РГКП «СГМА» |
ФОРМА КАЧЕСТВА |
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Методические рекомендации для ведения практических занятий |
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G-041.07.01.13-2007 |
Рев. 01 Дата ввода ревизии 31.11.2013 взамен: |
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Приложение № 10
S E M I P A L A T I N S K S T A T E M E D I C A L A C A D E M Y
Methodical guidance for classes (practical)
Specialty: General medicine
Discipline: Pharmacology-1
Chair: Pharmacology, Pharmacognosy
Course II
Theme № 11. Drugs Acting on Central Nervous System.
Antiinflammatory Drugs.
Editor: assistant-professor, candidate of medical sciences ______ S.K.Seilkhanov
.
Semey – 2008
На обороте титульного листа
Ratified at the meeting of the chair
Protocol №
the ___ of ______________________ 2009.
The Head of the chair_____________________M.N.Moussin
1. The theme: Drugs Acting on Central Nervous System. Antiinflammatory Drugs.
2. The aim: This lesson is held in repetition of Pharmacology of Drugs acting on Central Nervous system.
To study the Pharmacodynamics & Pharmacokinetics of Antiinflammatory Drugs.
3. The objectives:
You should know:
1. Classification of sedative-hypnotic drugs
2. Pharmacological actions of sedative-hypnotic drugs
3. Adverse effects of sedative-hypnotic drugs
1. To describe the sites and mechanisms of opioid actions
2. To state the properties of opioids, including pharmacokinetics and effects on tissue systems
3. To state the therapeutic uses
4. To be familiar with their untoward effects
1. Classification of Antiepileptic Drugs
2. Main mechanisms of suppression of excitability of brain neurons
3. Classification of Drugs Used in Parkinsonism & Other Movement Disorders.
4. Mechanisms of correction of extrapyramidal dyskinesias
Antiinflammatory Drugs.
Classification of Antiinflammatory Drugs.
Main mechnisms of suppression of inflammation.
You should be able to:
• Identify the major chemical classes of sedative-hypnotics.
• Describe the pharmacodynamics of benzodiazepines and barbiturates, including their mechanisms of action.
• Compare the pharmacokinetics of commonly used benzodiazepines and barbiturates and discuss how differences among them affect clinical use.
• Describe the clinical uses and the adverse effects of sedative-hypnotics.
• Identify the distinctive properties of buspirone and zolpidem.
List the receptors activated by opioid analgesics and the endogenous opioid peptides.
Give a list of major opioid agonists, rank them in order of analgesic efficacy.
Identify opioid receptor antagonists and mixed agonist-antagonists.
Describe the main pharmacodynamic and pharmacokinetic properties of agonist opioid analgesics and list their clinical uses.
List the main adverse effects of acute and chronic use of opioid analgesics.
Describe the clinical uses of the opioid receptor antagonists.
List two opioids used for antitussive effects and one used for antidiarrheal effects.
• List the major drugs used for partial seizures, generalized tonic-clonic seizures, absence and myoclonic seizures, and status epilepticus.
• Identify the mechanisms of anticonvulsant action.
• Describe the main pharmacokinetic features and the major adverse effects of each drug.
• Describe the factors that must be considered in designing a dosage regimen for an antiepileptic drug.
• Describe the mechanisms by which levodopa, bromocriptine, amantadine, selegiline, and muscarinic blocking drugs alleviate parkinsonism.
• Describe the therapeutic and toxic effects of the antiparkinsonism agents.
• List the chemical agents and drugs that cause parkinsonism symptoms.
• Identify the drugs used in management of tremor, Huntington's disease, drug-induced dyskinesias, and Wilson's disease.
Antiinflammatory Drugs.
• Describe the effects of aspirin on prostaglandin synthesis.
• List the toxic effects of aspirin.
• Contrast the actions of aspirin and the newer NSAIDs.
• Describe the mechanisms of action of three different drug groups used in gout
• Describe the effects and the major toxicity of acetaminophen.