3 курс / Фармакология / spravochnik

/*+%9 !'' /, ,0 ! / *!' , 0 + V ' ! +&'( 0 !,

/, $ 3&," *8 $ &,0 % +! 0 !!'# * 3,!*+) ( + !!,( 5*& !4 7 & " , ' "+ !,".,0'/ 0!*8 '9 ') # *!' '8 3, 0 * " *" !'0) 7 & !* ,$ !!,( 5*& !4) / !* !,( *&' ,) # *!' '8 #*&

.' 0'0) "' '! '( 7 & !%# / 0 8) /, 0' ,( "' '! '( '9 !' ,)'9 !,( *&' ,) *&'0) $ 0 * ' $) 0 ! $%) / * 0'0) $* ,$ !!,( 5* & !4) /* !,( *&' ,) /' &'0) /, $ * *!, !%#) / ': ' '# , 0'8 ' * "*+ 3*&*+!*3* $* 3,) /' *+,!' /, $, 9 8 ' $,0 ' ;+* + $( / *+ " !'( '! 0 $ !0,&4!%# ' & "*+,!'8<

% , !, ,20 &

?)? ?)?U 3 > , , + 0 ' $& 1 > , , + 0 '&( /' *+,!'( *&' $ "& !!* $&) , + "( + 1? $&

# ! '&' 1 2 ' + + +*, 0 "* & 0 !, !, ,20 ; , *+,( "* , 1? ? $3Z $, '$,&4!,(

0* !,( "* 1 ? $3<Z + +* , 0 *0 "* 1 & 0 ; , *+,( ? $3 1@ 0,5& 0') $, '$,&4!,( 0* !,( ?? $3<

`'/ + 0+'0 &4!* 04 / /, ,0 ) 3&, *$,

3 ,!' !!* / '$ !'$ / ' ," !*$ / " 0,0 &4!*8 7 & % ' +% ,7 !!*$ ,0 * & * * *!, !%# , 0 '8 '&'+, 0 / ' * 0,!!*$ ' /*&4 *+,!'' " 3'$'

'&'!;* *5 !!* / ' ++ " !''< 3'/*0 ! '2)

+% %+, $ 2 # '&'

! D '&'+, 0 /, $*&'0' '8 A:: 0 !'7, 0/, $*3 !! 2 , 0'+!* 04 ' ,!0'/, '! *!' '8 A:: 0

'

6 6 !' 7, ,) 3*&*+* 7 !' )

". 5' !' ) 3'/ 3'" * ) ,&& 3' '8 " $,0'0

'$/0*$%Y 5&* ,",) * 0,!*+ , ".,) /,,&' "%#,0 &4!*3* . !0 , !' Y '$/0*$,0' * ) ,!'$,.'*!!% $ */ '(0'(

/* ? $3 !

Z /* $&) *" 7,6' ? $3 ! + /' 0* +*"!*$ , 0+* "&( '!- .'8

.$ $ $/;qFIa[\E[FFNQP< , 0+* "&( '!- .'8) 0,5& 0 '

& ,&*'" 0*+!' , ; '&',<) $ 8 0+, &*7 !*.+ 0!%# ;j?=>?bO<U:<) 5&* ,0* ! ) *5&,",26'8 /, $*&'0' '$ A:: 0*$) * , %+, 0 / ($* &, ' 26 " 8 0+' !, 3&," ' $%9.% X&'!' '8 A:: 0 / *(+&( 0 ( + !'7 !'' 0*! , 3&,"*8 $ &,0 % 5 *!#*+) 7 & !%# / *0* *+ ' 7 & !*3* / % () +, *"'&, 0,.'' ' $'" ',

/, $% 3&," '# $%9. / ' ( + !!*8 5*& !' 7 & ", ' "+ !,".,0'/ 0!*8 '9 ') '9 !,() / !* !,() /* !,( *&' ,)

5 *!#',&4!,( , 0$,) 3'/ 0*!' ,( 5*& !4) 0 !* , "'() /, $% * "*+ 3*&*+!*3* $* 3,) 5*& +*8 '!" *$ / ' /,! ,0'0,) "' '! '( 7 & +%+* "(6'# / 0 8) :&2 A *:,3'0) 5 ,"', '0$'() *0 ,+& !'(

$ $ ', ) "', () +

#$ "&( , 9' !'( , , + "',3!* 0' '# ' & 5!%# . &(#

% , !, ,20 &

&( /' *+,!'( & / ' /, $,# 3&," '# $%9. 1 $& ?) C , 0+* , 0 ,/ +0' '# . &(# ;"*"%< ?)??> ?)??B 3 ; ?)??? ?)??> 3< > , , + 0 ' + 0 !'

