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Файл:Ординатура / Хирургия / Библиотека им академика М.И. Перельмана / Книга_5715_Библиотеки_им_академика_М_И_Перельмана
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250 Advances in Combinatorial Chemistry & High Throughput Screening, Vol. 1 Rathnam Chaguturu
Bradykinin 109-10
BSA 239
C
C-ELISA assays 147
C. racemosa 167, 171-3, 176-8
C. rubifolia 167, 171-3, 175, 178
Calcium mobilization assays 79
Calmodulin-M13 moiety 68-9
cAMP assays 68, 70-1, 90
cAMP biosensors 91
cAMP response element (CRE) 70, 94
Carcinogenicity 43
Carhart's atom pairs 40-1, 45
Casein kinase II (CKII) 114
Cell-based alkaline phosphatase assays 166
Cell-free ER-binding assays 174
Cell lysates 64-5, 70-1, 75, 78, 167
Cell signaling pathways 74-5, 79, 86, 108
Cell surface receptors 76, 84
CellKey system 99, 104
Cellular phenotypes 85
Chemogenomics 36
Chimeric 70, 238-9
Chinese hamster ovary (CHO) 104, 109, 114
Chloroform partition 167-8
CHO cells 102, 114
Cimicifuga racemosa 159, 162-3
Cimicifuga rubifolia 162-3, 169
Cisbio 90
Cognate receptors 105-6
Competitive ELISA 147-8
Данная книга находится в списке для перевода на русский язык сайта https://meduniver.com/
Index Advances in Combinatorial Chemistry & High Throughput Screening, Vol. 1 251
Competitive estrogen receptor binding assays 173
Competitor proteins/peptides 232
Compound solvent DMSO 200
Condensed graphs of reactions (CGR) 47
Cornus officinalis 162-3, 170
Cyan fluorescent protein (CFP) 68
Cytotoxicity 166, 168, 171, 174, 177-9
Cytotoxicity assay 166
D
DAG-binding proteins 101
DART 7
Daucus carota 162-3, 170
Daylight fingerprints 44-5
Depolarization 190
DEREK 43, 48
Desensitization 87-8, 111
Developing reporter gene assays 94
Diacyl glycerol (DAG) 90
Dichloromethane 162, 172-4, 178-9
Dichloromethane extracts 167-8, 171, 173, 175, 177, 179
DiscoveRx 70-1, 76, 90
DMC 46
DMR assays 106-7, 116
DMR profiling 106, 109, 114, 116
DMR signals 101-2, 105, 107-9, 114-15
DMR signals of quiescent A431 cells 107
DMSO 49, 164-5, 169-70, 172, 187, 196, 198-200, 202-3, 211, 232
DNA binding dye 76
DNA damage 88
Donor fluorophore 62, 74
Dopamine 67, 111, 115
Dual-luciferase reporter assay system 167
252 Advances in Combinatorial Chemistry & High Throughput Screening, Vol. 1 Rathnam Chaguturu
Dynamic mass redistribution (DMR) 84, 87, 101, 109, 111-12, 116
Dynamic protein-protein interactions 91
E
E-Plate station 99
Effective immunoassays 141
Effective protein binding ligands 142
Electrical biosensors 84, 95, 98, 108
Electrode-embedded microplate 98
Electroporation 167
ELISA assay development 147
Enantioselective catalysts 147-8
Endogenous bradykinin B2 receptors 109-10
Endogenous P2Y receptors 114
Enzyme fragment complementation (EFC) 76, 90
Enzyme linked immunosorbent assays (ELISA) 64, 130, 133, 145-6
EPI 14
EPI Suite 10, 13, 15
Epidermal growth factor receptor (EGFR) 76-7, 109, 139
Epinephrine 101, 112, 116-17
Epitopes 141, 145-6
Equilibrium fluorescence anisotropy assays 232
ER Alpha and ER Beta Competitive Assay 167
ER beta binding assays 168
Estrogen 159-60, 177-9
Estrogen-free media 167
Estrogen receptor (ER) 159-62, 164-5, 167, 169-79
Estrogen response element (ERE) 159-60, 174, 176
Estrogenic activity 159, 161, 163, 174, 178-9
Estrogenic ALP assay 168
Ethanol extracts 168, 171-3, 175, 178-9
Eukaryotic cells 139
Данная книга находится в списке для перевода на русский язык сайта https://meduniver.com/
Index Advances in Combinatorial Chemistry & High Throughput Screening, Vol. 1 253
F
Fatty acids 175
Fingerprints 38, 44-6
FITC-GoLoco motif probe 191, 210
FITC-GoLoco motif probe binding 191
