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Phytochemicals From Mangroves and Their Anti-Viral Applications
have an effective anti-viral nature. Hence, these identified compounds can be used for the repurposing of the drug against other related pathogenic viruses (Murugan et al., 2021; Mahmud et al., 2021;
Kharisma et al., 2021).
Figure 4. Year-wise publication of research article when searched in Google scholar (https://scholar.
google.com/) with the keyword antiviral compounds and Mangrove plant.
CONCLUSION
Traditionally the bioactive phytochemicals plants have been continuously exploited in the field of the
healthcare system for antiviral therapy. Plant product-based therapy is a preferred mode of medication
that is associated with less toxicity and minimal side effects. Several phytochemicals from the mangrove
source have been screened and identified for the treatment of pathogenic viruses such as influenza,
dengue, chikungunya, HIV, SARS-CoV-2 and so on. Mangrove plants have been used as a traditional
medicine for a long day, however, specifically the anti-viral compounds from the mangrove plant are
less exploited. In this chapter, a compressive review has been made to provide some of the important
information about the mangrove plants and their phytochemical constituents used as anti-viral agents.
Additionally, the common extraction and screening procedures that are frequently used for phytochemicals
have been presented. Also, the challenges and opportunities associated with the discovery of bioactive
compounds from mangrove plants have been discussed. Moreover, this chapter provides a thorough
analysis and discussion of different types of mangrove plants and their specific phytochemicals that
contain the metabolite having anti-viral properties by narrating the recent literature. It is expected that
the scientific analysis and screening of novel mangrove phytochemicals can be suitably used for the
development of potential antiviral drugs.
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Phytochemicals From Mangroves and Their Anti-Viral Applications
ACKNOWLEDGMENT
This research was supported by the OURIIP- SEED FUND grant, sponsored by Odisha State Higher
Education Council, Government of Odisha, India (OURIIP Seed fund -2020/06-Biotechnology).
REFERENCES
Abeysinghe, P. D. (2010). Antibacterial activity of some medicinal mangroves against antibiotic resistant
pathogenic bacteria. Indian Journal of Pharmaceutical Sciences, 72(2), 167–172. doi:10.4103/0250474X.65019 PMID:20838519
Abeysinghe, P. D., Wanigatunge, R. P., & Pathirana, R. N. (2006). Evaluation of antibacterial activity of
different mangrove plant extracts. Ruhuna Journal of Science, 1(0), 104–112. doi:10.4038/rjs.v1i0.70
Abubakar, A. R., & Haque, M. (2020). Preparation of medicinal plants: Basic extraction and fractionation procedures for experimental purposes. Journal of Pharmacy & Bioallied Sciences, 12(1), 1–10.
doi:10.4103/jpbs.JPBS_175_19 PMID:32801594
Adhikari, A., Ray, M., Sur, T. K., Biswas, S., & Das, A. K. (2017). Comparative evaluation of antidiabetic activity of fresh juice and ethanolic extract of Sunderban mangrove Rhizophora mucronata Lam.
leaves in animal model. International Journal of Basic and Clinical Pharmacology, 6(9), 2193–2198.
doi:10.18203/2319-2003.ijbcp20173743
Adhikari, B., Marasini, B. P., Rayamajhee, B., Bhattarai, B. R., Lamichhane, G., Khadayat, K., Adhikari, A., Khanal, S., & Parajuli, N. (2021). Potential roles of medicinal plants for the treatment of viral
diseases focusing on COVID‐19: A review. Phytotherapy Research, 35(3), 1298–1312. doi:10.1002/
ptr.6893 PMID:33037698
Ahmad, A., Kaleem, M., Ahmed, Z., & Shafiq, H. (2015). Therapeutic potential of flavonoids and their
mechanism of action against microbial and viral infections—A review. Food Research International,
77, 221–235. doi:10.1016/j.foodres.2015.06.021
Aljahdali, M. O., Molla, M. H. R., & Ahammad, F. (2021). Compounds identified from marine mangrove plant (Avicennia Alba) as potential antiviral drug candidates against WDSV, an in-silico approach.
