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Otolaryngology

Basic Science and Clinical Review

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OTOLARYNGOLOGY

Basic Science and Clinical Review

EDITOR

Thomas R.Van De Water, Ph.D.

Director

Cochlear Implant Research Program

University of Miami Ear Institute

Professor

Department of Otolaryngology

Miller School of Medicine

University of Miami

Miami, Florida

ASSOCIATE EDITOR

Hinrich Staecker, M.D., Ph.D.

Director

Otology and Neurotology Program

Associate Professor

Department of Otolaryngology–Head and Neck Surgery

University of Maryland School of Medicine

Baltimore, Maryland

Thieme

New York • Stuttgart

Thieme Medical Publishers, Inc.

333 Seventh Ave.

NewYork, NY 10001

Editor: Esther Gumpert

Associate Editor: Birgitta Brandenburg

Vice President, Production and Electronic Publishing:Anne T.Vinnicombe

Production Editor: Print Matters, Inc.

Sales Director: Ross Lumpkin

Associate Marketing Director:Verena Diem

Chief Financial Officer: Peter vanWoerden

President: Brian D. Scanlan

Compositor: Compset

Printer: Maple-Vail Book Manufacturing Group

Library of Congress Cataloging-in-Publication Data

Otolaryngology : basic science and clinical review / [edited by] Thomas R.Van De Water,

Hinrich Staecker.

 

 

 

p. ; cm.

 

 

 

Includes bibliographical references and index.

 

 

ISBN 0-86577-901-5 (US)—ISBN 3-13-124651-0 (GTV)

 

1. Otolaryngology.

2. Ear—Physiology. 3.

Respiratory organs—Physiology.

[DNLM: 1. Otorhinolaryngologic Diseases.

2. Ear—physiology.

3. Otorhinolaryngologic

Surgical Procedures.

4. Respiratory Physiology.

WV 150 088 2005]

I. Van De Water,

Thomas R. II. Staecker, Hinrich.

 

 

RF46.07525 2005

 

 

616.5'1—dc22

 

 

2005050640

Copyright ©2006 by Thieme Medical Publishers, Inc. This book, including all parts thereof, is legally protected by copyright. Any use, exploitation, or commercialization outside the narrow limits set by copyright legislation without the publisher’s consent is illegal and liable to prosecution. This applies in particular to photostat reproduction, copying, mimeographing or duplication of any kind, translating, preparation of microfilms, and electronic data processing and storage.

Important note: Medical knowledge is ever-changing.As new research and clinical experience broaden our knowledge, changes in treatment and drug therapy may be required.The authors and editors of the material herein have consulted sources believed to be reliable in their efforts to provide information that is complete and in accord with the standards accepted at the time of publication. However, in view of the possibility of human error by the authors, editors, or publisher of the work herein or changes in medical knowledge, neither the authors, editors, or publisher, nor any other party who has been involved in the preparation of this work, warrants that the information contained herein is in every respect accurate or complete, and they are not responsible for any errors or omissions or for the results obtained from use of such information. Readers are encouraged to confirm the information contained herein with other sources. For example, readers are advised to check the product information sheet included in the package of each drug they plan to administer to be certain that the information contained in this publication is accurate and that changes have not been made in the recommended dose or in the contraindications for administration.This recommendation is of particular importance in connection with new or infrequently used drugs.

Some of the product names, patents, and registered designs referred to in this book are in fact registered trademarks or proprietary names even though specific reference to this fact is not always made in the text.Therefore, the appearance of a name without designation as proprietary is not to be construed as a representation by the publisher that it is in the public domain.

Printed in the United States of America 5 4 3 2 1

TMP ISBN 0-86577-901-5

GTV ISBN 3 13 124651 0

Maxwell Abramson, M.D. (1935–1991)

This book is dedicated to the memory of Maxwell Abramson, M.D., husband, father, physician, educator, researcher, scholar, and friend. Max was an extraordinary human being whose life reflected his core humanitarian values. He was a gifted healer, creative scientist, and talented teacher in the discipline of otolaryngology. He possessed both a strong desire and an unbridled enthusiasm to pass along his knowledge of the basic science and clinical foundations of otolaryngology to the fellows, residents, and medical students at the Columbia University College of Physicians and Surgeons, where he was chair-

man of the otolaryngology department from 1977 until his untimely death in 1991. Max greatly loved both his family and his chosen profession. He was a valued friend to many of us in the otolaryngology community, and his absence is felt by all of us. I know that Max would be pleased to have this book dedicated to his memory because it continues the dissemination of basic and clinical sciences knowledge of otolaryngology.

Thomas R.Van DeWater, Ph.D.

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Contents

PREFACE . . . .

. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .

xi

FOREWORD . . .

. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .

xiii

Thomas J. Balkany, M.D., F.A.C.S., F.A.A.P.