>! " , '$,&4!% "* %Y , *+,( ?)?1 3Z 0* !,( ?)?> 3

`'/ + 0+'0 &4!* 04 / /, ,0 ) 3&, *$,) / !* !,( '@'&' /* !,( ! "* 0,0* !* 04) /, ,&'0' ,( ! / *#*"'$* 04 / ' ,0*!'' '9 !' ,) ( + !!%8 *&'0) $', 0 !'(

!0'#*&'! 3' 2 , 0'+

!* 04 /*0 !.' 20 '

0/V # ' ' !

/, ,0 / *&*!3' 0 !*0+* !%8 A:: 0 '

- Z '&'+, 0 " 8 0+' * '

) 0* $* '0 A:: 0% C 0 ,!( 0 5 ,"', "'2) 0*9!*0 ) +*0 ) *5 &*+& !! 2 ' 5 ,"' , "'2

#* 04 +* 0 ; !* 0*$'(<) $'" ' , ) , 0 *8 0+* , *$*",.'') +* 5 7" !' ) "* *3') ". 5' !' ) , 0',&4!,( 3'/*0 ! '() *"%9 ,) ,0*!'( '9 !' ,) ," 7 , $* '

'$/0*$%Y !* 0*$'() *# '/&* 04 3*&* ,), 0 *8 0+* 3&*0,!'() $'" ', ; *0 0 0+' $ , .'' !, + 0<) +* 5 7" !' V /* & " 26'$ 3! 0 !' $) , 0 *8 0+* * !,!'() 3,&&2.'!,

.'') "* *7!%8 '!" *$) "%#,0 &4!,( ! "* 0,0* !* 04) 3'/ 0 $'() 0, #' , "'() /* , ! !' *7') /, '9 !' ,) * 0 ,( ," 7 , $* '

!' Y :* ' *+,!!%8 "' ) ++ " !' !-'

; <) Z + 0(7 &%# & ,(#

) * '3 !*0 ,/'()

/* $&) *" 7,6' ?) C , 0+* "&( '!- .'8Z /* B $3

&

/* 1 .$/ ;qIQMHPIaNQ) ,) mPj[J uGHaP< ,/ &%) " ,7 ) 0,5& 0 '

ƒ $ !0!%8 / /, ,0) /*& , $%8 ' /*"7 & "* !*8 7 & % /!* 3* *3,0*3* *0,) *" 7,6'8Y " "-

) *$/ ! ' 26'# " :'.'0 : $ !0*+ /*"7 & "* !*8 7 & % ' /**5 0+ 26' , 6 /& !'2 ;"* <) ;"*

' % '!< ' - ;"* ' ! < ' !* $,&'26'# /'6 +, !'

, 0 *8 0+, /'6 +, !'( / ' !, 9 !'(# A!"*'!!*8 : ! .'' /*"7 & "* !*8 7 & % ;$ *+' .'"* ) # *!' '8 /,! ,0'0<) "' / / '') * 0*(!' /* & /,! ,0A 0*$'') '!" *$ $

# &4", ;'$ ) #$

$# ', %

" %

<) $ 0 * ' $) !, 9 !'( +* !'( /'6' ; * 0*(!' /* & .'' 7 & " , ' 0*! *3* '9 !' ,) /*3 9!* 0' + "' 0 / ' / ' $ 7' !*8) ! / '+% !*8 '&' 0 "!*/ +, '+, $*8 /'6') / ' ! +* !* 0' ' " <) # * !' ' ,5*& +,!'( / !' ' 7 & +%+*"(6'# / 0 8) '9 !% '! : .'' ' "

% , !, ,20 ;/ " '&' +* + $( "%) ! , 7 +%+,( ' ,/'+,( ! 5*&49'$ *&' 0+*$ 7'"* 0' 6 &* !*8 , .' 8<) '!"'+'" ,&4!* /*"5' ,( "* + ,+' '$* 0' *0 0 / !' , 0 *8 0+, /'6 +, !'( 5% !* + "* ?) B ?)B 3 > , +0 ' X & !'( *0 ! *&4 '# "! 8 ;/ ' , 0 *8 0+ /'6 +, !'( + & " 0+' /*3 9!* 0 8 + "' 0 < "* ! *&4 '# $ (. + / ' ! *5#* "'$* 0' *5 / !'( ,$ 0'0 &4!*8 0 ,/''

`'/ + 0+'0 &4!* 04 / /, ,0 ) ! / !* '$* 04 +'!'!%) * 0 %8 /,! ,0'0) *5* 0 !' # *!' *3* /,!