Marine Drugs, 19(5), 253. doi:10.3390/md19050253 PMID:33925208
Amparo, T. R., Seibert, J. B., Silveira, B. M., Costa, F. S. F., Almeida, T. C., Braga, S. F. P., da Silva,
G. N., Dos Santos, O. D. H., & de Souza, G. H. B. (2021). Brazilian essential oils as source for the
discovery of new anti-COVID-19 drug: A review guided by in silico study. Phytochemistry Reviews:
Proceedings of the Phytochemical Society of Europe, 20(5), 1013–1032. 10.100711101-021-09754-4
Anand, A. V., Balamuralikrishnan, B., Kaviya, M., Bharathi, K., Parithathvi, A., Arun, M., Senthilkumar,
N., Velayuthaprabhu, S., Saradhadevi, M., Al-Dhabi, N. A., Arasu, M. V., Yatoo, M. I., Tiwari, R., &
Dhama, K. (2021). Medicinal plants, phytochemicals, and herbs to combat viral pathogens including SARSCoV-2. Molecules (Basel, Switzerland), 26(6), 1775. doi:10.3390/molecules26061775 PMID:33809963
EBSCOhost - printed on 2/13/2023 11:18 AM via . All use subject to https://www.ebsco.com/terms-of-use
359
Phytochemicals From Mangroves and Their Anti-Viral Applications
Arumugham, T. K. R., Hasan, S. W., Show, P. L., Rinklebe, J., & Banat, F. (2021). Supercritical carbon
dioxide extraction of plant phytochemicals for biological and environmental applications–A review.
Chemosphere, 271, 129525. doi:10.1016/j.chemosphere.2020.129525 PMID:33445028
Bachar, S. C., Mazumder, K., Bachar, R., Aktar, A., & Al Mahtab, M. (2021). A Review of Medicinal
Plants with Antiviral Activity Available in Bangladesh and Mechanistic Insight Into Their Bioactive
Metabolites on SARS-CoV-2, HIV and HBV. Frontiers in Pharmacology, 12, 732891. doi:10.3389/
fphar.2021.732891 PMID:34819855
Bahadur Gurung, A., Ajmal Ali, M., Lee, J., Abul Farah, M., & Mashay Al-Anazi, K. (2020). Structurebased virtual screening of phytochemicals and repurposing of FDA approved antiviral drugs unravels
lead molecules as potential inhibitors of coronavirus 3C-like protease enzyme. Journal of King Saud
University. Science, 32(6), 2845–2853. doi:10.1016/j.jksus.2020.07.007 PMID:32837113
Bandaranayake, W. M. (1998). Traditional and medicinal uses of mangroves. Mangroves and Salt
Marshes, 2(3), 133–148. doi:10.1023/A:1009988607044
Bandaranayake, W. M. (2002). Bioactivities, bioactive compounds and chemical constituents of mangrove
plants. Wetlands Ecology and Management, 10(6), 421–452. doi:10.1023/A:1021397624349
Ben-Shabat, S., Yarmolinsky, L., Porat, D., & Dahan, A. (2020). Antiviral effect of phytochemicals from
medicinal plants: Applications and drug delivery strategies. Drug Delivery and Translational Research,
10(2), 354–367. doi:10.100713346-019-00691-6 PMID:31788762
Biswas, D., Nandy, S., Mukherjee, A., Pandey, D. K., & Dey, A. (2020). Moringa oleifera Lam. and
derived phytochemicals as promising antiviral agents: A review. South African Journal of Botany, 129,
272–282. doi:10.1016/j.sajb.2019.07.049
Calabrese, C., Berman, S. H., Babish, J. G., Ma, X., Shinto, L., Dorr, M., Wells, K., Wenner, C. A.,
& Standish, L. J. (2000). A Phase I Trial of andrographolide in HIV Positive Patients and normal
Volunteers. Phytotherapy Research, 14(5), 333–338. doi:10.1002/1099-1573(200008)14:5<333::AID-
PTR584>3.0.CO;2-D PMID:10925397
Chakraborthy, G. S., & Verma, P. (2013). Clerodendrum inerme: A current review. Pharmacophore,
4(6), 230–232.
