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Fig. 1.13 (a) Severe retroexion of the epiglottis. (b) Same patient; view of the larynx with rotation manoeuvre (and NBI imaging). (c) Same patient; view of same larynx on phonation showing glottic gap and severe muscle tension
Fig. 1.14 (a) Neutral. (b) The head tilted forward in a modied Killian’s position
1.7.4.6 Trachea
In a normal endoscopy, the view of the larynx is on a posterior/ anterior oblique angle. To get a view down the airway, the scope must be moved forward to come into alignment with the
descending airway. To do this, the head must be moved for­ward slightly and the chin tucked down in a modied Killian’s position (Fig.1.14). This will bring the tip of the scope above the larynx and a view down to the carina will be obtained.
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1.8 Imaging Modalities
Until quite recently, white light imaging (WLI) was the only means of looking at the larynx. FNs are designed along the principles of passing light along exible light source that shines from the tip of the scope. The image is transported back through the scope along a series of bres and when any of these breaks, the light no longer passes up them giving the image black spots and overall the image is pixelated.
These scopes are those that are very commonly used in clinics globally requiring the user to either look through the eyepiece or attach a camera to the scope to allow projection onto a screen. The larger the screen, the more pixelated the image became. More recently, chip-tip FNs have allowed a much higher-denition image to be obtained. The image is captured by the “chip” that is housed at the end of the scope and then transported electronically to the screen. This means the light has only to reach the tip of the scope rather than passing along the length of the scope, and subsequently, there is no pixilation of the image and the quality is much higher. There are no eyepieces on chip-tip scopes as the image is passed as an electrical signal rather than as light, so one must have a linked processor or stack system to be able to view the image.
With the progression of technology, different light modal­ities have been incorporated into these scopes to allow a greater range of examination possibilities and, hopefully, to allow the clinician to gain a greater diagnostic capability. Two of the most commonly used are narrow band imaging and stroboscopy.
1.8.1 Blue Light Imaging (BLI)
This is a technique that enhances the view of the supercial mucosa vascularity. It is named differently by different endo­scope manufacturers (see below), but the principle is the same.
Some common endoscope manufacturers and their named light sources include
green areas of the spectrum. This means that when WLI is employed, the whole light spectrum is absorbed by the tis­sues differentially and reected with blood vessels shining red, because the blue and green are absorbed and not reected. Accentuating the blue and green light and reducing the red spectrum means that red is not reected and the blue and green is absorbed but not reected by the haemoglobin. The blood vessels show up dark green or black.
In addition, the shorter wavelengths of the spectrum only penetrate the most supercial tissues so that the epithelial and immediate subepithelial vessels are highlighted with precision and clarity. With WLI, the longer wavelengths (red) penetrate deeper into the tissues and reect back, caus­ing a slight defocussing of the image, even with high­denition equipment. This means that a benet of BLI is of sharp-contrast images of the mucosa without the use of dyes.
BLI has been shown to be superior to WLI in the detec­tion of mucosal squamous cell carcinoma (SCC) in a number of studies [1517]. It also appears to be a promising imaging modality in the differentiation between benign and pre­malignant conditions [18]. A vascular pattern classication has been proposed by Ni etal. that shows great promise and may help the clinician decide whether to biopsy an indeter­minate lesion or have the condence to monitor as an out­patient [19] (Fig.1.15).
As with any technique or novel piece of equipment, it should be used regularly to get an appreciation of how it works with normal tissue as well as with the abnormal. Therefore, as the BLI is simply a button to press, the authors would advocate using it on every patient the has an endo­scope passed as part of their examination. This will ensure the clinician becomes accustomed to what normal tissues look like under BLI and then be able to ascertain how clearly abnormal tissues differ under BLI.Once these ends of the pathology spectrum are recognised, then and only then can diagnostic decisions about intermediary stages (IPCL III, IV, and possibly Va—see above) be attempted.
1.8.2 Others (OCT/Strobe)
Olympus Narrow Band Imaging (NBI) Pentax iScan Xion Piet Storz Spectra
The light source is changed from WLI, that uses all of the wavelengths of the visible spectrum, to more focussed wave­lengths. They concentrate around the blue and green spectra, at 415nm (blue and 540nm (green). The rest of the visible spectrum is reduced to almost nothing.
