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9)Каратеев А.Е., Яхно Н.Н., Лазебник Л.Б. и др. Применение нестероидных противовоспалительных препаратов. Клинические рекомендации. М.: ИМАПРЕСС, 2009.

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16)Ревматические болезни, номенклатура,классификация, стандарты диагностики и лечения.- В.Н. Коваленко, Н.М. Шуба - К.: ООО "Катран груп",

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20)И.С.Денисов, М.С.Елисеев, В.Г.Барскова Исходы подагры. Обзор литературы. Часть I. Эпидемиология подагры, факторы риска. Коморбидные заболевания, риск развития сердечно-сосудистых катастроф и смерти при подагре // Научно-практическая ревматология. – 2013. - 51 (№5). - С. 569-573.

21)И.С. Денисов, М.С. Елисеев, В.Г. Барскова Исходы подагры. Обзор литературы. Часть II. Коморбидные заболевания, риск развития сердечнососудистых катастроф и смерти при подагре // Научно-практическая ревматология. – 2013. - 51 (№6). – С. 703-710.

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27)A-K Tausche, M reuss-Borst, U Koch Urate lowering therapy with febuxostat in daily practice – a multicenter, open-label, prospective observational study //International Journal of Rheumatology. 2014article ID 123105

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31)Казахстанский Национальный формуляр лекарственных средств. www.knf.kz

22

Приложение 1

Список использованной литературы по определению шкалы уровня доказательности основных лекарственных средств:

1. Метилпреднизалон

19.Dinesh Khanna, Puja P. Khanna, John D. Fitzgerald, Sangmee Bae, Manjit K. Singh et al. 2012 American College of Rheumatology Guidelines for Management of Gout. Part 2: Therapy and Antiinflammatory Prophylaxis of Acute Gouty Arthritis. Arthritis Care & Research Vol. 64, No. 10, October 2012, pp 1447–1461 DOI 10.1002/acr.21773 ©

http://www.rheumatology.org/Portals/0/Files/ACR%20Guidelines%20for%20Managem ent%20of%20Gout_Part%202.pdf

20.W Zhang, M Doherty, T Bardin, E Pascual, V Barskova, P Conaghan, J Gerster, J

Jacobs, B Leeb, F Liotè, G McCarthy, P Netter, G Nuki, F Perez-Ruiz, A Pignone, J Pimentão, L Punzi, E Roddy, T Uhlig, and I Zimmermann-Gòrska. EULAR evidence based recommendations for gout. Part II: Management. Report of a task force of the EULAR Standing Committee for International Clinical Studies Including Therapeutics (ESCISIT). Ann Rheum Dis, Publish Online First 17 May 2006; 65: 1312 - 1324. Available from: http://ard.bmj.com/content/65/10/1312.full.pdf+html

21.Michael A Becker . Treatment of acute gout. ©2016 UpToDate, Inc. last updated:

Mar 14, 2016. Available from: http://www.uptodate.com/contents/treatment-of-acute- gout

22.Spanish Society of Rheumatology (SER). Clinical practice guidelines for management of gout. Madrid (Spain): Spanish Society of Rheumatology (SER); 2013. 161 p. Available from: http://www.ser.es/wp-content/uploads/2015/09/GuipClinGot_1140226_EN.pdf

23.Barry l. Hainer, Eric Matheson, and R. Travis Wilkes. Diagnosis, Treatment, and Prevention of Gout. Am Fam Physician. 2014 Dec 15;90(12):831-836. Available from: http://www.aafp.org/afp/2014/1215/p831.pdf

2.Преднизалон

19.Dinesh Khanna, Puja P. Khanna, John D. Fitzgerald, Sangmee Bae, Manjit K. Singh et al. 2012 American College of Rheumatology Guidelines for Management of Gout. Part 2: Therapy and Antiinflammatory Prophylaxis of Acute Gouty Arthritis. Arthritis Care & Research Vol. 64, No. 10, October 2012, pp 1447–1461 DOI 10.1002/acr.21773 ©

http://www.rheumatology.org/Portals/0/Files/ACR%20Guidelines%20for%20Managem ent%20of%20Gout_Part%202.pdf

