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95. Williams N, Jean-Louis G, Pandey A, Ravenell J, Boutin-Foster C, Ogedegbe G.Excessive
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Chapter 4
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The Future ofSleep Medicine: APatient-Centered Model ofCare
BarryG.Fields andIleneM.Rosen
Keywords Future of sleep medicine · Patient-centered care · Collaborative care ·
Sleep telemedicine · Articial intelligence
Nearly 70years ago, Nathaniel Kleitman, a professor of physiology at the University of Chicago, and his graduate student, Eugene Aserinksy, studied eye movements leading to a seminal paper in 1953 describing a new sleep state, rapid eye movement (REM) sleep. In 1957, Kleitman and William Dement, another graduate student, described the human sleep cycle of NREM sleep stages of increasing depth fol­lowed by periods of REM sleep, with the cycles repeating through the night [1]. These discoveries established sleep as a scientic discipline. Over the next 30years, sleep medicine developed as its own clinical discipline with development of American Academy Sleep Medicine (AASM)-accredited clinical training pathways starting in 1988 and certication available through the American Board of Sleep Medicine (ABSM) from 1991 to 2006. During this time, 3500 physicians were ABSM certied in sleep medicine. In 2005, Sleep Medicine training was ofcially recognized by the Accreditation Council of Graduate Medical Education (ACGME) with approval by the American Board of Medical Specialties (ABMS) to offer a certication examination.
Currently, there are approximately 200 positions available for one-year subspe­cialty training in sleep medicine nationwide [2] and approximately 175–180 are
B. G. Fields Emory University, Division of Pulmonary, Allergy and Critical Care Medicine, Atlanta, GA, USA
I. M. Rosen ( Division of Sleep Medicine, Perelman School of Medicine at the University of Pennsylvania PCAM, Philadelphia, PA, USA e-mail: ilene.rosen@pennmedicine.upenn.edu; Ilene.Rosen@uphs.upenn.edu
M. S. Badr, J. L. Martin (eds.), Essentials of Sleep Medicine, Respiratory Medicine, https://doi.org/10.1007/978-3-030-93739-3_4
*)
69© Springer Nature Switzerland AG 2022
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B. G. Fields and I. M. Rosen
trained each year. In the last decade, there were 3500 rst-time takers of the ABMS­certication exam in sleep medicine; this number is down 1500 since 2018 [3]. In the early years, many physicians practicing sleep medicine took the exam based on a clinical-experience waiver; these physicians, along with those who were still only certied by the ABSM, led to a peak number of nearly 6000 Board-Certied Sleep Medicine Physicians (BCSMPs) in 2018. Since that time, those numbers have waned. Starting in 2013, physicians needed to complete an ACGME-accredited sleep fellowship in order to sit for the certication exam. Furthermore, the total number of retired sleep physicians from 2013 to 2018 was 7 times the number of new BCSMPs during the same time period (AASM, email communication, October 2018).
As a result, the BCSMP workforce is insufcient to meet the demands of the enormous population of patients who have a sleep disease, including an estimated
23.5 million U.S. adults with undiagnosed OSA and the 24.2 million individuals with chronic insomnia [4]. This shortfall results from some unintended conse­quences of recognition of sleep medicine as a specialty by the ACGME and ABMS.First, there are now a limited number of ACGME-accredited training spots that allow physicians to sit for the certication examination. Second, interest in those slots has varied in recent years, perhaps because of the need for a full extra year of training along with concerns regarding reduced reimbursements as home sleep apnea testing becomes the norm [5].
These workforce pipeline issues interact with known factors at the individual (e.g., race), family (e.g., beliefs), and broader socio-cultural (e.g., insurance coverage) lev­els to limit access to sleep medicine care [6]. Pre-existing geographic barriers and accredited sleep centers’ clustering in more highly populated areas further exacerbate these disparities. This situation highlights the need for shared responsibility among BCSMPs and other providers for treating patients with sleep disorders. Given the magnitude of individuals who suffer with a sleep disorder and the benets associated with treatment, patients deserve a collective response from our healthcare system. There are six feeder specialties including Anesthesia, Family Medicine, Internal Medicine, Neurology, Otorhinolaryngology (Ear, Nose &Throat/ENT), and Pediatrics. Unfortunately, there has been a disconnect between the magnitude of the disease bur­den, the broad relevance across many specialties, and the lack of success of the efforts to infuse sleep education at all levels [7]. Not only is it difcult to gain traction for sleep medicine curricula in medical schools, but also in the feeder specialties into sleep medicine; only ENT has specic program requirements about education in sleep beyond the general ACGME requirements of fatigue mitigation strategies.
