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II. Answer the questions:

What scientists is it spoken about?

Where are they from?

What education did they obtained?

What are their research interests?

What are their advances in the field of medicine?

Study and remember the additional list of key words in medicine. How would you explain the meaning? Make a brief summary using additional texts. Express your opinion in a written form.

II. Take part in the discussion of recent advances in clinical biology based on the text:

Plenary Lecture 15

Role of Professional Antigen Presenting Cells in the Genesis of Immune Response to Protein Therapeutics

Dr. Suryararathi Dasgupta

Abstract: Development of neutralizing antibodies, is a crippling concern in the management of patients undergoing administration of protein therapeutics as evidenced in replacement therapy and other treatment procedures. Several issues in the genesis and modulation of such deleterious immune responses have been studied. While authors have focused on the downstream events of the specific immune response and suggested modification of protein therapeutics to eliminate epitopes that interact with B cell receptors, or MHCII molecules, the mechanisms underlying Ag interaction with APCs, a step upstream of immune effectors, have been grossly neglected. We wish to emphasize that the recent knowledge in understanding the capacities of an APC to handle an Ag and the importance of the surrounding microenvironment in this process are crucial for designing novel protein therapeutics with reduced immunogenicity.

This talk would highlight the increasing interest in understanding the role of critical cells in immune response – viz. the Dendritic Cells and Macrophages.

The scope of this knowledge is not limited to issues concerning immunogenicity.

Antigen presenting cells are essentially “cellular sinks” for an administered therapeutic. They have profound role(s) in catabolism of the therapeutic protein.

This talk will thus try to delineate the delicate balance between half-life of a therapeutic protein and its inherent immunogenicity from the standpoint of these cells.

This type of knowledge might be essential in designing novel protein therapeutic in the future.

III. What are the main advances? Express your opinion using phrases: It’s rather surprising, I wonder about, I’d like to stress. Test yourself

1. Give the meaning of the following words: проводиться, присутствовать, ряд, многочисленный, особенно, быть связанным с чем-то, описывать, в дополнение к, осознать, быть доступным, иметь целью, объяснять.

2. Compose sentences with the words: relate to, in this regard with, после.

2. Read, translate sentences. Find the verbs in Active and Passive Voice:

1. Several recent studies showed a connection between stress and illness.

2. Lack of sufficient insulin results in diabetes.

3. Antibiotic drugs have greatly improved the treatment of abscesses.

4. Doctors have been operating on fetuses since the early 1980s.

5. The use X-rays equipment in hospitals began in the late 1890s.

6. The surgeon is assisted by a large staff.

7. A date for the operation has been set.

8. They have been warned of the possible complications.

9. The first heart sound is followed after a short pause by the second.

10. The cells on the surface of the skin are constantly being replaced by new cells.