Neoplasms of the nervous system (including meninges) and melanin producing tissues

1. An eye of 53-year-old patient, excised at surgery due to neoplasm, presented in pathology department. Gross investigation reveled a 1×0,4 cm black lesion in the retina. Microscopic appearance of a tumor was characterized by nests of immature cell with eccentric nuclei, prominent macronucleoli and cytoplasm brown pigment. What is the most likely diagnosis?

A. *Melanoma

B. Neurinoma

C. Angiosarcoma

D. Neuroblastoma

E. Ganglioneuroblastoma

2. At autopsy a 8-year-old child is found to have a poorly circumscribed tumor of cerebellum. Histologically investigation reveled crowds of small immature cells with hyperchromatic, round-oval nuclei and scant cytoplasm. A few rosettes were also found by pathologist at slide examination. What is the most likely diagnosis in that case?

A. *Medulloblastoma

B. Astrocytoma

C. metastasis of cancer

D. metastasis of sarcoma

E. Glioblastoma

3. An elderly man with a 2-year history of right leg amputation presents with 2 cm encapsulated tumor at the area of a past surgical trauma of soft tissue. Histology investigation revealed disordered orientation of mature nerve fiber bundles inter mixed with connective tissue. Higher magnification showed bundles of axons, Schwann cells, fibroblasts and perineurial cells within tumor mass. What is most likely diagnosis?

A. Neurinoma

B. Neurofibroma

C. Malignant neurinoma

D. Soft fibroma

E. Fibrosarcoma

4. A 66-year-old woman present with right eye bad vision, ophtalmoscopy revealed a neoplasm of retina which was soon excised, at surgery together with an eye ball. Grossly, a neoplasm was soft, irregular in contour 1×1 cm in size and had a brown coloring. Under microscope a lesion demonstrated nodular aggregates of infiltrating cells. There cells contained large brown pigment nuclei with chromatin clumped at the periphery of nuclear membrane and prominent nucleoli. Atypical mitoses figures were also revealed. What is most likely diagnosis?

A. *Melanoma

B. Schwannoma

C. Glomus tumor

D. Paraganglioma

E. Angiosarcoma

5. A 38-year-old woman has a seizure while shopping and is taken to the hospital. A scan of a brain demonstrated a poorly circumscribed 5 cm tumor at right parietal lobe. A biopsy of this area contains of increased number of glial cell nuclei and an interening feltwork of file cell processes that give the background a fibrillary appearance. Abnormal mitoses and atypical central nervous system cells were absent within biopsy sample. What is the most likely diagnosis?

A. Astrocytoma

B. Oligodendroglioma

C. Ganglioneuroma

D. Ependimoma

E. Chorioid papilloma

6. A 50-year-old woman presented with a pigmented painful skin lesion above the ankle. It had been present for many years but in recent months it had enlarged quite rapidly, its outline got irregularity. Microscopic investigation of a lesion biopsy revealed nests of atypical cells and single cells with eccentric nuclei, prominent macronucleoli and cytoplasmic brown pigment. What is the most likely diagnosis?

A. *Melanoma

B. Basal cell carcinoma

C. Hemangioma.

D. Haematoma.

E. Carcinoid.

7. The man of 45 years has completely lost hearing on the right ear. Physical investigation has not revealed any pathological changes in system of the right acoustic analyzer. The tomography of a brain has revealed a neoplasm, 7 cm in diameter, homogeneous, without precise contours in a site of cerebellopontine angle. Name a neoplasm.

A. *Neurilemmoma