Огурцов А.Н. Выравнивание белковых последовательностей. – Харьков. НТУ ХПИ, 2015. – 80 с

Query

LSPADKTNVKAAWGKVGAHAGEYGAEALERMFLSFPTTKTYFPHF-DLSH-----

GSAQV

LS +K+ + A W KV

G +AL R+ + FP T+ YF F +LS+

G+A+V

Sbjct LSADEKSAINAVWSKVNIEND--GHDALTRLLVVFPWTQRYFSSFGNLSNVAAISGNAKV

Query

KGHGKKVADALTNAVAHVDDMPNALSALSDLHAHKLRVDPVNFKLLSHCLLVTLAAHLPA

+ HGKKV A+ ++ H+DD+ N LS LS HA +L VDP NFK L+ L++ LA

L A

Sbjct

RAHGKKVLSAVDESIHHLDDIKNFLSVLSTKHAEELHVDPENFKRLADVLVIVLAGKLGA

Query

EFTPAVHASLDKFLASVSTVLTSKY

141

FTP V A+ +KF A +

L+ Y

Sbjct

AFTPQVQAAWEKFSAGLVAALSHGY

146

Query

SPADKTNVKAAWGKVGAHAGEYGAEALERMFLSFPTTKTYFPHF-DLSH-----

GSAQVK

S +K

+ + W KV

E GAEAL R+ + +P T+ +F +F +LS

G+ +V+

Sbjct SAEEKQLITSVWSKVNVE--ECGAEALARLLIVYPWTQRFFDNFGNLSSPTAIIGNPKVR

Query

GHGKKVADALTNAVAHVDDMPNALSALSDLHAHKLRVDPVNFKLLSHCLLVTLAAHLPAE

HGKKV

+ AV ++D++ N + LS+LH KL VDP NF+LL + L++ LAAH +

Sbjct

AHGKKVLSSFGEAVKNLDNIKNTYAKLSELHCEKLHVDPENFRLLGNILIIVLAAHFTKD

Query

FTPAVHASLDKFLASVSTVLTSKY

141

FTP A K ++ V+ L KY

Sbjct

FTPTCQAVWQKLVSVVAHALAYKY

146

Query

LSPADKTNVKAAWGKVGAHAGEYGAEALERMFLSFPTTKTYFPHF-DLSHGSA-----

QV

+ +K + + W V

+ GAEAL R+ + +P T+ +F F +LS SA

+V

Sbjct FTAEEKAAITSTWKLVDVE--DAGAEALGRLLVVYPWTQRFFDSFGNLSSSSAIMGNPKV

Query

KGHGKKVADALTNAVAHVDDMPNALSALSDLHAHKLRVDPVNFKLLSHCLLVTLAAHLPA

K HGKKV

A +AV +VDD+ N

+ LS+LH +L VDP NFKLL + L++ LA +

Sbjct

KAHGKKVLTAFGDAVKNVDDLKNTFAHLSELHCDRLHVDPENFKLLGNVLVIVLAKYFGK

Query

EFTPAVHASLDKFLASVSTVLTSKY

141

EFTP V ++

K +A V+T L

KY

Sbjct

EFTPQVQSAWQKLVAGVATALAHKY

146

Query

LSPADKTNVKAAWGKVGAHAGEYGAEALERMFLSFPTTKTYFPHFDLSH------

GSAQV

+ +K V + W KV

G E+L R+ + +P T+ +F F +

G+ +V

Sbjct FTTEEKAAVASLWAKVNVEV--VGGESLARLLIVYPWTQRFFDSFGNLYSESAIMGNPKV

Query

KGHGKKVADALTNAVAHVDDMPNALSALSDLHAHKLRVDPVNFKLLSHCLLVTLAAHLPA

K HG+KV ++

NA+ H+DD+

+ LS+LH KL VDP NF+LL + +L+ LA H

Sbjct

KAHGRKVLNSFGNAIEHMDDLKGTFADLSELHCDKLHVDPENFRLLGNMILIVLATHFSK

Query

EFTPAVHASLDKFLASVSTVLTSKY

141

EFTP + AS K

+V+ L

KY

Sbjct

EFTPQMQASWQKLTNAVANALAHKY

146

S +++ + + W K+

+

E G +

L R+ + +P T+ YF F DLS SA

+V

Sbjct SDSERKTIASVWSKI--NVDEIGPQTLARVLVVYPWTQRYFGAFGDLSCASAIMGNPKVS

Query

GHGKKVADALTNAVAHVDDMPNALSALSDLHAHKLRVDPVNFKLLSHCLLVTLAAHLPAE

HGK V AL

AV +VDD+

+

LS LH KL VDP NFKLL+ CL + +A +

Sbjct

EHGKTVLKALEKAVKNVDDIKTTYAQLSQLHCEKLNVDPDNFKLLADCLSIVIATNFGPA

Query

FTPAVHASLDKFLASVSTVLTSKY

141

F PAV ++

K L+ V

LTS+Y

Sbjct