Re-centering the spotlight on patient-centered care requires reconsideration of the current model of care which presently involves nearly automatic referral of patients with a sleep complaint to a sleep specialist or to a sleep center for testing. Unfortunately, long waits and fragmented care have been the norm. Although the spread of telemedicine during the COVID-19 pandemic has potentially improved access to care by removing geographic barriers, the sleep eld still suffers from a conundrum: As the general public increasingly recognizes importance of sleep health, there is a scarcity of providers to ensure it. Thus, we propose a patient­centered point of care model that facilitates the patient receiving the best possible
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care for their sleep complaints to promote sleep health which utilizes patient, pro­vider, educational, and technological resources.
A Patient-Centered Model ofSleep Care
Figures 4.1 and 4.2 outline our proposed integrated model for the future of sleep care, and they will be referenced throughout the rest of this chapter. The emphasis is on a patient-centered approach, so that a patient can get the sleep care they need at a time and place that is convenient for them, regardless of the availability of a one-on-one appointment with a sleep specialist. Figure4.1 traces a patient’s evalu­ation and diagnosis pathway from left to right, starting with their symptomatic con­cerns and nishing with patient-centered education and treatment. This intervention may occur through a referral to sleep specialist or non-sleep specialist workup. Figure4.2 follows a patient from treatment initiation through ongoing management. Here, the stress is on ongoing collaboration between non-sleep medicine specialists and sleep medicine specialists. Points A–F indicated throughout Figs.4.1 and 4.2 refer to topics presented in each of the next ve sections.
Primary Care andBroader Medical Community Collaboration (Point A)
Existing Paradigms There is a growing body of evidence that espouses primary care provider involvement in the care of patients with a sleep complaint. Internationally, there have been randomized controlled trials that support primary care physicians and nurses in the management of OSA [8–11]. Additionally, identi-
prob OSA
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E
E
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related
work-up
Fig. 4.1 Patient-centered access to sleep care: entry, diagnosis, and initiation of treatment. A Primary care and broader medical community collaboration, B Non-sleep specialty care collabora­tion, C Development of sound screening protocols, D Leveraging telemedicine, E Provider-to­provider interaction, F Ongoing sleep concerns requiring sleep medicine referral. *In person, telemedicine, or online. **In person or telemedicine
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Patient-
centered
treatment
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education
A & B
Non-sleep specialist (NSS) +/-sleep medicine/team support (embedded sleep provider, e-consult)
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Medicine referral
depending on primary
care/non-sleep
specialist knowledge
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patient’s
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NSS whom patient sees
regularly with
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team (in person,
e-consult,
telehealth) for
concerning
changes in status
Alternating visits
with NSS and sleep team (via telehealth or in
person)
Sleep Team
(in person or via telehealth)
Fig. 4.2 Patient-centered access to sleep care: long-term care management, patient and provider education and collaboration. A Primary care and broader medical community collaboration, B Non-sleep specialty care collaboration, D Leveraging telemedicine, E Provider-to-provider inter­action. *In person, telemedicine, or online
cation of OSA has been augmented by community pharmacist involvement in screening and appropriate communication with primary care providers [12, 13]. In the United States, similar models have been employed in family practice clinics, the Wisconsin Department of Corrections [14], and the Veterans Health Administration, as well as at Kaiser Permanente. However, the success of these programs has not been systematically studied. Newer models involve healthcare businesses, such as CVS Health, utilizing direct-to-consumer marketing and treatment [15].
Although the majority of these models have a primary focus on obstructive sleep apnea, more recently there has been attention to models to treat insomnia outside of sleep specialists and accredited-sleep centers [16–18]. A majority of patients with insomnia present to their primary care provider with complaints of insomnia [19,
20], but primary care has a shortage of treatment options [21]. Many primary care
providers recognize the limitations of the use of prescription hypnotic medications; they may or may not share sleep hygiene recommendations depending on their knowledge of and comfort with such suggestions. Despite the recommendations for non-pharmacologic treatments such as cognitive behavioral therapy for insomnia (CBTi), [22–24] many non-sleep providers rarely provide such therapies likely due to a lack of knowledge [25–27], training [25, 27, 28], and time [25, 29]. Despite these barriers, improvement in important sleep variables has been noted when nurses in primary care deliver strictly manual-based cognitive behavioral therapy for insomnia (CBTi), [16, 17] mental health nurse practitioners provide brief behav- ioral therapy for insomnia to elderly patients in a primary care practice [30], and health district nurses offer cognitive-behavioral therapy for insomnia to patients in
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primary health care center [21]. Additionally, it has been recognized that primary care providers play an important role in the diagnosis and initial treatment of rest­less leg syndrome [31].