,0'0,

& " 0 / +%9,04 "*/

0'$ 2 0* ! 2 "* 1B? ??? ?? ??? '@ 3) * *5 ! !* / ' $ *+' .'"* /, ,0 !'7, 0 + , %+, $* 04 %;/ ' "&'

0 &4!*$ / '$ ! !''<) + +( ' $ "*/*&!'0 &4!* !, !, ,20 '

%

'$/0*$% '9 !*8 ! / *#*"'$* 0') ,&& 3' ' , .'' ! $ "& !!*3* 0'/, ;* *5 !!* / ' $ *+'

.'"* <

) *" 7,6'

;' /*"7 & "* !*8 7 & % +'! 8< $'!'$,&4!*8 , 0'+!*042 " >B?? ;i $ $ <Z " ?? '

" B?

.$[ * $%.;1= 0*%. *.;, &) DEG\E[aGF< 0,5& 0') ' */ "&( / ' $, ) , 0+* "&( '!- .'8

'6 !!%8 A 0 , 0 * , + 7'# , ;js@UPU bq?pu=ub< 3 /,0*/ *0 0* ) & 9,26'8 * 0*(!' $

'Z * , %+,26'8 $* 3*!!* ' 3'/*, *0 $' * " 8 0+' ) !'

7,26'8 *+ !4 5'&' 5'!, + *+') + &' '+,26'8 *00* 7 & ') $ !4 9,26'8 +! 0 '/ !* !%8 #*& 0, ' / *(+&(26'8 ,!0'* '",!0! 2 , 0'+!* 04

'$/0*$,0' * & !' , 0 *8 0+ /'6 +,

!'( ;$ 0 * ' $) *0 %7 ,) 0*9!*0,) 0(7 04 + A/'3, 0 ''<) / *:'&, 0' , 3 0* *+ 7 !6'! +% * '$ ' *$ '# , +'0'() 0 ,! !' +*0% 5$ !!%# ;+ * 0,+ *$/& !*3* & !'(<) " $,0* 5 $ !!%#) 7 &0 #, 5 $ !!%# + "* &'!' *8 0,"'' VCN ) / *:'&, 0' ,

$#;+ * 0,+ *$/& !*8 0 ,/''<Z / ' +! 0 '/ !* !*$ #*& 0, 5 $ !!%#

% , !, ,20 &

;/ " "*8<Y > 0,5& 0 ' ;'&' )B B $& , 0+* , "&( / ' $,

< > , , + 0 ' X 0 ,/'' 1? ? 0) 7 $ ( !* ' ! *5#* "'$* 0' !, !, ,20 1 '!- .'' + 0 ' + 0 !' U 1B 0

;$ "& !!*) 0 8!*< *" 7'$* 1 ,$/ & + *99 #

1 , + 0 ' + 0 !' U 1B "! 8 + ;+ ,+' '$* 0' *0 +* , 0,< !, !, ,20 1 0,5& 0 ' > , , + 0 ' ;/ " "*8< */ 0'$* !, !,!' / /, ,0, ; , + " !!*3* + +*" < + :* $ , 0+* , "&( / ' $,

+ "* ) * 0,+&(26 8 1@ 1@ "* %) / '$ !( $*8 & 5 ,$

Y / *:'&, 0' , 3 0* *+ 7 !6'! +% * '$ ' *$ '#, +'0'( /* 0,5& 0 ' > , , + 0 ' , 1B ? $'! "* "% + 0 !' >! " + 0 '$ 0 ' 0, *8 7 +* 0 '$ 0 &(/' *+,!'( +*0% 5 $ !!%# ;+ * 0,+ *$/& !*3* & !'(< /* B 1? $& 0 8!* '&' ,/ &4!* + *99 # /*& " 26'$ / ' $*$ / /, ,0, +! 0 4 /* 0,5& 0 ' > , , + 0 ' + 0

!' > ! " ' !' % !5 $ !!%# /* B 1? $& 0 8 !* '&' ,/ &4!* ;1 '!: '8< '&' /* 0,5& 0 ' > , , + 0 ' + 0 !' > ! " "* &'!' *8 0,"'' VCN )/* 0,5& 0 ' > , , + 0 ' + 0 !' > ! ") / ' ! *5#*"'$* 0' + * 0,!'' ++ " !' $ /* B 1? $& ;1 '!: '8< 5 $ !!%# + ,+' '$* 0' *0 0,"'' / *. , '&' &( / *:'&, 0' ' $

#;+ * 0,+ *$/& !*3* & !'(< 7 !6'! ' 3 // /*+% 9 !!*3* ' , /* 0,5& 0 ' > , , + 0 ' + 0 !' > ! " + * ' "* 1 ! ") + ? ! ") >? > ! " *$/& !*$ & !'' $

