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A. A. Seixas et al.

Chapter 4
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The Future ofSleep Medicine:
APatient-Centered Model ofCare
BarryG.Fields andIleneM.Rosen
Keywords Future of sleep medicine · Patient-centered care · Collaborative care ·
Sleep telemedicine · Articial intelligence
Nearly 70years ago, Nathaniel Kleitman, a professor of physiology at the University
of Chicago, and his graduate student, Eugene Aserinksy, studied eye movements
leading to a seminal paper in 1953 describing a new sleep state, rapid eye movement
(REM) sleep. In 1957, Kleitman and William Dement, another graduate student,
described the human sleep cycle of NREM sleep stages of increasing depth followed by periods of REM sleep, with the cycles repeating through the night [1].
These discoveries established sleep as a scientic discipline. Over the next 30years,
sleep medicine developed as its own clinical discipline with development of
American Academy Sleep Medicine (AASM)-accredited clinical training pathways
starting in 1988 and certication available through the American Board of Sleep
Medicine (ABSM) from 1991 to 2006. During this time, 3500 physicians were
ABSM certied in sleep medicine. In 2005, Sleep Medicine training was ofcially
recognized by the Accreditation Council of Graduate Medical Education (ACGME)
with approval by the American Board of Medical Specialties (ABMS) to offer a
certication examination.
Currently, there are approximately 200 positions available for one-year subspecialty training in sleep medicine nationwide [2] and approximately 175–180 are
B. G. Fields
Emory University, Division of Pulmonary, Allergy and Critical Care Medicine,
Atlanta, GA, USA
I. M. Rosen (
Division of Sleep Medicine, Perelman School of Medicine at the University of Pennsylvania
PCAM, Philadelphia, PA, USA
e-mail: ilene.rosen@pennmedicine.upenn.edu; Ilene.Rosen@uphs.upenn.edu
M. S. Badr, J. L. Martin (eds.), Essentials of Sleep Medicine,
Respiratory Medicine, https://doi.org/10.1007/978-3-030-93739-3_4
*)
69© Springer Nature Switzerland AG 2022

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B. G. Fields and I. M. Rosen
trained each year. In the last decade, there were 3500 rst-time takers of the ABMScertication exam in sleep medicine; this number is down 1500 since 2018 [3]. In
the early years, many physicians practicing sleep medicine took the exam based on
a clinical-experience waiver; these physicians, along with those who were still only
certied by the ABSM, led to a peak number of nearly 6000 Board-Certied Sleep
Medicine Physicians (BCSMPs) in 2018. Since that time, those numbers have
waned. Starting in 2013, physicians needed to complete an ACGME-accredited
sleep fellowship in order to sit for the certication exam. Furthermore, the total
number of retired sleep physicians from 2013 to 2018 was 7 times the number of
new BCSMPs during the same time period (AASM, email communication,
October 2018).
As a result, the BCSMP workforce is insufcient to meet the demands of the
enormous population of patients who have a sleep disease, including an estimated
23.5 million U.S. adults with undiagnosed OSA and the 24.2 million individuals
with chronic insomnia [4]. This shortfall results from some unintended consequences of recognition of sleep medicine as a specialty by the ACGME and
ABMS.First, there are now a limited number of ACGME-accredited training spots
that allow physicians to sit for the certication examination. Second, interest in
those slots has varied in recent years, perhaps because of the need for a full extra
year of training along with concerns regarding reduced reimbursements as home
sleep apnea testing becomes the norm [5].
These workforce pipeline issues interact with known factors at the individual (e.g.,
race), family (e.g., beliefs), and broader socio-cultural (e.g., insurance coverage) levels to limit access to sleep medicine care [6]. Pre-existing geographic barriers and
accredited sleep centers’ clustering in more highly populated areas further exacerbate
these disparities. This situation highlights the need for shared responsibility among
BCSMPs and other providers for treating patients with sleep disorders. Given the
magnitude of individuals who suffer with a sleep disorder and the benets associated
with treatment, patients deserve a collective response from our healthcare system.