FNPAVQSTWQKLLSVVVAALTSRY

146

Query

DKTNVKAAWGKVGAHAGEYGAEALERMFLSFPTTKTYFPHF-DLSH-----

GSAQVKGHG

+K + W KV

E GAEAL R+ + +P T+ +F HF DLS

G+A+VK HG

Sbjct NKALITGFWSKV--KVDEVGAEALGRLLVVYPWTQRFFEHFGDLSTADAVLGNAKVKAHG

Query

KKVADALTNAVAHVDDMPNALSALSDLHAHKLRVDPVNFKLLSHCLLVTLAAHLPAEFTP

KKV D+ +N V H+DD+

+ LS+LH KL VDP NF+LL + L+V LA H EFTP

Sbjct

KKVLDSFSNGVQHLDDLKGTFAQLSELHCDKLHVDPENFRLLGNVLVVVLARHFGKEFTP

Query

AVHASLDKFLASVSTVLTSKY

141

+ A K +A V++ L

+Y

Sbjct

ELQAEFQKVVAGVASALAHRY

141

+ +K V + W K+

E G EAL R+ + +P T+ +F F +LS

G+ +V

Sbjct FTAEEKAAVTSLWSKINVE--ETGGEALGRLLVVYPWTQRFFDSFGNLSSPSAILGNPKV

Query

KGHGKKVADALTNAVAHVDDMPNALSALSDLHAHKLRVDPVNFKLLSHCLLVTLAAHLPA

K HGKKV

+ +A+ ++D++

A + LS+LH KL VDP NFKLL + +++ LA H

Sbjct

KAHGKKVLTSFGDAIKNMDNLKTAFAKLSELHCDKLHVDPENFKLLGNVMVIILATHFGR

Query

EFTPAVHASLDKFLASVSTVLTSKY

141

EFTP V A+

K +++V+ L

KY

Sbjct

EFTPEVQAAWQKLVSAVAIALAHKY

146

Query

LSPADKTNVKAAWGKVGAHAGEYGAEALERMFLSFPTTKTYFPHF-DLSH-----GSAQV

LS +K+ + A W KV

G EAL R+ + +P T+ YF F +LS+

G+A+V

Sbjct

LSADEKSAINAVWQKVDIEKD--GHEALTRLLVVYPWTQRYFSSFGNLSNVTAISGNAKV

Query

VLSPADKTNVKAAWGKVGAHAGEYGAEALERMFLSFPTTKTYFPHF-DLSHGSA-----Q

+L+ +K V A WGKV

E G EAL R+ + +P T+ +F F DLS A

+

Sbjct

MLTAEEKAAVTAFWGKV--KVDEVGGEALGRLLVVYPWTQRFFESFGDLSTADAVMNNPK

Query

DKTNVKAAWGKVGAHAGEYGAEALERMFLSFPTTKTYFPHF-DLSH-----

GSAQVKGHG

+K

V + W K+

E G EAL R+ + +P T+ +F F +LS

G+ +VK HG

Sbjct EKAAVTSLWSKMNVE--EAGGEALGRLLVVYPWTQRFFDSFGNLSSPSAILGNPKVKAHG

Query

KKVADALTNAVAHVDDMPNALSALSDLHAHKLRVDPVNFKLLSHCLLVTLAAHLPAEFTP

KKV

+

+A+ ++D++

A + LS+LH KL VDP NFKLL + +++ LA H EFTP

Sbjct

KKVLTSFGDAIKNMDNLKPAFAKLSELHCDKLHVDPENFKLLGNVMVIILATHFGKEFTP

Query

AVHASLDKFLASVSTVLTSKY

141

V A+

K +++V+ L

KY

Sbjct

EVQAAWQKLVSAVAIALAHKY

146

Query

SPADKTNVKAAWGKVGAHAGEYGAEALERMFLSFPTTKTYFPHF-DLSH-----GSAQVK

S +K + + W KV

E GAEAL R+ + +P T+ +F F +LS

G+ +V+

Sbjct

SAEEKQLITSVWSKVNVE--ECGAEALARLLIVYPWTQRFFASFGNLSSPTAIMGNPRVR

Query

DKTNVKAAWGKVGAHAGEYGAEALERMFLSFPTTKTYFPHF-DLSH-----

GSAQVKGHG

+K

+ + W KV

+ G EAL R+ + +P T+ YF F +LS+

G+A+V+ HG

Sbjct EKAAITSVWQKVNLE--QDGHEALTRLLVVYPWTQRYFSSFGNLSNVTAVSGNAKVRAHG

Query

KKVADALTNAVAHVDDMPNALSALSDLHAHKLRVDPVNFKLLSHCLLVTLAAHLPAEFTP

KV

A+ NA+AH+D++

L

LS+ HA KL VDP NFK L L++ LA+ L FTP

Sbjct

NKVLSAVGNAIAHLDNVKGTLHDLSETHAFKLHVDPENFKRLGEVLVIVLASKLGTAFTP

Query

AVHASLDKFLASVSTVLTSKYR

142

+

+ +KF+A + L+ Y

Sbjct

QIQGAWEKFVAVLVDALSQGYN