 

CONTRIBUTORS

. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .

xv

PART I

THE BASIC PRINCIPLES

 

CHAPTER 1

SURGICAL HEMOSTASIS . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .

3

 

Christopher Hartnick and Hinrich Staecker

 

CHAPTER 2

WOUND HEALING . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .

9

 

Jane A. Petro, Mark D. Suski, and Howard D. Stupak

 

CHAPTER 3

BASIC PRINCIPLES OF ALLERGIC DISEASES . . . . . . . . . . . . . . . . . . . . .

32

 

David Rosenstreich, Ashok Vaghjimal, and Golda Hudes

 

CHAPTER 4

HEAD AND NECK MANIFESTATIONS OF RHEUMATOLOGICAL DISEASES . . . . .

43

 

Derek D. Sloan and Jeffrey P. Harris

 

CHAPTER 5

PULMONARY PHYSIOLOGY AND MECHANICAL VENTILATION . . . . . . . . . . .

59

 

Karen B. Zur and Gregory J. Schilero

 

CHAPTER 6

BIOLOGY AND TREATMENT OF SLEEP APNEA . . . . . . . . . . . . . . . . . . .

71

 

Hector P. Rodriguez and Diana V.-A. Berggren

 

CHAPTER 7

MICROBIOLOGY, VIROLOGY, AND MECHANISMS OF INFECTION . . . . . . . . .

83

 

Ruy Soeiro and Bettie Steinberg

 

CHAPTER 8

PRINCIPLES OF PHARMACOLOGY . . . . . . . . . . . . . . . . . . . . . . . . . .

98

 

Christopher J. Hartnick, Alexander W. Gotta, and Ira M. Leviton

 

CHAPTER 9

OTOTOXICITY . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .

129

 

Leonard P. Rybak, John S. Touliatos, and Kathleen Campbell

 

CHAPTER 10A

ONCOLOGY OF HEAD AND NECK TUMORS . . . . . . . . . . . . . . . . . . . .

137

 

Elizabeth Franzmann, Scott Lilly, David Huang, Giovana Thomas

 

CHAPTER 10B

IMMUNOBIOLOGY AND IMMUNOTHERAPY OF HEAD

 

 

AND NECK SQUAMOUS CARCINOMA . . . . . . . . . . . . . . . . . . . . . . .

150

 

Giovana Thomas,William J. Richtsmeier, and Hari Nadiminti

 

viii CONTENTS

 

 

CHAPTER 11

CLINICAL RADIATION BIOLOGY AND RADIOTHERAPY . . . . . . . . . . . . . .

158

 

Steven R. Isaacson and Lanny Garth Close

 

CHAPTER 12

ENVIRONMENTAL EFFECTS ON THE UPPER AIRWAY . . . . . . . . . . . . . . . .

164

 

Andrew Blitzer

 

CHAPTER 13

HOW TO CONDUCT CLINICAL RESEARCH . . . . . . . . . . . . . . . . . . . .

168

 

Steven D. Rauch

 

CHAPTER 14

BASIC PRINCIPLES AND CURRENT APPLICATIONS OF LASERS IN HEAD

 

 

AND NECK SURGERY . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .

178

 

Daniel B. Kuriloff

 

CHAPTER 15

MOLECULAR BIOLOGY FOR THE OTOLARYNGOLOGIST . . . . . . . . . . . . . .

192

 

Jeffrey Wolfe, Hinrich Staecker, and Thomas R.Van De Water

 

CHAPTER 16

PHYSIOLOGY OF THE PEDIATRIC PATIENT . . . . . . . . . . . . . . . . . . . . .

199

 

Lewis P. Singer

 

CHAPTER 17

BRANCHIAL CLEFT ANATOMY AND CONGENITAL NECK MASSES . . . . . . . .

207

 

Gerald B. Healy

 

CHAPTER 18

PATHOPHYSIOLOGY OF STRIDOR AND AIRWAY DISEASE . . . . . . . . . . . . .

212

 

John H. Greinwald and Robin T. Cotton

 

CHAPTER 19

CLINICAL GENETICS IN OTOLARYNGOLOGY . . . . . . . . . . . . . . . . . . . .

225

 

Simon I. Angeli, Nancy Sculerati, and Thomas R.Van De Water

 

PART II

THE EAR, HEARING, AND BALANCE

 

CHAPTER 20

EMBRYOLOGY OF THE OUTER, MIDDLE, AND INNER EAR . . . . . . . . . . . .

251

 

Thomas R.Van De Water and Hinrich Staecker

 

CHAPTER 21

ACOUSTICS AND MIDDLE EAR MECHANICS FOR OTOLARYNGOLOGY . . . . . .

259

 

John J. Rosowski and Saumil N. Merchant

 

CHAPTER 22

SURGICAL ANATOMY OF THE TEMPORAL BONE . . . . . . . . . . . . . . . . . .

