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Файл:Ординатура / Хирургия / Библиотека им академика М.И. Перельмана / Книга_6036_Библиотеки_им_академика_М_И_Перельмана.pdf
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- •Foreword
- •Preface
- •Acknowledgments
- •Contents
- •Contributors
- •1: MOSS: A Patient-Centered Approach
- •Background
- •Historical Approaches
- •Medical/Mental Component
- •Oncologic Component
- •Stenosis (Ambulatory/Neurologic) Component
- •Stability Component
- •Summary
- •Application of MOSS: Three Case Reports
- •Case 1
- •Case 2
- •MOSS, A Patient-Centered Approach to Metastatic Disease of the Spine
- •Case 3
- •References
- •2: Relative Radiosensitivity of Metastatic Spine Disease
- •References
- •3: Relative Chemo-, Hormonal, and Immunosensitivity
- •Introduction
- •Assessing Response to Treatment
- •Tissue Procurement
- •Variability of Sensitivity
- •Breast Cancer
- •Lung Cancer
- •Prostate Cancer
- •Renal Cell Carcinoma
- •Lymphoma
- •Myeloma
- •Sarcoma
- •Bone Antiresorptive Therapy
- •References
- •4: NOMS
- •NOMS Framework
- •Neurologic
- •Oncologic
- •Radiation
- •Mechanical
- •Systemic
- •Surgical Considerations
- •Separation Surgery
- •Surgical Stabilization
- •Case Illustrations
- •References
- •Introduction
- •Initial Evaluation
- •Clinical Evaluation
- •Radiographic Evaluation
- •Plain Radiographs
- •Nuclear Medicine Scans
- •Computed Tomography
- •Magnetic Resonance
- •Denis
- •Taneichi
- •Asdourian
- •SINS
- •References
- •6: Imaging Metastatic Spinal Disease
- •Background
- •Imaging Considerations
- •Radiography
- •Computed Tomography
- •Magnetic Resonance Imaging
- •Bone Scintigraphy
- •Positron-Emission Tomography
- •Approach to Evaluating the Spine
- •Illustrative Cases in Diagnostic Imaging
- •Case 1
- •Case 2
- •Case 3
- •Case 4
- •Case 5
- •Case 6
- •Case 7
- •Case 8
- •Case 9
- •References
- •7: Management of Metastatic Spinal Cord Compression Without Stereotactic Radiotherapy and Targeted Adjuvant Chemotherapy
- •Introduction
- •Role of Spine Surgery in Metastatic Spinal Cord Compression Treatment
- •The Role of Minimally Invasive (MI) Techniques in MESCC
- •Decision-Making in Case of Metastatic Spinal Cord Compression
- •Flow Chart for Multidisciplinary Management of Metastases in the Mobile Spine
- •Experience at Our Institution
- •Materials and Methods
- •Results
- •References
- •8: Metastatic Spine Disease: Critical Evaluation of the Current Literature
- •Introduction
- •Steroids
- •Radiotherapy
- •Background
- •Indications
- •Stereotactic Radiosurgery
- •Surgery
- •Treatment Framework
- •References
- •9: Indications for En Bloc Spondylectomy for Metastatic Spine Disease
- •Surgical Considerations
- •Outcomes
- •References
- •10: Occipitocervical and Upper Cervical Metastatic Spinal Disease
- •Introduction
- •Epidemiology
- •Presentation
- •Diagnostic Workup
- •Laboratory Studies
- •Treatment Strategy
- •Radiation
- •Surgery
- •References
- •11: Mid-cervical Metastatic Spinal Disease
- •Epidemiology
- •Pathology
- •Clinical Presentation
- •Diagnosis
- •Surgical Approaches
- •Anterior
- •Posterior
- •Complication Avoidance
- •References
- •12: Cervicothoracic Metastatic Spine Disease
- •General Spinal Metastasis
- •Patient Presentation
- •Evaluation, Imaging, and Work-Up
- •General Indications for Surgery
- •Surgical Goals and Approaches
- •Cervical Spine
- •Thoracic Spine
- •Tumor Resection Strategies and Extent of Resection
- •Surgical Complications
- •References
- •13: Surgical Treatment for Patients with Thoracic Spinal Metastasis
- •Introduction
- •Preoperative Planning
- •Identify the Problem
- •Establish Reasonable Goals
- •Select an Approach
- •Establish the Surgical Plan and a Backup Plan
- •Optimize the Patient
- •Surgical Techniques