147

Query

LSPADKTNVKAAWGKVGAHAGEYGAEALERMFLSFPTTKTYFPHF-DLSH-----

GSAQV

+ +K

V + W K+

E G EAL R+ + +P T+ +F F +LS

G+ +V

Sbjct FTAEEKAAVTSLWSKMNVE--ETGGEALGRLLVVYPWTQRFFDSFGNLSSPSAILGNPKV

Query

KGHGKKVADALTNAVAHVDDMPNALSALSDLHAHKLRVDPVNFKLLSHCLLVTLAAHLPA

K HGKKV

+ +A+ ++D++

+ LS+LH KL VDP NFKLL + +++ LA H

Sbjct

KAHGKKVLTSFGDAIKNMDNLKITFAKLSELHCDKLHVDPENFKLLGNVMVIILATHFGK

Query

DKTNVKAAWGKVGAHAGEYGAEALERMFLSFPTTKTYFPHF-DLSH-----

GSAQVKGHG

+K

+ + W KV

G!+AL R+ + +P T+ YF +F +LS+

G+A+V+ HG

Sbjct EKAAITSVWQKVNVE--HDGHDALGRLLIVYPWTQRYFSNFGNLSNSAAVAGNAKVQAHG

Query

KKVADALTNAVAHVDDMPNALSALSDLHAHKLRVDPVNFKLLSHCLLVTLAAHLPAEFTP

KKV

A+ NA++H+D + ++L

LS +HA +L VDP NFK

L++ L A L FTP

Sbjct

KKVLSAVGNAISHIDSVKSSLQQLSKIHATELFVDPENFKRFGGVLVIVLGAKLGTAFTP

Query

AVHASLDKFLASVSTVLTSKYR

142

V A+ +KF+A +

L+ Y

Sbjct

KVQAAWEKFIAVLVDGLSQGYN

147

Query

DKTNVKAAWGKVGAHAGEYGAEALERMFLSFPTTKTYFPHF-DLSH-----

GSAQVKGHG

+K

+

WGKV +

E!GAEAL R+ + +P T+ +F F +LS

G+

V+ HG

Sbjct EKQLITGLWGKV--NVAECGAEALARLLIVYPWTQRFFASFGNLSSATAIIGNPMVRAHG

Query

KKVADALTNAVAHVDDMPNALSALSDLHAHKLRVDPVNFKLLSHCLLVTLAAHLPAEFTP

KKV

+

AV ++D++

+ + LS LH KL VDP NF+LL L++ LA+H

+FTP

Sbjct

KKVLSSFGEAVKNLDNIKKSFAQLSKLHCDKLHVDPENFRLLGDILIIVLASHFSKDFTP

Query

AVHASLDKFLASVSTVLTSKY

141

A A+ K + V+ L +Y

Sbjct

ASQAAWQKMVRVVAHALAHEY

146

Query

LSPADKTNVKAAWGKVGAHAGEYGAEALERMFLSFPTTKTYFPHFDLSH------

GSAQV

+ + V + W KV

G E+L R+ +

P T+ +F F +

G+ +V

Sbjct FTTEENVAVASLWAKVNVEV--VGGESLARLLIVCPWTQRFFDSFGNLYSESAIMGNPKV

Query

KGHGKKVADALTNAVAHVDDMPNALSALSDLHAHKLRVDPVNFKLLSHCLLVTLAAHLPA

K +G+KV ++

NA+ H+DD+

+ LS+LH

KL VDP NF+LL + +L+ LA H

Sbjct

KVYGRKVLNSFGNAIKHMDDLKGTFADLSELHCDKLHVDPENFRLLGNMILIVLATHFSK

Query

EFTPAVHASLDKFLASVSTVLTSKY

141

EFTP + A+ K

+V+

LT KY

Sbjct

EFTPQMQAAWQKLTNAVANALTHKY

146

Query

LSPADKTNVKAAWGKVGAHAGEYGAEALERMFLSFPTTKTYFPHF-DLSH-----GSAQV

+ +K + + W KV

+ G E L R+ + +P T+ +F F +LS

G+ ++

Sbjct

FTAEEKAAIISIWEKVDLE--KIGGETLGRLLIVYPWTQRFFDKFGNLSSALAIMGNPRI

Query

ADKTNVKAAWGKVGAHAGEYGAEALERMFLSFPTTKTYFPHF-DLS

-----HGSAQVKGH

A+K+ + A WGKV

+

E G

AL R+ + +P T+ YF F D+S

G+ +V H

Sbjct AEKSTISAVWGKVDIN--EVGPLALARVLIVYPWTQRYFGSFGDVSTPAAIMGNPKVAAH

Query

GKKVADALTNAVAHVDDMPNALSALSDLHAHKLRVDPVNFKLLSHCLLVTLAAHLPAEFT

GK V AL

AV ++ ++

+LS+ HA+KL VDP NF++L+

L + +AA A FT

Sbjct

GKVVCGALDKAVKNMGNILATYKSLSETHANKLFVDPDNFRVLADVLTIVIAAKFGASFT

Query