Haemoglobin, like all matter, has an absorption spectrum of light, but it has two main absorption peaks in the blue and
Stroboscopy is an instrument rather than a technique per se and works by making cyclically moving objects appear slow­moving. This can be very helpful in examining the vocal folds as when phonating the folds vibrate hundreds of times per second. When viewed with the naked eye, this appears as a blur; so, small lesions on the edges of the vocal folds that only become apparent when the vocal folds are vibrating are sometimes only seen when the stroboscopy is employed.
Stroboscopy is routinely employed in specialist voice clinics, but when looking for malignant lesions in and around the larynx, it is less useful. However, the post-radiotherapy larynx patient often has hoarseness due to stiffening of the
1 Clinical Diagnostic Nasopharyngolaryngoscopy
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Fig. 1.15 IPCL classication (From [19]; with permission)
supercial lamina propria and reduced or asymmetrical vibration of the vocal folds. This asymmetry will be picked up on stroboscopy, as will acyclical waveforms.
As technology advances, newer experimental imaging modalities may be added to either the endoscopy software or hardware, allowing the clinician to examine the upper aero­digestive tract in a number of different ways to get a multi­faceted assessment of a lesion.
One such modality is optical coherence tomography (OCT). This currently involves placing a light source close to the tissue in question. This “scans” the tissue up to a few mil­limeters in depth and registers the differential reection of light. This is turn can be turned into an image showing differ­ent tissue characteristics. This has been termed an “optical biopsy.” It has been shown both invivo and exvivo studies to correlate well with histological sections and appears to be able to distinguish between healthy and abnormal tissues in a number of organs.
As the technology is miniaturised, it could be incorpo­rated into the chip-tip software so that one can imagine an endoscopic FN examination in clinic to involve WLI, BLI, OCT, and stroboscopy. This could be followed by a biopsy under local anaesthetic and a full diagnostic workup could be done in one sitting.
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1.9 Extended Uses
Recent technological advancements in the types of transna­sal endoscopes, instrument miniaturisation, and topical anaesthetic techniques have led to a shift in management from the operation room to ofce-based settings. This enables clinicians to perform procedures under topical anaesthesia, such as transnasal oesophagoscopy (TNE), ex-
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ible endoscopic biopsy (FEB), or certain exible endoscopic procedures. A exible endoscopic laryngeal laser-assisted surgical technique has been recently proposed for patients with early glottic cancer and difcult laryngoscopy (trismus secondary to previous maxillofacial trauma requiring com­plex surgery, signicant restriction of cervical spine mobil­ity, or marked glossomegaly secondary to severe obstructive sleep apnoea) [20].
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1.9.1 Transnasal (O)Esophagoscopy (TNE)
Unsedated transnasal esophagogastroduodenoscopy (T-EGD) was initially introduced by gastroenterologist Shaker [21]. However, it was not widely adopted by his col­leagues, presumably because of a lack of familiarity with nasal anatomy or a reluctance to perform EGD without intra­venous sedation. Because of a greater acceptance among head and neck surgeons, TNE has evolved into an important addition to the diagnosis and treatment of dysphagia, globus, and other disorders of the oesophagus, such as squamous cell carcinoma [22, 23]. Since then, TNE has been extensively reported on, and has proved to accurately diagnose oesopha­geal pathology [23]. Several studies showed better patient acceptability and less cardiopulmonary stress (i.e. rise in blood pressure and heart rate) during TNE, compared to tran­soral esophagoscopy [23].
Most oesophageal pathologies are found in patients suf­fering from both globus pharyngeus and dysphagia; thus, this combination might be a strong indication to perform TNE (). An ongoing point of discussion is the screening for second primary tumours in the oesophagus in patients with hypopharyngeal carcinoma, given the relatively higher inci­dence of oesophageal carcinoma in these patients [23].
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Traditional diagnostics consisted of exible pharyngolar­yngoscopy, video uoroscopy, rigid oesophagoscopy under general anaesthesia, and referral to a gastroenterologist in cases requiring exible oesophageal inspection. Furthermore, in the diagnostic workup of hypopharyngeal carcinoma, inspection of the proximal oesophagus has been usually per­formed under general anaesthesia to determine the distal bor­der of the tumour. With the introduction of TNE, patients with suspected hypopharyngeal carcinoma can have it per­formed in ofce the same day to identify the distal border of the tumour and biopsies taken if necessary. Ofce-based TNE is a signicant cost savings procedure, for patients with globus pharyngeus and/or dysphagia, and suspicion of hypo­pharyngeal carcinoma. Furthermore, this procedure has good patient acceptance and few complications [22].
