Букринская А.Г., Жданов В.М. Молекулярные основы патогенности вирусов
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rJIHK03HJIHpycTC5!, npeBpama5!Cb B fJIHKOrrpoTeH,II, C M0JJeKyJJ5!p H0}! MaccoiI 108 000 [Su eHpHact al., 1987]. KoMIIOHCHT c
Maccott 31 000 rrpouecCHpyeTc5! Jl0 npQllYKTa c Macco11 34 000 H ceKpen1pyeTC5! 3apa)KCHHOH KJICTKOH. HeBHpyca IICCB,Q06e WCHCTBa rrpoHCX0,11,5!T TaKne rrpouecCbl Hape3aHH5! H ceKpeum1 BHpyCHoro rnHKOrrpoTeHJta QX [Rea T. et al., 1987].. Y UHT0MeraJIOBHpyca gp55 o6pa3yeTC5! rrpH Hape3aHHH rrpC/lillCCTBCH HHKa gpl30 H rrpeJtcTaBJJ5!eT co6011 ero C-KOHUeBy10 qacn, [Spactc eHpct al., 1988].
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Ubl MoryT BOl1TH B C0CT3B TI0JIHC0M, BH0Bb o6pasyJOUJ,HXC51 Ha BHpyccue1mqrnt1ec1rnx MPHK. HsnecTHO, lJT0 UHT0ilJI33M3TH4e CKHe MPHK, CHHTe3Hp0B3HHble )1.0 sapaMeHHH, nepecTalOT TpaHCJIHP0B3TbCH 6.naro;1,ap51 6JJOKHpOB3HHIO Tp3HCJIHUHH Ha cTa.n.1111 KaK HHHUHaUHH, TaK H 3JJonrau,HH [Katze M. et al., 1986]. B I(JleTKax, 3apa)l{eHHblX a,'J,NIOBHpycaMH, 6JJ0KHpyeTCH TpattcrropT KJieT0llHhIX MPHK us HJl.pa B rvrTonJiasMy, a B KJieT Kax, 3apa)KeHHbIX BHpycoM rpHnrra, KJieT0lJHbie TpaHCKpHilTbl ;1,erpa,i1,Hpy10T B HJJ.pe. fieJ10K HHH! H3UHH TpaHCJ1HUHH HH0r)l.a o6yCJJOBJleH yMeHhllieHHeM aKTHBH0CTH ::,yxapH0THt(CCK0f0 l!HH· u1rnpy1om:ero <paKTOpa Tp3HCJl51U,HH 3H<l>2 3a ClleT (j)OCQJOPH· JIHp0B3HH51 a-cy61,e,nHHHUbl 3T0f0 cpaKTopa. Ha paHHHX cTa ,ll,H51X umpeKUJHI B KJieTKax, 3apa)KeHHblX a,ll,eH0BHpycoM, BH pycoM 0CIT0B3KUHHbl, MeHr0BHpycoM, l10.5lBJIHeTC51 KHH33H351 3KTl1BH0CTh, BHpyCHHJlYUilp0B3HH351 KH!-1333 <!Joccjlop1vmpyc1 a-cy61,e,l],HHH!.J.Y 3H<l>2 B ca1'he, KOTOpblli He cpoccj)opH.flHpyeTC51 Apyn1M11 KHHa3aM11. K1rna3H3H aKTHB110cTb IT0HBJrnCTCH B KJier Kax, 3apa}KeHHb!X MCHr0Bllf)YC0M, BHi.llJa,)le B UllT0ITJl33Me (•1e pe3 1-3 l[ IT0CJie 3apatKemrn)' IT03)I{e BO <pp3Kil,HH l10JIHC0M (t1epe3 5 11 IT0CJle 33pa)KeHH51). O,nH3KO <poccjJOpHJJHpOBaHHe qiaKTOpa, rreo6xo)J.HMOro )I.Ml HHHU,Hau,m Tp3HCJJHUHH, Jl0JI,KH0 110,1].3BJI.5!Tb CllHTe3 K3K KJleT04HbIX, T3K H BHpycI-bIX 6eJIKOB, a y pn,ll,a BHpycoB B03HHK3!OT .LL0IT0JIHHTeJJbHbie np0.LLYKTbl BH pyc1-Jb!XreH0B ,LLJI.51 npe.LL0TBpa1ueHH51 9TOro aKTa B nepH0.LL HH TeHCHBHOH penpo.LLyKUHH.
B KJJeTKax, 3apa)l{CHHblX 3JJ.eH0BttpycoM, aKTHB3UHH KHHa31,J 6JJOKHpyeTCH 6Jiaro)lapH cnHTe3y oco6oro KJiacca PHK, VAl PHK, npo.n.yKTa PHK-nomrnepa3hI III; 3Ta PHK npe
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