Choi, J. G., Lee, H., Kim, Y. S., Hwang, Y. H., Oh, Y. C., Lee, B., Moon, K. M., Cho, W. K., & Ma, J.
Y. (2019). Aloe vera and its Components Inhibit influenza A virus-Induced Autophagy and Replication. The American Journal of Chinese Medicine, 47(6), 1307–1324. doi:10.1142/S0192415X19500678
PMID:31505936
Dai, Y. G., Wu, J., Padmakumar, K. P., & Shen, L. (2017). Sundarbanxylogranins A–E, five new limonoids from the Sundarban Mangrove, Xylocarpus granatum. Fitoterapia, 122, 85–89. doi:10.1016/j.
fitote.2017.08.013 PMID:28864040
Dhawan, B. N. (2012). Anti-viral activity of Indian plants. Proceedings of the National Academy of Sci-
ences, India. Section B, 82(1), 209–224. doi:10.100740011-011-0016-7 PMID:32226204
360
EBSCOhost - printed on 2/13/2023 11:18 AM via . All use subject to https://www.ebsco.com/terms-of-use
Phytochemicals From Mangroves and Their Anti-Viral Applications
El-Ansari, M. A., Ibrahim, L. F., & Sharaf, M. (2020). Anti-HIV activity of some natural phenolics.
Herba Polonica, 66(2), 34–43. doi:10.2478/hepo-2020-0010
Elanchezhiyan, M., Rajarajan, S., Rajendran, P., Subramanian, S., & Thyagarajan, S. P. (1993). Antiviral properties of the seed extract of an Indian medicinal plant, Pongamia pinnata, Linn., against herpes
simplex viruses: In-vitro studies on Vero cells. Journal of Medical Microbiology, 38(4), 262–264.
doi:10.1099/00222615-38-4-262 PMID:8386251
Eswaraiah, G., Peele, K. A., Krupanidhi, S., Kumar, R. B., & Venkateswarulu, T. C. (2020). Studies
on phytochemical, antioxidant, antimicrobial analysis and separation of bioactive leads of leaf extract
from the selected mangroves. Journal of King Saud University. Science, 32(1), 842–847. doi:10.1016/j.
jksus.2019.03.002
Gasparini, R., Amicizia, D., Lai, P. L., & Panatto, D. (2012). Clinical and socioeconomic impact of
seasonal and pandemic influenza in adults and the elderly. Human Vaccines & Immunotherapeutics,
8(1), 21–28. doi:10.4161/hv.8.1.17622 PMID:22252007
Ghildiyal, R., Prakash, V., Chaudhary, V. K., Gupta, V., & Gabrani, R. (2020). Phytochemicals as antiviral agents: Recent updates. In Plant-Derived Bioactives (pp. 279–295). Springer. doi:10.1007/978981-15-1761-7_12
Ghorbanpour, M., Hadian, J., Nikabadi, S., & Varma, A. (2017). Importance of medicinal and aromatic plants in human life. In Medicinal Plants and Environmental Challenges (pp. 1–23). Springer.
doi:10.1007/978-3-319-68717-9_1
Gong, K. K., Li, P. L., Qiao, D., Zhang, X. W., Chu, M. J., Qin, G. F., Tang, X. L., & Li, G. Q. (2017).
Cytotoxic and antiviral triterpenoids from the mangrove plant Sonneratia paracaseolaris. Molecules
(Basel, Switzerland), 22(8), 1319. doi:10.3390/molecules22081319 PMID:28792469
Govindappa, M., Hemmanur, K. C., Nithin, S., Poojari, C. C., Bhat, G., & Channabasava, K. (2015). In
vitro anti-HIV activity of partially purified coumarin (s) isolated from fungal endophyte, Alternaria species
of Calophyllum inophyllum. Pharmacology & Pharmacy, 6(07), 321–328. doi:10.4236/pp.2015.67034
Hafeez, A., Ahmad, S., Siddqui, S. A., Ahmad, M., & Mishra, S. (2020). A review of COVID-19
(coronavirus Disease-2019) diagnosis, treatments and prevention. European Journal of Medicine and
Oncology, 4(2), 116–125.