PAVHASLDKFLASVSTVLTSKY

141

P + A+

KF+

V

+ S+Y

Sbjct

PEIQATWQKFMKVVVAAMGSRY

146

Query

LSPADKTNVKAAWGKVGAHAGEYGAEALERMFLSFPTTKTYFPHF-DLSH-----GSAQV

+ +K + + W KV

+ G E L R+ + +P T+ +F F +LS

G+ ++

Sbjct

FTAEEKAAITSIWDKVDLE--KVGGETLGRLLIVYPWTQRFFDKFGNLSSALAIMGNPRI

Query

LSPADKTNVKAAWGKVGAHAGEYGAEALERMFLSFPTTKTYFPHF-DLSH-----GSAQV

LS +K V A W KV

E G!EAL R+ + +P T+ +F F DLS+

G+ +V

Sbjct

LSGEEKAAVLALWDKVNEE--EVGGEALGRLLVVYPWTQRFFDSFGDLSNPGAVMGNPKV

Query

EYGAEALERMFLSFPTTKTYFPHFDLSHGSAQVKG----

--HGKKVADALTNAVAHVDDM

+ G

AL R + +P T+ YF +F + +A ++G

HGK V

L

AV ++DD+

Sbjct

DVGPAALSRCLVVYPWTQRYFGNFGNLYNAAAIQGNPMVAAHGKTVLRGLDRAVKNMDDI

Query

PNALSALSDLHAHKLRVDPVNFKLLSHCLLVTLAAHLPAEFTPAVHASLDKFLASVSTVL

+ LS LH+ KLRVDP NF+LL+ CL + +AA + A+FT V

+

KFLA V + L

Sbjct

KATYAELSVLHSEKLRVDPDNFRLLADCLTIVVAARMGADFTADVQGAFQKFLAVVVSSL

Query

TSKY

141

+Y

Sbjct

GRQY

146

Query

DKTNVKAAWGKVGAHAGEYGAEALERMFLSFPTTKTYFPHF-DLS-----

HGSAQVKGHG

+++ +

WGK+

E G +AL R+ + P T+ +F F +LS

G+ V HG

Sbjct ERSAIVGLWGKISVD--EIGPQALARLLIVSPWTQRHFSTFGNLSTPAAIMGNPAVAKHG

Query

KKVADALTNAVAHVDDMPNALSALSDLHAHKLRVDPVNFKLLSHCLLVTLAAHL-PAEFT

K V

L AV ++DD+ N

+ALS +H+ KL VDP NF+LL+ C+ V +AA L PA F+

Sbjct

KTVMHGLDRAVQNLDDIKNTYTALSVMHSEKLHVDPDNFRLLADCITVCVAAKLGPAVFS

Query

PAVHASLDKFLASVSTVLTSKY 141

+

KFLA V + L

+Y

Query

LSPADKTNVKAAWGKVGAHAGEYGAEALERMFLSFPTTKTYFPHF-DLS

------HGSAQ

L+

++ +

W K+ A

G +AL

M ++P T+ YF F +LS

H +A

Sbjct LTAKERQLITGTWSKICAKT--LGKQALGSMLYTYPWTQRYFSSFGNLSSIEAIFHNAA-

Query

VKGHGKKVADALTNAVAHVDDMPNALSALSDLHAHKLRVDPVNFKLLSHCLLVTLAAHLP

V

HG+KV

++ A+ H+DD+

+ LS

H+ L VDP NFK

C ++++A L

Sbjct

VATHGEKVLTSIGEAIKHMDDIKGYYAQLSKYHSETLHVDPYNFKRFCSCTIISMAQTLQ

Query

EYGAEALERMFLSFPTTKTYFPHF-DLSHGSA-----

QVKGHGKKVADALTNAVAHVDDM

E G +AL+R + +P T+ YF F +L + A

+V HG

V

L A+ ++DD+

Sbjct

EAGPKALQRALIVYPWTQRYFGSFGNLYNAEAIINNPKVAAHGTVVLHGLDRAMKNMDDI

Query

PNALSALSDLHAHKLRVDPVNFKLLSHCLLVTLAAHLPAEFTPAVHASLDKFLASVSTVL

N

+ LS LH+ KL VDP NF+LL+ CL + +A+ + A FT

+ A+

KFLA V + L

Sbjct

KNTYAELSVLHSEKLHVDPDNFRLLADCLTIVIASTMGAAFTADMQAAWQKFLAVVVSAL

Query

TSKY

141

+Y

Sbjct

QRQY

146

Query

MVLSPADKTNVKAAWGKVGAHAGEYGAEALERMFLSFPTTKTYFPHF------DLSHGSA

M S A+ + + AW K+ A + G L RMF P TK+YF HF

+

S

Sbjct

MSFSEAEVQSARGAWEKMYVDAEDNGTAVLVRMFTEHPDTKSYFTHFKGMDSAEEMKQSD

Query

QVKGHGKKVADALTNAVAHVDDMPNALSALSDL---HAHKLRVDPVNFKLLSHCLLVTLA

QV+GHGK+V

A+ + V

H+D+

L