- •Biopsy Technique
- •Fine Needle Aspiration Biopsy
- •Core Needle or Trephine Biopsy
- •Posterolateral Decompression and Fusion in the Upper Thoracic Spine
- •Surgical Techniques
- •MIS Fixation Techniques
- •Separation Surgery
- •Mid-thoracic Metastases: Combined Anterior and Posterior Reconstruction
- •Reconstruction of the Thoracic Spine
- •Posterior Instrumentation
- •Anterior Reconstruction
- •MIS Techniques for the Lower Thoracic and Thoracolumbar Spine
- •Vertebroplasty and Kyphoplasty
- •References
- •14: Thoracolumbar Metastatic Spinal Disease
- •Introduction
- •Anterolateral Corridor Techniques
- •Anterolateral Corridor Obstacles
- •Patient Selection
- •Surgical Approaches: Localization
- •Planning the Surgical Incision
- •Open Thoracoabdominal Approach (Retroperitoneal, Intrathoracic)
- •Intrathoracic Portion
- •Retroperitoneal Portion
- •Extracoelomic Approach Technique
- •Chest Tube Placement
- •Red Rubber Catheter Technique for Evacuation of Retropleural Air
- •Minimal Access Lateral Corpectomy Approach
- •Approach
- •Minimally Invasive Surgical Approaches
- •Positioning
- •Optimizing Fluoroscopic Imaging
- •Retractor Placement
- •Corpectomy and Tumor Resection
- •Exposure of T12
- •Exposure of L1
- •Discectomies
- •T12 Corpectomy
- •Place Anterior Column Support With or Without Side Plate and Screw Instrumentation
- •Posterior Pedicle Screw Fixation
- •References
- •Introduction
- •Indications
- •Biomechanics
- •Cervicothoracic Junction Approaches
- •Low Anterior Approach
- •Sternal-Splitting Approaches
- •Reconstruction Techniques
- •Complications
- •Thoracic/Thoracolumbar Approaches
- •Transthoracic Approach (T3-T11)
- •Corpectomy Technique
- •Thoracoabdominal Transdiaphragmatic Approach (T10–L2)
- •Reconstruction Techniques
- •Complications
- •Lumbar Approaches
- •Anterior Retroperitoneal Approach
- •Transperitoneal Approach
- •Lateral Flank Retroperitoneal Approach
- •Reconstruction Techniques
- •Complications
- •References
- •Introduction
- •Anatomy
- •Clinical Presentation
- •Imaging
- •Workup
- •Treatment Strategy
- •Nonoperative Treatment
- •Corticosteroids
- •Chemotherapy
- •Radiotherapy
- •Operative Treatment
- •Neural Compression
- •Instability
- •Local Control
- •Pain
- •References
- •17: Vertebral Body Reconstruction in Metastatic Spine Disease
- •Introduction
- •Fixation
- •Augmentation
- •Surgical Selection
- •Radiographic Studies
- •Preoperative Diagnosis
- •Presurgical Planning and Approach
- •Positioning
- •Reconstruction of the Vertebral Body
- •Technical Considerations
- •Discussion
- •References
- •18: Lumbosacral Metastatic Spine Disease
- •Introduction
- •Lumbopelvic Bony Anatomy and Biomechanics
- •Neurovascular Anatomy
- •Surgical Indications and Preoperative Management
- •Resection Considerations
- •Anterior Approach
- •Posterior Approach
- •Reconstruction and Stabilization
- •Authors’ Preferred Technique for Resection and Reconstruction
- •Postoperative Care
- •References
- •19: Sacral Metastases
- •Introduction
- •Anatomy of the Sacrum
- •Clinical and Diagnostic Features
- •Imaging and Biopsy
- •Management of Sacral Metastasis
- •References
- •20: Radiation Therapy for Spinal Metastases
- •References
- •21: Reconstructive Flap Coverage
- •Background
- •Principles of Flap Coverage
- •Surgical Timing and Risk Factors for Wound Complications
- •Strategies for Delayed Management of Complex Spine Wounds
- •Regional Approach to Flap Selection
- •Summary
- •References
- •22: Complications
- •Introduction
- •Preoperative Planning
- •Biopsy
- •Surgical Decision-Making and Approach
- •Positioning
- •Appropriate Level and Side
- •Complications
- •Neurological Complications
- •Dural Tears
- •Complications Associated with Spinal Instrumentation
- •Visceral Injury
- •Pulmonary Complications