There are six feeder specialties including Anesthesia, Family Medicine, Internal
Medicine, Neurology, Otorhinolaryngology (Ear, Nose &Throat/ENT), and Pediatrics.
Unfortunately, there has been a disconnect between the magnitude of the disease burden, the broad relevance across many specialties, and the lack of success of the efforts
to infuse sleep education at all levels [7]. Not only is it difcult to gain traction for
sleep medicine curricula in medical schools, but also in the feeder specialties into
sleep medicine; only ENT has specic program requirements about education in sleep
beyond the general ACGME requirements of fatigue mitigation strategies.
Re-centering the spotlight on patient-centered care requires reconsideration of
the current model of care which presently involves nearly automatic referral of
patients with a sleep complaint to a sleep specialist or to a sleep center for testing.
Unfortunately, long waits and fragmented care have been the norm. Although the
spread of telemedicine during the COVID-19 pandemic has potentially improved
access to care by removing geographic barriers, the sleep eld still suffers from a
conundrum: As the general public increasingly recognizes importance of sleep
health, there is a scarcity of providers to ensure it. Thus, we propose a patientcentered point of care model that facilitates the patient receiving the best possible

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The Future ofSleep Medicine: APatient-Centered Model ofCare
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4
71
care for their sleep complaints to promote sleep health which utilizes patient, provider, educational, and technological resources.
A Patient-Centered Model ofSleep Care
Figures 4.1 and 4.2 outline our proposed integrated model for the future of sleep
care, and they will be referenced throughout the rest of this chapter. The emphasis
is on a patient-centered approach, so that a patient can get the sleep care they need
at a time and place that is convenient for them, regardless of the availability of a
one-on-one appointment with a sleep specialist. Figure4.1 traces a patient’s evaluation and diagnosis pathway from left to right, starting with their symptomatic concerns and nishing with patient-centered education and treatment. This intervention
may occur through a referral to sleep specialist or non-sleep specialist workup.
Figure4.2 follows a patient from treatment initiation through ongoing management.
Here, the stress is on ongoing collaboration between non-sleep medicine specialists
and sleep medicine specialists. Points A–F indicated throughout Figs.4.1 and 4.2
refer to topics presented in each of the next ve sections.
Primary Care andBroader Medical Community Collaboration
(Point A)
Existing Paradigms There is a growing body of evidence that espouses primary
care provider involvement in the care of patients with a sleep complaint.
Internationally, there have been randomized controlled trials that support primary
care physicians and nurses in the management of OSA [8–11]. Additionally, identi-
prob OSA
↓ prob other non-
Patient symptoms
A
Primary care provider
Specialty provider
- Pulmonology
- Cardiology
- Neurology
- Bariatric Medicine
-Otolaryngology
- Psychiatry
B
insomnia sleep d/o
C
S
↑ prob OSA
↑ prob insomnia
c
↑ prob OSA
r
↑ prob other noninsomnia sleep d/o
e
↓ prob OSA
e
↑ prob other noninsomnia sleep d/o
n
↓ prob OSA
i
↑ prob insomnia
n
↓ prob OSA
↓ prob other non-
g
insomnia sleep d/o
OR
D
HSAT
E
Provider
comfortable w/
dx & tx of sleep
disorder
CBT-I
Referral
CBT-I Referral∗,
if appropriate
Sleep
Medicine
Provider
E
E
∗
Consider
non-sleep
related
work-up
Fig. 4.1 Patient-centered access to sleep care: entry, diagnosis, and initiation of treatment. A
Primary care and broader medical community collaboration, B Non-sleep specialty care collaboration, C Development of sound screening protocols, D Leveraging telemedicine, E Provider-toprovider interaction, F Ongoing sleep concerns requiring sleep medicine referral. *In person,
telemedicine, or online. **In person or telemedicine
D
E
Patient-
D
∗∗
centered
treatment
D
D
F
and
education

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B. G. Fields and I. M. Rosen
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Patient-
centered
treatment
and
education
A & B
Non-sleep specialist
(NSS) +/-sleep
medicine/team support
(embedded sleep
provider, e-consult)
Possible Sleep
Medicine referral
depending on primary
care/non-sleep
specialist knowledge
and workload
Lack of
patient
response
Ongoing
management
with provider of
patient’s
preference and
