биохимия атеросклероза

mouse peritoneal macrophages leads to the depletion of ER calcium stores and leads to UPR activation and apoptotic cell death [131]. Furthermore, it was recently shown that there is an association between free cholesterol accumulation, apoptotic cell death and ER stress in advanced atherosclerotic lesions from apoE-deficient mice [132]. Answers to these and other important questions will enhance our understanding of the mechanisms by which HHcy atherothrombotic disease and its clinical outcomes.

Acknowledgments: D. W. Jacobsen is a recipient of a grant to support homocysteine research (HL52234) from the National Institutes of Health. R.C. Austin is a Career Investigator of the Heart and Stroke Foundation of Ontario and is supported by Research Grants from the Heart and Stroke Foundation of Ontario (T5385) and the Canadian Institutes of Health Research (MOP-67116, MOP-74477). We apologize to many of our colleagues whose work could not be directly acknowledged due to space limitations.

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