Heywood, V. H. (2002). The conservation of genetic and chemical diversity in medicinal and aromatic
plants. In Biodiversity (pp. 13–22). Springer. doi:10.1007/978-1-4419-9242-0_2
Inoue, M., & Craker, L. E. (2014). Medicinal and aromatic plants—Uses and functions. In Horticulture
[Springer.]. Plants for People and Places, 2, 645–669.
Inoue, M., Hayashi, S., & Craker, L. E. (2019). Role of medicinal and aromatic plants: Past, present,
and future. Pharmacognosy-Medicinal Plants, 1–13.
Irwin, K. K., Renzette, N., Kowalik, T. F., & Jensen, J. D. (2016). Antiviral drug resistance as an
adaptive process. Virus Evolution, 2(1), vew014. Advance online publication. doi:10.1093/ve/vew014
PMID:28694997
EBSCOhost - printed on 2/13/2023 11:18 AM via . All use subject to https://www.ebsco.com/terms-of-use
361
Phytochemicals From Mangroves and Their Anti-Viral Applications
Joel, E. L., & Bhimba, V. (2010). Isolation and characterization of secondary metabolites from the
mangrove plant Rhizophora mucronata. Asian Pacific Journal of Tropical Medicine, 3(8), 602–604.
doi:10.1016/S1995-7645(10)60146-0
Kapoor, R., Sharma, B., & Kanwar, S. S. (2017). Antiviral phytochemicals: An overview. Biochemistry
and Physiology: Open Access, 6(2), 7. doi:10.4172/2168-9652.1000220
Kathiresan, K., & Bingham, B. L. (2001). Biology of mangroves and mangrove ecosystems. Advances
in Marine Biology, 40, 81–251. doi:10.1016/S0065-2881(01)40003-4
Kaur, N., & Ahmed, T. (2021). Bioactive secondary metabolites of medicinal and aromatic plants and
their disease-fighting properties. Medicinal & Aromatic Plants, 113–142.
Kharisma, V. D., W., M. H., Ansori, A. N. M., Nege, A. S., Naw, S. W., & Nugraha, A. P. (2021). Tea
catechin as antiviral agent via apoptosis agonist and triple inhibitor mechanism against HIV-1 infection:
A bioinformatics approach. Journal of Pharmacy & Pharmacognosy Research, 9(4), 435–445.
Kokpal, V., Miles, D. H., Payne, A. M., & Chittarwong, V. (1990). Chemical constituents and bioactive
compounds from mangrove plants. Studies in Natural Products Chemistry, 7, 175–199.
Kokpol, U., Miles, D. H., Payne, A. M., & Chittawong, V. (1990). Chemical constituents and bioactive
compounds from mangrove plants. In Studies in natural products chemistry. Elsevier Science Publishers B. V.
Krishnamoorthy, M., Sasikumar, J. M., Shamna, R., Pandiarajan, C., Sofia, P., & Nagarajan, B. (2011).
Antioxidant activities of bark extract from mangroves, Bruguiera cylindrica (L.) Blume and Ceriops
decandra Perr. Indian Journal of Pharmacology, 43(5), 557–562. doi:10.4103/0253-7613.84972
PMID:22022000
Kumar, S., & Pandey, A. K. (2013). Chemistry and biological activities of flavonoids: An overview.
TheScientificWorldJournal, 162750, 1–16. Advance online publication. doi:10.1155/2013/162750
PMID:24470791
Kwon, S., Lee, Y., Park, H. J., & Hahm, D. H. (2017). Coarse needle surface potentiates analgesic effect
elicited by acupuncture with twirling manipulation in rats with nociceptive pain. BMC Complementary
and Alternative Medicine, 17(1), 1. doi:10.118612906-016-1505-2 PMID:28049463
Li, W., Jiang, Z., Shen, L., Pedpradab, P., Bruhn, T., Wu, J., & Bringmann, G. (2015). Antiviral limonoids
including khayanolides from the Trang mangrove plant Xylocarpus moluccensis. Journal of Natural
Products, 78(7), 1570–1578. doi:10.1021/acs.jnatprod.5b00151 PMID:26114936
Lipson, S. M., Karalis, G., Karthikeyan, L., Ozen, F. S., Gordon, R. E., Ponnala, S., Bao, J., Samarrai,
W., & Wolfe, E. (2017). Mechanism of anti-rotavirus synergistic activity by epigallocatechin gallate
and a proanthocyanidin-containing nutraceutical. Food and Environmental Virology, 9(4), 434–443.
