The genetics of dogs

Mucopolysaccharidosis VII, Sly

German Shepherd

Bone marrow transplant, haematopoi-

Haskins et al. (1991); Sammarco et al.

syndrome, 13-glucuronidase deficiency

etic stem cell therapy, ex vivo gene

(2000); Martin et al. (2006); Walton

- GUSB

therapy, neural cell transplant

and Wolfe (2007, 2008); Herati et al.

(2008); Gagliardi and Bunnell

(2009)

Metal transport disorder

Copper toxicosis - COMMDI

Bedlington Terrier

Understanding copper homeostasis

van De Sluis et al. (2002); de Bie et al.

(2007); Vonk et al. (2008)

Muscular disorders

Duchenne muscular dystrophy - DMD

Beagle, Cavalier King Charles

Gene therapy, anti-sense RNA

Howell etal. (1997, 1998); McClorey

Spaniel, Golden Retriever

induced exon skipping, stem cell

et al. (2006); Sampaolesi et al.

therapy

(2006); Yokota et al. (2009);

Walmsley et al. (2010)

Renal diseases

Hereditary

Samoyed

Gene therapy

Cox et al. (2003); Harvey et al. (2003);

nephropathy X-linked - COL4A5

Tsai et al. (2007)

Hyperuricosuria and hyperuricaemia -

Dalmatian

Organ transplant, understanding urate

Bannasch et al. (2008)

SLC2A9

transport

Skin/ectoderm diseases

Hypohydrotic

German Shepherd

Enzyme replacement

Casal et al. (2007); Mauldin et al.

ectodermal dysplasia -EDA

(2009)

Tumours

Glioblastoma multiforme (GBM)

Boxer

Treatment with transgene expression

Candolfi et al. (2007)

in brain

Cushing's disease from ACTH

Various

Adenoma control via effecting

de Bruin etal. (2008)

(adrenocorticotrophin)-producing

receptor expression

pituitary adenoma

General

Bone marrow transplant

Mixed breed

Cell targets for gene transfer

Suter et al. (2004)