# ) '&' ' */ 0 0+ 26 8 A 0 ,3 !' 0,&4!*8 /,0*&*3'' '&' + ,+' '$* 0' *0 0(7 0' * 0*( !'( ' # # ! 5 $ !!%# %/* 0,5& 0 ' > , , + 0 ' + 0 !' 1 1)B $ " +%/*&! !' $ #) '0%+,(

" ' " 8 0+' !) 3* +&'(!' !, ;CVR< ' !, !' CVR+ , +'0'' 3!*8!* /0' '# * &*7! !'8 /* & #' 3' *3* +$ 9,0 &4 0+,) /

/, ,0 !, !, ,20 /* 0,5& 0 ' > , , + 0 ' + 0 !' > ! "

/ *#*"'$* 04 7 & !%# / *0* *+) 0( 7 &,( :* $, / !* !*8 ! "* 0,0* !* 0'

0,.'*!, !%# &*+'(# "* / 0'$* + &' !' /, !0 ,&4!*8 "* % / /, ,0, ,'$*" 8 0+'( "

3'$' & , 0+ !!%$' " 0+,$' ! *5!, 7 !*

' "&'0 &4!*$ & !'' +% * '$' "*,$' +* $*7!, 0(7 &,( "', (

'$/0*$%Y '& !' "', ' !' Y *0$ !, / /, ,0,) '$/0*$,0' *

) *" 7,6' * '6 !!%8 A 0 , 0* , + 7'# &' 04 + , ?? $3 ' / * ' '!3 "' !0% ;!,

/*&!'0 &'Y !

!Z , '0 &4 %<Z /* 1 ? $&) *"

7,6' , 0+* "&( / * ,&4!*3* / '$ ! !'(Z /* B $&) *" 7,6', 0+* "&( ' '!- .'8

*." 3 ;OIMaLFG]P ]NHL\< ' */

'!0 0' '8 /*&' ,#, '" 3'/*,$$*!' $' * " 0+*) 0'$ &' 6 , $!*7 !' JUq<?rUqOppub UqOc?>lOpub ' JUq<?rUqOppub rOvOcub + ' 9 !' /, ,0 , 6 /&( 0 ( + '9 !' *5 , *+,!' $ #$

') !'7,26 8 *" 7'$*3* '9 !' , , 0'+' ,.' 8 / '0,&40' ') $ !49,26 8 *5 , *+,!' % " ! # !

" + / * '$,&4!*$ *0" & 0*& 0*3* '9 !' , ' '# ,5 * 5.'2) + &''+,26 8 / $ 6 !' ' *+' + '9 !' X&'!' * " 8 0+' / /, ,0, / *(+&( 0 ( + &,5'0 &4!*$ A:: 0

*!' ,( / !* !,( A!. :,&*/,0'( ;/ *:'&, 0' , / *$% ' *$%<) !, 9 !' 5, 0 ',&4!*8 :&* % '9 !' ,) # *!'

,( *5 0'/,.'() '!" *$ 3!'&* 0!*8 "' / / '' ,!! 3* +* , 0, / ' * 0 %# /'6 +%# *0 ,+& !'(#

% , !, ,20 &

/* 1B B $&@ 0 + ,+' '$* 0' *0 0(7 0' * 0*(!'( /,.' !0, '&'!' *3* A:: 0, ' 0 ,/'' / !* !*8 A!. :,&*/,0'' 0* !,( "* , $*7 0 5%04 + &' !, "* i? 1i? $&@ 0 + > / ' $, + + +* , 0 "* 1 3*", !, !, ,20 B $&@ 0) 0, 9 1 3*", B 1B $&@ 0 *"!* ,0!*

`'/ + 0+'0 &4!* 04 / /, ,0 ) 3, &, 0* $'(

* 0* *7!* 042 !, !, ,20 5*&4!%$ 3, 0 * , "',&4!%$ '!" *$*$ ;+* ' 5 7,!'

/ /, ,0 !, !, ,20 !, ,&, + !'7 !!%# "* ,#) /* 0 / !!* + &' '+,(<' /*(+& !'' "', ' 0 ,/'2 *0$ !(20 0 * ' $ / *#*"'0 ,$* 0*( 0 &4!* /* & > 0 & !'( , 0+ !!* + ,'$*" 8 0+' / /, ,0, ! */' ,!*

0 * ' $) "', (Z " * /*0 ' A& 0 *&'0*+

/* ?? $&) *" 7,6' ' */

' ' " 3' '!3 "' !0%Y ;! n1 C<) - ;! nU C<

"

.$/$/ ;g\HGaNQNQ) 4) kGH^Gf) * &) DGQaH[‚IF)