We propose the integration of primary care into the paradigm of evaluation and treatment of common sleep disorders including a combination of both stepped care and hub and spoke models [32]. If the hub is the BSCMP, the Sleep Team and the accredited sleep center, the spokes are primary care providers and non-sleep spe­cialists. A stepped care model would outline patient populations and tasks that could be shifted to these non-sleep medicine providers and appropriate team members in the spokes that may not ever require interaction with the hub. Such models have been proposed for obstructive sleep apnea [32] and chronic insomnia [33]. Accounting for the high prevalence of OSA and insomnia as well as the reality of OSA with signicant comorbid insomnia [34, 35], a truly patient-centered care model would consider the management of both of these disorders. Given the known barriers which typically limit access to the specialist in the stepped model, clear delineations of hubs and the leveraging of telemedicine will need to be considered [14, 18, 32, 36]. Additionally, identication of barriers and facilitators of care with relevant stakeholders, inclusive of providers and patients, is required to ensure opti­mal sleep care delivery [37].
Project ECHO To support the “proof of concept” programs described above, edu­cational opportunities are needed for practicing primary care providers in sleep medicine management (Fig. 4.1, Point A). One strategy utilized in the Veterans Administration (VA) system has been Specialty Care Access Network-Extension for Community Healthcare Outcomes (Scan-ECHO), subsequently re-labeled Project ECHO.The program, developed at the University of New Mexico in 2003, was implemented to better serve rural patients with limited access to specialty care. Frequently, their challenge is not actually seeing a specialist; clinical video tele­health is lling this role more and more. Rather, the challenge is the limited number of specialists available. Project ECHO seeks to involve more primary care providers in specialty care through education, thereby improving access to that care.
The VA-based program (VA-ECHO) leverages telehealth (described more below) to drive educational outcomes. Specialists present short didactic sessions to primary care clinicians through real-time video over the course of months. As the program progresses, the generalists may engage in case discussions with the specialists. Other professionals such as nurses, pharmacists, and technicians are often involved on both sides of the camera to enhance a team-based approach to patient care [38]. VA-ECHO has been deployed in many specialties, with positive outcomes pub­lished in hepatology, [39] geriatrics [40], and pain management [41]. Sleep VA-ECHO has also emerged. A pilot program at the VA Puget Sound Health Care System (VAPSHCS) found rural providers receptive to its curriculum over the 3-month course. Participants reported enhanced comfort managing common sleep complaints (e.g., sleep-disordered breathing, insomnia, PTSD-related sleep prob­lems) and providing appropriate patient education [42].
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Programs like Project ECHO could enhance current sleep medicine care models by expanding the number of providers from which that care can be delivered, even if they are not BCSMPs. However, challenges remain. The authors at the VAPSHCS surveyed rural providers who had not taken part in the training; lack of protected time was the most common reason [42]. For already-overburdened providers, it can be difcult to t regular specialty training into their day. Another challenge is one of generalizability. That is, how well does VA ECHO translate outside of a single­payer health system? Signicant investment is needed, in both time and money, for any health system to implement the program. Strong business cases are required to show that patient health and their healthcare expenditures could be optimized if more non-subspecialist providers could integrate sleep medicine care into that which they already provide. Data on the success of non-VA ECHO type programs is lacking.
B. G. Fields and I. M. Rosen
Non-Sleep Specialty Care Collaboration (Point B)
As noted above, a collaborative sleep care model involving non-BCSMPs hinges on non-specialty trained providers’ sufcient education in the specialty. While board certication in sleep medicine requires both completion of a 1-year Accreditation Council for Graduate Medical Education (ACGME)-accredited fellowship and passing a certication examination, many non-BCSMPs can participate substan­tively in patients’ care. Opportunities for this education may come either during professional training (i.e., medical school, residency, non-sleep medicine fellow­ship) or after that training as part of continuing medical education (CME).
American medical schools allot just 2–4hours to sleep education, 0.06% of their preclinical curriculum [43]. There have been pilot projects aimed at increasing that proportion. In one study, faculty presented 87 Johns Hopkins University medical students with online learning modules. These students showed signicant improve­ment in sleep-related knowledge after viewing these 20- to 30-minute modules com­pared to “sham” modules [44]. Nevertheless, similar efforts have not gained a wide-scale footing. A frequently cited challenge is time; medical school faculty are increasingly challenged to t the breadth of human medicine into a limited schedule while attending to other needs such as students’ wellness and early clinical exposure. Neurology educators have suggested including sleep medicine content into medical students’ neuroscience curriculum. They propose this content be presented for 2–4hours per year as ipped-classroom sessions, didactics, and clinical opportuni­ties depending on the year of training [45]. This dovetailing of sleep content with existing curriculum blocks offers another strategy to expose medical students to more substantive sleep education throughout their undergraduate medical training.
