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Ростовский Государственный Медицинский Университет

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Книга_5657_Библиотеки_им_академика_М_И_Перельмана

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234

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Index

Nasal pressurized metered dose inhaler, 219 Nasal spray pump, 219 Nebulizers, 197, 201–204 Negative heat of solution, 95 New drug application (NDA), 19, 20 New molecular entity, 20, 88 Newtonian ow, 114, 115 Non-Newtonian ow, 114, 115 Nonpareils, 78, 82 Noyes-Whitney equation, 29, 95, 96

Oil-in-water (O/W) emulsion, 125, 132–138,

140, 160–162

Ointment, 142, 146, 147, 149, 160–162, 167,

176, 184 Oleaginous, 132, 161, 162, 188–190, 192 One-compartment model, 16 Opacier, 58, 59 Ophthalmic delivery, 142, 147 Ophthalmic emulsions, 147 Ophthalmic gels, 147 Ophthalmic ointments, 146, 147 Ophthalmic solutions, 146, 227 Ophthalmic suspensions, 146 Orally inhaled drug products, 196 Oral mucosa, 53, 172–177 Orange Book, 5, 7, 8, 20, 229 Orange peel (tablet coating), 56, 63 Organogel, 162 Osmotic pump systems, 78, 83, 85 Ostwald ripening, 116–118, 121, 207 Otic delivery, 142 Oxidation, 41–43, 80, 98, 99, 165, 189, 192

Paracellular permeation, 173 Parenteral drug delivery, 101 Partially miscible, 95 Partition coefcient, 6, 26, 29–31, 81, 155,

159, 188 Passive dry powder inhalers, 209, 210 Paste, 118, 160 Peel adhesion, 163 Peeling (tablet coating), 56, 64 Pegylation, 223 Percutaneous absorption, 153, 157, 158, 166 Periocular administration, 142 Peripheral compartment, 16 Permeation enhancer, 156, 158, 167

Pharmacokinetics, 14–17, 20, 25, 77, 229 Phase inversion, 140 Phase transitions, 36 pH-dependent enteric coating, 75, 76 Phlebitis, 103 Photolysis, 42 Physical stability, 33–35, 40, 44, 51, 116,

125, 229

Physicochemical properties, 6, 7, 10, 14, 25,

26, 35, 70, 93, 94, 105, 156, 172,

183, 217, 223 Picking (tablet coating), 56, 62 pKa, 6, 28–29, 34, 94, 95, 173 Plasticizer, 50, 51, 56, 58, 59, 69, 82, 84,

165, 177 Plastic or interfacial lm theory, 135 Polyacrylate copolymers, 164, 165 Polyisobutylenes (PIBs), 164, 165 Polymer, 33, 34, 43, 49–51, 56, 58, 59, 67–69,

75, 76, 79–84, 95, 104, 115, 116,

121, 123, 125–127, 133, 137, 147,

158, 159, 163–166, 176, 177, 184,

186, 187, 217 Polymeric emulsiers, 125, 126, 136 Polymorph, 35–37, 40, 66, 117, 188, 189 Polysiloxanes, 158, 164, 165 Porogen, 81, 82, 84 Positive heat of solution, 95 Pre-class reading assignment, 2 Preformulation studies, 25–40, 45–46,

59, 94, 95 Preservatives, 97–99, 101, 102, 105, 122, 127,

138, 144, 145, 163, 168, 208,

217, 218 Pressurized metered dose inhalers, 197,

198, 204 Priming, 205, 219 Prodrug, 45, 88 Prolonged release, 77 Protective layer, 164 Pulsatile release systems, 86 Purple Book, 8, 229 Push-pull system, 83 Pyrogens, 101, 105, 106, 228

Relative bioavailability, 18 Relative humidity (RH), 43, 44 Relative solubility, 94 Reservoir system (vaginal rings), 186 Reservoir-type patch, 164 Respirable fraction (RF), 213

Index

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235

Respiratory airway, 198 Rheology, 114–115 Roller compaction, 55, 60

Salting-in, 95 Salting-out, 95 Saturated solution, 26, 93, 155 Scintigraphic studies, 212 Sedimentation (particle deposition), 116,

