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52 M. G. Fabiano et al.
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prepared from uncharged single-chain surfactants and cholesterol, whereas liposomes are prepared from double-chain phospholipids (neutral or charged) and
cholesterol. Surfactants can furthe r enhance the functions of the nanocarriers.
There are many cases where nanomecidines that are highly effective in vitro do
not work well in vivo because of unexpected problems that arise when applied to
humans.
Current information on surfactant vesicles is insufficient to overcome these
concerns. Therefore, continuing research is needed to obtain reliable information
in the future. Recently, advances in machine learning and artificial intelligence
allowed for the modelling of cell–nanomaterial interactions, enabling the prediction
of nanomedicine safety and efficacy (Singh et al. 2020; von Ranke et al. 2022).
As with liposomes, the in vitro/in vivo properties of nioso mes depend both on the
composition of the bilayer and on their method of production. Niosomal drug
delivery has yet to make its clinical debut, even though these systems have been
demonstrated to yield promising therapeutics. Niosomes alter the plasma clearance
kinetics, tissue distribution, metabolism, and cellular interaction of the drug. Despite
the many promising proof of concept studies, there is still a long road ahead for
niosomes to become a clinical reality. This means there are still many challenges that
need to be overcome, and there are still opportunities for academic and industrial
scientists to make a decisive impact.
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