To augment these efforts, many non-BCSMPs would benet from sleep medi­cine exposure during their post-graduate training years (i.e., residency and fellow­ship). While otolaryngology (ENT) residents are eligible for sleep medicine
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fellowship training upon completion of their residency, they could also serve a unique role in sleep disorders management without that subspecialty training. A recent survey revealed that ENT attendings vary widely in their sleep surgical prac­tice and, therefore, the amount of sleep training they provide to their residents. An ENT surgeon having obtained sleep medicine board certication predicted the extent of trainee exposure to the subspecialty [46]. Another survey used consensus among academic otolaryngologists involved in sleep disorder treatment to create sleep-related learning objectives for ENT residencies. These objectives form the basis of online learning modules, enhancing the level of sleep education even among non-sleep-focused otolaryngologists [47]. Such strategies may also help widen the pipeline of ENT trainees entering sleep medicine fellowships. Neurologists found that residency programs investing more heavily in sleep education report more pro­gram graduates entering the subspecialty [48].
In addition to ENT and neurology trainees, pulmonary medicine fellows are uniquely positioned to participate in collaborative sleep care whether or not they subspecialize in sleep medicine. Indeed, sleep content accounts for about 10% of the American Board of Internal Medicine’s pulmonary medicine examination [49]. A multi-society panel was convened to develop sleep-related curricular recommen­dations for pulmonary medicine fellowships. After 5 rounds of voting, they created 52 elements, ranging from recognizing central apnea on sleep testing to insomnia and narcolepsy evaluation. Therefore, they advocate pulmonologists not only be well-versed in sleep-disordered breathing, but also in more psychologically and neurologically based sleep disorders. Threshold for referral to a sleep medicine specialist is left to the individual provider based on self-perception of knowledge base and local availability of such subspecialization [50]. Of course, as in under­graduate medical education, time in a pulmonary medicine fellowship is limited. Program directors could integrate sleep content with training modules that already exist to enhance efciency of its delivery (e.g., nocturnal PAP therapy for severe COPD) [51].
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Development ofSound Screening Protocols (Point C)
Questionnaires Point of care interventions to further facilitate screening and man-
agement of sleep disorders have included clinician chart reminders [52] and efforts to promote shared decision making [53] including patient decision aids [54–57] and patient educational websites [58–60]. The promotion of screeners for sleepiness [61] and questionnaires such as the STOP-BANG for OSA, [62–64] Insomnia Severity Index for insomnia, [61, 65] and several for restless leg syndrome [66–69] with appropriate clinical nudges [70] have been shown to facilitate appropriate diagnosis and access to care for patients with these sleep disorders. Additionally, there are several questionnaires that screen for multiple sleep disorders at one time which may be suitable as a general sleep disorders screener [71].
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Despite such available tools, a majority of the screening initiatives have focused narrowly on OSA.While increased screening, evaluation, and treatment for OSA alone will undoubtedly have a signicant impact, broader consideration of sleep disorders will better facilitate access to care in a patient-centered fashion. To our knowledge, the only trans-sleep-disorders approach to be adopted exists in the Veterans Health Administration (VHA) [72]. The VHA TeleSleep system utilizes non- sleep specialists to increase patient screening with subsequent referral to a Sleep Center “Hub” for diagnosis and treatment. However, this model of relying on the provider to identify signs and symptoms of a sleep disorder has been noted to be an inconsistent and unreliable paradigm [73]. Adding patient-administered screen­ers, which then serves as a chart-based “nudge” to the busy primary care provider, is an innovation that fundamentally changes sleep-care paradigms by leveraging technology and patient empowerment [74].
Articial Intelligence/Machine Learning Despite sleep disorders’ prevalence and a myriad of available screening tools, sleep problems can be challenging to screen for and identify in busy, non-sleep specialized clinical environments. Robust, accessible tools are needed to guide the clinicians who work in them without disrup­tion to their other duties. Articial intelligence (AI) holds promise to ll this vital role. AI refers to computers’ ability to perform tasks traditionally completed by humans [75]. Machine learning (ML) is a term often used interchangeably with AI; instead of relying on direct computer programming for each action, ML algorithms “learn” from previous experience to enhance future performance on tasks such as disease classication. A recent American Academy of Sleep Medicine (AASM) Position Statement on AI suggests that multi-channel polysomnographic (PSG) data lends itself particularly well to this type of ML analyses [75]. However, the oppor­tunity for AI in sleep medicine care goes far beyond the sleep laboratory.