. & &) tHI][FGF< &'*:'&' ' *+,!!%8 /* *9* "&( / '3*0*+& !'( '!- .'8

!0': $ !0!%8 / /, ,0 ;/*& , $%8 ' & 3 '# /!*3* *3,0*3**0,<) *5&,",26'8 #$ !3'5' 0 / *0 *&'0' ' : $ !0% ;!<) 0* $* '0 :'5 '!*&' ' * , %+, 0 3 $* 0,0' * " 8 0+' / '

! R&* ' *+,!' $ ' /* +*&( 0 ' /*&4 * +,04 / /, ,0 "&( / *:'&, 0' ' ' & !'( , &' !%# :* $ 9* ,

*:'&, 0' , ' & !' , &' !%# :* $ 9* ,) * 0%8 ' # *!' '8 /,! ,0'0) /,! *! * ) / *:'&, 0' , : $ !0, 0'+!*3* , 0*&' , /*"7 & "* !*8 7 & % /* & #' 3' '# +$ 9, 0 &4 0+) * &*7! !'( 0 *$5*&'0' *8 0 ,/'') 3'/ :'5 '!*&'0' '*+*0 !'(

% , !, ,20 &

$ "& !!* ; ,/ &4!* '&' 0 8!*< + '!"'+'" ,&4!* /*"*5 ,!!*8 "* ) + , +' '$* 0' *0 * 0*(!'( 5*&4!*3* , ,&4!,( "* , * 0,+&( 0 >B? ??? ) /* & " 26' 1 ? ??? ,7"% "* !* $,&' ,.'' 3 $* 0, , ', 0 *8 0+,# 3 $* 0, , *7 !'. / '$ !(20 + !, ,&4!*8 "* W?? ??? ) ,0 $ 1 ? ??? '!0 +,&*$ + 1 "* / ,6 !'( *+* 0 !'( / '$ !(20 + "* 1 ??? @ 3@ 0

; 0 '$ 0 <

3'/ + 0+'0 &4!* 04 / /, ,0 ) '!" *$

+*"(0 5*&4!%$ 0*&4 * + /* &*7 !'' & 7, " ++ " !' $ / *+*"(0 %"&( */ " & !'( '!"'+'" ,&4!*8 / !* '$* 0' * 0* *7!* 042 !, !, ,20 5*&4!%$)&*!!%$ ,&& 3'' *+$ 0'$ ' '!: '*!!%$', 0+* ,$') *" 7,6'$' '' -% )

; '& !' ! '5'&' ,.''< /, ,0 !'7, 0 , 0'+!* 04 '

' ' ' ' , +'0'' ,!,:'&, 0' *8 , .'' ++ " !' / /, ,0, / ,6,20

*9!*0,) +*0,) , 0 ',&4!,( 3'/*0 !'() 0,#' , "'() 5 *!#'*&* /, $) / 0,!!* 04 * !,!'() 3,&&2.'!,.'') / '#* %) ,&& 3' ' , .'' ; %/4<) ,!,:'&, '(Z $ 0!* 0 *$ 5*:& 5'0

/* $& , 0+* *$ "&( '!- .'8)*" 7,6'$ 1? ??? 0 SX*!0 ' ,&TZ /* 1? $& , 0+* *$ "&( '!- .'8) *" 7,6'$ 1?? ??? X S`* "* TZ

/* ' B $&) , 0+* *$ "&( '!- .'8) *" 7,6'$ 1?? ??? '?? ??? X ) **0+ 0 0+ !!* S , '&*&T

&

#

!1. 1. 3 /;wPaIJPaEI]GQP) +) sN\HG]\IQ) # &) DPFP]aG^PHJ< $, 4) $) 0,5& 0 ') ,/&' ;&* 4*!<) , 0+* "&( '!- .'8'!0 0' '8) :0* *" 7,6'8 3*$*&*3 ) *5&,",26'8

' &,5*8 ;+ *0&' ' *0 " 3'# <

$ , 0'+!* 042 !'7, 0 '$$ !!%8 *0+ 0 * 3,!' $, !, , &' !% :, 0* %) / *(+&( 0 +% ,7 !!%8 / *0'+*+* /,&'0 &4!%8) / *0'+*,&& 3'

'8) " ! '5'&' ' 26'8 ' 3 $*/*A0' '8 A:: 0% ,'$*" 8 0+0 * / .':' '$' . /0* ,$' + .'0*/&, $ & 0 ') 0'$ &' 0 '! 0 ) '!" .' 26'8 *5 , *+,!' 5 & *+