inclusive of
collaboration
with Sleep
medicine/Team
∗
Support
Collaborative guidelines
adjustments as needed
D & E
D & E
D & E
could be set for this
nationally with local
NSS whom
patient sees
regularly with
outreach to sleep
team (in person,
e-consult,
telehealth) for
concerning
changes in status
Alternating visits
with NSS and
sleep team (via
telehealth or in
person)
Sleep Team
(in person or
via telehealth)
Fig. 4.2 Patient-centered access to sleep care: long-term care management, patient and provider
education and collaboration. A Primary care and broader medical community collaboration, B
Non-sleep specialty care collaboration, D Leveraging telemedicine, E Provider-to-provider interaction. *In person, telemedicine, or online
cation of OSA has been augmented by community pharmacist involvement in
screening and appropriate communication with primary care providers [12, 13]. In
the United States, similar models have been employed in family practice clinics, the
Wisconsin Department of Corrections [14], and the Veterans Health Administration,
as well as at Kaiser Permanente. However, the success of these programs has not
been systematically studied. Newer models involve healthcare businesses, such as
CVS Health, utilizing direct-to-consumer marketing and treatment [15].
Although the majority of these models have a primary focus on obstructive sleep
apnea, more recently there has been attention to models to treat insomnia outside of
sleep specialists and accredited-sleep centers [16–18]. A majority of patients with
insomnia present to their primary care provider with complaints of insomnia [19,
20], but primary care has a shortage of treatment options [21]. Many primary care
providers recognize the limitations of the use of prescription hypnotic medications;
they may or may not share sleep hygiene recommendations depending on their
knowledge of and comfort with such suggestions. Despite the recommendations for
non-pharmacologic treatments such as cognitive behavioral therapy for insomnia
(CBTi), [22–24] many non-sleep providers rarely provide such therapies likely due
to a lack of knowledge [25–27], training [25, 27, 28], and time [25, 29]. Despite
these barriers, improvement in important sleep variables has been noted when
nurses in primary care deliver strictly manual-based cognitive behavioral therapy
for insomnia (CBTi), [16, 17] mental health nurse practitioners provide brief behav-
ioral therapy for insomnia to elderly patients in a primary care practice [30], and
health district nurses offer cognitive-behavioral therapy for insomnia to patients in

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primary health care center [21]. Additionally, it has been recognized that primary
care providers play an important role in the diagnosis and initial treatment of restless leg syndrome [31].
We propose the integration of primary care into the paradigm of evaluation and
treatment of common sleep disorders including a combination of both stepped care
and hub and spoke models [32]. If the hub is the BSCMP, the Sleep Team and the
accredited sleep center, the spokes are primary care providers and non-sleep specialists. A stepped care model would outline patient populations and tasks that could
be shifted to these non-sleep medicine providers and appropriate team members in
the spokes that may not ever require interaction with the hub. Such models have
been proposed for obstructive sleep apnea [32] and chronic insomnia [33].
Accounting for the high prevalence of OSA and insomnia as well as the reality of
OSA with signicant comorbid insomnia [34, 35], a truly patient-centered care
model would consider the management of both of these disorders. Given the known
barriers which typically limit access to the specialist in the stepped model, clear
delineations of hubs and the leveraging of telemedicine will need to be considered
[14, 18, 32, 36]. Additionally, identication of barriers and facilitators of care with
relevant stakeholders, inclusive of providers and patients, is required to ensure optimal sleep care delivery [37].
Project ECHO To support the “proof of concept” programs described above, educational opportunities are needed for practicing primary care providers in sleep
medicine management (Fig. 4.1, Point A). One strategy utilized in the Veterans
Administration (VA) system has been Specialty Care Access Network-Extension
for Community Healthcare Outcomes (Scan-ECHO), subsequently re-labeled
Project ECHO.The program, developed at the University of New Mexico in 2003,
was implemented to better serve rural patients with limited access to specialty care.