doi:10.100712560-017-9299-z PMID:28466464
362
EBSCOhost - printed on 2/13/2023 11:18 AM via . All use subject to https://www.ebsco.com/terms-of-use
Phytochemicals From Mangroves and Their Anti-Viral Applications
Mahmud, S., Paul, G. K., Afroze, M., Islam, S., Gupt, S. B. R., Razu, M. H., Biswas, S., Zaman, S.,
Uddin, M. S., Khan, M., Cacciola, N. A., Emran, T. B., Saleh, M. A., Capasso, R., & Simal-Gandara, J.
(2021). Efficacy of phytochemicals derived from Avicennia officinalis for the management of COVID-19:
A combined in silico and biochemical study. Molecules (Basel, Switzerland), 26(8), 2210. doi:10.3390/
molecules26082210 PMID:33921289
Mahmud, S., Uddin, M. A. R., Paul, G. K., Shimu, M. S. S., Islam, S., Rahman, E., Islam, A., Islam,
M. S., Promi, M. M., Emran, T. B., & Saleh, M. A. (2021). Virtual screening and molecular dynamics simulation study of plant-derived compounds to identify potential inhibitors of main protease from
SARS-CoV-2. Briefings in Bioinformatics, 22(2), 1402–1414. doi:10.1093/bib/bbaa428 PMID:33517367
Meenakshi, S. V., & Jayaprakash, K. (2014). Mosquito larvicidal efficacy of leaf extract from mangrove
plant Rhizophora mucronata (Family: Rhizophoraceae) against Anopheles and Aedes species. Journal
of Pharmacognosy and Phytochemistry, 3(1), 78–83.
Mitra, S., Naskar, N., & Chaudhuri, P. (2021). A review on potential bioactive phytochemicals for novel
therapeutic applications with special emphasis on mangrove species. Phytomedicine Plus, 1(4), 100107.
Advance online publication. doi:10.1016/j.phyplu.2021.100107
Mitter, C. S., & Jadhav, B. L. (2011). Bactericidal and bioactivity guided fractionation studies of mangrove species Derris indica and D. trifoliata. Research Journal of Biotechnology, 6(4), 57–61.
Mpiana, P. T., Ngbolua, K. T., Tshibangu, D. S. T., Kilembe, J. T., Gbolo, B. Z., Mwanangombo, D.
T., Inkoto, C. L., Lengbiye, E. M., Mbadiko, C. M., Matondo, A., Bongo, G. N., & Tshilanda, D. D.
(2020). Identification of potential inhibitors of SARS-CoV-2 main protease from Aloe vera compounds:
A molecular docking study. Chemical Physics Letters, 754, 137751. doi:10.1016/j.cplett.2020.137751
PMID:33518775
Mukhtar, M., Arshad, M., Ahmad, M., Pomerantz, R. J., Wigdahl, B., & Parveen, Z. (2008). Antiviral
potentials of medicinal plants. Virus Research, 131(2), 111–120. doi:10.1016/j.virusres.2007.09.008
PMID:17981353
Murugan, N. A., Pandian, C. J., & Jeyakanthan, J. (2021). Computational investigation on Andrographis
paniculata phytochemicals to evaluate their potency against SARS-CoV-2 in comparison to known antiviral compounds in drug trials. Journal of Biomolecular Structure & Dynamics, 39(12), 4415–4426.
doi:10.1080/07391102.2020.1777901 PMID:32543978
Nabeelah Bibi, S., Fawzi, M. M., Gokhan, Z., Rajesh, J., Nadeem, N., & Kannan, R. R. R. (2019). Ethnopharmacology, Phytochemistry, and Global Distribution of Mangroves-A Comprehensive Review.