FITC-GPSM 194, 197-201
FITC-KB-1755 231-2
FITC-RGS 193, 197-203, 205
FITCGPSM 197-8, 200, 202
FLICA reagent 75
Fluo-4 calcium assay 73
Fluorescein 187, 190, 197
Fluorescence 60-1, 63, 70, 73, 75, 78, 92, 144, 232
Fluorescence anisotropy (FA) 187, 190-1, 227
Fluorescence emission 79, 232
Fluorescence polarization (FP) 62, 68, 70, 187, 190-1, 195, 197, 202, 207, 211
Fluorescence polarization assays 191-2
Fluorescence polarization measurements 194, 210
Fluorescence signal 65, 71
Fluorescence spectroscopic assays 232
Fluorescent assays 60, 63, 71, 79
Fluorescent cell-based assays 72, 79-80
Fluorescent cell-based surrogate ion assays 80
Fluorescent cellular assays 63
Fluorescent cellular assays for GPCRs 67
Fluorescent inhibitor of caspases (FLICA) 75
Fluorescent live-cell imaging 111
Fluorescent probes 60-3, 67, 77
Fluorescent proteins 61, 68, 71-2, 77-8, 92
Fluorescent signal 63, 65
Fluorescent substrate 61, 70, 76
Fluorogenic assays 61
Fluorophore assay 207
254 Advances in Combinatorial Chemistry & High Throughput Screening, Vol. 1 Rathnam Chaguturu
Fluorophore-labeled peptide 196, 231
Fluorophore-type assay 213
Fluorophores 60-1, 77-8, 91, 190, 206-7
Formoterol 112-13
Förster resonance energy transfer (FRET) 62-3, 68, 74, 91
FP assay 70, 187, 197, 199-200, 202-4, 206, 210-11
FP-based HTS assay 201
Free cAMP 70
FRET assay 62-3, 68
Fungal heterotrimeric G-protein signal transduction pathways 225
Fusion protein 139, 195, 204
Fuzzy pharmacophore triplets (FPT) 40
G
G-protein activation 234, 242
G-protein agonism 240
G-protein alpha subunit 187
G-protein binding peptides 222
G protein coupled receptor (GPCRs) 60, 66-7, 70-2, 79-80, 84-91, 93-4, 97, 101,
104-5, 108-9, 111, 188, 220-1, 223, 237-8
G protein-coupled receptors (GPCRs) 84, 188, 219-20
G-protein signal transduction 223
G-protein signaling 220, 223, 225, 233
G-protein signaling box 189
G-protein signaling cycle 222
G-protein signaling dynamics 222
G-protein signaling modulator 189
G-protein signaling pathways 225
G-protein subfamilies 220
G-protein subunit binding peptides 242
G-protein subunit interaction 238
G-proteins 220, 222, 224, 235, 238
GDP injections 195
Данная книга находится в списке для перевода на русский язык сайта https://meduniver.com/
Index Advances in Combinatorial Chemistry & High Throughput Screening, Vol. 1 255
GDP interaction 200
GDP protein 195, 200-1, 203, 205
GDP release 220
GEF activity 220, 234
GEFs 220-1, 223
Gene reporter cAMP assay 90
Glutamax-1 165
Glycerol 193
GPCR activation 71-2, 87, 91-2, 94, 101, 103
GPCR assays 61
GPCR drug discovery 84-6
GPCR SCREENING 84, 86, 90, 105, 116
GPCR signaling 86, 89, 102, 108-9, 116
GPCR signaling cycle 91-2
Gq-coupled receptor signaling 101-2
Gq-coupled receptors 94, 101
Green assay 196, 206-7
Green fluorescent protein (GFP) 64-5, 71, 76, 92, 94
Green probe 204, 206
Gs-coupled receptors 102, 238
Gs-DMR signals 101-2
GST 195
GTP 188, 220-1, 239
GTP binding 221
GTP hydrolysis 221-2
GTPase-accelerating proteins (GAPs) 220-1
GTPase-activating protein domain 189
Guanine nucleotide exchange factors (GEFs) 220-1
H
HeLa cells 87, 109, 111
Henry's Law Constant 24
Heterotrimeric G-proteins 187, 219, 221-2, 237
256 Advances in Combinatorial Chemistry & High Throughput Screening, Vol. 1 Rathnam Chaguturu
Hierarchical partial order ranking (HPOR) 3, 5, 9, 14, 23, 31
High assay variability 99
High content imagers 71
High content screening (HCS) 60, 75, 92
High throughput ELISA assay 147
High throughput methods 130, 145
High throughput screening (HTS) 60, 67-8, 70, 84, 86, 91, 94, 115, 130, 132,
145, 147, 190, 200, 212
Histamine 116-17
Hormone-receptor 161