The goal of TNE is to evaluate the oesophageal inlet and the upper third of the oesophagus in order to stage adequately hypopharyngeal pathology or detect upper third oesophageal cancer.
1.9.1.1 Technique
TNE can be performed as a continuation or not of exible hypopharyngeal evaluation. The procedure is performed with the patient sitting upright in an examination chair across from the endoscopist. Two sprays of 20% benzo­caine are then administered to the oropharynx. The endo­scope is lubricated with 2% viscous lidocaine. The examiner waits at least 5min to allow the topical anaesthesia to take effect. The patient’s head is then exed forward towards their chest (Killian’s manoeuvre) as the bre-optic scope is passed towards the cricopharyngeus muscle (Fig. 1.16). The patient is asked to swallow or belch, and the instrument is gently advanced. Our standard practice is to advance the instrument as far as it gets. Using a combination of air insufation and irrigation, the mucosa of the oesophagus can be examined whilst the scope is slowly withdrawn. If mucosal lesions or irregularities are noted, biopsy forceps are passed through the biopsy port and multiple biopsies are obtained.
1.9.2 Flexible Endoscopic Biopsies (FEB)
Advanced stage laryngopharyngeal cancer has poor progno­sis and early diagnosis is crucial for improving treatment results and survival [22]. The initial work-up starts in the ofce with history, physical examination, and imaging request, despite a biopsy being essential for the histological diagnosis. Traditionally, the biopsy of laryngopharyngeal lesions has been performed under general anaesthesia; never­theless, Ofce-based FEB is reported to be safe, feasible, cost-effective, and easy to perform [23]. The advantages are an awake patient who is sitting in an upright position and able to control laryngeal function during the procedure, which can result in adequate visualisation. Furthermore, there is avoid­ance of general anaesthesia with possible health benets and its costs are relatively low. By arranging a fast diagnostic track, patients are evaluated sooner by the pathologist (<1week) and the diagnostic process can be shortened.
The disadvantages of FEB are the need for a cooperative patient (e.g. able to sit still, minimal gag reex) and the inability to perform deep biopsies of submucosal tumours.
1.9.2.1 Technique
After acquiring informed consent from the patient, the phar­ynx and larynx are sprayed with 10% lidocaine spray tran­sorally, just prior to the procedure. In case of a laryngeal biopsy, additional anaesthesia is injected intratracheally (1.0mL of 10% lidocaine) through the cricothyroid mem­brane and topically on the vocal cords.
Biopsies are obtained using a 2.0mm diameter working channel and a single-use 1.8 mm diameter exible biopsy forceps. During biopsy, the exible videoendoscope is inserted transnasally in a sitting position. After visualisation of the laryngopharyngeal lesion, a biopsy fórceps is passed through the working channel. The lesion is approached with an open jaw biopsy forceps, pushed deep into the lesion, and closed. The biopsy forceps is then pulled back swiftly, whilst feeling for resistance when removing the tissue from the sus­pected lesion, which indicates a deeply taken biopsy.
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Fig. 1.16 (a–d) The patient’s head is then exed forward towards their chest (Killian’s manoeuvre) as the bre-optic scope is passed towards the cricopharyngeus muscle
1.10 Summary
tioned in this Chapter will be possible. However, the caveat is that none of these will be possible without good knowl-
FN has revolutionised the examination of the upper aero­digestive tract and the scope of use has now extended beyond the connes of pure examination into the treatment of pathol­ogy. In-ofce procedures are becoming more commonplace
edge of the equipment and sound FN examination technique by the clinician. Whenever a clinician thinks that a technique has been mastered, it is always worth going back to the basics to check.
and as technology advances, more adjuncts to those men-
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More technology will surely be incorporated into the soft­ware available on the FN equipment so that a patient will be able to undergo an array of diagnostic investigations in the out-patient setting followed by a biopsy. In one visit, it may be possible for the patient to get a complete diagnosis and a treatment plan. The future of out-patient endoscopy is very bright.
References
1. Garritano FG, Goldenberg D.Telemedicine in otolaryngology head and neck surgery. Ear Nose Throat J. 2012;91:226–7.
2. Quimby AE, Kohlert S, Caulley L, etal. Smartphone adapters for exible nasolaryngoscopy: a systematic review. J Otolaryngol Head Neck Surg. 2018;47:30.