23

20.W Zhang, M Doherty, T Bardin, E Pascual, V Barskova, P Conaghan, J Gerster, J

Jacobs, B Leeb, F Liotè, G McCarthy, P Netter, G Nuki, F Perez-Ruiz, A Pignone, J Pimentão, L Punzi, E Roddy, T Uhlig, and I Zimmermann-Gòrska. EULAR evidence based recommendations for gout. Part II: Management. Report of a task force of the EULAR Standing Committee for International Clinical Studies Including Therapeutics (ESCISIT). Ann Rheum Dis, Publish Online First 17 May 2006; 65: 1312 - 1324. Available from: http://ard.bmj.com/content/65/10/1312.full.pdf+html

21.Michael A Becker . Treatment of acute gout. ©2016 UpToDate, Inc. last updated:

Mar 14, 2016. Available from: http://www.uptodate.com/contents/treatment-of-acute- gout

22.Spanish Society of Rheumatology (SER). Clinical practice guidelines for management of gout. Madrid (Spain): Spanish Society of Rheumatology (SER); 2013. 161 p. Available from: http://www.ser.es/wp-content/uploads/2015/09/GuipClinGot_1140226_EN.pdf

23.Barry l. Hainer, Eric Matheson, and R. Travis Wilkes. Diagnosis, Treatment, and Prevention of Gout. Am Fam Physician. 2014 Dec 15;90(12):831-836. Available from: http://www.aafp.org/afp/2014/1215/p831.pdf

3.Бетаметазон

19.Dinesh Khanna, Puja P. Khanna, John D. Fitzgerald, Sangmee Bae, Manjit K. Singh et al. 2012 American College of Rheumatology Guidelines for Management of Gout. Part 2: Therapy and Antiinflammatory Prophylaxis of Acute Gouty Arthritis. Arthritis Care & Research Vol. 64, No. 10, October 2012, pp 1447–1461 DOI 10.1002/acr.21773 ©

http://www.rheumatology.org/Portals/0/Files/ACR%20Guidelines%20for%20Managem ent%20of%20Gout_Part%202.pdf

20.W Zhang, M Doherty, T Bardin, E Pascual, V Barskova, P Conaghan, J Gerster, J Jacobs, B Leeb, F Liotè, G McCarthy, P Netter, G Nuki, F Perez-Ruiz, A Pignone, J Pimentão, L Punzi, E Roddy, T Uhlig, and I Zimmermann-Gòrska. EULAR evidence based recommendations for gout. Part II: Management. Report of a task force of the EULAR Standing Committee for International Clinical Studies Including Therapeutics (ESCISIT). Ann Rheum Dis, Publish Online First 17 May 2006; 65: 1312 - 1324. Available from: http://ard.bmj.com/content/65/10/1312.full.pdf+html

4.Колхицин

18.Dinesh Khanna, John D. Fitzgerald, Puja P. Khanna, Sangmee Bae, Manjit K. Singh et al. 2012 American College of Rheumatology Guidelines for Management of Gout. Part 1: Systematic Nonpharmacologic and Pharmacologic Therapeutic Approaches to Hyperuricemia. Arthritis Care & Research Vol. 64, No. 10, October 2012, pp 1431–1446 DOI

24

10.1002/acr.21772 © 2012, American College of Rheumatology. Available from: http://www.rheumatology.org/Portals/0/Files/ACR%20Guidelines%20for%20Managem ent%20of%20Gout_Part%201.pdf

19.Dinesh Khanna, Puja P. Khanna, John D. Fitzgerald, Sangmee Bae, Manjit K. Singh et al. 2012 American College of Rheumatology Guidelines for Management of Gout. Part 2: Therapy and Antiinflammatory Prophylaxis of Acute Gouty Arthritis. Arthritis Care & Research Vol. 64, No. 10, October 2012, pp 1447–1461 DOI 10.1002/acr.21773 ©

http://www.rheumatology.org/Portals/0/Files/ACR%20Guidelines%20for%20Managem ent%20of%20Gout_Part%202.pdf