L+ L

HA!+L++DP NF+++ +L

Sbjct QVRGHGKRVFTAINDMVQHLDNTEAFLGILNPLGQKHATQLKIDPKNFRIICDIILQL--

Query

AHLPAEFTPAVHASLDKFLASVSTVLTSKYR

142

+ +F

AS +K

+ T LT+

Y+

Sbjct

--MEEKFGGDCKASFEKVTNEICTHLTNIYK

147

Query

LSPADKTNVKAAWGKVGAHAGEYGAEALERMFLSFPTTKTYFPHF-DLS-----

HGSAQV

L+ ++ +K

W +V A + G

L R F++FP+ K YF F D+

S+Q+

Sbjct

LTDVERGIIKDTWARVYASCEDVGVTILIRFFVNFPSAKQYFSQFQDMEDPEEMEKSSQL

Query

KGHGKKVADALTNAVAHVDDMPNALSALSDL----HAHKLRVDPVNFKLLSHCLLVTLAA

+ H ++V +A+

V ++ D P

+S++ L

HA K +V+PV FK+LS

+L LA

Sbjct

RKHARRVMNAINTVVENLHD-PEKVSSVLVLVGKAHAFKYKVEPVYFKILSGVILEILAE

Query

LSPADKTNVKAAWGKVGAHAGEYGAEALERMFLSFPTTKTYFPHFD------LSHGSAQV

++ +++

+K

W +V A+

+ G

L R F++FP+ K +F F

GS Q+

Sbjct

ITESERGVIKETWARVYANCEDVGVSILIRFFVNFPSAKQHFSQFKHMEDPLEMEGSVQL

Query KGHGKKVADALTNAVAHVDD---MPNALSALSDLHAHKLRVDPVNFKLLSHCLLVTLAAH

+ HG++V

A+ + V ++ D

+

LS +

HA K +V+PV FK+L+

+L A

Sbjct

RKHGRRVMGAVNSVVENLGDPEKVTTVLSIVGKSHALKHKVEPVYFKILTGVMLEVFAEE

Query

LPAEFTPAVHASLDKFLASVSTVLTSKYR

142

+FTP V

+K + + + + S Y+

Sbjct

YAKDFTPDVQLVWNKLRSLIYSHVQSAYK

167

Query

LSPADKTNVKAAWGKVGAHAGEYGAEALERMFLSFPTTKTYFPHFD------LSHGSAQV

+S A+K

++

W +V A+

+ G L R F++FP+ K YF F

S Q+

Sbjct

ISDAEKKVIQETWSRVYANCEDVGVSILIRFFVNFPSAKQYFSQFKHMDDTLEMERSLQL

Query KGHGKKVADALTNAVAHVDD---MPNALSALSDLHAHKLRVDPVNFKLLSHCLLVTLAAH

+ H ++V

A+

V ++DD

+ + L+ + HA K +V+PV FK L+

+L +A

Sbjct

RKHAQRVMGAINTVVENLDDPEKVSSVLALVGKAHALKHKVEPVYFKKLTGVMLEVIAEA

Query

LSPADKTNVKAAWGKVGAHAGEYGAEALERMFLSFPTTKTYFPHFD------LSHGSAQV

++ +++

+K

W +V A+

+ G

L R F++FP+ K +F F

GS Q+

Sbjct

ITESERGVIKETWARVYANCEDVGVSILIRFFVNFPSAKQHFSQFKHMEDPLEMEGSVQL

Query KGHGKKVADALTNAVAHVDD---MPNALSALSDLHAHKLRVDPVNFKLLSHCLLVTLAAH

+ H ++V

A+ + V ++!D

+

LS +

HA K +VDPV FK+L+

+L +A

Sbjct

RKHARRVMGAVNSVVENLGDPEKITTVLSIVGKSHALKHKVDPVYFKILTGVMLEVIAEE

Query

LPAEFTPAVHASLDKFLASVSTVLTSKYR

142

+FTP V

+ +K + + + + S Y+

Sbjct

YAKDFTPDVQLAWNKLRSHLYSHVLSAYK

167

Query

LSPADKTNVKAAWGKVGAHAGEYGAEALERMFLSFPTTKTYFPHFDLSHG------SAQV

L +++ +K W KV +

+ G L R+F++FP++K YF F

SAQ+

Sbjct

LCDSEREMIKDTWAKVYQNCDDVGVAILIRLFVNFPSSKQYFSQFQQVEDPGELERSAQL

Query KGHGKKVADALTNAVAHV---DDMPNALSALSDLHAHKLRVDPVNFKLLSHCLLVTLAAH

+ H ++V +A+

V ++

D M + L + HA + V+PV FK+L

+L L A

Sbjct

RKHSRRVMNAINTLVENLHDGDKMVSVLKLVGKAHALRHNVEPVYFKILCGVILEVLVAD

Query

LPAEFTPAVHASLDKFLASV

133

P TP V

+ K L ++

Sbjct

FPDYITPEVAVAWTKLLDAI

158

LS A+

