Добавил:
Upload
Опубликованный материал нарушает ваши авторские права? Сообщите нам.
Вуз:
Предмет:
Файл:Prescriber's Guide_ Stahl's Ess - Stephen M. Stahl.docx
X
- •Table of Contents
- •If It Works 224
- •If It Works 234
- •If It Doesn’t Work 234
- •If It Works 246
- •If It Doesn’t Work 246
- •If It Works 260
- •If It Doesn’t Work 261
- •If It Works 274
- •If It Doesn’t Work 274
- •If It Works 315
- •If It Doesn’t Work 316
- •If It Works 330
- •If It Doesn’t Work 330
- •If It Works 339
- •If It Doesn’t Work 340
- •If It Works 351
- •If It Doesn’t Work 351
- •If It Works 361
- •If It Doesn’t Work 362
- •If It Works 369
- •If It Doesn’t Work 369
- •If It Works 378
- •If It Doesn’t Work 378
- •If It Works 386
- •If It Doesn’t Work 386
- •If It Works 398
- •If It Doesn’t Work 399
- •If It Works 404
- •If It Doesn’t Work 405
- •If It Works 411
- •If It Works 423
- •If It Doesn’t Work 424
- •If It Works 433
- •If It Doesn’t Work 433
- •If It Works 445
- •If It Doesn’t Work 445
- •If It Works 457
- •If It Doesn’t Work 458
- •If It Works 472
- •If It Doesn’t Work 472
- •If It Works 483
- •If It Doesn’t Work 483
- •If It Works 493
- •If It Doesn’t Work 494
- •If It Works 503
- •If It Doesn’t Work 504
- •If It Works 517
- •If It Doesn’t Work 518
- •If It Works 530
- •If It Doesn’t Work 530
- •If It Works 544
- •If It Doesn’t Work 544
- •If It Works 556
- •If It Doesn’t Work 557
- •If It Works 564
- •If It Doesn’t Work 564
- •If It Works 580
- •If It Doesn’t Work 580
- •If It Works 587
- •If It Doesn’t Work 587
- •If It Works 597
- •If It Doesn’t Work 597
- •If It Works 611
- •If It Doesn’t Work 612
- •If It Works 627
- •If It Doesn’t Work 628
- •If It Works 641
- •If It Doesn’t Work 641
- •If It Works 652
- •If It Doesn’t Work 652
- •If It Works 659
- •If It Doesn’t Work 660
- •If It Works 667
- •If It Doesn’t Work 668
- •If It Works 674
- •If It Doesn’t Work 674
- •If It Works 683
- •If It Doesn’t Work 683
- •If It Works 696
- •If It Doesn’t Work 697
- •If It Works 706
- •If It Doesn’t Work 707
- •If It Works 718
- •If It Doesn’t Work 719
- •If It Works 726
- •If It Doesn’t Work 726
- •If It Works 740
- •If It Works 752
- •If It Doesn’t Work 752
- •If It Works 762
- •If It Doesn’t Work 762
- •If It Works 770
- •If It Doesn’t Work 770
- •If It Works 783
- •If It Doesn’t Work 783
- •If It Works 790
- •If It Doesn’t Work 790
- •If It Works 802
- •If It Doesn’t Work 803
- •If It Works 815
- •If It Doesn’t Work 816
- •If It Works 830
- •If It Doesn’t Work 830
- •If It Works 839
- •If It Works 855
- •If It Works 863
- •If It Doesn’t Work 863
- •If It Works 886
- •If It Doesn’t Work 886
- •If It Works 899
- •If It Doesn’t Work 900
- •If It Works 912
- •If It Doesn’t Work 913
- •If It Works 923
- •If It Doesn’t Work 923
- •If It Works 933
- •If It Doesn’t Work 933
- •If It Works 939
- •If It Doesn’t Work 940
- •If It Works 953
- •If It Doesn’t Work 954
- •If It Works 967
- •If It Doesn’t Work 967
- •If It Works 980
- •If It Doesn’t Work 981
- •If It Works 987
- •If It Doesn’t Work 987
- •If It Works 998
- •If It Doesn’t Work 998
- •If It Works 1033
- •If It Doesn’t Work 1033
- •If It Works 1041
- •If It Doesn’t Work 1041
- •If It Works 1048
- •If It Doesn’t Work 1048
- •If It Works 1061
- •If It Doesn’t Work 1061
- •If It Works 1072
- •If It Doesn’t Work 1072
- •If It Works 1085
- •If It Doesn’t Work 1085
- •If It Works 1094
- •If It Doesn’t Work 1095
- •If It Works 1103
- •If It Doesn’t Work 1103
- •If It Works 1110
- •If It Doesn’t Work 1110
- •If It Works 1118
- •If It Doesn’t Work 1119
- •If It Works 1130
- •If It Doesn’t Work 1130
- •If It Works 1144
- •If It Doesn’t Work 1145
- •If It Works 1159
- •If It Doesn’t Work 1160
- •If It Works 1169
- •If It Works 1180
- •If It Doesn’t Work 1180
- •If It Works 1195
- •If It Doesn’t Work 1195
- •If It Works 1209
- •If It Doesn’t Work 1210
- •If It Works 1218
- •If It Doesn’t Work 1219
- •If It Works 1230
- •If It Doesn’t Work 1230
- •If It Works 1244
- •If It Doesn’t Work 1244
- •If It Works 1252
- •If It Doesn’t Work 1253
- •If It Works 1262
- •If It Doesn’t Work 1263
- •If It Works 1272
- •If It Doesn’t Work 1272
- •If It Works 1279
- •If It Works 1288
- •If It Doesn’t Work 1288
- •If It Works 1297
- •If It Doesn’t Work 1297
- •If It Works 1309
- •If It Doesn’t Work 1309
- •If It Works 1317
- •If It Doesn’t Work 1318
- •If It Works 1331
- •If It Doesn’t Work 1331
- •If It Works 1339
- •If It Doesn’t Work 1339