20.W Zhang, M Doherty, T Bardin, E Pascual, V Barskova, P Conaghan, J Gerster, J

Jacobs, B Leeb, F Liotè, G McCarthy, P Netter, G Nuki, F Perez-Ruiz, A Pignone, J Pimentão, L Punzi, E Roddy, T Uhlig, and I Zimmermann-Gòrska. EULAR evidence based recommendations for gout. Part II: Management. Report of a task force of the EULAR Standing Committee for International Clinical Studies Including Therapeutics (ESCISIT). Ann Rheum Dis, Publish Online First 17 May 2006; 65: 1312 - 1324. Available from: http://ard.bmj.com/content/65/10/1312.full.pdf+html 21.Michael A Becker . Treatment of acute gout. ©2016 UpToDate, Inc. last updated:

Mar 14, 2016. Available from: http://www.uptodate.com/contents/treatment-of-acute- gout

24. Terkeltaub RA, Furst DE, Bennett K, et al. High versus low dosing of oral colchicine for early acute gout flare: twenty-four-hour outcome of the first multicenter, randomized, double-blind, placebo-controlled, parallel-group, dose-comparison colchicine study. Arthritis Rheum 2010; 62: 1060-1068. 25. van Echteld I, Wechalekar MD, Schlesinger N, Buchbinder R, Aletaha D. Colchicine for acute gout. Cochrane Database Syst Rev. 2014 Aug 15;(8):CD006190. doi: 10.1002/14651858.CD006190.pub2.

Available from: http://onlinelibrary.wiley.com/doi/10.1002/14651858.CD006190.pub2/abstract

5. Аллопуринол

18.Dinesh Khanna, John D. Fitzgerald, Puja P. Khanna, Sangmee Bae, Manjit K. Singh

2012 American College of Rheumatology Guidelines for Management of Gout. Part 1: Systematic Nonpharmacologic and Pharmacologic Therapeutic Approaches to Hyperuricemia. Arthritis Care & Research Vol. 64, No. 10, October 2012, pp 1431–1446 DOI

10.1002/acr.21772 © 2012, American College of Rheumatology. Available from: http://www.rheumatology.org/Portals/0/Files/ACR%20Guidelines%20for%20Managem ent%20of%20Gout_Part%201.pdf

20.W Zhang, M Doherty, T Bardin, E Pascual, V Barskova, P Conaghan, J Gerster, J

25

Jacobs, B Leeb, F Liotè, G McCarthy, P Netter, G Nuki, F Perez-Ruiz, A Pignone, J Pimentão, L Punzi, E Roddy, T Uhlig, and I Zimmermann-Gòrska. EULAR evidence based recommendations for gout. Part II: Management. Report of a task force of the EULAR Standing Committee for International Clinical Studies Including Therapeutics (ESCISIT). Ann Rheum Dis, Publish Online First 17 May 2006; 65: 1312 - 1324. Available from: http://ard.bmj.com/content/65/10/1312.full.pdf+html

21.Michael A Becker . Treatment of acute gout. ©2016 UpToDate, Inc. last updated:

Mar 14, 2016. Available from: http://www.uptodate.com/contents/treatment-of-acute- gout

22.Spanish Society of Rheumatology (SER). Clinical practice guidelines for management of gout. Madrid (Spain): Spanish Society of Rheumatology (SER); 2013. 161 p. Available from: http://www.ser.es/wp-content/uploads/2015/09/GuipClinGot_1140226_EN.pdf

23.Barry l. Hainer, Eric Matheson, and R. Travis Wilkes. Diagnosis, Treatment, and Prevention of Gout. Am Fam Physician. 2014 Dec 15;90(12):831-836. Available from: http://www.aafp.org/afp/2014/1215/p831.pdf

26.Stamp LK, Taylor WJ, Jones PB, et al. Starting dose is a risk factor for allopurinol hypersensitivity syndrome: a proposed starting dose of allopurinol. Arthritis Rheum

27. Stamp LK, O'Donnell JL, Zhang M, et al. Using allopurinol above the dose based on creatinine clearance is effective and safe in patients with chronic gout, including those with renal impairment. Arthritis Rheum 2011; 63: 412-421.