3. Hiss S, Postma G.Fiberoptic endoscopic evaluation of swallowing. Laryngoscope. 2003;113:1386–93.
4. Shah JP, Shaha AR, Spiro RH, etal. Carcinoma of the hypophar­ynx. Am J Surg. 1976;132:439–43.
5. Lee KD, Lu CH, Chen PT, etal. The incidence and risk of develop­ing a second primary esophageal cancer in patients with oral and pharyngeal carcinoma: a population-based study in Taiwan over a 25year period. BMC Cancer. 2009;9:373.
6. Watanabe A, Hosokawa M, Taniguchi M, etal. Impact of endo­scopic screening on early detection of hypopharyngeal cáncer. Head Neck. 2006;28:350–4.
7. Ni XG, Zhang QQ, Zhu JQ, etal. Hypopharyngeal cancer associ­ated with synchronous oesophageal cancer: risk factors and ben­ets of image-enhanced endoscopic screening. J Laryngol Otol. 2018;132:154–61.
8. Tsunoda A, Ishihara A, Kishimoto S, etal. Head torsion technique for detailed observation of larynx and hypopharynx. J Laryngol Otol. 2007;121:489–90.
9. Spraggs PD, Harries ML. The modied Valsalva manoeuvre to improve visualization of the hypopharynx during exible nasopha­ryngoscopy. J Laryngol Otol. 1995;109:863–4.
10. Hillel AD, Schwartz AN. Trumpet maneuver for visual and CT examination of the pyriform sinus and retrocricoid area. Head Neck. 1989;11:231–6.
11. Purser S, Antippa P.Maneuver to assist examination of the hypo­pharynx. Head Neck. 1995;17:389–93.
12. Sakai A, Okami K, Ebisumoto K, et al. New techniques to detect unknown primaries in cervical lymph node metastasis. Laryngoscope. 2010;120:1779–83.
13. Murono S, Tsuji A, Endo K, etal. Evaluation of modied Killian’s method: a technique to expose the hypopharyngeal space. Laryngoscope. 2014;124:2526–30.
14. Ni XG, Cheng RR, Lai SQ, etal. Novel laryngoscopic strategies to improve evaluation of the site and extent of primary hypopharyn­geal tumours. J Laryngol Otol. 2013;127:882–9.
15. Chu PY, Tsai TL, Tai SK, Chang SY.Effectiveness of narrow band imaging in patient with oral squamous cell carcinoma after treat­ment. Head Neck. 2012;34(2):155–61.
16. Lin YC, Wang WH, Lee KF, Tsai WC, Weng HH.Value of narrow band imaging endoscopy in early mucosal head and neck cancer. Head Neck. 2012;34(11):1574–9.
17. Piazza C, Dessouky O, Peretti G, Cocco D, De Benedetto L, Nicolai P.Narrow-band imaging: a new tool for evaluation of head and neck squamous cell carcinomas. Review of the literature. Acta Otorhinolaryngol Ital. 2008;28(2):49–54.
18. Bertino G, Caciola S, Fernandes WB Jr, etal. Effectiveness of nar­row band imaging in the detection of premalignant and malignant lesions of the larynx: validation of a new endoscopic clinical clas­sication. Head Neck. 2015;37(2):215–22.
19. Ni XG, He S, Xu ZG, etal. Endoscopic diagnosis of laryngeal can­cer and precancerous lesions by narrow band imaging. J Laryngol Otol. 2011;125(3):288–96.
20. Karkos PD, Stavrakas M, Markou K. Early glottic cancer and difcult laryngoscopy: exible endoscopic diode laryngeal laser­assisted surgery—a pilot study of an oncologically safe tool. Clin Otolaryngol. 2016;41:830.
21. Shaker R. Unsedated trans-nasal pharyngoesophagogastroduode­noscopy (T-EGD): technique. Gastrointest Endosc. 1994;40:346–8.
22. Mohammed H, Del Pero M, Coates M, etal. Ofce-based transna­sal esophagoscopy biopsies for histological diagnosis of head and neck patients. Laryngoscope. 2019;129:2721–6.
23. Wellenstein DJ, Honings J, Schutte HW, et al. Cost analysis of ofce-based transnasal esophagoscopy. Eur Arch Otorhinolaryngol. 2019;276:1457–63.
