Ординатура / Хирургия / Библиотека им академика М.И. Перельмана / Книга_5370_Библиотеки_им_академика_М_И_Перельмана

Mg-3Sc-3Y alloy after thermal oxidation at 500 to 25 h. The oxide layer formed on this alloy was mainly composed of scandium oxide than yttrium oxide, with a higher volume fraction of scandium oxide. Oxidation of the Mg-3Sc-3Y alloy for 24 h enabled a decrease in the rate of degradation by almost 100-fold and a negligible degradation rate in Hank’s balanced salt solution at 37 for up to 23 days (Figure 2.1). The degradation products of the Mg-3Sc-3Y alloy showed no significant toxicity to osteoblastic cells and promoted cell attachment and proliferation. The findings of Brar et al. (2013) confirmed that selective oxidation through alloying Mg with scandium and yttrium is indeed an effective method to control the rate of degradation of Mg alloys. The absence of any significant toxicity and the promotion of cell attachment and proliferation makes this type of modification more promising. Brar et al. (2013) suggested that this approach is suitable for applica­tions in which the implant geometry restricts the use of coating technologies. This approach, however, could not be extended to all types of Mg alloys.

addition, this modification increased the number of MC3T3-E1 preosteoblasts after 5 h of cell culture, indicating its ability to promote higher initial cell adhesion during the early stages of cell culturing. The larger number of adherent cells on the modified AZ91 Mg alloy surface after 1, 3, and 7 days of cell culture confirmed its improved cell viability and cell proliferation.