- •If It Works 1349
- •If It Doesn’t Work 1350
- •If It Works 1366
- •If It Doesn’t Work 1366
- •If It Works 1377
- •If It Doesn’t Work 1378
- •If It Works 1396
- •If It Doesn’t Work 1396
- •If It Works 1406
- •If It Doesn’t Work 1406
- •If It Works 1420
- •If It Doesn’t Work 1421
- •If It Works 1428
- •If It Doesn’t Work 1429
- •If It Works 1438
- •If It Doesn’t Work 1438
- •If It Works 1445
- •If It Doesn’t Work 1445
- •If It Works 1456
- •If It Doesn’t Work 1457
- •If It Works 1466
- •If It Works 1476
- •If It Doesn’t Work 1476
- •If It Works 1483
- •If It Works 1494
- •If It Doesn’t Work 1494
- •If It Works 1507
- •If It Doesn’t Work 1507
- •If It Works 1517
- •If It Doesn’t Work 1517
- •If It Works 1525
- •If It Doesn’t Work 1526
- •If It Works 1535
- •If It Doesn’t Work 1535
- •If It Works 1551
- •If It Doesn’t Work 1552
- •If It Works 1565
- •If It Works 1578
- •If It Doesn’t Work 1579
- •If It Works 1586
- •If It Doesn’t Work 1586
- •If It Works 1600
- •If It Doesn’t Work 1600
- •If It Works 1612
- •If It Doesn’t Work 1613
- •If It Works 1623
- •If It Doesn’t Work 1623
- •If It Works 1631
- •If It Doesn’t Work 1632
- •If It Works 1646
- •If It Doesn’t Work 1646
- •If It Works 1655
- •If It Works 1662
- •If It Doesn’t Work 1662
- •If It Works 1670
- •If It Doesn’t Work 1670
- •If It Works 1680
- •If It Doesn’t Work 1681
- •Prescriber’s Guide
- •Stahl’s Essential Psychopharmacology Prescriber’s Guide
- •Contents
- •Introduction
- •Introduction
- •List of icons
- •If It Doesn’t Work
- •Best Augmenting Combos for Partial Response or Treatment Resistance
- •Breast Feeding
- •If It Doesn’t Work
- •Best Augmenting Combos for Partial Response or Treatment Resistance
- •Dosing Tips
- •Pharmacokinetics
- •Drug Interactions
- •Other Warnings/Precautions
- •How Long Until It Works
- •If It Works
- •If It Doesn’t Work
- •Best Augmenting Combos for Partial Response or Treatment Resistance
- •Before starting an atypical antipsychotic
- •Monitoring after starting an atypical antipsychotic
- •Elderly
- •Children and Adolescents
- •Pregnancy
- •Switching from Oral Antipsychotics to Amisulpride
- •How Long Until It Works
- •If It Works
- •If It Doesn’t Work
- •Best Augmenting Combos for Partial Response or Treatment Resistance
- •Other Warnings/Precautions
- •Elderly
- •Children and Adolescents
- •Pregnancy
- •Breast Feeding
- •How Long Until It Works
- •If It Works
- •If It Doesn’t Work
- •Best Augmenting Combos for Partial Response or Treatment Resistance
- •Other Warnings/Precautions
- •Elderly
- •Children and Adolescents
- •Pregnancy
- •Breast Feeding
- •How Long Until It Works
- •If It Works (for adhd)
- •If It Doesn’t Work (for adhd)
- •Best Augmenting Combos for Partial Response or Treatment Resistance
- •Other Warnings/Precautions
- •Pregnancy
- •How Long Until It Works
- •If It Works (for adhd)
- •If It Doesn’t Work (for adhd)
- •Best Augmenting Combos for Partial Response or Treatment Resistance
- •Dosing Tips
- •Drug Interactions
- •Other Warnings/Precautions
- •Pregnancy
- •How the Drug Works
- •How Long Until It Works
- •If It Works
- •If It Doesn’t Work
- •Best Augmenting Combos for Partial Response or Treatment Resistance
- •Tests Before starting an atypical antipsychotic
- •Monitoring after starting an atypical antipsychotic
- •Aripiprazole: side effects How Drug Causes Side Effects
- •Dosing Tips – Oral
- •Children and Adolescents
- •Pregnancy
- •Switching from Oral Antipsychotics to Aripiprazole
- •How the Drug Works
- •Other Warnings/Precautions
- •How Long Until It Works
- •If It Works
- •If It Doesn’t Work
- •Best Augmenting Combos for Partial Response or Treatment Resistance
- •Tests Before starting an a typical antipsychotic
- •Monitoring after starting an atypical antipsychotic
- •Asenapine: side effects How Drug Causes Side Effects
- •Notable Side Effects
- •Life-Threatening or Dangerous Side Effects
- •Dosing Tips
- •Children and Adolescents
- •Pregnancy
- •Switching from Oral Antipsychotics to Asenapine
- •How Long Until It Works
- •If It Works
- •If It Doesn’t Work
- •Best Augmenting Combos for Partial Response or Treatment Resistance
- •Atomoxetine: side effects How Drug Causes Side Effects
- •Notable Side Effects
- •Dosing Tips
- •Other Warnings/Precautions
- •If It Doesn’t Work
- •Best Augmenting Combos for Partial Response or Treatment Resistance
- •Tests Before starting any atypical antipsychotic