There are many opportunities for AI utilization throughout sleep medicine and other specialties that interface with it. Patients possess a wealth of symptomatic, demographic, and comorbidity-based data “channels” even at their initial presenta­tion to primary care providers and non-sleep specialists (Fig.4.1, Points A & B). It is likely that AI will leverage ML using electronic medical record (EMR) data and patients’ symptomatic reports to identify individuals at risk for a sleep disorder who may benet from a thorough sleep evaluation. For instance, there is growing evi­dence that obstructive sleep apnea (OSA) symptom phenotypes can be clustered into disturbed sleep, slightly sleepy, moderately sleepy, and excessively sleepy sub­types [76, 77] Identifying patients with sleepier subtypes is important given these subtypes’ association with worsened CVD, CHF, and CAD [78]. An ML system integrated into the EMR could function in this manner, alerting providers that a patient’s objective (e.g., age, gender, and BMI) and subjective (e.g., sleepiness) phe­notype places that individual into a high-risk group if found to have OSA.More detailed OSA screening could be prioritized for such a subset of patients.
The importance of AI-based phenotypic subtyping may also extend to OSA treatment initiation. A more nuanced, personalized treatment plan could develop as more is learned about etiologic OSA subtypes. Emerging data suggest that this
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disorder is the nal common endpoint of diverse, sleep-induced pathophysiological processes such as impaired pharyngeal dilator muscle function, increased sensitiv­ity to airway narrowing (low arousal threshold), and respiratory control instability from the central nervous system. ML that incorporates these parameters could reveal more targeted and personalized treatment options a given patient may tolerate best [79]. If more conventional positive airway pressure (PAP) is the chosen inter­vention, AI would once again have a role. Although some studies have cast doubt on the cardiovascular disease benets of PAP, many of the sleepiest patients were excluded from these analyses [80, 81]. Given the increased CVD implications in OSA patients with excessive sleepiness, AI may help identify those patients who could benet most from PAP use [82]. Providers would be better informed as to whom to focus cloud-based PAP adherence monitoring, and patients could experi­ence enhanced motivation to continue with that therapy.
AI’s involvement in sleep medicine may also extend to other disorders, such as narcolepsy. Multiple sleep latency testing (MSLT) has limited specicity (73.3% at the <8minute mean sleep onset latency cutoff), due at least in part to suboptimal interrater reliability among epochs scored [83]. Researchers have leveraged ML to stage as little as 5seconds of sleep, a level of precision much greater than the con­ventional 30-second epoch scoring. They demonstrated 96% sensitivity and 91% specicity for narcolepsy Type 1, a specicity that rises to 99% when adding HLA­DQB1*06:02 typing to their model [84]. As the authors state, AI-guided diagnosis should not supplant BCSMP review and judgment. On the contrary, AI can be uti­lized as another type of twenty-rst century “physician extender,” allowing them to focus more efciently on the most complex patient management issues while reach­ing a larger population. Reviewing Fig.4.1, one can foresee AI assisting both sleep clinicians and non-clinicians at each step in the initial symptom presentation and evaluation process. Indeed, even non-sleep clinicians could be guided to order home sleep apnea testing (HSAT) in the higher risk patients for OSA (Fig.4.1, Point D). AI could then assist BCSMPs in interpreting the studies, prescribing the most effec­tive therapies, and assisting clinicians with ongoing follow up (e.g., anticipate needed changes in PAP settings or to other modes of treatment).
Patient and Provider Portals
ment that leads a provider to suspect a sleep disorder, further symptom-based screening is typically indicated (Fig. 4.1). This screening is essential to gauge potential sleep disorder severity, delineate among potential disorders, and create a symptomatic baseline with which to compare symptoms after any treatment has commenced. Screening tools can also help primary care physicians and non-sleep providers triage this group of patients; as noted above, some clinicians may choose to order HSAT for patients with a high probability of OSA but a low probability of other sleep disorders (Fig.4.1, Point D).
One strategy to expedite and streamline patients’ symptomatic information ow to providers (both at initial presentation and during follow-up) has been through dual-facing, internet-based patient and provider portals. Although there are no pub­lished clinical trials utilizing such a portal, one is currently being conducted using
Whether it is a nudge from AI or from clinical judg-