Frequently, their challenge is not actually seeing a specialist; clinical video telehealth is lling this role more and more. Rather, the challenge is the limited number
of specialists available. Project ECHO seeks to involve more primary care providers
in specialty care through education, thereby improving access to that care.
The VA-based program (VA-ECHO) leverages telehealth (described more below)
to drive educational outcomes. Specialists present short didactic sessions to primary
care clinicians through real-time video over the course of months. As the program
progresses, the generalists may engage in case discussions with the specialists.
Other professionals such as nurses, pharmacists, and technicians are often involved
on both sides of the camera to enhance a team-based approach to patient care [38].
VA-ECHO has been deployed in many specialties, with positive outcomes published in hepatology, [39] geriatrics [40], and pain management [41]. Sleep
VA-ECHO has also emerged. A pilot program at the VA Puget Sound Health Care
System (VAPSHCS) found rural providers receptive to its curriculum over the
3-month course. Participants reported enhanced comfort managing common sleep
complaints (e.g., sleep-disordered breathing, insomnia, PTSD-related sleep problems) and providing appropriate patient education [42].

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Programs like Project ECHO could enhance current sleep medicine care models
by expanding the number of providers from which that care can be delivered, even
if they are not BCSMPs. However, challenges remain. The authors at the VAPSHCS
surveyed rural providers who had not taken part in the training; lack of protected
time was the most common reason [42]. For already-overburdened providers, it can
be difcult to t regular specialty training into their day. Another challenge is one
of generalizability. That is, how well does VA ECHO translate outside of a singlepayer health system? Signicant investment is needed, in both time and money, for
any health system to implement the program. Strong business cases are required to
show that patient health and their healthcare expenditures could be optimized if
more non-subspecialist providers could integrate sleep medicine care into that
which they already provide. Data on the success of non-VA ECHO type programs is
lacking.
B. G. Fields and I. M. Rosen
Non-Sleep Specialty Care Collaboration (Point B)
As noted above, a collaborative sleep care model involving non-BCSMPs hinges on
non-specialty trained providers’ sufcient education in the specialty. While board
certication in sleep medicine requires both completion of a 1-year Accreditation
Council for Graduate Medical Education (ACGME)-accredited fellowship and
passing a certication examination, many non-BCSMPs can participate substantively in patients’ care. Opportunities for this education may come either during
professional training (i.e., medical school, residency, non-sleep medicine fellowship) or after that training as part of continuing medical education (CME).
American medical schools allot just 2–4hours to sleep education, 0.06% of their
preclinical curriculum [43]. There have been pilot projects aimed at increasing that
proportion. In one study, faculty presented 87 Johns Hopkins University medical
students with online learning modules. These students showed signicant improvement in sleep-related knowledge after viewing these 20- to 30-minute modules compared to “sham” modules [44]. Nevertheless, similar efforts have not gained a
wide-scale footing. A frequently cited challenge is time; medical school faculty are
increasingly challenged to t the breadth of human medicine into a limited schedule
while attending to other needs such as students’ wellness and early clinical exposure.
Neurology educators have suggested including sleep medicine content into medical
students’ neuroscience curriculum. They propose this content be presented for
2–4hours per year as ipped-classroom sessions, didactics, and clinical opportunities depending on the year of training [45]. This dovetailing of sleep content with
existing curriculum blocks offers another strategy to expose medical students to
more substantive sleep education throughout their undergraduate medical training.
To augment these efforts, many non-BCSMPs would benet from sleep medicine exposure during their post-graduate training years (i.e., residency and fellowship). While otolaryngology (ENT) residents are eligible for sleep medicine

4 The Future ofSleep Medicine: APatient-Centered Model ofCare
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fellowship training upon completion of their residency, they could also serve a
unique role in sleep disorders management without that subspecialty training. A
recent survey revealed that ENT attendings vary widely in their sleep surgical practice and, therefore, the amount of sleep training they provide to their residents. An
ENT surgeon having obtained sleep medicine board certication predicted the
extent of trainee exposure to the subspecialty [46]. Another survey used consensus
among academic otolaryngologists involved in sleep disorder treatment to create
sleep-related learning objectives for ENT residencies. These objectives form the
basis of online learning modules, enhancing the level of sleep education even among
non-sleep-focused otolaryngologists [47]. Such strategies may also help widen the
pipeline of ENT trainees entering sleep medicine fellowships. Neurologists found
that residency programs investing more heavily in sleep education report more program graduates entering the subspecialty [48].