- •Genitourinary Complications
- •Dysphagia and Hoarseness
- •Ileus/Gastrointestinal
- •Vascular
- •Thoracic Duct Injury
- •Thromboembolic Disease
- •Infection
- •Wound Complications
- •Radiation-Associated
- •Complications Associated with Corticosteroid Utilization
- •Deformity
- •Fluid and Electrolyte Imbalance
- •References
- •23: Percutaneous Thermal Ablation of Spine Metastasis
- •Background
- •Fundamental Concepts
- •Procedural Technique
- •Risks and Limitations
- •References
- •24: Minimally Invasive Spine Surgery for Metastatic Spine Disease
- •Introduction
- •Survival
- •Quality of Life
- •Adjuvant Therapy
- •Vertebral Augmentation with Cement
- •Posterior Percutaneous Stabilization
- •Minimally Invasive Decompression
- •Case Example No. 1
- •References
- •Index

Index
305
Norian non-exothermic hydroxyapatite cement, 214
Norian skeletal repair system, 214
Nurick and Ranawat scales, 42
O
Occipitocervical and upper cervical spine diseases
clinical presentation, 126
CT angiography, 126
epidemiology, 125
laboratory studies, 127
MRI, 126
radiation, 128
surgical intervention, 128–131
Ogilvie’s syndrome, 273
Oligometastasis, 117
Open surgical stabilization, 49
Osseous metastases, 67, 69
P
Para-pedicular approach, 284
Patchell criteria, 148
Patchell study, 2–4, 9, 93, 109, 207
Pedicle screw placement technique, 219
Pelvic splanchnic nerves, 236
PET Response Criteria in Solid Tumors (PERCIST), 30
PLL, see Posterior longitudinal ligament (PLL)
Polymethyl methacrylate (PMMA), 167, 169, 230
Posterior longitudinal ligament (PLL), 230
Post-RFA ablation syndrome, 288
Proteomic methods, 22
Q
Quantitative Analysis of Normal Tissue Effects in the
Clinic (QUANTEC), 247
R
Radiation Therapy Oncology Group (RTOG), 246
Radiofrequency ablation (RFA), 295
ablation probes, 284
bilateral transpedicular approaches, 283
cement augmentation, 283, 286
osteolytic metastases, 282
paraplegia, 283
post-ablation radiculopathy, 283
pre-procedural planning, 282
risks and limitations, 287, 288
VAS pain scores, 286
Radionuclides, 245
Radiosensitive histology, 44
Radiosensitivity
BED, 25
cancer cell, 21, 22
CRT, 22–24
2 Gray method, 22
MF treatment, 23
plasma miRNA analysis, 26
pretreatment tumor hypoxia, 22
pretreatment tumor oxygenation measurement, 22
proteomic analysis, 26
relative radiosensitive histologies, 22
SBRT, 24, 25
treatment recommendations, 25
tumor histology, 22, 26
upfront decompressive surgery, 24
Radium-223, 245
Recurrent laryngeal nerve (RLN), 137
Response Evaluation Criteria in Solid Tumors (RECIST)
version 1.1, 29, 30
Roland Morris Disability Questionnaire (RMDQ), 5, 110
S
Sacral metastases, 238–241
biopsy, 238
clinical features, 236, 237
CT-guided biopsy, 237, 238
diagnostic features, 237
imaging, 237
multiple myeloma, 238, 239
nonoperative treatment, 238
renal carcinoma, 238–240
sacroiliac resection, 241
SRS, 241
surgical lesioning, 239
treatment, 235, 241
Sacral plexus, 236, 237
Sacroplasty, 241
Sacrum, 235, 236
Sciatic nerve, 236, 237
Separation surgery, 48, 50, 151
Short tau/T1 inversion recovery (STIR) image, 73
Single-dose (8 Gy) radiotherapy, 107
Single-fraction spinal SBRT, 25
Single-fraction treatment (SFT), 246
Six-point grading scale, 42
Smith-Robinson approach, 136
Spinal instability, 56–58
cervical spine checklist, 62
clinical instability, 55, 56
iatrogenic instability, 55
lumbar spine checklist, 62
radiographic evaluation
CT, 57, 58
MRI, 57, 58
nuclear medicine scans, 57
plain radiographs, 56–57
SINS, 63, 64
thoracolumbar collapse, 60
three-column model, 58–60
trauma, 55
vertebral body collapse, 60, 61
White and Panjabi’s denition, 61, 63
Spinal instability neoplastic score (SINS), 4, 10, 14, 16,
18, 46, 63, 64, 97, 108, 118, 135, 188, 189,
204, 208, 238
Spinal pathologies, 68, 69
Spinal stereotactic radiosurgery (SSRS), 248, 249