199, 200 Shear rate, 114, 115 Shear strength, 163 Shear stress, 114, 115 Shear-thickening/dilatant ow, 115 Shear-thinning/pseudoplastic ow, 115 Sieve, 55 Sink condition, 155 Slug, 55 Small-volume parenterals, 107 Solid dispersions, 66–70 Solubility, 6, 18, 26–29, 32–35, 39, 40, 45, 51,

53, 66, 69, 71, 75, 77, 80–82, 87,

93–96, 99, 100, 103, 111, 117, 121,

122, 125, 126, 132, 144, 146, 147,

149, 158, 159, 163, 165, 173, 187,

190, 199, 207, 208, 217 Solution based dosage forms, 93–107 Solvate/pseudopolymorph, 35 Solvents, 27, 29, 30, 32, 34, 35, 37, 40, 41, 51,

54, 56, 64, 67, 70, 71, 82, 84, 87,

93–98, 101, 102, 104, 111, 124,

158, 162, 164, 165, 204, 224 Solvent casting method, 165 Sonophoresis, 159 Spacers, 207 Spray drying, 34, 67, 70, 71, 209 Spring and parachute, 67–69 Stereoisomer, 44–46 Steric stabilization, 117, 125, 136 Sterilization, 8, 105–106, 128–129 Stokes-Einstein equation, 120 Stratum corneum, 153–156, 158, 159, 165 Structured vehicle, 116 Subconjunctival administration, 142 Subcutaneous (SC) administration, 103 Sublimation, 104, 105 Sublingual administration, 172, 176 Supersaturated solution, 26, 69, 159 Suppositories, 30, 182, 184–194 Suprachoroidal administration, 142 Surface active agent (surfactant), 59, 99, 100,

114, 136, 147 Surface free energy, 116–117, 122, 135

Surface tension theory, 135 Surfactant, 59, 69, 82, 99–102, 111, 117–127,

132, 133, 135–138, 147, 158, 188, 190–192, 200, 204, 208, 217, 224, 229

Suspension, 27, 34, 104, 111–128, 134, 142,

146, 149, 190, 193, 201, 202, 204,

206–208, 216, 217, 219 Sustained release, 54, 59, 77, 177 Syringeability, 103–104

Tablet, 34, 49–71, 74, 75, 78–86, 175, 177,

178, 186, 187 Tablet ejection, 52 Tableting die, 52, 54 Tablet punch, 52 Tack, 158, 163, 165 Tapped density, 38 Team-based learning, 1, 2 Thermogravimetric analysis (TGA), 35–37 Thixotropic ow, 115 Time to maximum concentration (Tmax),

16, 17, 21 Topical drug delivery, 153 Transcellular permeation, 173 Transcellular route (passive diffusion), 155,

156, 173 Transdermal drug delivery, 153–166 Turbulent ow, 211 Two-compartment model, 16 Tyndall effect, 119

Ultrasonic nebulizers, 201–203 United States Pharmacopeia (USP), 8, 27, 29,

30, 32, 61, 64, 65, 76, 86–87, 93,

94, 97, 102, 106, 107, 126, 155,

160–162, 175, 178, 189, 204,

213, 224–226

Vibrating mesh nebulizers, 201–204 Viscoplastic ow, 115 Viscosity, 34, 40, 56, 69, 80, 82, 96, 97,

112, 114–116, 120, 122, 138,

140, 145, 149, 161, 163, 164,

167, 184, 190, 193, 201–204,

209, 219 Viscosity-enhancing agents, 122, 184,

192, 218 Volume-weighted distribution, 39

236

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Index

Water-in-oil (W/O) emulsion, 132–138, 140,

160, 161 Water-removable base, 161, 162 Water-soluble base, 188, 193 Wet ball milling, 121 Wet granulation, 54 Wet gum method, 138 Wetting agent, 118, 123–125, 136

X-ray diffraction (XRD), 35, 36

Zero-order release, 82, 83, 166 Zeta potential, 114–117, 127 Zwitterion, 28, 29

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