Marine Drugs, 17(4), 231. doi:10.3390/md17040231 PMID:31003533
Namazi, R., Zabihollahi, R., Behbahani, M., & Rezaei, A. (2013). Inhibitory activity of Avicennia marina,
a medicinal plant in Persian folk medicine, against HIV and HSV. Iranian Journal of Pharmaceutical
Research, 12(2), 435–443. PMID:24250619
Nováková, L., Pavlík, J., Chrenková, L., Martinec, O., & Červený, L. (2018). Current antiviral drugs and
their analysis in biological materials – part II: Antivirals against hepatitis and HIV viruses. Journal of
Pharmaceutical and Biomedical Analysis, 147, 378–399. doi:10.1016/j.jpba.2017.07.003 PMID:29031512
EBSCOhost - printed on 2/13/2023 11:18 AM via . All use subject to https://www.ebsco.com/terms-of-use
363
Phytochemicals From Mangroves and Their Anti-Viral Applications
Paul, G. K., Mahmud, S., Aldahish, A. A., Afroze, M., Biswas, S., Gupta, S. B. R., & Saleh, M. A. (2022).
Computational screening and biochemical analysis of Pistacia integerrima and Pandanus odorifer plants
to find effective inhibitors against Receptor-Binding domain (RBD) of the spike protein of SARS-Cov-2.
Arabian Journal of Chemistry, 15(2). PMID:34909068
Piyusha, G., Shelar, S., Reddy, V. K. S., Shelar, G. S., & Reddy, V. (2012). Medicinal value of Mangroves
and its antimicrobial properties—A review. Continental. Journal of Fisheries and Aquatic Science, 6(1),
26–37.
Poompozhil, S., & Kumarasamy, D. (2014). Studies on phytochemical constituents of some selected
mangroves. Journal of Academia and Industrial Research, 2(10), 590–592.
Premanathan, M., Arakaki, R., Izumi, H., Kathiresan, K., Nakano, M., Yamamoto, N., & Nakashima, H.
(1999). Antiviral properties of a mangrove plant, Rhizophora apiculata Blume, against human immunodeficiency virus. Antiviral Research, 44(2), 113–122. doi:10.1016/S0166-3542(99)00058-3 PMID:10669261
Premanathan, M., Chandre, K., Bajpai, S. K., & Kathiresan, K. (1994). Antiviral activity of marine
plants against New castle disease virus. Tropical Biomedicine, 10, 31–33.
Premanathan, M., Kathiresan, K., Yamamoto, N., & Nakashima, H. (1999). In vitro anti-human immunodeficiency virus activity of polysaccharide from Rhizophora mucronata Poir. Bioscience, Biotechnology,
and Biochemistry, 63(7), 1187–1191. doi:10.1271/bbb.63.1187 PMID:10478446
Premanathan, M., Nakashima, H., Kathiresan, K., Rajendran, N., & Yamamoto, N. (1996). In vitro anti
human immunodeficiency virus activity of mangrove plants. The Indian Journal of Medical Research,
103, 278–281. PMID:8707365
Premnathan, M., Chandra, K., Bajpai, S. K., & Kathiresan, K. (1992). A survey of some Indian marine plants for antiviral activity. Botanica Marina, 35(4). Advance online publication. doi:10.1515/
botm.1992.35.4.321
Quraishi, F. M., Jadhav, B. L., & Kumar, N. (2015). In vitro antioxidant activities and phytochemical
analysis of methanol extracts of leaves and stems of Lumnitzera racemosa. European Journal of Me-
dicinal Plants, 8(1), 50–59. doi:10.9734/EJMP/2015/16226
Reddy, A. R. K., & Grace, J. R. (2016). In vitro evaluation of antioxidant activity of methanolic extract
of selected mangrove plants. Medicinal & Aromatic Plants, 5(3), 250.
Satpathy, R. (2020). Therapeutic importance and application of boswellic acid from the plant Boswellia
serrata. In Advanced Pharmacological Uses of Medicinal Plants and Natural Products (pp. 302–315).