- •Monitoring after starting any atypical antipsychotic
- •Dosing Tips
- •Other Warnings/Precautions
- •How Long Until It Works
- •If It Works
- •If It Doesn’t Work
- •Best Augmenting Combos for Partial Response or Treatment Resistance
- •Bupropion: side effects How Drug Causes Side Effects
- •Notable Side Effects
- •Life-Threatening or Dangerous Side Effects
- •Dosing Tips
- •Other Warnings/Precautions
- •Pregnancy
- •Breast Feeding
- •If It Doesn’t Work (for bipolar disorder)
- •Best Augmenting Combos for Partial Response or Treatment Resistance
- •Dosing Tips
- •Drug Interactions
- •Other Warnings/Precautions
- •Pregnancy
- •Breast Feeding
- •If It Doesn’t Work
- •Best Augmenting Combos for Partial Response or Treatment Resistance
- •Pharmacokinetics
- •Drug Interactions
- •Other Warnings/Precautions
- •Pregnancy
- •How the Drug Works
- •How Long Until It Works
- •If It Works
- •If It Doesn’t Work
- •Best Augmenting Combos for Partial Response or Treatment Resistance
- •Chlorpromazine: side effects How Drug Causes Side Effects
- •Other Warnings/Precautions
- •Children and Adolescents
- •Pregnancy
- •How Long Until It Works
- •If It Works
- •If It Doesn’t Work
- •Best Augmenting Combos for Partial Response or Treatment Resistance
- •Citalopram: side effects How Drug Causes Side Effects
- •Notable Side Effects
- •Other Warnings/Precautions
- •Pregnancy
- •Breast Feeding
- •How Long Until It Works
- •If It Works
- •If It Doesn’t Work
- •Best Augmenting Combos for Partial Response or Treatment Resistance
- •Other Warnings/Precautions
- •Elderly
- •Children and Adolescents
- •Pregnancy
- •Breast Feeding
- •How Long Until It Works
- •If It Works
- •If It Doesn’t Work
- •Best Augmenting Combos for Partial Response or Treatment Resistance
- •Pharmacokinetics
- •Drug Interactions
- •Other Warnings/Precautions
- •How the Drug Works
- •How Long Until It Works
- •If It Works
- •If It Doesn’t Work
- •Best Augmenting Combos for Partial Response or Treatment Resistance
- •Dosing Tips
- •Pharmacokinetics
- •Drug Interactions
- •Other Warnings/Precautions
- •If It Doesn’t Work
- •Best Augmenting Combos for Partial Response or Treatment Resistance
- •Dosing Tips
- •Pharmacokinetics
- •Drug Interactions
- •Other Warnings/Precautions
- •How Long Until It Works
- •If It Works
- •If It Doesn’t Work
- •Best Augmenting Combos for Partial Response or Treatment Resistance
- •Before starting an atypical antipsychotic
- •Monitoring after starting an atypical antipsychotic
- •Clozapine: side effects How Drug Causes Side Effects
- •Notable Side Effects
- •Life-Threatening or Dangerous Side Effects
- •Weight Gain
- •Sedation
- •What to Do About Side Effects
- •Other Warnings/Precautions
- •Children and Adolescents
- •Pregnancy
- •Switching from Oral Antipsychotics to Clozapine
- •How Long Until It Works
- •If It Works
- •If It Doesn’t Work
- •Best Augmenting Combos for Partial Response or Treatment Resistance
- •Cyamemazine: side effects How Drug Causes Side Effects
- •Notable Side Effects
- •Pharmacokinetics
- •Drug Interactions
- •Other Warnings/Precautions
- •How Long Until It Works
- •If It Works
- •If It Doesn’t Work
- •Best Augmenting Combos for Partial Response or Treatment Resistance
- •Desipramine: side effects How Drug Causes Side Effects
- •Notable Side Effects
- •Life-Threatening or Dangerous Side Effects
- •Other Warnings/Precautions
- •Elderly
- •Children and Adolescents
- •Pregnancy
- •Breast Feeding
- •How Long Until It Works
- •If It Works
- •If It Doesn’t Work
- •Best Augmenting Combos for Partial Response or Treatment Resistance
- •Desvenlafaxine: side effects How Drug Causes Side Effects
- •Overdose
- •Other Warnings/Precautions
- •Elderly
- •Children and Adolescents
- •Pregnancy
- •Breast Feeding
- •Other Warnings/Precautions
- •How the Drug Works
- •How Long Until It Works
- •If It Works
- •If It Doesn’t Work
- •Best Augmenting Combos for Partial Response or Treatment Resistance
- •Dosing Tips
- •Pharmacokinetics
- •Drug Interactions
- •Other Warnings/Precautions
- •How Long Until It Works
- •If It Works
- •If It Doesn’t Work
- •Best Augmenting Combos for Partial Response or Treatment Resistance
- •Other Warnings/Precautions
- •Elderly
- •Children and Adolescents
- •Pregnancy
- •Breast Feeding
- •How the Drug Works
- •How Long Until It Works
- •If It Works
- •If It Doesn’t Work
- •Best Augmenting Combos for Partial Response or Treatment Resistance
