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Fused Deposition Modeling (FDM) of
Pharmaceuticals
Silke Henry, Valérie Vanhoorne, and Chris Vervaet
Abstract
A shift in treatment strategy from generalized to personal healthcare has
sparked the interest for flexible production techniques capable of producing
patient-specific dosage forms. Fused deposition modeling could be utilized for
such personalized treatment, and its interest has grown rapidly, with over 350
published papers in the field of pharmaceutical science in the last decade. The
advantages of the technique are indeed manifold. Apart from being desktopsized, FDM has also been praised for its simplicity and cost-effectiveness. The
aim of this chapter is to summarize 10 years of research on pharmaceutical
FDM 3D-printing in a concise and comprehensive way. Therefore, this chapter
first provides information about the FDM 3D-printing equipment and its process
mechanism. Next, the typical formulation constituents and specific characterization techniques for the printed dosage forms will be discussed. Finally, a
variety of possible pharmaceutical applications like oral therapies, transdermal
or transmucosal films and implants will also be reviewed.
2
Keywords
Fused deposition modeling · Fused filament fabrication · Solid dosage forms ·
Drug delivery · Personalised healthcare · Additive manufacturing
S. Henry · V. Vanhoorne · C. Vervaet ()
Laboratory of Pharmaceutical Technology, Ghent University, Ghent, Belgium
e-mail:
Silke.Henry@UGent.be; Va l e r i e.Vanhoorne@UGent.be; Chris.Vervaet@UGent.be
© The Author(s), under exclusive license to Springer Nature Singapore Pte Ltd. 2023
S. Banerjee (ed.), Additive Manufacturing in Pharmaceuticals,
https://doi.org/10.1007/978-981-99-2404-2_2
45
46 S. Henry et al.
Данная книга находится в списке для перевода на русский язык сайта https://meduniver.com/
2.1 Introduction
Pharmaceutical production processes are generally focused on mass production of
dosage forms, suiting the average patient in the population. Recently, a shift in
treatment strategy was initiated moving generalized healthcare towards personalization. Such treatment personalization is only possible if a versatile production
technique able to create high-quality unique dosage forms is developed. Additive
manufacturing or 3D-printing is such an innovative production technique with
seemingly unlimited flexibility, capable to produce any wanted end-product in a
layer-by-layer fashion (Auriemma et al.,
Additive manufacturing or 3D-printing is an umbrella term encompassing a
variety of 7 different printing techniques which are all classified as computeraided design (CAD), utilizing an in-silico model to drive production. These printing
techniques are binder jetting, material jetting, vat photo-polymerization, sheet
lamination, directed energy deposition, powder bed fusion and material extrusion.
Material extrusion is characterized by the deposition of a material through an orifice
to create semi-solid strands which solidify on the build plate. The material extrusion
technique includes both semi-solid extrusion and fused deposition modeling (FDM).
The semi-solid technique utilizes gels or pastes and pressure-assisted microsyringes,
while FDM utilizes thermoplastic starting materials which are deposited in a molten
state (Awad et al.,
2018; Auriemma et al., 2022).
The FDM 3D-printing technique was developed in 1988 by S. Scott Crump, after
he attempted to create a 3D-object using a glue gun. Following commercialization
by the company Stratasys, the technique was named fused deposition modeling
(FDM) (Ligon et al.,
2017). After expiration of the patent, the technique became
commonly known as fused filament fabrication (FFF) (Shaqour et al.,
The popularity of the FDM or FFF technique is apparent by its use in many
industries like rapid prototyping, manufacturing or tooling of specific applications
in for example the aircraft industry (Wang et al.,
et al.,
2019), electronic devices (MacDonald et al., 2014), architecture (Gosselin
et al.,
2016) and microfluidics (Pranzo et al., 2018). To suit this broad extent of
applications, a variety of materials have been developed like glass fiber reinforced
polypropylene (Carneiro et al.,
2015), acrylonitrile butadiene styrene (ABS)-based
nanocomposite material (Ceretti et al., 2022), ABS-based material containing
metallic filler (Masood and Song,
et al.,
2022). At present, FDM 3D-printing is also the most broadly investigated 3D-
printing technique in healthcare since it is cheap and easy-to-use. As a result, it is
excellently suited to provide on-site production of personalized dosage forms (Ligon
et al.,
2017). The printing technique has been used to produce for example dental
devices (Dawood et al.,
2015), scaffolds for tissue engineering (Zein et al., 2002)
or customized prosthetics (Barrios-Muriel et al.,
the use of FDM to produce drug delivery devices containing active pharmaceutical
ingredients (API).
2022; Henry et al., 2021a).
2020).
2019), automotive industry (Yadav
2004) or sustainable feedstock materials (Fico
2020). This chapter will focus on
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