*7" !!,( 3'/*/&, '( !,"/* !' *+) !,"/*

!' *+,( ! "* 0,0* !* 04) 9* ;,!,:'&, 0' '8) 3 $*"'!,$' '8 ' " <) +$,0*'"!%8 , 0 '0) +$* , "'0) ' 0 $!,( , !,( +*& ,! ,) &*" $'() 0' *0* ' '8 ' ) 5*& !4 R #0 +,) 5 *!#',&4!,( , 0$,) 5*& !4 X *!,) ! 8 *" $'0) A '0 *" $'() , $*&* !*8 7 & %) , / " 0,0 &4!*8 7 & %) / * ', ) ,&& 3' ' *!-2! 0'+'0% ' ( +, * 3*+'.% ' "

% , !, ,20

' & ;+* + $( "%< + $, &*8 "* *"!* ,0!*) / "/* 0'0 &4!* 0 *$) + 5*&49*8 "* +

>/ ' $, *0 ?) B ?) $3@ 0 "* W) U $3@ 0 ' / *&*!3' *+,!!*$

& !'( "* !'7,20 /* 0 / !!* !, ?) B ?)B $3 ,7"% > "!( +$,0'

' ,5*& +,!'(Y !, ,&4!,( "* , 1 )B $3@ 0) /*"" 7'+,26,( ?)B 1)B $3@ 0 R *!#',&4!,( , 0$, >)B $3@ 0 /* & " 26'$ !'7 !' $ "* % "* ?) B ?)B $3@ 0 0$,0' '8 0,0 >)B )B $3@ 0 *&&'!*% 1)B )B $3@ 0 + !, !, ,20 + "* ?)? B ?) $3@ 3@ 0

& % 0 8!* '&' ,/ &4!* ;$ "& !!*< + !, ,&4!*8 "* U $3@ 0 ;/ ' ! *5#*"'$* 0' i ? $3@ 0<) /*"" 7'+,26 8 $3@ 0Z $3@ 0 ;$, '$,&4!* i $3@ 0<' *00* 7 !'' /* !*3* 0 ,! /&,!0,0, ,/ &4!* ? $3 + 0 !'

+ ?)? 1 ?)1 B $3@ 3@ 0 ( !, /* ,7 !!% , 0 '*7' !,!* (0 $ '&' $, 4 ;0*! '$ &* $< '&' &* 4*! ;! *&4 * ,/ &4<

, + 0 ' "* $*$ !0, /*& !'( &'!' *3* A:: 0,

3'/ + 0+'0 &4!* 04 / /, ,0 ) ( + !!,( 5*& !4 7 & " , ' "+ !,".,0'/ 0!*8 '9 ') / /0' ' ( +% 7 & " ,) , 0 ',&4!,( 3'/ 0 !'() , 0*8!,( " !,( ! "* 0,0* !* 04) $', 0 !'() *0 %0* 3*&4!,( :*

>>U † ` ) }_€h X_

$, 3&, *$%) !, 9 !'( + 0%+,!'( *+' ' Y , 0'+!%8 0 5 & ) / * 0*8 3 / ) + 0 (!,( * /,) ' 0 $!% $' * %)x '!: .'() +' !% ,5*& +,!'( ' " (Y 3 ' ;*5% !*+ !!% )* *+% <) '!: .'' *7' ' +*&* ' 0*8 , 0' 3*&*+%) %/4 ' "

* 0* *7!* 042 !, !, ,20 &'.,$ /*7'&*3* ' 0, *3* +* , 0, ; ' , 0 ',&4!*8 3'/ 0 ! ''<)

;0*&4 * !, :*! ,!0'5, 0 ',&4!*8 0 ,/''<) 5*&4!%$ ,#, !%$ "',5 0*$) ' 0 $!*8 , !*8 +*& ,! *8) / * 0%$ 3 / *$ *3*+'.%) * 0 */* * *$ ' " W ' ' ' ' '&'+,20 A: : 0Z A ' ' # ' ' '

/*+%9,20 + *(0!* 04 , +'0'( , '0$'8Z ' ( + !!* A * '+ !%# *+*0 !'8 + 7 & "* !* '9 !*$ 0 , 0 CA7 '

/, ,0 !'7, 0 *" 7,!' + /&, $ ' ) '&'+, 0 3 /,0*0* ' !* 04 !'7, 0 3'/*3&' $' '8 A:: 0

# ! ' ) ,!0' *,3 &(!0!%8 / *' +*"!%#

' ) ''' ' 3'/*0'* ' .' * / !' , 0'+!* 04 / /, ,0, +* , 0, 0 * + $( , &!'( & " 0 ' 5 3,04 '$$ !' ,.'' ' /*0 5& !'(

, 0 *8 0+* !,) A8:* '() +* 5 7" !' ) / '#* ) " / '() 3'/* ,&' $'() , 0 ',&4!,( 3'/ 0 ! '() $'* , "'*"' 0 *:'() $%9 !,( &,5* 04) $'*/,0'() * 0 */* * ) /*!0,!!% /