- •Doxepin: side effects How Drug Causes Side Effects
- •Notable Side Effects
- •Life-Threatening or Dangerous Side Effects
- •Dosing Tips
- •Pharmacokinetics
- •Drug Interactions
- •Other Warnings/Precautions
- •Elderly
- •Children and Adolescents
- •Pregnancy
- •Breast Feeding
- •How Long Until It Works
- •If It Works
- •If It Doesn’t Work
- •Best Augmenting Combos for Partial Response or Treatment Resistance
- •Duloxetine: side effects How Drug Causes Side Effects
- •Other Warnings/Precautions
- •Pregnancy
- •Breast Feeding
- •If It Doesn’t Work
- •Best Augmenting Combos for Partial Response or Treatment Resistance
- •Escitalopram: side effects How Drug Causes Side Effects
- •Notable Side Effects
- •Other Warnings/Precautions
- •Pregnancy
- •Breast Feeding
- •Pharmacokinetics
- •Drug Interactions
- •Other Warnings/Precautions
- •How the Drug Works
- •How Long Until It Works
- •If It Works
- •Pharmacokinetics
- •Drug Interactions
- •Other Warnings/Precautions
- •How the Drug Works
- •How Long Until It Works
- •If It Works
- •If It Doesn’t Work
- •Best Augmenting Combos for Partial Response or Treatment Resistance
- •Fluoxetine: side effects How Drug Causes Side Effects
- •Notable Side Effects
- •Other Warnings/Precautions
- •Pregnancy
- •Breast Feeding
- •If It Doesn’t Work
- •Best Augmenting Combos for Partial Response or Treatment Resistance
- •Flupenthixol: side effects How Drug Causes Side Effects
- •Other Warnings/Precautions
- •Children and Adolescents
- •Pregnancy
- •If It Doesn’t Work
- •Best Augmenting Combos for Partial Response or Treatment Resistance
- •Fluphenazine: side effects How Drug Causes Side Effects
- •Dosing Tips – Oral
- •Dosing Tips – Depot
- •Other Warnings/Precautions
- •Children and Adolescents
- •Pregnancy
- •Pharmacokinetics
- •Drug Interactions
- •Other Warnings/Precautions
- •If It Doesn’t Work
- •Best Augmenting Combos for Partial Response or Treatment Resistance
- •Fluvoxamine: side effects How Drug Causes Side Effects
- •Notable Side Effects
- •Dosing Tips
- •Other Warnings/Precautions
- •Pregnancy
- •Breast Feeding
- •How Long Until It Works
- •If It Works
- •If It Doesn’t Work (for neuropathic pain or bipolar disorder)
- •Best Augmenting Combos for Partial Response or Treatment Resistance
- •Dosing Tips
- •Gabapentin: special populations Renal Impairment
- •Pregnancy
- •Breast Feeding
- •How Long Until It Works
- •If It Works
- •How the Drug Works
- •How Long Until It Works
- •If It Works
- •If It Doesn’t Work
- •Best Augmenting Combos for Partial Response or Treatment Resistance
- •Haloperidol: side effects How Drug Causes Side Effects
- •Dosing Tips – Oral
- •Dosing Tips – Depot
- •Other Warnings/Precautions
- •Children and Adolescents
- •Pregnancy
- •How the Drug Works
- •How Long Until It Works
- •If It Works
- •If It Works
- •If It Doesn’t Work
- •Best Augmenting Combos for Partial Response or Treatment Resistance
- •Other Warnings/Precautions
- •Children and Adolescents
- •Pregnancy
- •Switching from Oral Antipsychotics to Iloperidone
- •How Long Until It Works
- •If It Works
- •If It Doesn’t Work
- •Best Augmenting Combos for Partial Response or Treatment Resistance
- •Other Warnings/Precautions
- •Elderly
- •Children and Adolescents
- •Pregnancy
- •Breast Feeding
- •If It Doesn’t Work
- •Best Augmenting Combos for Partial Response or Treatment Resistance
- •Other Warnings/Precautions
- •Pregnancy
- •Breast Feeding
- •Other Warnings/Precautions
- •How the Drug Works
- •How Long Until It Works
- •If It Works
- •If It Doesn’t Work (for bipolar disorder)
- •Best Augmenting Combos for Partial Response or Treatment Resistance (for bipolar disorder)
- •Weight Gain
- •Sedation
- •What to Do About Side Effects
- •Best Augmenting Agents for Side Effects
- •Lamotrigine: dosing and use Usual Dosage Range
- •Dosage Forms
- •How to Dose
- •Dosing Tips
- •Drug Interactions
- •Other Warnings/Precautions
- •Pregnancy
- •Breast Feeding
- •How the Drug Works
- •How Long Until It Works
- •If It Works
- •If It Doesn’t Work (for bipolar disorder or neuropathic pain)
- •Levetiracetam: special populations Renal Impairment
- •Breast Feeding
- •How Long Until It Works
- •If It Works
- •If It Doesn’t Work
- •Best Augmenting Combos for Partial Response or Treatment Resistance
- •Levomilnacipran: side effects How Drug Causes Side Effects
- •Other Warnings/Precautions
- •Pregnancy
- •Breast Feeding
- •How Long Until It Works