IGI Global. doi:10.4018/978-1-7998-2094-9.ch016
Satpathy, R. (2021). Application of some medicinal plants and their constituents in the treatment of
diabetes mellitus. In Advances in Medical Diagnosis, Treatment, and Care (pp. 32–47). IGI Global.
doi:10.4018/978-1-7998-4808-0.ch002
Savithramma, N., Rao, M. L., & Suhrulatha, D. (2011). Screening of medicinal plants for secondary
metabolites. Middle East Journal of Scientific Research, 8(3), 579–558.
364
EBSCOhost - printed on 2/13/2023 11:18 AM via . All use subject to https://www.ebsco.com/terms-of-use
Phytochemicals From Mangroves and Their Anti-Viral Applications
Sharma, B. R., Kumar, V., Kumar, S., & Panesar, P. S. (2020). Microwave assisted extraction of phytochemicals from Ficus racemosa. Current Research in Green and Sustainable Chemistry, 3, 100020.
Advance online publication. doi:10.1016/j.crgsc.2020.100020
Sharma, M., & Kaushik, P. (2021). Vegetable phytochemicals: An update on extraction and analysis
techniques. Biocatalysis and Agricultural Biotechnology, 36, 102149. Advance online publication.
doi:10.1016/j.bcab.2021.102149
Sofowora, A., Ogunbodede, E., & Onayade, A. (2013). The role and place of medicinal plants in the
strategies for disease prevention. African Journal of Traditional, Complementary, and Alternative Medi-
cines, 10(5), 210–229. doi:10.4314/ajtcam.v10i5.2 PMID:24311829
Starmans, D. A. J., & Nijhuis, H. H. (1996). Extraction of secondary metabolites from plant material:
A review. Trends in Food Science & Technology, 7(6), 191–197. doi:10.1016/0924-2244(96)10020-0
Stéphane, F. F. Y., Jules, B. K. J., Batiha, G. E. S., Ali, I., & Bruno, L. N. (2021). Extraction of bioactive
compounds from medicinal plants and herbs. In Natural Medicinal Plants. IntechOpen.
Subudhi, B. B., Chattopadhyay, S., Mishra, P., & Kumar, A. (2018). Current strategies for inhibition of
chikungunya infection. Viruses, 10(5), 235. doi:10.3390/v10050235 PMID:29751486
Vadlapudi, V., & Naidu, K. C. (2009). Bioefficiency of mangrove plants Lumintzeraracemosa and Bruguieragymnorhiza. Journal of Pharmacy Research, 2, 1591–1592.
Velavan, S. (2015). Phytochemical techniques-a review. World Journal of Science and Research, 1(2),
80–91.
Zhang, G., Sun, S., Zhu, T., Lin, Z., Gu, J., Li, D., & Gu, Q. (2011). Antiviral isoindolone derivatives
from an endophytic fungus Emericella sp. associated with Aegiceras corniculatum. Phytochemistry,
72(11–12), 1436–1442. doi:10.1016/j.phytochem.2011.04.014 PMID:21601895
EBSCOhost - printed on 2/13/2023 11:18 AM via . All use subject to https://www.ebsco.com/terms-of-use
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Chapter 19
Anticancer Effect of
tagala
and
Curcuma caesia
Acting Through Tumor
Necrosis Factor-α:
Mediated Nuclear Factor κB Pathway
Khetbadei Lysinia Hynniewta Hadem
North Eastern Hill University, India
Lakhon Kma
North Eastern Hill University, India
Rajeshwar N. Sharan
North Eastern Hill University, India
Arnab Sen
Indian Council of Agricultural Research, Research Center for North East Region, India
Aristolochia
ABSTRACT
This chapter begins with a brief description of the events associated with carcinogenesis such as what
led a normal cell to transform into a pre-neoplastic one, their multiplication, and development into
cancer. The authors also described how reactive oxygen species (ROS) are generated endogenously
and from carcinogens, their role in carcinogenesis, and the link between inflammation and cancer.
Elucidation of how cancer arises contributes to understanding the molecular mechanisms of action of
some natural products. Herbal natural products contain metabolites that exert a physiological action
on human body. These metabolites are used therapeutically in modern medical practices to prevent and
cure various diseases including cancer. This chapter discusses the anticancer property of two herbal
plants Aristolochia tagala Cham. and Curcuma caesia Roxb. in diethylnitrosamine-induced mouse liver
cancer and describes the most probable molecular mechanisms of action of the metabolites present in
these plants contributing to their anticancer effect.