Spine Oncology Study Group (SOSG), 4, 97, 188

306
Index
Spine pathologies, 67
Stereotactic body radiation therapy (SBRT)
advantages, 251
ASTRO inclusion and exclusion criteria, 248
vs. en bloc spondylectomy, 118
high-dose hypofractionated SBRT, 249
limitations, 118
long-term local control, 248, 249
low-dose hypofractionated SBRT, 249
RCC metastasis, 118
recurrent spinal metastases, 282
Stereotactic radiosurgery (SRS), 4, 44, 45, 49, 50, 107,
108, 110, 164, 241
Steroids, 106
Strontium-89, 245
Superior gluteal artery perforator ap (SGAP), 263
Surgical debulking procedure, 4
Surgical site infection (SSI), 142
T
Table-based retractors, 178
Tamoxifen, 36
Thoracic duct injury, 274, 275
Thoracic spinal metastasis, 161–163, 165
core needle/trephine biopsy, 160, 161
ne needle aspiration biopsy, 160
mid region (see Mid-thoracic metastases)
patient optimization, 159
posterolateral decompression, 157
separation surgery, 164, 165
surgical and backup plan, 159
surgical technique, 158–160
dura volar surface, 162, 163
titanium reconstruction cage, 163
transpedicular corpectomy, 161, 162
vertebral defect after instrumentation, 162, 163
tests, 158
treatment goals, 158
Thoracic/thoracolumbar approach
complications, 194
corpectomy, 193
patient positioning, 191, 192
reconstruction technique, 193
thoracoabdominal transdiaphragmatic approach,
193–195
transthoracic approach(T3-T11), 192
Thoracolumbar metastatic spinal disease
anatomical considerations, 173
anterolateral corridor obstacles, 174, 175
anterolateral corridor technique, 173, 174
corpectomy and tumor resection
anterior column support with/without side plate,
185
discectomies, 185
L1 exposure, 184
posterior pedicle screw xation, 186
T12 corpectomy, 185
T12 exposure, 184
extracoelomic approach
advantage, 178
chest tube placement, 179
procedure, 178
red rubber catheter, 179, 180
minimal access lateral corpectomy approach,
180–182
minimally invasive surgery
uoroscopic imaging, 182, 183
patient positioning, 182
retractor placement, 183, 184
open thoracoabdominal approach
intrathoracic portion, 177
retroperitoneal portion, 177, 178
surgical incision, 175, 176
Thromboembolic disease, 275
Tissue procurement, 30, 32
T6 metastasis, 50
Tokuhashi index, 215
Tokuhashi score, 8, 11, 12, 17, 117, 135
Tomita classication, 215
Tomita score, 8, 11, 12, 17, 116
Tomita system, 134–135
Toomey syringe, 230
Transforaminal lumbar interbody fusion (TLIF), 230
Transpedicular biopsy, 31
Transpedicular technique, 230, 231
Transthoracic corpectomy, 192
Triple-negative paradox, 33
Tumor dissemination, 89
Tumor extirpation, 255
U
Unilateral transpedicular approach, 284
Up-front radiation therapy, 11
Upper cervical/CVJ tumor, see Occipitocervical and
upper cervical spine diseases
V
Variability of sensitivity
additional variables, 32
breast cancer, 33
hormonal therapy, 32
lung cancer, 33, 34
lymphoma, 34, 35
myeloma, 35
myxoid liposarcoma, 35
prostate cancer, 34
renal cell carcinoma, 34
tumor microenvironment, 32
Vertebral augmentation with cement, 295
Vertebral body reconstruction
bone cement, 214
bone grafts, 214, 215
cage expandability, 219, 220
challenges, 222
decision-making in surgery, 217
xation, 213, 214
kyphoplasty, 218

Index
307
metastatic colon cancer, 218
methyl methacrylate, 222
patient positioning, 217, 218
pedicle screw placement, 219
preoperative diagnosis, 216, 217
presurgical planning, 217
radiographic imaging, 215, 216
surgical selection, 215
Vertebral body replacement (VBR) device,
188, 189, 191
Vertebral compression fractures (VCF), 107
Vertebrectomy, 2
Vertebroplasty, 164, 169, 170, 287
Visual analog pain scores (VAS), 286
W
Weinstein-Boriani-Biagini (WBB) surgical staging
system, 119, 250
White and Panjabi’s criteria, 16, 18
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