6.Фебуксостат

18.Dinesh Khanna, John D. Fitzgerald, Puja P. Khanna, Sangmee Bae, Manjit K. Singh et al. 2012 American College of Rheumatology Guidelines for Management of Gout. Part 1: Systematic Nonpharmacologic and Pharmacologic Therapeutic Approaches to Hyperuricemia. Arthritis Care & Research Vol. 64, No. 10, October 2012, pp 1431–

1446 DOI 10.1002/acr.21772 © 2012, American College of Rheumatology. Available from: http://www.rheumatology.org/Portals/0/Files/ACR%20Guidelines%20for%20Managem ent%20of%20Gout_Part%201.pdf

19.Dinesh Khanna, Puja P. Khanna, John D. Fitzgerald, Sangmee Bae, Manjit K. Singh et al. 2012 American College of Rheumatology Guidelines for Management of Gout. Part 2: Therapy and Antiinflammatory Prophylaxis of Acute Gouty Arthritis. Arthritis Care & Research Vol. 64, No. 10, October 2012, pp 1447–1461 DOI 10.1002/acr.21773

© 2012, American College of Rheumatology.

Available from: http://www.rheumatology.org/Portals/0/Files/ACR%20Guidelines%20for%20Managem ent%20of%20Gout_Part%202.pdf

21.Michael A Becker . Treatment of acute gout. ©2016 UpToDate, Inc. last updated:

26

Mar 14, 2016. Available from: http://www.uptodate.com/contents/treatment-of-acute- gout

23. Barry l. Hainer, Eric Matheson, and R. Travis Wilkes. Diagnosis, Treatment, and Prevention of Gout. Am Fam Physician. 2014 Dec 15;90(12):831-836. Available from: http://www.aafp.org/afp/2014/1215/p831.pdf

28. Becker MA, Schumacher HR, Espinoza LR, et al. The urate-lowering efficacy and safety of febuxostat in the treatment of the hyperuricemia of gout: the CONFIRMS trial. Arthritis Res Ther 2010; 12: R63.

7.Диклофенак

19.Dinesh Khanna, Puja P. Khanna, John D. Fitzgerald, Sangmee Bae, Manjit K. Singh et al. 2012 American College of Rheumatology Guidelines for Management of Gout. Part 2: Therapy and Antiinflammatory Prophylaxis of Acute Gouty Arthritis. Arthritis Care & Research Vol. 64, No. 10, October 2012, pp 1447–1461 DOI 10.1002/acr.21773 ©

http://www.rheumatology.org/Portals/0/Files/ACR%20Guidelines%20for%20Managem ent%20of%20Gout_Part%202.pdf

21.Michael A Becker . Treatment of acute gout. ©2016 UpToDate, Inc. last updated:

Mar 14, 2016. Available from: http://www.uptodate.com/contents/treatment-of-acute- gout

23. Barry l. Hainer, Eric Matheson, and R. Travis Wilkes. Diagnosis, Treatment, and Prevention of Gout. Am Fam Physician. 2014 Dec 15;90(12):831-836. Available from: http://www.aafp.org/afp/2014/1215/p831.pdf

30.van Durme CM, Wechalekar MD, Buchbinder R, Schlesinger N, van der Heijde D, Landewé RB. Non-steroidal anti-inflammatory drugs for acute gout. Cochrane Database Syst Rev. 2014 Sep 16;(9):CD010120. doi: 10.1002/14651858.CD010120.pub2. Available from: http://onlinelibrary.wiley.com/doi/10.1002/14651858.CD010120.pub2/abstract

31.Cheng TT , Lai HM , Chiu CK and Chem YC. A single-blind, randomized, controlled trial to assess the efficacy and tolerability of rofecoxib, diclofenac sodium, and meloxicam in patients with acute gouty arthritis. Clinical therapeutics, 2004, 26(3), 399

8.Ацеклофенак

19.Dinesh Khanna, Puja P. Khanna, John D. Fitzgerald, Sangmee Bae, Manjit K. Singh et al. 2012 American College of Rheumatology Guidelines for Management of Gout. Part 2: Therapy and Antiinflammatory Prophylaxis of Acute Gouty Arthritis. Arthritis Care & Research Vol. 64, No. 10, October 2012, pp 1447–1461 DOI 10.1002/acr.21773 ©

http://www.rheumatology.org/Portals/0/Files/ACR%20Guidelines%20for%20Managem ent%20of%20Gout_Part%202.pdf

21.Michael A Becker . Treatment of acute gout. ©2016 UpToDate, Inc. last updated:

Mar 14, 2016. Available from: http://www.uptodate.com/contents/treatment-of-acute- gout

23. Barry l. Hainer, Eric Matheson, and R. Travis Wilkes. Diagnosis, Treatment, and Prevention of Gout. Am Fam Physician. 2014 Dec 15;90(12):831-836. Available from: http://www.aafp.org/afp/2014/1215/p831.pdf

30. van Durme CM, Wechalekar MD, Buchbinder R, Schlesinger N, van der Heijde D, Landewé RB. Non-steroidal anti-inflammatory drugs for acute gout. Cochrane Database Syst Rev. 2014 Sep 16;(9):CD010120. doi: 10.1002/14651858.CD010120.pub2. Available from: http://onlinelibrary.wiley.com/doi/10.1002/14651858.CD010120.pub2/abstract

9.Нимесулид

19.Dinesh Khanna, Puja P. Khanna, John D. Fitzgerald, Sangmee Bae, Manjit K. Singh et al. 2012 American College of Rheumatology Guidelines for Management of Gout. Part 2: Therapy and Antiinflammatory Prophylaxis of Acute Gouty Arthritis. Arthritis Care & Research Vol. 64, No. 10, October 2012, pp 1447–1461 DOI 10.1002/acr.21773 ©

http://www.rheumatology.org/Portals/0/Files/ACR%20Guidelines%20for%20Managem ent%20of%20Gout_Part%202.pdf

21.Michael A Becker . Treatment of acute gout. ©2016 UpToDate, Inc. last updated:

Mar 14, 2016. Available from: http://www.uptodate.com/contents/treatment-of-acute- gout

23. Barry l. Hainer, Eric Matheson, and R. Travis Wilkes. Diagnosis, Treatment, and Prevention of Gout. Am Fam Physician. 2014 Dec 15;90(12):831-836. Available from: http://www.aafp.org/afp/2014/1215/p831.pdf

30.van Durme CM, Wechalekar MD, Buchbinder R, Schlesinger N, van der Heijde D, Landewé RB. Non-steroidal anti-inflammatory drugs for acute gout. Cochrane Database Syst Rev. 2014 Sep 16;(9):CD010120. doi: 10.1002/14651858.CD010120.pub2. Available from: http://onlinelibrary.wiley.com/doi/10.1002/14651858.CD010120.pub2/abstract

31.Cheng TT , Lai HM , Chiu CK and Chem YC. A single-blind, randomized, controlled trial to assess the efficacy and tolerability of rofecoxib, diclofenac sodium, and meloxicam in patients with acute gouty arthritis. Clinical therapeutics, 2004, 26(3), 399

10.Лорноксикам

19.Dinesh Khanna, Puja P. Khanna, John D. Fitzgerald, Sangmee Bae, Manjit K. Singh et al. 2012 American College of Rheumatology Guidelines for Management of Gout. Part 2:

28

Therapy and Antiinflammatory Prophylaxis of Acute Gouty Arthritis. Arthritis Care & Research Vol. 64, No. 10, October 2012, pp 1447–1461 DOI 10.1002/acr.21773 © 2012, American College of Rheumatology. Available from: http://www.rheumatology.org/Portals/0/Files/ACR%20Guidelines%20for%20Managem ent%20of%20Gout_Part%202.pdf

21.Michael A Becker . Treatment of acute gout. ©2016 UpToDate, Inc. last updated:

Mar 14, 2016. Available from: http://www.uptodate.com/contents/treatment-of-acute- gout

23. Barry l. Hainer, Eric Matheson, and R. Travis Wilkes. Diagnosis, Treatment, and Prevention of Gout. Am Fam Physician. 2014 Dec 15;90(12):831-836. Available from: http://www.aafp.org/afp/2014/1215/p831.pdf

30. van Durme CM, Wechalekar MD, Buchbinder R, Schlesinger N, van der Heijde D, Landewé RB. Non-steroidal anti-inflammatory drugs for acute gout. Cochrane Database Syst Rev. 2014 Sep 16;(9):CD010120. doi: 10.1002/14651858.CD010120.pub2. Available from: http://onlinelibrary.wiley.com/doi/10.1002/14651858.CD010120.pub2/abstract