- •If It Works (for adhd)
- •If It Doesn’t Work (for adhd)
- •Best Augmenting Combos for Partial Response or Treatment Resistance
- •Other Warnings/Precautions
- •Pregnancy
- •Breast Feeding
- •Lisdexamfetamine: the art of psychopharmacology Potential Advantages
- •Potential Disadvantages
- •Primary Target Symptoms
- •How Long Until It Works
- •If It Works
- •If It Doesn’t Work
- •Best Augmenting Combos for Partial Response or Treatment Resistance
- •Other Warnings/Precautions
- •Children and Adolescents
- •Pregnancy
- •Breast Feeding
- •How Long Until It Works
- •If It Works
- •If It Doesn’t Work
- •Best Augmenting Combos for Partial Response or Treatment Resistance
- •Other Warnings/Precautions
- •Elderly
- •Children and Adolescents
- •Pregnancy
- •Breast Feeding
- •If It Doesn’t Work
- •Best Augmenting Combos for Partial Response or Treatment Resistance
- •Pharmacokinetics
- •Drug Interactions
- •Other Warnings/Precautions
- •How Long Until It Works
- •If It Works
- •If It Doesn’t Work
- •Best Augmenting Combos for Partial Response or Treatment Resistance
- •Pharmacokinetics
- •Drug Interactions
- •Other Warnings/Precautions
- •If It Doesn’t Work
- •Best Augmenting Combos for Partial Response or Treatment Resistance
- •Loxapine: side effects How Drug Causes Side Effects
- •Dosing Tips
- •Drug Interactions
- •Other Warnings/Precautions
- •Children and Adolescents
- •Pregnancy
- •How Long Until It Works
- •If It Works
- •If It Doesn’t Work
- •Best Augmenting Combos for Partial Response or Treatment Resistance
- •Tests Before starting any atypical antipsychotic
- •Monitoring after starting any atypical antipsychotic
- •Other Warnings/Precautions
- •Children and Adolescents
- •Pregnancy
- •Switching from Oral Antipsychotics to Lurasidone
- •How Long Until It Works
- •If It Works
- •If It Doesn’t Work
- •Best Augmenting Combos for Partial Response or Treatment Resistance
- •Other Warnings/Precautions
- •Elderly
- •Children and Adolescents
- •Pregnancy
- •Breast Feeding
- •Mesoridazine: side effects How Drug Causes Side Effects
- •Other Warnings/Precautions
- •Elderly
- •Children and Adolescents
- •Pregnancy
- •How Long Until It Works
- •If It Works
- •If It Doesn’t Work
- •Best Augmenting Combos for Partial Response or Treatment Resistance
- •Other Warnings/Precautions
- •How Long Until It Works
- •If It Works (for adhd)
- •If It Doesn’t Work (for adhd)
- •Best Augmenting Combos for Partial Response or Treatment Resistance
- •Dosing Tips
- •Other Warnings/Precautions
- •Pregnancy
- •How Long Until It Works
- •If It Works (for adhd)
- •If It Doesn’t Work (for adhd)
- •Best Augmenting Combos for Partial Response or Treatment Resistance
- •How to Dose
- •Dosing Tips
- •Other Warnings/Precautions
- •Pregnancy
- •How Long Until It Works
- •If It Works
- •If It Doesn’t Work
- •Best Augmenting Combos for Partial Response or Treatment Resistance
- •Other Warnings/Precautions
- •Pregnancy
- •Breast Feeding
- •How Long Until It Works
- •If It Works
- •If It Doesn’t Work
- •Best Augmenting Combos for Partial Response or Treatment Resistance
- •Milnacipran: side effects How Drug Causes Side Effects
- •Notable Side Effects
- •Other Warnings/Precautions
- •Pregnancy
- •Breast Feeding
- •How Long Until It Works
- •If It Works
- •If It Doesn’t Work
- •Best Augmenting Combos for Partial Response or Treatment Resistance
- •Other Warnings/Precautions
- •Pregnancy
- •Breast Feeding
- •If It Doesn’t Work
- •Best Augmenting Combos for Partial Response or Treatment Resistance
- •Moclobemide: side effects How Drug Causes Side Effects
- •Other Warnings/Precautions
- •Pregnancy
- •Breast Feeding
- •How the Drug Works
- •Other Warnings/Precautions
- •If It Doesn’t Work
- •Best Augmenting Combos for Partial Response or Treatment Resistance
- •Molindone: side effects How Drug Causes Side Effects
- •Other Warnings/Precautions
- •Children and Adolescents
- •Pregnancy
- •Other Warnings/Precautions
- •Dosing Tips
- •Other Warnings/Precautions
- •If It Doesn’t Work
- •Best Augmenting Combos for Partial Response or Treatment Resistance
- •Nefazodone: side effects How Drug Causes Side Effects
- •Other Warnings/Precautions
- •Pregnancy
- •Breast Feeding
- •How Long Until It Works
- •If It Works
- •If It Doesn’t Work
- •Best Augmenting Combos for Partial Response or Treatment Resistance
- •Other Warnings/Precautions
- •Elderly
- •Children and Adolescents
- •Pregnancy
- •Breast Feeding
