Ординатура / Хирургия / Библиотека им академика М.И. Перельмана / Книга_5413_Библиотеки_им_академика_М_И_Перельмана

Today, drugs for practically every disease are available or in the process of developing to alleviate all diseases known to man and chemical drug design play an important role in finding new drugs or medicines based on the knowledge of a biological target. The drug molecules, generally organic substances, activate or deactivate the function of the biomolecules like proteins, lipids, carbohydrates, nucleic acids, etc. which in turn lead to the corresponding therapeutic benefits to the living being. Other classes of compounds including inorganic or organometallic compounds are also useful as drugs. Therefore, chemical drug design involves the design of small chemical com­pounds that can interact and bind efficiently to the biological target. In recent past, though an exhaustive study has been conducted in the field of drug design, there is still a great need of developing new drugs for future library. The present book is an attempt to present an invaluable and informative addition to field of drug design and discovery. The book contains eleven chapters contributed by international scientists and academicians focused on overview of basics in chemical drug design and the recent developments made in present scenario. The chapter 1 provides an overview of some basic techniques used in chemical drug design. The chapter 2 gives an update on recent developments in the field of drug designing paving the way for novel drug dis­covery and describes how knowledge of the state-of-art techniques has led research­ers to find out the best method for the development of new drugs. Chapter 3 enlight­ens the new concept of structure and ligand based drug designing. It also covers in detail about the 2D QSAR and 3D QSAR approaches, descriptors as well as different parameters used in QSAR studies. The chapter 4 describes the drug design applied to natural products against neglected diseases. It introduces general concepts, and discusses the neglected diseases, reporting on some of the enzymatic targets studied when developing new drugs to treat these ills. The chapter 5 describes the develop­ments made of newer hybrid drugs from natural products, especially for the treatment of infections and cancer. The advantage of this concept over a combinatorial chemis­try approach is the high diversity and the inherent biological activity of the hybrids. The chapter 6 describes how does the drug metabolism play a major role in the drug design and discovery process and determine the fate of the prospective drugs. In chapter 7, the anticancer rationale of mistletoe lectins (the carbohydrate-binding pro­teins) is discussed. Its mechanism of discrimination between cell surface antigens of normal and cancer cells is also emphasized. The chapter 8 highlights the structural­activity relationship of different classes of typical and atypical antipsychotic drugs and provides some considerations concerning new treatment research. The chapter 9 describes the applications of high performance chromatographic techniques in the standardization of herbal drugs. The study focuses on the various chromatographic techniques, chemometric tools and interpretation of results by HCA & PCA in various guggulu samples. In chapter 10, the role of copper and its complexes with reference to toxicity level, sources, progress in the development of drugs and various important