12.Эторикоксиб

19.Dinesh Khanna, Puja P. Khanna, John D. Fitzgerald, Sangmee Bae, Manjit K. Singh et al. 2012 American College of Rheumatology Guidelines for Management of Gout. Part 2: Therapy and Antiinflammatory Prophylaxis of Acute Gouty Arthritis. Arthritis Care & Research Vol. 64, No. 10, October 2012, pp 1447–1461 DOI 10.1002/acr.21773 ©

http://www.rheumatology.org/Portals/0/Files/ACR%20Guidelines%20for%20Managem ent%20of%20Gout_Part%202.pdf

21.Michael A Becker . Treatment of acute gout. ©2016 UpToDate, Inc. last updated:

Mar 14, 2016. Available from: http://www.uptodate.com/contents/treatment-of-acute- gout

23. Barry l. Hainer, Eric Matheson, and R. Travis Wilkes. Diagnosis, Treatment, and Prevention of Gout. Am Fam Physician. 2014 Dec 15;90(12):831-836. Available from: http://www.aafp.org/afp/2014/1215/p831.pdf

30. van Durme CM, Wechalekar MD, Buchbinder R, Schlesinger N, van der Heijde D, Landewé RB. Non-steroidal anti-inflammatory drugs for acute gout. Cochrane Database Syst Rev. 2014 Sep 16;(9):CD010120. doi: 10.1002/14651858.CD010120.pub2. Available from: http://onlinelibrary.wiley.com/doi/10.1002/14651858.CD010120.pub2/abstract

13.Кетопрофен

29

3. J Braun, R van den Berg, X Baraliakos, H Boehm, R Burgos-Vargas, E CollantesEstevez, H Dagfinrud, B Dijkmans, M Dougados, P Emery, P Geher, M Hammoudeh, RD Inman, M Jongkees, MA Khan, U Kiltz, TK Kvien, M Leirisalo-Repo, WP Maksymowych, I Olivieri, K Pavelka, J Sieper, E Stanislawska-Biernat, D Wendling, S

Özgocem, C van Drogen, BJ van Royen, D Van der Heijde

2010 update of the ASAS/EULAR recommendations for the management of ankylosing spondylitis. Ann Rheum Dis 2011;70:896-904 doi:10.1136/ard.2011.151027 Published Online: 2 May 2011. Available from: http://ard.bmj.com/content/70/6/896.full.pdf+html 10. Michael M. Ward, Atul Deodhar, Elie A. Akl, Andrew Lui, Joerg Ermann, et al. American College of Rheumatology/Spondylitis Association of America/Spondyloarthritis Research and Treatment Network 2015 Recommendations for the Treatment of Ankylosing Spondylitis and Nonradiographic Axial Spondyloarthritis. Arthritis & Rheumatology. DOI 10.1002/ART.39298 VC 2015, American College Of Rheumatology. Available from: http://www.rheumatology.org/Portals/0/Files/Recommendations%20for%20the%20Tre atment%20of%20Ankylosing%20Spondylitis.pdf

11.P Mandl, V Navarro-Compán, L Terslev, P Aegerter, D van der Heijde, M A D'Agostino, X Baraliakos, S J Pedersen, A G Jurik, E Naredo, C SchuellerWeidekamm, U Weber, M C Wick, P A C Bakker, E Filippucci, P G Conaghan, M Rudwaleit, G Schett, J Sieper, S Tarp, H Marzo-Ortega, M Østergaard. EULAR recommendations for the use of imaging in the diagnosis and management of spondyloarthritis in clinical practice. Ann Rheum Dis 2015;74:1327-1339 doi:10.1136/annrheumdis-2014-206971

12.Van der Heijde, D., Purcaru, O., Kavanaugh, A. High economic burden of axial spondyloarthritis related to paid work and household productivity at baseline in the rap- id-axspa study: differences and similarities between ankylosing spondylitis and nonradiographic axial spondyloarthritis. Ann Rheum Dis 2013;72:A523-A524 doi:10.1136/annrheumdis-2013-eular.1566.

13.TNF-alpha inhibitors for ankylosing spondylitis and non-radiographic axial spondyloarthritis. NICE technology appraisal guidance [TA383]. Published date: 01 February

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