- •How the Drug Works
- •How Long Until It Works
- •If It Works
- •If It Doesn’t Work
- •Best Augmenting Combos for Partial Response or Treatment Resistance
- •Tests Before starting an atypical antipsychotic
- •Monitoring after starting an atypical antipsychotic
- •Olanzapine: side effects How Drug Causes Side Effects
- •Notable Side Effects
- •Dosing Tips – Oral
- •Dosing Tips – Depot
- •Children and Adolescents
- •Pregnancy
- •Switching from Oral Antipsychotics to Oral Olanzapine
- •Switching from Oral Antipsychotics to Olanzapine lai
- •If It Doesn’t Work
- •Best Augmenting Combos for Partial Response or Treatment Resistance
- •Pharmacokinetics
- •Drug Interactions
- •Other Warnings/Precautions
- •Dosing Tips
- •Drug Interactions
- •Other Warnings/Precautions
- •Pregnancy
- •Breast Feeding
- •If It Doesn’t Work
- •Best Augmenting Combos for Partial Response or Treatment Resistance
- •Tests Before starting an atypical antipsychotic:
- •Monitoring after starting an atypical antipsychotic:
- •Paliperidone: side effects How Drug Causes Side Effects
- •Dosing Tips – Oral
- •Children and Adolescents
- •Pregnancy
- •Switching from Oral Antipsychotics to Paliperidone er
- •Switching from Oral Antipsychotics to Paliperidone Palmitate
- •How the Drug Works
- •How Long Until It Works
- •If It Works
- •If It Doesn’t Work
- •Best Augmenting Combos for Partial Response or Treatment Resistance
- •Paroxetine: side effects How Drug Causes Side Effects
- •Notable Side Effects
- •Dosing Tips
- •Pharmacokinetics
- •Drug Interactions
- •Other Warnings/Precautions
- •Pregnancy
- •Breast Feeding
- •If It Doesn’t Work
- •Best Augmenting Combos for Partial Response or Treatment Resistance
- •Before starting an atypical antipsychotic
- •Monitoring after starting an atypical antipsychotic
- •If It Doesn’t Work
- •Best Augmenting Combos for Partial Response or Treatment Resistance
- •Perphenazine: side effects How Drug Causes Side Effects
- •Other Warnings/Precautions
- •Children and Adolescents
- •Pregnancy
- •If It Doesn’t Work
- •Best Augmenting Combos for Partial Response or Treatment Resistance
- •Phenelzine: side effects How Drug Causes Side Effects
- •Other Warnings/Precautions
- •Pregnancy
- •Breast Feeding
- •Other Warnings/Precautions
- •Pimozide: side effects How Drug Causes Side Effects
- •Other Warnings/Precautions
- •Elderly
- •Children and Adolescents
- •Pregnancy
- •If It Doesn’t Work
- •Best Augmenting Combos for Partial Response or Treatment Resistance
- •Pipothiazine: side effects How Drug Causes Side Effects
- •Other Warnings/Precautions
- •Children and Adolescents
- •Pregnancy
- •Other Warnings/Precautions
- •How Long Until It Works
- •If It Works
- •If It Doesn’t Work (for neuropathic pain)
- •Best Augmenting Combos for Partial Response or Treatment Resistance
- •Dosing Tips
- •Pregabalin: special populations Renal Impairment
- •How the Drug Works
- •How Long Until It Works
- •If It Works
- •If It Doesn’t Work
- •Best Augmenting Combos for Partial Response or Treatment Resistance
- •Other Warnings/Precautions
- •How Long Until It Works
- •If It Works
- •If It Doesn’t Work
- •Best Augmenting Combos for Partial Response or Treatment Resistance
- •Protriptyline: side effects How Drug Causes Side Effects
- •Notable Side Effects
- •Life-Threatening or Dangerous Side Effects
- •Other Warnings/Precautions
- •Elderly
- •Children and Adolescents
- •Pregnancy
- •Breast Feeding
- •Pharmacokinetics
- •Drug Interactions
- •Other Warnings/Precautions
- •How the Drug Works
- •How Long Until It Works
- •If It Works
- •If It Doesn’t Work
- •Best Augmenting Combos for Partial Response or Treatment Resistance
- •Tests Before starting an atypical antipsychotic
- •Monitoring after starting an atypical antipsychotic
- •Quetiapine: side effects How Drug Causes Side Effects
- •Dosing Tips
- •Children and Adolescents
- •Pregnancy
- •Switching from Oral Antipsychotics to Quetiapine
- •Other Warnings/Precautions
- •How Long Until It Works
- •If It Works
- •If It Doesn’t Work
- •Best Augmenting Combos for Partial Response or Treatment Resistance
- •Other Warnings/Precautions
- •Pregnancy
- •Breast Feeding
- •How the Drug Works
- •How Long Until It Works
- •If It Works
- •If It Doesn’t Work
- •Best Augmenting Combos for Partial Response or Treatment Resistance
- •Tests Before starting an atypical antipsychotic
- •Monitoring after starting an atypical antipsychotic