DOI: 10.4018/978-1-6684-5129-8.ch019
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Anticancer Eect of Aristolochia tagala and Curcuma caesia Acting Through Tumor Necrosis Factor-α
INTRODUCTION
Carcinogenesis is a term that describes the process that occurs during tumor cell transformation. Both
genetic and epigenetic factors are involved in the disruption of normal cell growth and its control leading
to the development of cancer. These factors play a role in each of the different stages of carcinogenesis
which are initiation, promotion and progression. A change in the genetic makeup of cell can lead to
alterations of four broad categories of cancer genes, namely the activation of oncogenes, inactivation of
tumor suppressors, evasion of apoptosis genes, and defective DNA repair genes (Malarkey et al., 2013).
Selective clonal expansion of mutated cells leads to the appearance of a benign lesion or preneoplastic
focus and rapid growth of these cells enhances the probability of accumulation of additional genetic
damage (Mehta, 1995; Gomes-Carneiro et al., 1997). Additional mutations and structural variation in
chromosomes lead to a formation of neoplastic and metastasized cells which are invasive, fast growing
and have biochemical, metabolically and morphological characteristics different from normal healthy
cells (Pitot & Dragan, 1991; Butterworthet al., 1998, Klaunig et al., 2000).
Endogenous and environmental factors are known to play a role in the progression of carcinogenesis
which involves different biochemical mechanism and genetic elements. Endogenous factors include unavoidable spontaneous mutations that arise as a result of random errors in DNA replication, hormonal
imbalance, growth factors and complex endogenous processes like ageing, inflammation, and obesity.
These factors are together influenced by the exogenous or environmental factors and hereditary (Pitot,
1991; Wu et al., 2018). Many environmental factors have been shown to be carcinogenic. The environ-
mental factors can be broadly divided into (a) Physical factors which comprises of ionizing radiations
(IR) and UV light (b) Chemical factors like benzo[α] pyrene, heterocyclic amine, ethyl alcohol, aflatoxin,
asbestos, cadmium, etc. and (c) Biological factors likehepatitis B virus, hepatitis C virus, epstein-Barr
virus (EBV), human herpesvirus 8 (HHV-8), HTLV-1 (human T-lymphotrophic virus type 1), human
papilloma virus (HPV).
ROS INVOLVEMENT IN CARCINOGENESIS
Reactive oxygen species collectively refers to radicals, ions or molecules that have a single unpaired
electron in their outermost shell of electrons. ROS are unstable and highly reactive. Superoxide (O
•
hydroxyl radical (
categorized as free oxygen radicals. Hydrogen peroxide (H
), organic hydroperoxides (ROOH), hypochloride (HOCl) etc. are categorized as non-radical ROS
(O
3
(Liou & Storz, 2010).
ROS are produced endogenously as byproducts of oxygen metabolism. During mitochondrial oxidative
metabolism, single electron reduction of O
The mitochondrial electron transport chain is the major contributor of endogenous ROS in mammalian
tissues (Saybaşili et al., 2001; St-Pierre et al., 2002; Klaunig & Kamendulis, 2004). Enzymatic reactions catalysed by NADPH oxidase, xanthine oxidase, lipoxygenases and cylooxgenases within the cells
also contributes to the ROS pool (Babior, 1999; Griendling et al., 2000; Curtin et al., 2002; Schrader &
Fahimi, 2006; Sharan et al., 2011). Superoxide can be converted to hydrogen peroxide (H
al.,2008) and H
terbourn, 1995).
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OH), nitric oxide (NO•), organic radicals (R•), peroxyl radicals (ROO•), etc. are
), singlet oxygen (1O2), ozone/trioxygen
2O2
leads to the production of O
2
generated can be converted to hydroxyl free radicals via the Fenton reaction (Win-
2O2
•-
in the mitochondrial matrix.
2
) (Juarez et
2O2
•−
2
367
),