Transnasal Oesophagoscopy
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andAdvanced Applications
YakubuKaragama, AinaBrunet-Garcia, NatalieA.Watson, andAsitArora
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2.1 Introduction
Transnasal oesophagoscopy (TNO) is a specialised chan­nelled bre-optic endoscope that allows the practitioner to perform a full endoscopic examination of the upper aerodi­gestive tract in an ofce set-up under local anaesthetic. Although not entirely new, TNO is still not widely practiced worldwide [13]. It is not known why TNO has not been so widely adopted, but there are suggestions that initially there were doubts on the ability to examine the post-cricoid area fully, the cost of setting up such a service, and the relevant experience required. Most recently, however, there has been a gradual increased interest in this practice possibly owing to the added features on the TNO endoscope, such as the work­ing channel, suction and insufation, and the length of the TNO, which has made it possible to perform both diagnostic and therapeutic examination of the entire aerodigestic tract in the ofce under local anaesthetic.
Y. Karagama Guy’s and St Thomas’s NHS Foundation Trust, London, UK
ENT Department, Guy’s Hospital, London, UK e-mail: Yacubu.Karagama@gstt.nhs.uk
A. Brunet-Garcia Department of Otorhinolaryngology and Head and Neck Surgery, Guy’s and St Thomas NHS Foundation Trust, London, UK e-mail: aina.brunet@nhs.net
N. A. Watson ST8 Otolaryngology, Guy’s and St Thomas’s NHS Foundation Trust, London, UK e-mail: nataliewatson@nhs.net
A. Arora (*) Department of Head and Neck Surgery, Guy’s and St Thomas’s NHS Foundation Trust, London, UK e-mail: asitarora@doctors.org.uk
2.2 Indications forTNO
• Examination of the pharynx, oesophagus, stomach, and
duodenum, also known as Video Panendoscopy (VIP) examination of the aerodigestive tract.
• Balloon dilatation in the management of dysphagia
caused by cricopharyngeal spasm or hypertonicity, web or stricture (particularly after surgery or after radiother­apy treatment), or oesophageal ring.
• Placement of Bravo™capsule for pH monitoring.
• Insertion of nasogastric tube.
• Removal of foreign body in the aerodigestive tract.
• Biopsy of lesions in the upper aerodigestive tract.
• Laser therapy for ablation of lesions with bre KTP, blue
laser, or bre CO2 laser.
• Secondary tracheo-oesophageal puncture and placement
of speech valve.
• Cancer surveillance, especially in post-cricoid
tumours.
2.3 Equipment Set-up
• Video stack system.
• Transnasal oesophagoscope.
• Local anaesthetic (LA).
• Extra equipment depends on transnasal intervention, for
example biopsy (biopsy forceps), injection (injectable substance and injectable applicator), laser (exible KTP, blue light or CO2 laser), balloon dilatation (balloons of different sizes and pump), oesophageal speech valve, or Bravo™capsule for pH monitor etc.
© Springer Nature Switzerland AG 2024 R. Simo et al. (eds.), Atlas of Head and Neck Surgery, Springer Surgery Atlas Series,
https://doi.org/10.1007/978-3-031-36593-5_2
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2.4 TNO Procedures
2.4.1 Technique forTNO
This procedure is performed in the outpatient set-up with the patient sitting up comfortably. The nasal passage is anaesthe­tised with 2.5mL of lidocaine 5% HCL w/v with phenyleph­rine 0.5% w/v. The throat is further sprayed with 5–10 puffs of 10% lidocaine oral spray. The TNO (Fig. 2.1) is intro­duced transnasally and the nasal cavity, pharynx, and larynx are inspected before passing the TNO into the oesophageal inlet. It is important to ask the patient to swallow immedi­ately when the TNO is placed in the piriform fossa and gen­tle pressure is applied until the upper oesophagus is visualised. Sometimes the oesophagus may need to be insuf­ated to enhance visualisation. This is mostly helpful during examination of the gastro-oesophageal junction. It is impor­tant not to over-inate the stomach. This can be avoided by aspirating the air every so often.
2.4.2 TNO-Guided Balloon Dilatation
2.4.2.1 Preoperative Preparation
Full clinical history and examination and patient selection based on symptoms, examination ndings, and diagnosis from Barium swallow and TNO ndings.