- •Risperidone: side effects How Drug Causes Side Effects
- •Notable Side Effects
- •Dosing Tips – Oral Formulation
- •Dosing Tips – Long-Acting Microsphere Depot Formulation
- •Children and Adolescents
- •Pregnancy
- •Breast Feeding
- •Risperidone: the art of psychopharmacology Potential Advantages
- •Potential Disadvantages
- •Primary Target Symptoms
- •Switching from Oral Antipsychotics to Risperidone
- •Switching from Oral Antipsychotics to Risperidone lai
- •Other Warnings/Precautions
- •How Long Until It Works
- •If It Works
- •If It Doesn’t Work
- •Best Augmenting Combos for Partial Response or Treatment Resistance
- •Selegiline: side effects How Drug Causes Side Effects
- •Notable Side Effects
- •Life-Threatening or Dangerous Side Effects
- •Drug Interactions
- •Other Warnings/Precautions
- •Pregnancy
- •Breast Feeding
- •If It Doesn’t Work
- •Best Augmenting Combos for Partial Response or Treatment Resistance
- •Before starting an atypical antipsychotic
- •Monitoring after starting an atypical antipsychotic
- •Other Warnings/Precautions
- •Children and Adolescents
- •Pregnancy
- •How Long Until It Works
- •If It Works
- •If It Doesn’t Work
- •Best Augmenting Combos for Partial Response or Treatment Resistance
- •Sertraline: side effects How Drug Causes Side Effects
- •Notable Side Effects
- •Dosing Tips
- •Other Warnings/Precautions
- •Pregnancy
- •Breast Feeding
- •Sertraline: the art of psychopharmacology Potential Advantages
- •Potential Disadvantages
- •Primary Target Symptoms
- •If It Doesn’t Work
- •Best Augmenting Combos for Partial Response or Treatment Resistance
- •Sulpiride: side effects How Drug Causes Side Effects
- •Children and Adolescents
- •Pregnancy
- •Pharmacokinetics
- •Drug Interactions
- •Other Warnings/Precautions
- •Thioridazine: side effects How Drug Causes Side Effects
- •Other Warnings/Precautions
- •Elderly
- •Children and Adolescents
- •Pregnancy
- •If It Doesn’t Work
- •Best Augmenting Combos for Partial Response or Treatment Resistance
- •Thiothixene: side effects How Drug Causes Side Effects
- •Other Warnings/Precautions
- •Children and Adolescents
- •Pregnancy
- •If It Doesn’t Work (for neuropathic pain or anxiety disorders)
- •Best Augmenting Combos for Partial Response or Treatment Resistance
- •Dosing Tips
- •Other Warnings/Precautions
- •If It Doesn’t Work
- •Pregnancy
- •Breast Feeding
- •Dosing Tips
- •Other Warnings/Precautions
- •Pregnancy
- •Breast Feeding
- •If It Doesn’t Work
- •Best Augmenting Combos for Partial Response or Treatment Resistance
- •Other Warnings/Precautions
- •Pregnancy
- •Breast Feeding
- •If It Works
- •If It Doesn’t Work
- •Best Augmenting Combos for Partial Response or Treatment Resistance
- •Dosing Tips
- •Other Warnings/Precautions
- •Pregnancy
- •Breast Feeding
- •Pharmacokinetics
- •Drug Interactions
- •Other Warnings/Precautions
- •If It Doesn’t Work
- •Best Augmenting Combos for Partial Response or Treatment Resistance
- •Trifluoperazine: side effects How Drug Causes Side Effects
- •Other Warnings/Precautions
- •Children and Adolescents
- •Pregnancy
- •If It Doesn’t Work (for depression)
- •Other Warnings/Precautions
- •How Long Until It Works
- •If It Works
- •If It Doesn’t Work
- •Best Augmenting Combos for Partial Response or Treatment Resistance
- •Other Warnings/Precautions
- •Elderly
- •Children and Adolescents
- •Pregnancy
- •Breast Feeding
- •Best Augmenting Combos for Partial Response or Treatment Resistance (for bipolar disorder)
- •How to Dose
- •Dosing Tips
- •Other Warnings/Precautions
- •Breast Feeding
- •How Long Until It Works
- •If It Works
- •If It Doesn’t Work
- •Best Augmenting Combos for Partial Response or Treatment Resistance
- •Venlafaxine: side effects How Drug Causes Side Effects
- •Pharmacokinetics
- •Drug Interactions
- •Other Warnings/Precautions
- •Elderly
- •Children and Adolescents
- •Pregnancy
- •Breast Feeding
- •How Long Until It Works
- •If It Works
- •If It Doesn’t Work
- •Best Augmenting Combos for Partial Response or Treatment Resistance
- •Vilazodone: side effects How Drug Causes Side Effects
- •Notable Side Effects
- •Other Warnings/Precautions
- •Breast Feeding
- •How Long Until It Works
- •If It Works
- •If It Doesn’t Work
- •Best Augmenting Combos for Partial Response or Treatment Resistance
- •Vortioxetine: side effects How Drug Causes Side Effects
- •Other Warnings/Precautions
- •Pregnancy
- •Breast Feeding
- •How Long Until It Works