++

WG V +

+ G

L R F++FP+ K YF F D+

S+Q+

Sbjct

LSDAEMEIIQHTWGHVYKNCEDVGVSVLIRFFVNFPSAKQYFSQFQDMQDPEEMEKSSQL

Query

KGHGKKVADALTNAVAHVDD---MPNALSALSDLHAHKLRVDPVNFKLLSHCLLVTLAAH

+ H ++V

+A+

V ++ D

+ + L+

+ HA K +V+P+ FK+ S

+L L+

Sbjct

RQHARRVMNAINTVVENLQDPEKVSSVLALVGKAHAVKHKVEPIYFKIXSGVMLSVLSED

Query

LPAEFTPAVHASLDKFLASVSTVLTSKY

141

P FT

V

K +A+V

+T

Y

Sbjct

FPEFFTAEVQLVWTKLMAAVYWHVTGAY

181

Query

LSPADKTNVKAAWGKVGAHAGEYGAEALERMFLSFPTTKTYFPHF-DLS-----

HGSAQV

L+

D ++ W

V A

G L R F +FP+ K YF HF +L

+AQ+

Sbjct

LTEEDVCVIQDTWKPVYAERDNAGVAVLVRFFTNFPSAKQYFEHFRELQDPAEMQQNAQL

Query

KGHGKKVADALTNAVAHV---DDMPNALSALSDLHAHKLRVDPVNFKLLSHCLLVTLAAH

K HG++V +AL

V ++

D +

+ +

HA + +VDPV FK+L+

+L L

Sbjct

KKHGQRVLNALNTLVENLRDADKLNTIFNQMGKSHALRHKVDPVYFKILAGVILEVLVEA

Query

LPAEFTPA-VHASLDKFLASVSTVLTSKY

141

P

F+PA V +S

K + +

+

Y

Sbjct

FPQCFSPAEVQSSWSKLMGILYWQMNRVY

164

Ala (A)

6

–7

–4

–3

–6

–4

–2

–2

–7

–5

–6

–7

–5

–8

–2

0

–1

–13

–8

–2

Arg (R)

–7

8

–6

–10

–8

–2

–9

–9

–2

–5

–8

0

–4

–9

–4

–3

–6

–2 –10

–8

Asn (N)

–4

–6

8

2

–11

–3

–2

–3

0

–5

–7

–1

–9

–9

–6

0

–2

–8

–4

–8

Asp (D)

–3 –10

2

8

–14

–2

2

–3

–4

–7 –12

–4

–11 –15

–8

–4

–5

–15 –11

–8

Cys (C)

–6

–8 –11

–14

10

–14

–14

–9

–7

–6 –15

–14

–13 –13

–8

–3

–8

–15

–4

–6

Gln (Q)

–4

–2

–3

–2

–14

8

1

–7

1

–8

–5

–3

–4 –13

–3

–5

–5

–13 –12

–7

Glu (E)

–2

–9

–2

2

–14

1

8

–4

–5

–5

–9

–4

–7 –14

–5

–4

–6

–17

–8

–6

Gly (G)

–2

–9

–3

–3

–9

–7

–4

6

–9

–11 –10

–7

–8

–9

–6

–2

–6

–15 –14

–5

His (H)

–7

–2

0

–4

–7

1

–5

–9

9

–9

–6

–6

–10

–6

–4

–6

–7

–7

–3

–6

Ile (I)

–5

–5

–5

–7

–6

–8

–5 –11

–9

8

–1

–6

–1

–2

–8

–7

–2

–14

–6

2

Leu (L)

–6

–8

–7

–12

–15

–5

–9 –10

–6

–1

7

–8

1

–3

–7

–8

–7

–6

–7

–2

Lys (K)

–7

0

–1

–4

–14

–3

–4

–7

–6

–6

–8

7

–2 –14

–6

–4

–3

–12

–9

–9

Met (M)

–5

–4

–9

–11

–13

–4

–7

–8 –10

–1

1

–2 11

–4

–8

–5

–4

–13 –11

–1

Phe (F)

–8

–9

–9

–15

–13 –13

–14

–9

–6

–2

–3

–14

–4

9

–10

–6

–9

–4

2

–8

Pro (P)

–2

–4

–6

–8

–8

–3

–5

–6

–4

–8

–7

–6

–8 –10

8

–2

–4

–14 –13

–6

Ser (S)

0

–3

0

–4

–3

–5

–4

–2

–6

–7

–8

–4

–5

–6

–2

6

0

–5

–7

–6

Thr (T)

–1

–6

–2

–5

–8

–5

–6

–6

–7

–2

–7

–3

–4

–9

–4

0

7

–13

–6

–3

Trp (W)

