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20 Hypoxia Pathway: 18F- FAZA
https://t.me/med1917
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Fig. 20.5 18F-FAZA PET/CT and MRI guide biopsy of brain lesion
both high-perfusion MRI markers and high 18F-FAZA uptake was selected for biopsy after appropriate image fusion (D). The histological analysis conrmed the presence of a grade IV glioblastoma.
Images from database of Nuclear Medicine Department, IRCCS San Raffaele Scientic Institute, Milan, Italy.
Acknowledgments This work was supported by the Italian Ministry of Health, Ricerca Finalizzata (GR-2009­the Italian Association for Cancer Research (grant IG 2014 Id.1524; EudraCT:2015-000679-28).
1575612; EudraCT: 2011-002647-98) and by
330
https://t.me/med1917
P. Alongi et al.
References
1. Ruan K, Song G, Ouyang G. Role of hypoxia in the hallmarks of human cancer. J Cell Biochem. 2009;107:1053.
Joyce JA, Pollard JW.Microenvironmental regulation
2. of metastasis. Nat Rev Cancer. 2009;9:239.
doi.org/10.1038/nrc2618
Denko NC.Hypoxia, HIF1 and glucose metabolism
3. in the solid tumour. Nat Rev Cancer. 2008;8:705.
https://doi.org/10.1038/nrc2468.
Pouysségur J, Dayan F, Mazure NM. Hypoxia sig-
4. nalling in cancer and approaches to enforce tumour regression. Nature. 2006;441:437.
org/10.1038/nature04871
Harris AL. Hypoxia—a key regulatory factor in
5. tumour growth. Nat Rev Cancer. 2002;2:38.
doi.org/10.1038/nrc704
Semenza GL.Evaluation of HIF-1 inhibitors as anti-
6. cancer agents. Drug Discov Today. 2007;12:853.
https://doi.org/10.1016/j.drudis.2007.08.006.
Nguyen DX, Bos PD, Massagué J.Metastasis: from
7. dissemination to organ-specic colonization. Nat Rev Cancer. 2009;9:274.
Chandel NS, Simon MC. Hypoxia-inducible factor:
8. roles in development, physiology, and disease. Cell Death Differ. 2008;15:619.
cdd.2008.11
Cao Y.Observation of incipient tumor angiogenesis
9. that is independent of hypoxia and hypoxia induc­ible factor-1 activation. Cancer Res. 2005;65:5498.
https://doi.org/10.1158/0008- 5472.CAN- 04- 4553.
Krishnamachary B. Regulation of colon carcinoma
10. cell invasion by hypoxia-inducible factor 1. Cancer Res. 2003;63:1138.
Le QT, Courter D.Clinical biomarkers for hypoxia
11. targeting. Cancer Metastasis Rev. 2008;27:351.
https://doi.org/10.1007/s10555- 008- 9144- 9.
Lundgren K, Holm C, Landberg G. Hypoxia and
12. breast cancer: prognostic and therapeutic implica­tions. Cell Mol Life Sci. 2007;64:3233.
org/10.1007/s00018-
Kumar P, Stypinski D, Xia H, McEwan AJB, Machulla
13. H, Wiebe LI.Fluoroazomycin arabinoside (FAZA): synthesis, 2H and 3H-labelling and preliminary bio­logical evaluation of a novel 2-nitroimidazole marker of tissue hypoxia. J Label Compd Radiopharm. 1999;42:3.
1344(199901)42:1<3::aid- jlcr160>3.3.co;2- 8.
Savi A. First evaluation of PET-based human bio-
14. distribution and dosimetry of imaging tumor hypoxia. J Nucl Med. 2017;58:1224.
https://doi.org/10.2967/jnumed.113.122671.
Wack LJ, et al. Comparison of [18F]-FMISO,
15.
18
F]-FAZA and [18F]-HX4 for PET imag-
[ ing of hypoxia—a simulation study. Acta Oncol.
https://doi.org/10.1002/jcb.22214.
.
.
.
https://doi.org/10.1038/nrc2622.
https://doi.org/10.1038/
.
007- 7390- 6.
https://doi.org/10.1002/(sici)1099-
18
F-FAZA, a tracer for
https://
https://doi.
https://
https://doi.
2015;54:1370.
86X.2015.1067721
Provost C, Mammar H, Belly-Poinsignon A, Madar
16.
https://doi.org/10.3109/02841
.
O, Champion L. Pharmacokinetic analysis of [ FAZA dynamic PET imaging acquisitions for high­lighting sacrum tumor proles. Clin Nucl Med. 2020 Jan;45(1):e36–8.
RLU.0000000000002813
Mapelli P. 18F-FAZA PET/CT in pretreatment
17.
https://doi.org/10.1097/
.
assessment of hypoxic status in high-grade glioma: correlation with hypoxia immunohistochemical bio­markers. Nucl Med Commun. 2021;42:763.
doi.org/10.1097/MNM.0000000000001396
Postema EJ.Initial results of hypoxia imaging using
18. 1-α-d-(5-deoxy-5-[18F]-fluoroarabinofuranosyl)­2-nitroimidazole ( Imaging. 2009;36:1565.
009- 1154- 5.
s00259-
Bruine De Bruin L. Assessment of hypoxic
19. subvolumes in laryngeal cancer with 18F-uoroazomycinarabinoside (
18
F-FAZA). Eur J Nucl Med Mol
https://doi.org/10.1007/
18
https://
.
F-FAZA)-PET/ CT scanning and immunohistochemistry. Radiother Oncol. 2015;117:106.
radonc.2015.07.012
Mapelli P. Hypoxia 18F-FAZA PET/CT imaging in
20.
https://doi.org/10.1016/j.
.
lung cancer and high-grade glioma: open issues in clin­ical application. Clin Translat Imaging. 2017;5:389.
https://doi.org/10.1007/s40336- 017- 0240- 0.
Muzi M. 18F -uoromisonidazole quantication
21. of hypoxia in human cancer patients using image­derived blood surrogate tissue reference regions. J Nucl Med. 2015;56:1223.
jnumed.115.158717
Kawai N. Correlation between 18F -uoromisonida-
22.
.
https://doi.org/10.2967/
zole PET and expression of HIF-1α and VEGF in newly diagnosed and recurrent malignant gliomas. Eur J Nucl Med Mol Imaging. 2014;41:1870.
doi.org/10.1007/s00259-
Bittner MI.Analysis of relation between hypoxia PET
23.
014- 2776- 9.
https://
imaging and tissue-based biomarkers during head and neck radiochemotherapy. Acta Oncol. 2016;55:1299.
https://doi.org/10.1080/0284186X.2016.1219046.
Grosu AL. Hypoxia imaging with FAZA-PET and
24. theoretical considerations with regard to dose paint­ing for individualization of radiotherapy in patients with head and neck cancer. Int J Radiat Oncol Biol Phys. 2007;69:541.
ijrobp.2007.05.079
Mortensen LS. FAZA PET/CT hypoxia imaging in
25.
.
https://doi.org/10.1016/j.
patients with squamous cell carcinoma of the head and neck treated with radiotherapy: results from the DAHANCA 24 trial. Radiother Oncol. 2012;105:14.
Mapelli P. 18F-FAZA PET/CT hypoxia imaging of
26. high-grade glioma before and after radiotherapy. Clin Nucl Med. 2017;42:e525.
RLU.0000000000001850
https://doi.org/10.1097/
.
18
F]