- •If It Works
- •If It Doesn’t Work
- •Best Augmenting Combos for Partial Response or Treatment Resistance
- •Tests Before starting an atypical antipsychotic
- •Monitoring after starting an atypical antipsychotic
- •Ziprasidone: side effects How Drug Causes Side Effects
- •Dosing Tips
- •Children and Adolescents
- •Pregnancy
- •Breast Feeding
- •Ziprasidone: the art of psychopharmacology Potential Advantages
- •Potential Disadvantages
- •Primary Target Symptoms
- •Switching from Oral Antipsychotics to Ziprasidone
- •Dosing Tips
- •Other Warnings/Precautions
- •How Long Until It Works
- •If It Works
- •If It Doesn’t Work
- •Best Augmenting Combos for Partial Response or Treatment Resistance
- •Before starting an atypical antipsychotic
- •Monitoring after starting an atypical antipsychotic
- •Zotepine: side effects How Drug Causes Side Effects
- •Other Warnings/Precautions
- •Elderly
- •If It Doesn’t Work
- •Best Augmenting Combos for Partial Response or Treatment Resistance
- •Zuclopenthixol: side effects How Drug Causes Side Effects
- •Dosing Tips
- •Other Warnings/Precautions
- •Children and Adolescents
- •Pregnancy
- •Index by Drug Name
- •Index by Use
- •Valproate (divalproex) 711
- •Valproate (divalproex) 711
- •Valproate (divalproex) 711
- •Index by Class
- •Abbreviations
Switching from Oral Antipsychotics to Clozapine
• With aripiprazole, amisulpride, and paliperidone ER, immediate stop is possible; begin clozapine at middle dose
• With risperidone, ziprasidone, iloperidone, and lurasidone, begin clozapine gradually, titrating over at least 2 weeks to allow patients to become tolerant to the sedating effect
* Benzodiazepine or anticholinergic medication can be administered during cross-titration to help alleviate side effects such as insomnia, agitation, and/or psychosis. However use with caution in combination with clozapine as this can increase the risk of circulatory collapse.
Suggested Reading
Iqbal MM, Rahman A, Husain Z, Mahmud SZ, Ryan WG, Feldman JM. Clozapine: a clinical review of adverse effects and management. Ann Clin Psychiatry 2003;15:33–48.
Lieberman JA. Maximizing clozapine therapy: managing side effects. J Clin Psychiatry 1998;59(Suppl 3):38–43.
Schulte P. What is an adequate trial with clozapine?: therapeutic drug monitoring and time to response in treatment-refractory schizophrenia. Clin Pharmacokinet 2003;42:607–18.
Tiihonen J, Lonnqvist J, Wahlbeck K, et al. 11-year follow-up of mortality in patients with schizophrenia: a population-based cohort study (FIN11 study). Lancet 2009; 374(9690):620–7.
Wagstaff A, Perry C. Clozapine: in prevention of suicide in patients with schizophrenia or schizoaffective disorder. CNS Drugs 2003;17:273–80.
Wahlbeck K, Cheine M, Essali A, Adams C. Evidence of clozapine’s effectiveness in schizophrenia: a systematic review and meta-analysis of randomized trials. Am J Psychiatry 1999;156:990–9.
CYAMEMAZINE
CYAMEMAZINE: THERAPEUTICS
Brands
• Tercian
see index for additional brand names
Generic?
Not in the U.S.
Class
• Conventional antipsychotic (neuroleptic, phenothiazine, dopamine 2 antagonist, serotonin dopamine antagonist)
Commonly Prescribed for
(bold for FDA approved)
• Schizophrenia
✽ Anxiety associated with psychosis (short-term)
• Anxiety associated with nonpsychotic disorders, including mood disorders and personality disorders (short-term)
• Severe depression
• Bipolar disorder
• Other psychotic disorders
• Acute agitation/aggression (injection)
• Benzodiazepine withdrawal
How the Drug Works
• Blocks dopamine 2 receptors, reducing positive symptoms of psychosis
✽ Although classified as a conventional antipsychotic, cyamemazine is a potent serotonin 2A antagonist
• Affinity at a myriad of other neurotransmitter receptors may contribute to cyamemazine’s efficacy
✽ Specifically, antagonist actions at 5HT2C receptors may contribute to notable anxiolytic effects in many patients
• 5HT2C antagonist actions may also contribute to antidepressant actions in severe depression and to improvement of cognitive and negative symptoms of schizophrenia in some patients
How Long Until It Works
• Psychotic symptoms can improve with high doses within 1 week, but it may take several weeks for full effect on behavior
• Anxiolytic actions can improve with low doses within 1 week, but it may take several days to weeks for full effect on behavior
Соседние файлы в предмете [НЕСОРТИРОВАННОЕ]