- •Are there any risks associated with comt gene polymorphism in the presence of cannabis?
- •Abstract
- •Introduction
- •Tetrahydrocannabinol
- •Endogenous ligands
- •Gene variations of cnr1 and cnr2 in neuropsychiatric disorders
- •GxE interactions
- •Comt polymorphism is a mediator of the link between cannabis and psychosis.
- •Materials and Methods
- •Results The effect of adolescent cannabis use on adult psychosis is controlled by genetic variation in the comt gene.
- •Determination of allele frequencies by dna pooling and ld between snPs
- •Determination of genetic association with schizophrenia by employing individual genotyping
- •Association analysis at individual snPs
- •Linkage disequilibrium analysis
- •Comt rs4680 in relation to psychotic experiences
- •Discussion
- •Conclusion
- •References
Conclusion
Through the analyses of different studies this project aimed to provide insight about the effects of COMT polymorphism and cannabis use on psychotic disorders. From the data analysed it is possible to assume that every person experiences different response to psychotogenic effects of cannabis due to different genetic and environmental background. Indeed, COMT is a main enzyme controlling dopamine pathways, although there is an evidence for other genes, which might be involved in various neurotransmitter systems to interact with cannabis and associate with psychotic outcomes. Examined SNPs at the COMT locus showed to be influenced by cannabis use, therefore might be involved in the susceptibility of schizophrenia.
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