&*$%) 0 *'"!%8 "',5 0) / '( $

') 3' 0' $) "' $ !* () '!" *$ *0$ !%) + &' !' $, % 0 &,Z $ 0!* ") 3'/ $'() 77 !' ) #* 04) !, 9 !' /'3$ !0,.'' ' "

'$/0*$%Y 0*9!*0,) +*0,) , 0 *8 0+, !,) +* 5 7" !' ) A8:* '() " / '() 3'/ 0 ! '() '$/0*$% 3'/ * 0'.' $,) + &2 ,( '!" *$ . ! * X 9'!3, ' " !' Y /*"" 7,!' 7' ! !!* +,7!%# : ! .'8 * 3,!' $,) * .'( A& 0 *&'0!*3* 5,&,! ,) !,

!, !' Z / ' (+& !'(# '!"*$, . ! * X 9'!3,

/* B?? $ 3

SV & 0*!TZ /* 1 $&) , 0+* *$ "&( '!- .'8) *" 7,6'$ + 1 $& ;+ :* $ < $3 '

;+ :* $ < B $3 S '/ * /,!TZ /* 1B) ?) >? 3 ?)1 C $, 42 '&' $*$ ;1 3 $, ' '&' $, *" 7,0 1 $3

< SR 0!*+ 80T '&' $, 42 '&' $*$ ;1 3 $, ' '&' $, *" 7,0 ?) $3 < SX 0 '"T

! *$.$/;wHGJGMHN\aNQP) () gKPHlNQP< 0,5& 0 ''!0 0' * / *' +*"!* ,& ,&*'", /* %!4' - ) 0*

$* (6 .'2 3* $*!*+ / "! 8 "*&' 3'/*:' , ' 0'$ &' 26

# F*' + 3*&*+!*$ $* 3 !3'5' 0 '! .'2

) /*",+&( 0 :' '*&*3' 2 &, 0,.'2) !* $,&' 0 $ ! 0

,&4! 2 : ! .'2) !'7, 0 ; 5*&4!%# , *$ 3,&' 8< *" 7,!'

+ /&, $ *+') $ !49, 0 " / '+! 2 '$/0*$,0' ) /* *5 0+0 #$ / ", + !'3 * 0 ',&4!*8 ' 0 $ ) / *(+&(( ,!0' /, '! *!' '8 A:: 0

R /&*"' ' "' $ !* ( !, :*! 3'/ / *" .''

) 3'/ / *&, 0'! $'( ;+ 0*$ ' & / ' / ' $ ! '!'

'!/ /, ,0*+<) /* & *"*+,( &, 0,.'( ;/ ' ! *5#*"'$* 0'

/*",+& !'(<) , *$ 3,&'() "*5 * , 0+ !!% &*+% '&' ' 0* !% ' $ ! !'( $*&* !%# 7 & ) 5*& !4 , '! *!,

% , !, ,20 &

;+* + $( "%< )B $3 , , + 0 ' + 0 !' 1? 1W "! 8 ' /*& *"*+*$ '!" *$ 3,&, 0* ' ,$ !* 'Z "' : ! .'' (' !' *+ ' 5

/&*"'' ;*5 &*+& !!*$ 3'/ / *&, 0'! $' 8< 1) B $3 > , , + 0 ' + 0 !' > $ ' 5*& !' . ! * X 9'!3, + !, ,&4!*8 "*

W)B $3@ 0 /* & " 26'$ !'7 !' $ "* % "* B )B $3@ 0 ' / #*"*$

> ! " /*"" 7'+,26 8 "* )B $3@ 0 X & !'( U $

' , *$ 3,&'' ' /*&4 20 "* B 1? $3@ 0 ' /, '! *!' $ !,,&4!,( "* , 1) B $3 ;/ " !*$<) "!(( 1? ? $3@ 0 ;/ ' ! *5#* "'$* 0' "*/ 0'$* + &' !' "* >? ? $3@ 0<

`'/ + 0+'0 &4!* 04 / /, ,0 ) 3' /*0 ! '() '!:, 0 $'* , ", ;! ",+!* / ! !!%8<) +% ,7 !!% ,0 *8 0+, '0$, ".,) / '#' ' ,5*& +,!'(

*+$ 0'$

0/V ' ) $ !49, 0 , '! '2) *5 &*+& !! 2 / ' $*$ )

!'7, 0 A:: 0 $ ''!