In addition to ENT and neurology trainees, pulmonary medicine fellows are
uniquely positioned to participate in collaborative sleep care whether or not they
subspecialize in sleep medicine. Indeed, sleep content accounts for about 10% of
the American Board of Internal Medicine’s pulmonary medicine examination [49].
A multi-society panel was convened to develop sleep-related curricular recommendations for pulmonary medicine fellowships. After 5 rounds of voting, they created
52 elements, ranging from recognizing central apnea on sleep testing to insomnia
and narcolepsy evaluation. Therefore, they advocate pulmonologists not only be
well-versed in sleep-disordered breathing, but also in more psychologically and
neurologically based sleep disorders. Threshold for referral to a sleep medicine
specialist is left to the individual provider based on self-perception of knowledge
base and local availability of such subspecialization [50]. Of course, as in undergraduate medical education, time in a pulmonary medicine fellowship is limited.
Program directors could integrate sleep content with training modules that already
exist to enhance efciency of its delivery (e.g., nocturnal PAP therapy for severe
COPD) [51].
75
Development ofSound Screening Protocols (Point C)
Questionnaires Point of care interventions to further facilitate screening and man-
agement of sleep disorders have included clinician chart reminders [52] and efforts
to promote shared decision making [53] including patient decision aids [54–57] and
patient educational websites [58–60]. The promotion of screeners for sleepiness
[61] and questionnaires such as the STOP-BANG for OSA, [62–64] Insomnia
Severity Index for insomnia, [61, 65] and several for restless leg syndrome [66–69]
with appropriate clinical nudges [70] have been shown to facilitate appropriate
diagnosis and access to care for patients with these sleep disorders. Additionally,
there are several questionnaires that screen for multiple sleep disorders at one time
which may be suitable as a general sleep disorders screener [71].

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B. G. Fields and I. M. Rosen
Despite such available tools, a majority of the screening initiatives have focused
narrowly on OSA.While increased screening, evaluation, and treatment for OSA
alone will undoubtedly have a signicant impact, broader consideration of sleep
disorders will better facilitate access to care in a patient-centered fashion. To our
knowledge, the only trans-sleep-disorders approach to be adopted exists in the
Veterans Health Administration (VHA) [72]. The VHA TeleSleep system utilizes
non- sleep specialists to increase patient screening with subsequent referral to a
Sleep Center “Hub” for diagnosis and treatment. However, this model of relying on
the provider to identify signs and symptoms of a sleep disorder has been noted to be
an inconsistent and unreliable paradigm [73]. Adding patient-administered screeners, which then serves as a chart-based “nudge” to the busy primary care provider,
is an innovation that fundamentally changes sleep-care paradigms by leveraging
technology and patient empowerment [74].
Articial Intelligence/Machine Learning Despite sleep disorders’ prevalence
and a myriad of available screening tools, sleep problems can be challenging to
screen for and identify in busy, non-sleep specialized clinical environments. Robust,
accessible tools are needed to guide the clinicians who work in them without disruption to their other duties. Articial intelligence (AI) holds promise to ll this vital
role. AI refers to computers’ ability to perform tasks traditionally completed by
humans [75]. Machine learning (ML) is a term often used interchangeably with AI;
instead of relying on direct computer programming for each action, ML algorithms
“learn” from previous experience to enhance future performance on tasks such as
disease classication. A recent American Academy of Sleep Medicine (AASM)
Position Statement on AI suggests that multi-channel polysomnographic (PSG) data
lends itself particularly well to this type of ML analyses [75]. However, the opportunity for AI in sleep medicine care goes far beyond the sleep laboratory.