–13

–2

–8

–15

–15 –13

–17 –15

–7

–14

–6

–12

–13

–4 –14

–5 –13

13

–5 –15

Tyr (Y)

–8 –10 –4

–11

–4 –12

–8 –14

–3

–6

–7

–9

–11

2

–13

–7

–6

–5 10 –7

Val (V)

–2

–8

–8

–8

–6

–7

–6

–5

–6

2

–2

–9

–1

–8

–6

–6

–3

–15

–7

7

A R N D C Q E G H I L K M

F P S T W Y V

Ala (A)

5

–4

–2

–1

–4

–2

–1

0

–4

–2

–4

–4

–3

–6

0

1

1

–9

–5

–1

Arg (R)

–4

8

–3

–6

–5

0

–5

–6

0

–3

–6

2

–2 –7 –2

–1

–4

0

–7

–5

Asn (N)

–2

–3

6

3

–7

–1

0

–1

1

–3

–5

0

–5 –6 –3

1

0

–6

–3

–5

Asp (D)

–1

–6

3

6

–9

0

3

–1

–1

–5

–8

–2

–7 –10

–4

–1

–2 –10

–7

–5

Cys (C)

–4

–5

–7

–9

9

–9 –9 –6 –5

–4 –10

–9

–9 –8 –5

–1

–5 –11

–2

–4

Gln (Q)

–2

0

–1

0

–9

7

2

–4

2

–5

–3

–1

–2 –9 –1

–3

–3

–8

–8

–4

Glu (E)

–1

–5

0

3

–9

2

6

–2

–2

–4

–6

–2

–4 –9 –3

–2

–3 –11

–6

–4

Gly (G)

0

–6

–1

–1

–6

–4

–2

6

–6

–6

–7

–5

–6 –7 –3

0

–3 –10

–9

–3

His (H)

–4

0

1

–1

–5

2

–2

–6

8

–6

–4

–3

–6 –4 –2

–3

–4

–5

–1

–4

Ile (I)

–2

–3

–3

–5

–4

–5 –4 –6

–6

7

1

–4

1

0

–5

–4

–1

–9

–4

3

Leu (L)

–4

–6

–5

–8 –10

–3 –6 –7

–4

1

6

–5

2

–1

–5

–6

–4

–4

–4

0

Lys (K)

–4

2

0

–2

–9

–1 –2 –5

–3

–4

–5

6

0

–9

–4

–2

–1

–7

–7

–6

Met (M)

–3

–2

–5

–7

–9

–2 –4 –6

–6

1

2

0

10

–2

–5

–3

–2

–8

–7

0

Phe (F)

–6

–7

–6

–10

–8

–9 –9 –7

–4

0

–1

–9

–2

8

–7

–4

–6

–2

4

–5

Pro (P)

0

–2

–3

–4

–5

–1 –3 –3

–2

–5

–5

–4

–5

–7

7

0

–2

–9

–9

–3

Ser (S)

1

–1

1

–1

–1

–3

–2

0

–3

–4

–6

–2

–3

–4

0

5

2

–3

–5

–3

Thr (T)

1

–4

0

–2

–5

–3 –3 –3

–4

–1

–4

–1

–2 –6 –2

2

6

–8

–4

–1

Trp (W)

–9

0

–6

–10 –11

–8 –11 –10

–5

–9

–4

–7

–8 –2 –9

–3

–8

13

–3 –10

Tyr (Y)

–5

–7

–3

–7

–2

–8 –6 –9

–1

–4

–4

–7

–7

4

–9

–5

–4

–3

9

–5

Val (V)

–1

–5

–5

–5

–4

–4 –4 –3 –4

3

0

–6

0

–5

–3

–3

–1 –10

–5

6

A R N D C Q E G H I L K M F P S T W Y V

Ala (A)

3

–3

–1

0

–3

–1

0

1

–3

–1

–3

–2

–2

–4

1

1

1

–7

–4

0

Arg (R)

–3

6

–1 –3 –4

1

–3

–4

1

–2

–4

2

–1 –5 –1

–1

–2

1

–5

–3

Asn (N)

–1

–1

4

2

–5

0

1

0

2

–2

–4

1

–3 –4 –2

1

0

–4

–2

–3

Asp (D)

0

–3

2

5

–7

1

3

0

0

–3

–5

–1

–4 –7 –3

0

–1 –8 –5

–3

Cys (C)

–3

–4

–5

–7

9

–7 –7 –4 –4

–3

–7

–7

–6 –6 –4

0

–3 –8 –1

–3

Gln (Q)

–1

1

0

1

–7

6

2

–3

3

–3

–2

0

–1

–6

0

–2

–2 –6 –5

–3

Glu (E)

0

–3

1

3

–7

2

5

–1

–1

–3

–4

–1

–3 –7 –2

–1

–2 –8 –5

–3

Gly (G)

1

–4

0

0

–4

–3

–1

5

–4

–4

–5

–3

–4 –5 –2

1

–1 –8 –6

–2

His (H)

