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Index
1,3-beta-glucan synthase, 64
11-beta hydroxylase, 176
17-alpha hydroxylase, 176
4-hydroxyphenylpyruvate dioxygenase,
80
A
Acarbose, 85
Acenocoumarol, 112
acid(s)
arylpropionic, 101
clavulanic, 51, 52
fatty acid synthase, 161
adenosine deaminase, 115
ADEPT (antibody directed enzyme
prodrug therapy), 185
AEF (alternating electric field), 186
Agalsidase
alfa, 169
beta, 169
alanine racemase, 31
alcohol dehydrogenase, 81
aldehyde dehydrogenase, 81
aldose reductase, 72
Alfalastin, 144
Alglucerase, 170
Aliskiren, 113
Allopurinol, 92
alpha-
amylase, 162
antitrypsin, 144
glucosidase, 84, 175
Alteplase, 110
Aminoglutethimide, 127, 128
Aminopterin, 117, 119
Ampicillin, 46, 51, 52, 58
Amrinone, 112
Anagrelide, 94, 95
Anidulafungin, 64, 65
Apixaban, 108
arabinosyltransferases, 32
Arachidonate 5-lipoxygenase, 163
Argatroban, 110
Asfotase alfa, 144
Atazanavir, 25
Atorvastatin, 88–90
ATPase
H
+
/K
+
, 86
Na
+
/K
+
, 111
avalglucosidase alfa, 175
Avibactam, 59, 68
Axitinib, 134
Aztreonam, 59
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202 Enzymes and Drugs
B, C
Benserazide, 77
Benzbromarone, 91
Bifonazole, 65
Boceprevir, 30
Brinzolamide, 71
C1 esterase inhibitor, 109
Camptothecin, 121, 122
Captopril, 113
Carbidopa, 77
carboxypeptidases, 45, 165
Carfilzomide, 124
caspases, 165
Caspofungin, 64, 65
catechol-O-methyltransferase, 77
Cefalexin, 46
Cefotaxime, 46
Ceftiofur, 46
Celecoxib, 105
Ceritinib, 133
Cerivastatin, 88
Cétuximab, 133
Chloramphenicol, 41, 44
Chloroquine, 67
Ciclosporin, 117, 131
Cidofovir, 20, 27
Cladribine, 116
Clofarabine, 126, 130
Clometacine, 103
congenital adrenal hyperplasia, 176
CPK, 88
Crisantaspase, 144
CRISPR/Cas9, 191, 192
Crizotinib, 136
Cycloserine, 31
D, E
Dabigatran, 111
Dabrafenib, 138, 139
Dapsone, 64
Darunavir, 24, 25
Dasabuvir, 30
Dasatinib, 137
Daunorubicin, 122
Delaviridine, 27
Denosumab, 129
Deprenyl, 76
DHP-1, 57
Diclofenac, 103
Didanosine, 27
Diflusinal, 100, 103
Digoxine, 111
dihydrofolate
synthetase, 60
dioxygenases, 165
Dipyridamole, 94
Disulfiram, 82
DNA topoisomerase, 34, 121
DNA-dependent RNA polymerase, 33
Dolutegravir, 29
Dorzolamide, 71
Doxorubicin, 122, 183
Efavirenz, 27, 29
Eflornithine, 66
Eliglustat, 167, 170
Elvitegravir, 29, 129
Emtricitabine, 29, 129
Enalapril, 113
Enasidenib, 129, 130
Entacapone, 77
Epalrestat, 73
Epirubicin, 122
ERK, 138
Erlotinib, 133
Ertapenem, 57
Ethambutol, 32
Etodolac, 101
Etoposide, 122
Etoricoxib, 105
Exagamglogene autotemcel, 192
Exenatide, 84
F, G
Famciclovir, 20
https://t.me/med1917
Index 203
farnesyl-diphosphate
farnesyltransferase, 163
Febuxostat, 92
Felbamate, 79
Fenbufen, 103
Fentiazac, 103
Finasteride, 120
Florfenicol, 41
Fluvastatin, 88–90
Fomepizole, 81
Fomivirsen, 194
Foscarnet, 20
Fosfomycin, 51, 60
GABA transaminase, 78
Gabapentine, 79
GDEPT (gene-directed enzyme prodrug
therapy), 185
Gefitinib, 132
Gentamycin, 36, 38–40
Gilteritinib, 136, 137
GIP, 82, 83
GLP-1, 83–85
Glybera, 193
H, I
hereditary orotic aciduria, 176
histidine decarboxylase, 106
HMG-CoA reductase, 87–90
Hydroxycarbamide, 125, 137
hypophosphatasia, 144
Ibrutinib, 139
Icofungipen, 161, 177
Idarubicin, 122