2.4.2.2 Materials
– There are different sizes of balloon, but most patients will
require a 20mm size. There are different manufacturers, for example Cook® Medical and Boston Scientic bal­loons that are suitable.
– Pressure pump syringe (size 60mL for Cook® Medical)
– Transnasal oesophagoscope and a Videostack system (e.g.
from PENTAX Medical, Olympus, Storz, and DP medi­cals are available)
– 2.5mL lidocaine HCL 5% w/v and phenylephrine HCL
0.5% w/v topical nasal spray
– 2mL of 10% Xylocaine throat spray
2.4.3 Procedure
This procedure is performed with the patient sitting up at approximately 60°. Good topical anaesthesia of the nasal passages and pharynx is essential in order to complete the whole procedure successfully. This can be achieved with at least 2 mL local anaesthetic spray in both nasal cavities ±2mL of 4% lidocaine nebuliser. A mild sedation may be required in anxious and nervous patients.
A transnasal oesophagoscopy is performed to examine the larynx and pharynx. The TNO is advanced into the upper oesophagus transnasally via the most patent of the two nasal cavities. A full oesophagoscopy down to the gastro­oesophageal junction and into stomach may be performed at this stage if necessary.
Once the TNO is placed past the cricopharyngeus muscle, a guide wire (Fig.2.2a) is introduced through the TNO chan­nel until the guide wire tip emerges at the distal end of the TNO.The TNO is then withdrawn out of the patient com­pletely, whilst the guide wire remains in the oesophagus. It is not always possible to pass the TNO through the cricopha­ryngeus muscle especially in a very tight stricture. In such cases, the TNO is placed over the piriform fossa and the guide wire introduced into the cricopharyngeal inlet under direct view. The guide wire is only about 1.5mm in diameter, so it can usually be introduced through the smallest stricture unless there is a complete blockage of the stricture. In such
Fig. 2.1 A transnasal oesophagoscope (TNO) with labels to the nger controls, channel, suction, insufation buttons, and dials to control the movement of the tip
Finger
control
5 mm
Suction & insufflation
2mm channel
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Fig. 2.2 (a) Cook® Medical balloon; (b) TNO balloon dilatation
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b
Fig. 2.2 (continued)
Y. Karagama et al.
cases, a retrograde dilatation might be necessary via a percu­taneous endoscopic gastrostomy (PEG) tube route.
Once the guide wire tip is placed beyond the stricture, the TNO is re-introduced nasally via the most patent nasal cav­ity. The un-inated balloon is then passed over the guide wire nasally until it passes through the area to be dilated. Both TNO and the balloon cables may be passed via the same nostril if the opposite nasally is too narrow. The balloon is positioned with the proximal metallic silver marker visible approximately 1cm above the level to be dilated. The bal­loon is then inated (Fig.2.2b) using the pressure pump syringe until 20 mm (6 atm, 60 Fr) full dilatation (for a 18-19-20 balloon). This is then deated after 1min and the balloon is removed with the guide wire. In some cases of webbing, two 20mm balloons (40mm) maximum may be used simultaneously. However, this carries a higher risk of perforation and may be more painful requiring more sedation.
2.4.4 Postoperative Instruction
The authors recommend the patient to be nil by mouth for 40–60min post-procedure. Most patients will be day cases unless there are any complications: oesophageal tear. If such unfortunate complications occur, the patient will be man­aged nil by mouth until a water-soluble contrast swallow test is performed to check for a perforation.
2.5 Complications
The main signicant complication is oesophageal perfora­tion, but this is rare with this technique with only one reported perforation reported [4]. Other minor complica­tions are bleeding, nose or throat pain, need for further procedures, and failure of the procedure to improve symptoms.
2.5.1 TNO-Guided Removal Foreign Body
A foreign body in the throat such as a sh bone may be removed with the use of TNO and exible forceps in the ofce under LA (Fig.2.3).
2.5.2 TNO andSuspected Head andNeck Malignancy
TNO is a safe and reliable adjunct to panendoscopy under general anaesthesia for the assessment of patients with sus­pected head and neck lesions [58]. In particular, patients with potentially suspicious head and neck lesions who are not t for general anaesthesia are good candidates for TNO to provide a tissue diagnosis. This can help to expedite man­agement and initiate treatment by allowing radiotherapy, for example, to commence in a timely fashion. Moreover, appro-