275

 

Hinrich Staecker and Adrien A. Eshraghi

 

CHAPTER 23

HISTOLOGY AND HISTOPATHOLOGY OF THE TEMPORAL BONE . . . . . . . . .

283

 

Joseph B. Nadol, Jr.

 

CHAPTER 24

ULTRASTRUCTURAL ANATOMY OF THE COCHLEA . . . . . . . . . . . . . . . .

313

 

David J. Lim

 

CHAPTER 25

HAIR CELL FUNCTION . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .

332

 

Peter G. Gillespie

 

CHAPTER 26

AUDITORY PROCESSING IN SENSORINEURAL HEARING LOSS . . . . . . . . . . .

340

 

M. Charles Liberman

 

CHAPTER 27

PATHWAYS OF HEARING AND BALANCE . . . . . . . . . . . . . . . . . . . . . .

350

 

Alan D. Legatt

 

CHAPTER 28

ASSESSMENT OF CENTRAL AUDITORY FUNCTION . . . . . . . . . . . . . . . . .

361

 

Philippe P. Lefebvre and Alan D. Legatt

 

 

CONTENTS

ix

CHAPTER 29

LANGUAGE AND THE PLASTIC BRAIN . . . . . . . . . . . . . . . . . . . . . . . .

368

 

Robert J. Ruben

 

CHAPTER 30

PRINCIPLES OF AUDIOMETRY . . . . . . . . . . . . . . . . . . . . . . . . . . . .

374

 

Jackson Roush and John Grose

 

CHAPTER 31

HEARING AIDS, BONE-ANCHORED HEARING AIDS,

 

 

AND COCHLEAR IMPLANTS . . . . . . . . . . . . . . . . . . . . . . . . . . . . .

385

 

Adrien A. Eshraghi, Susan B.Waltzman, Joseph G. Feghali,

 

 

Thomas R.Van De Water, and Noel L. Cohen

 

CHAPTER 32

MECHANISM OF NOISE-INDUCED HEARING LOSS

 

 

AND OTOPROTECTIVE STRATEGIES . . . . . . . . . . . . . . . . . . . . . . . . .

395

 

Richard D. Kopke, John K.M. Coleman, Jianzhong Liu, Ronald L. Jackson,

 

 

and Thomas R.Van De Water

 

CHAPTER 33

VESTIBULAR SYSTEM PHYSIOLOGY . . . . . . . . . . . . . . . . . . . . . . . . .

409

 

John Carey

 

CHAPTER 34

TESTING BALANCE AND THE VESTIBULAR SYSTEM . . . . . . . . . . . . . . . .

415

 

Hinrich Staecker

 

CHAPTER 35

MORPHOPHYSIOLOGY OF THE FACIAL NERVE . . . . . . . . . . . . . . . . . . .

421

 

K. Paul Boyev and Adrien A. Eshraghi

 

CHAPTER 36

RADIOLOGY OF THE TEMPORAL BONE . . . . . . . . . . . . . . . . . . . . . .

431

 

Barbara Zeifer

 

PART III

THE NOSE, OLFACTION, AND THE SINUSES

 

CHAPTER 37

DEVELOPMENT OF THE NOSE . . . . . . . . . . . . . . . . . . . . . . . . . . .

449

 

Bradley J. Goldstein and Thomas R.Van De Water

 

CHAPTER 38

SURGICAL ANATOMY OF THE NOSE

 

 

AND PARANASAL SINUSES . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .

455

 

Dinesh Mehta and Walter M. Ralph Jr.

 

CHAPTER 39

NASAL AND PARANASAL SINUS PHYSIOLOGY . . . . . . . . . . . . . . . . . . .

472

 

Erich P.Voigt and David R. Edelstein

 

CHAPTER 40

THE BIOLOGY AND TESTING OF OLFACTORY DYSFUNCTION . . . . . . . . . .

485

 

James E. Schwob, Daniel B. Kurtz, and Bradley J. Goldstein

 

PART IV

THE LARYNX, VOICE, AND NECK

 

CHAPTER 41

THE BRANCHIAL ARCHES AND THEIR DERIVATIVES . . . . . . . . . . . . . . . .

499

 

Jeffrey T. Laitman, Joy S. Reidenberg, Armand Balboni,

 

 

Andrew Bergemann, and Peter Som

 

CHAPTER 42

MORPHOPHYSIOLOGY OF THE LARYNX . . . . . . . . . . . . . . . . . . . . . .

505

 

Joy S. Reidenberg and Jeffrey T. Laitman

 

CHAPTER 43

NEUROLOGICAL DISORDERS OF THE LARYNX . . . . . . . . . . . . . . . . . . .

516

 

Abigail Arad-Cohen and Andrew Blitzer