Hormone replacement therapy (HRT) 160
HRP 147
Human antibodies 136, 138
Human embryonic kidney (HEK) 105, 107, 114
Human extracellular receptor domains 136
Human IgG 144, 147-9
Hybridoma cells 131
I
I-coupled receptors 111
IgG-secreting plasma cells 137
Imaging device 71, 78
Imidazole 193
Immobilization buffer 239
Immunoassays 130-1
Immunoglobulins 133-6, 142-4
Immunological methods 144
Impedance 84, 103-4
Impedance-based cell assay 103
Impedance signals 104
Improved assay sensitivity 206
Inductive learning programming 48
Inhibition threshold 115
Данная книга находится в списке для перевода на русский язык сайта https://meduniver.com/
Index Advances in Combinatorial Chemistry & High Throughput Screening, Vol. 1 257
Intact immune cells 237
Interference-mediated knockdown 189
Interfering compounds 211
Intracellular cAMP 90, 94
Intramolecular self-quenching 61
Ion channel activity 72, 74
IP-One assay 70
IPLF 41
Ishikawa alkaline phosphatase assay 160, 162, 172, 176
Ishikawa alkaline phosphatase induction assays 159, 166
Ishikawa alkaline phosphatase inhibition assay 171
Ishikawa ALP assay 174
Ishikawa assay 177-8
Ishikawa cell line 161, 165, 168, 178-9
Ishikawa cells 165, 173
K
Kinase activity 64-5
Kinase antibodies 64-5
Kinase inhibitors 109
L
Label-dependent cell-based assays 89
Label-free biosensor-enabled cell-based assays 84
Label-free cell assays 109, 112-14
Label-free cell-based assays 86, 95, 98, 105, 108
Label-free cellular assays 89, 116
Label-free phenotypic assays 87
Labeled cAMP 68, 70
Lanthanides 63, 70
Ligand binding 88, 115, 161
Ligand-binding assays 86
258 Advances in Combinatorial Chemistry & High Throughput Screening, Vol. 1 Rathnam Chaguturu
Ligand-binding screening 86
Ligand-directed functional selectivity 84, 88, 112
Ligand displacement assay 192
Ligand-induced changes 95, 97-100
Ligand-receptor 130, 164
Ligand-receptor interaction 113-14, 140
Ligand receptors mimicking antibody specificity 135
Ligand screening 142-3
Linear extensions 7, 18, 31
Lipid bilayer 74
Local Partial Order Model (LPOMext) 21
Luciferase 71, 94
Luminex assay 78
M
MEF cells 93
Membrane-bound receptors 188, 220
Membranes of Sf9 insect cells 239
Menopausal symptoms 160, 163
Menopause 159-60, 174, 176
Menstrual disorders 160, 163
Microtiter plate 144, 146
Miniaturization of FP assay 206
Mitogen-activated protein kinase (MAPK) 76, 189
Mobilization assay 79
Modulate G-protein activity 222
Molecular libraries small molecule repository (MLSMR) 204, 212
Monoclonal antibodies 131, 141, 146
mRNA display 222-3, 231
Mu-expressing HEK-293 cells 115
Multiplexed fluorescent assay approaches 63
Muscarinic acetylcholine receptor 242
Данная книга находится в списке для перевода на русский язык сайта https://meduniver.com/
Index Advances in Combinatorial Chemistry & High Throughput Screening, Vol. 1 259
Mutagenicity 43
Myeloma cells 131
N
Novel binding proteins 135
Nuclear factor 94
Nucleotide-dependent protein-protein interactions 219
O
Oligomerization 88
Opioid receptor 88, 93
Optical biosensor 84
P
Partial order ranking (POR) 3, 5-10, 12-14, 17, 22-6, 28, 30-1
PBT 3-4, 27-8
PBT substances 3, 28
Peptide-based assay of 2-adrenergic receptor 239
Peptide-based assay of 2-AR stimulation 239
Peptide-based FP assay 207
Petroleum ether extracts 167-8, 171-3, 175-6, 178
Pharmaceutically active compounds 116
Pharmacological assays 85
Pharmacologically active compounds 240
Pharmacophores 37-8, 40, 45
Phenotypic assays 85
Phenylalanine 201
Phosphorylated kinase 64
Pilot screening assay 240
Plasma membrane 74, 87-8, 221
Plate format assay 192
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