Adelphane For the treatment of hypertension

Composition and form of issue

3,4,5 - Trimethoxybenzol-methyl-reserpate

Reserpine is a pure Rauvolfia alkaloid. 1,4 Dihydrazinophthalazine

Dihydralazine is a phthalazine derivative.

Tablets containing 0.1mg reserpine and 10mg dihydralazine sulphate.

Properties

Adelphane contains two components which have different sites of action and whose blood pressure lowering effects are mutually complementary.

Reserpine

Reserpine depletes the catecholamine depots in the post-ganglionic sympathetic nerve endings and in the central nervous system, this depletion being followed by a relatively prolonged inability to store catecholamines. As a result, sympathetic tone diminishes, whereas the activity of the parasympathetic nervous system remains unaffected. Elevated blood pressure is thus lowered, while at the same time the heart rate decreases and a sedative influence is exerted on the central nervous system. As a rule, the maximum response is attained only after 2-3 weeks.

Dihydralazine

By acting directly upon muscle tissue in the blood vessels-primarily in the arterioles-dihydralazine induces peripheral vasodilation, thereby lowering elevated blood pressure. Characteristic of dihydralazine is the fact that is also reduces vascular resistance in the brain and in the kidneys. Renal blood flow is satisfactorily maintained during long-term treatment. Dihydralazine lowers blood pressure in both the standing and the lying position without provoking any marked symptoms of postural hypotension.

Indication

Hypertension

Dosage

The dosage of Adelphane should be individualized. Treatment is initiated with doses as low as possible, which-depending on the patient’s response-may slowly be raised; one should not exceed a daily dosage of 5 tablets. The daily dosage should be taken in 2-3 single doses. For maintenance therapy, the lower dosage that still proves adequate should be employed. On the average, 1-3 tablets daily suffice. The drug should be taken with liquid at mealtimes.

Reserpine

Caution is indicated in patients with a history of gastric or duodenal ulceration, with acute erosive gastritis, or with gallstones, as well as in patients with disorders of cardiac conduction or sinus bradycardia and in those who are known to have suffered from depression in the past.

Dihydralazine

In patients with disorders of hepatic function, a reduction in the dosage or prolongation of the interval between doses may be indicated so as to avoid accumulation.

Unwanted effects

Since the individual components of Adelphane are present in low doses, unwanted effects are likely to be met with only on a small scale, provided the recommended dosage is adhered to Adelphane may nevertheless occasionally give rise to tiredness, muzziness, dizziness, headache, and sleep disturbances. Depression and anxiety states may set in.

Gastro-intestinal upset such as nausea, vomiting, and diarrhoea can occur.

Nasal congestion, flushing, purpura, and sodium and water retention have also been reported.

Higher doses cause postural hypotension.

Storage

Protect from heat, light and humidity.

Packages

Tablets: Boxes of 5 Composite pack of 5x10 in blister packs

Medicines should be kept out of the reach of children.

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