–3

1

2

0

–4

3

–1

–4

7

–4

–3

–2

–4 –3 –1

–2

–3 –3 –1

–3

Ile (I)

–1

–2

–2 –3 –3

–3 –3 –4

–4

6

1

–3

1

0

–3

–2

0

–6

–2

3

Leu (L)

–3

–4

–4 –5 –7

–2 –4 –5

–3

1

5

–4

3

0

–3

–4

–3 –3 –2

1

Lys (K)

–2

2

1

–1

–7

0

–1

–3

–2

–3

–4

5

0

–7

–2

–1

–1 –5 –5

–4

Met (M)

–2

–1

–3 –4 –6

–1 –3 –4

–4

1

3

0

8

–1

–3

–2

–1 –6 –4

1

Phe (F)

–4

–5

–4 –7 –6

–6 –7 –5

–3

0

0

–7

–1

8

–5

–3

–4

–1

4

–3

Pro (P)

1

–1

–2 –3 –4

0

–2

–2

–1

–3

–3

–2

–3

–5

6

1

–1 –7 –6

–2

Ser (S)

1

–1

1

0

0

–2

–1

1

–2

–2

–4

–1

–2

–3

1

3

2

–2

–3

–2

Thr (T)

1

–2

0

–1

–3

–2 –2 –1

–3

0

–3

–1

–1 –4 –1

2

4

–6

–3

0

Trp (W)

–7

1

–4 –8 –8

–6 –8 –8

–3

–6

–3

–5

–6 –1 –7

–2 –6 12 –2

–8

Tyr (Y)

–4

–5

–2 –5 –1

–5 –5 –6

–1

–2

–2

–5

–4

4

–6

–3

–3

–2

8

–3

Val (V)

0

–3

–3 –3 –3

–3 –3 –2 –3

3

1

–4

1

–3

–2

–2

0

–8

–3

5

A R N D C Q E G H I L K M F P S T W Y V

Ala (A)

2

–2

0

0

–2

0

0

1

–1 –1 –2

–1 –1 –3

1

1

1

–6

–3

0

Arg (R)

–2

6

0

–1

–4

1

–1

–3

2

–2

–3

3

0

–4

0

0

–1

2

–4

–2

Asn (N)

0

0

2

2

–4

1

1

0

2

–2

–3

1

–2

–3

0

1

0

–4 –2 –2

Asp (D)

0

–1

2

4

–5

2

3

1

1

–2

–4

0

–3

–6

–1

0

0

–7 –4 –2

Cys (C)

–2

–4

–4

–5 12 –5

–5

–3

–3 –2 –6

–5 –5 –4

–3

0

–2

–8

0

–2

Gln (Q)

0

1

1

2

–5

4

2

–1

3

–2

–2

1

–1

–5

0

–1

–1

–5 –4 –2

Glu (E)

0

–1

1

3

–5

2

4

0

1

–2

–3

0

–2

–5

–1

0

0

–7 –4 –2

Gly (G)

1

–3

0

1

–3

–1

0

5

–2 –3 –4

–2 –3 –5

0

1

0

–7 –5 –1

His (H)

–1

2

2

1

–3

3

1

–2

6

–2

–2

0

–2

–2

0

–1

–1

–3

0

–2

Ile (I)

–1

–2

–2

–2 –2 –2

–2

–3

–2

5

2

–2

2

1

–2

–1

0

–5

–1

4

Leu (L)

–2

–3

–3

–4 –6 –2

–3

–4

–2

2

6

–3

4

2

–3

–3

–2

–2

–1

2

Lys (K)

–1

3

1

0

–5

1

0

–2

0

–2

–3

5

0

–5

–1

0

0

–3 –4 –2

Met (M)

–1

0

–2

–3 –5 –1

–2

–3

–2

2

4

0

6

0

–2

–2

–1

–4

–2

2

Phe (F)

–3

–4

–3

–6 –4 –5

–5

–5

–2

1

2

–5

0

9

–5

–3

–3

0

7

–1

Pro (P)

1

0

0

–1

–3

0

–1

0

0

–2

–3

–1 –2 –5

6

1

0

–6 –5 –1

Ser (S)

1

0

1

0

0

–1

0

1

–1 –1 –3

0

–2

–3

1

2

1

–2 –3 –1

Thr (T)

1

–1

0

0

–2

–1

0

0

–1

0

–2

0

–1

–3

0

1

3

–5

–3

0

Trp (W)

–6

2

–4

–7 –8 –5

–7

–7

–3 –5 –2

–3

–4

0

–6

–2

–5

17

0

–6

Tyr (Y)

–3

–4

–2

–4

0

–4

–4

–5

0

–1

–1

–4

–2

7

–5

–3

–3

0

10

–2

Val (V)

0

–2

–2

–2 –2 –2

–2

–1

–2

4

2

–2

2

–1

–1

–1

0

–6

–2

4

A R N D C Q E G H I L K M F P S T W Y V