There are many opportunities for AI utilization throughout sleep medicine and
other specialties that interface with it. Patients possess a wealth of symptomatic,
demographic, and comorbidity-based data “channels” even at their initial presentation to primary care providers and non-sleep specialists (Fig.4.1, Points A & B). It
is likely that AI will leverage ML using electronic medical record (EMR) data and
patients’ symptomatic reports to identify individuals at risk for a sleep disorder who
may benet from a thorough sleep evaluation. For instance, there is growing evidence that obstructive sleep apnea (OSA) symptom phenotypes can be clustered
into disturbed sleep, slightly sleepy, moderately sleepy, and excessively sleepy subtypes [76, 77] Identifying patients with sleepier subtypes is important given these
subtypes’ association with worsened CVD, CHF, and CAD [78]. An ML system
integrated into the EMR could function in this manner, alerting providers that a
patient’s objective (e.g., age, gender, and BMI) and subjective (e.g., sleepiness) phenotype places that individual into a high-risk group if found to have OSA.More
detailed OSA screening could be prioritized for such a subset of patients.
The importance of AI-based phenotypic subtyping may also extend to OSA
treatment initiation. A more nuanced, personalized treatment plan could develop as
more is learned about etiologic OSA subtypes. Emerging data suggest that this

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77
disorder is the nal common endpoint of diverse, sleep-induced pathophysiological
processes such as impaired pharyngeal dilator muscle function, increased sensitivity to airway narrowing (low arousal threshold), and respiratory control instability
from the central nervous system. ML that incorporates these parameters could
reveal more targeted and personalized treatment options a given patient may tolerate
best [79]. If more conventional positive airway pressure (PAP) is the chosen intervention, AI would once again have a role. Although some studies have cast doubt on
the cardiovascular disease benets of PAP, many of the sleepiest patients were
excluded from these analyses [80, 81]. Given the increased CVD implications in
OSA patients with excessive sleepiness, AI may help identify those patients who
could benet most from PAP use [82]. Providers would be better informed as to
whom to focus cloud-based PAP adherence monitoring, and patients could experience enhanced motivation to continue with that therapy.
AI’s involvement in sleep medicine may also extend to other disorders, such as
narcolepsy. Multiple sleep latency testing (MSLT) has limited specicity (73.3% at
the <8minute mean sleep onset latency cutoff), due at least in part to suboptimal
interrater reliability among epochs scored [83]. Researchers have leveraged ML to
stage as little as 5seconds of sleep, a level of precision much greater than the conventional 30-second epoch scoring. They demonstrated 96% sensitivity and 91%
specicity for narcolepsy Type 1, a specicity that rises to 99% when adding HLADQB1*06:02 typing to their model [84]. As the authors state, AI-guided diagnosis
should not supplant BCSMP review and judgment. On the contrary, AI can be utilized as another type of twenty-rst century “physician extender,” allowing them to
focus more efciently on the most complex patient management issues while reaching a larger population. Reviewing Fig.4.1, one can foresee AI assisting both sleep
clinicians and non-clinicians at each step in the initial symptom presentation and
evaluation process. Indeed, even non-sleep clinicians could be guided to order home
sleep apnea testing (HSAT) in the higher risk patients for OSA (Fig.4.1, Point D).
AI could then assist BCSMPs in interpreting the studies, prescribing the most effective therapies, and assisting clinicians with ongoing follow up (e.g., anticipate
needed changes in PAP settings or to other modes of treatment).
Patient and Provider Portals
ment that leads a provider to suspect a sleep disorder, further symptom-based
screening is typically indicated (Fig. 4.1). This screening is essential to gauge
potential sleep disorder severity, delineate among potential disorders, and create a
symptomatic baseline with which to compare symptoms after any treatment has
commenced. Screening tools can also help primary care physicians and non-sleep
providers triage this group of patients; as noted above, some clinicians may choose
to order HSAT for patients with a high probability of OSA but a low probability of
other sleep disorders (Fig.4.1, Point D).
One strategy to expedite and streamline patients’ symptomatic information ow
to providers (both at initial presentation and during follow-up) has been through
dual-facing, internet-based patient and provider portals. Although there are no published clinical trials utilizing such a portal, one is currently being conducted using
Whether it is a nudge from AI or from clinical judg-
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