*9!*0,) +*0,) ,/* %) , 0 ',&4!,( 3'/*0 ! '() 3*&*+!,( 5*&4) !,5 #,!' &' ' 0%# *5*&* ) /*5& "! !' ;/ ' *#&,7" !''< /,&4. + ' !*3Z " * * 0* 0,0' ,( 3'/*0 ! '()*&&,/

/* )B 3

4$+ * .$3 / ;„[^HGMGHaNjGQP< &'*:'&' ' *+,!!%8 /* * 9* "&( / '3*0*+& !'( '!- .'8) / ! '( "&( '!- .'8) $, 4) $) &* 4*!

`* $*!) 0' $%8 * *8 !,"/* !' *+ '!0 0' ' / /, , 0% ' *5&,",20 9' *'$ / 0 *$ " 8 0+'() * , %+,( ,!0',&& 3' * ) ,!0'0* ' * ) ,! 0'A ",0'+!* ) " ! '5'&' ' 26* ) '$$ !* / '+!* ) / *0'+*+* /,&'0 &4!* ' / *0'+* "!* " 8 0+'

0$,0' * * 0*(!' ) 0(7 &%8 / ' 0 / 5 *!#' ,&4!*8 , 0$%) %+* *0* !,( 5*& !4) *!!%8 ,&& 3' '8 '!'0) 3' / + 0+'0 &4!* 04 ++ " !!%$ & , 0+ !!%$ " 0+,$) &

, 0 ',&4!,( 3'/*0 ! '() '!:, 0 $'* , ",) *&&,/ / ' 5*

> ? † ` ) }_€h X_

& !' ""' *!,) '!" *$ * 3,!4' ",$ , 0* , ; $

"$

$ '! &

, # ' '&

'! , ! ' ' " ! ,

<) '!" *$ *0 #, , ƒ '" ' !, ;%

# # ! " ' %

' % $ $#

'&

" # # - <) '!" *$ ::&, ; S

- #$ T !

" , % -

- <) ! : *0' '8 '!" *$ 5 / ' !, *+ $'') +$,0*'"!%8 , 0 '0 ' "

%, !, ,20 &

*0 B? >?? $3 "* 1??? 1B?? $3@ 0 , / &4!* ;$ "& !!*<) , + "( + B?? $& # !

'&' 1 2 ' B B $3 ' 5*& + '

*0 > $ "* 1 3*", B $3Z *0 1 3*", "* & 0 B B? $3Z *0 W "* 1 & 0 B? WB $3& 5 5++*"(0 & 1?? 1B? $3 ,7"% + 0 !' U ) ,0 $ ,7"% U 1 '&' 1?? B?? $3 + 0!' >? ' + 0*8 7 "* '!0 +,&*$ + 1) >) ' 1? /* & / +*8 '!-

.'' + ,7"% /* 1 $3@ 3 ; 0* !,( "* , i $3@ 3< &( 0,/'' !, /* ,7 !!% , 0 ' *7' !,!* (0 0*! '$ &* $ $, 4 ;$* ! 6' ' +* /,&'0 &4!% * 0*(!'( $) &* 4*!< > , , + 0 ' `&, ! 2 $, 4 , &,"%+,20 + *!-2! 0'+,&4!%8 $ 9* > , , + 0 '

,$ $ ;' , *" 7,!'( <) 3'/ + 0+'0 &4!* 04 / /, ,0 ) ' 0 $!% 3 '5 *+% '!: .'') * 0% / '#* %) +% ,7 !!,( , 0 ',&4!,( 3'/ 0 ! '() " *$/ ! ' *+,!!%8,#, !%8 "',5 0) ( + !!,( 5*& !4 7 & " , ' "+ !,".,0'/ 0!*8 '9 ') * 0 */* * ) 5*& !4 X 9'!3,) 0 *$5*:'&' ' * 0*(!'() /* !,( ! "*0,0* !* 04 +' !% ' 3 '5 *+% /* ,7 !'( 3&, ) ' "

* + $( & !'( ! / *+* "'04 +, .'!,.'2 + " !' 5*&49'# "* "*/ 0'$* + 0 !' ! 5*& U

W ++ " !' "*/ 0'$* ! ,6 1 , , + > ! ") + &* +'(# 0 *7,89 8 , /0' ' ' ,!0' /0' ' ;0*&4 * /* & ' &2 !'( '! : .'*!!*3* / *. , + 0,+ < ++*"(0 $, '$,&4!* 3& 5* * + (3* "' ! 2 *5&, 04 ;"&( / "*0+ ,6 !'( , +'0'( $%9 !*8 ,0 *:''<

0'+!* 04 !'7, 0 ( + / ' 0 0+'' '!

-# ! CA7 ) /* +%9,20 ' *5 , *+,!'( ( , + 7 & "* !* '9 !*$ 0 , 0 )