Idelalisib, 140
Idursulfatase, 171
Imatinib, 141, 143
Imiglucerase, 170
Indinavir, 25
Indometacin, 103
inhibitors, 3, 4, 7, 11, 21, 23, 24, 28, 29,
84, 87, 89, 92, 106, 133, 138
inosine monophosphate deyhydrogenase,
108
Iproniazid, 32, 75
isocitrate dehydrogenase, 129
Isoniazid, 32, 74, 75
Ivosidenib, 129, 130, 146
K, L
Kanamycin, 36, 38
Ketorolac, 101
kinase(s), 132, 137, 139
BTK, 139
MEK, 139
L-amino aromatic acid decarboxylase, 77
L-Asparaginase, 144
L-DOPA decarboxylase, 73, 77
Lamivudine, 29
Lansoprazole, 87
Lapatinib, 133
Larotrectinib, 134
Leflunomide, 107
Levodopa, 74, 77
Liraglutide, 84
Lixisenatide, 84
Lopinavir, 25
Lumiracoxib, 106
M, N
Mefloquine, 79
Meloxicam, 104
Methotrexate, 64, 117–119
Micafungin, 64, 65
Midostaurin, 142
Miglitol, 85
Miglustat, 167, 170, 174
Mipomersen, 194
Misoprostol, 99
Moclobemide, 76
Molsidomine, 115
Mozenavir, 25
murA, 60
Namubetone, 106
https://t.me/med1917
204 Enzymes and Drugs
Nelfinavir, 25
Neomycin, 36
Neostigmine, 73
Nevirapine, 27, 28
Nialamide, 32, 75
Nicorandil, 115
Nimesulide, 105
Nitisinone, 80
Norfloxacin, 35
O, P
Ofloxacin, 35
Omeprazole, 86, 87
Onasemnogene abeparvovec, 193
Orlistat, 91
Ornithine décarboxylase, 66
Ouabain, 111
Oxametacin, 103
Paclitaxel, 183
Panobinostat, 123
Pantoprazole, 87
Parecoxib, 105
Pegloticase, 143
Pelitrexol, 164
Pemetrexed, 118, 120, 164
Pentamidine, 66
Pentostatine, 116
Phenobarbital, 117
Phenprocoumon, 24
phenylalanine hydroxylase, 80
Phenylbutazone, 105
phosphatases, 131
Phosphatome, 131
phosphodiesterases, 94
Phospholipase A2, 96
phosphoribosylglycinamide
formyltransferase, 164
PI3K, 140
Piperacillin, 58
Pirarubicin, 122
Piroxicam, 104
PKC, 142
plasma kallikrein, 109
plasmin, 109
plasmodium, 67
Ponatinib, 142
Pravastatin, 88, 89
primary hyperpxaluria, 176
Prolastin, 144
Pyrimethamine, 62, 63
Q, R
quinolones, 35
Racecatodril, 93
RAF, 143
Ralitrexed, 118
Rasagiline, 76
Regorafenib, 143
Respreeza, 144
Reteplase, 110
Rifampicine, 33
Rifamycin B, 33
Ritonavir, 25
Rivaroxaban, 108
Rofecoxib, 105
Rosuvastatin, 90
Rucaparib, 130
S, T
Sapropterin, 80
Saquinavir, 25
Selegiline, 76
Simeprevir, 30
Simvastatin, 88
Sofosbuvir, 30
squalene mono-oxygenase, 65
Stavudine, 27
Streptomycin, 36, 37
Strimvelis, 193
succinate semi-aldehyde dehydrogenase,
78
Sulbactam, 58
Sulfinpyrazone, 91
Sulindac, 103
https://t.me/med1917
Index 205
Sultamicillin, 58
Sunitinib, 135
Tamoxifen, 126–128
Telaprevir, 30
Temsirolimus, 140
Tenechteplase, 110
Teniposide, 122
Tenofovir, 27
Tenoxicam, 104
Teriflunomide, 107
Thienamycin, 57
thrombin, 110
Thyroxine-5’-deiodinase, 164
Tilarginine, 115
Timoprazole, 86
Tipranavir, 24, 25
Tisopurine, 92
Tofersen, 194
Tolcapone, 77
Tolnaftate, 65
Toloxatone, 76
Tolrestat, 73
Trametinib, 139
Trastuzumab, 133
triacylglycerol lipases, 90
Trilostane, 81
Trimethoprim, 62, 63
Trinitrine, 115
Tritoqualine, 106, 107
Trypsone, 144
Tryptamine, 76
U, V
UDP-N-acetylglucosamine
1-carboxyvinyltransferase, 60
urease, 60
Valdecoxib, 105
Vandetanib, 135
Vardenafil, 95
VDEPT (virus-directed enzyme prodrug
therapy), 186
Vemurafenib, 138, 139
W, X, Z
Warfarin, 24, 112
xanthine oxidase, 91
Zanamivir, 21, 22
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