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x Contents
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Syed Salman Ali, Chandra Kala, Najam Ali Khan, Mohd. Abid,
Alankar Shrivastva, Syed Sarim Imam, and Snigdha Bhardwaj
Mohammed Jafar, Syed Sarim Imam, and Syed Azizullah Ghori
10. Rosmarinic Acid: A Boon in the Management of
Cardiovascular Disease.............................................................................. 229
Md. Adil Shaharyar, Mahfoozur Rahman, Kumar Anand,
Chowdhury Mobaswar Hossain, Imran Kazmi, and Sanmoy Karmakar
11. Long-Term Toxicity and Regulations for
Iqbal Ahmad, Sobiya Zafar, Shakeeb Ahmad, Suma Saad, S. M. Kawish,
Sanjay Agarwal, and Farhan Jalees Ahmad
Shakir Saleem, Ruqaiyah Khan, and Sandeep Arora
13. Thymoquinone-Loaded Nanocarriers for
Ruqaiyah Khan, Himani Nautiyal, and Shakir Saleem
Contributors
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Mohd. Abid
Faculty of Pharmacy, IFTM University, Lodhipur Rajput, Delhi Road (NH-24), Moradabad – 244102,
Uttar Pradesh, India
Muhammad Afzal
Department of Pharmacology, College of Pharmacy, Jouf University, Sakaka, Kingdom of Saudi Arabia,
E-mail: afzalgufran@gmail.com
Sanjay Agarwal
Formulation Research Lab., Advance Nanomeds, Plot No. 142/20A, NSEZ, Noida – 201305,
Uttar Pradesh, India
Farhan Jalees Ahmad
Nanomedicine Research Lab., Department of Pharmacy, School of Pharmaceutical Education and
Research, Jamia Hamdard, New Delhi – 110025, India
Iqbal Ahmad
Formulation Research Lab., Advance Nanomeds, Plot No. 142/20A, NSEZ, Noida – 201305,
Uttar Pradesh, India; Nanomedicine Research Lab., Department of Pharmacy,
School of Pharmaceutical Education and Research, Jamia Hamdard, New Delhi – 110025, India
Shakeeb Ahmad
Nanomedicine Research Lab., Department of Pharmacy, School of Pharmaceutical Education and
Research, Jamia Hamdard, New Delhi – 110025, India
Farhan Jalees Ahmed
Department of Pharmaceutics, School of Pharmacy, Glocal University, Saharanpur – 247121,
Uttar Pradesh, India
Syed Salman Ali
Assistant Professor, Faculty of Pharmacy, IFTM University, Lodhipur Rajput, Delhi Road (NH-24),
Moradabad – 244102, Uttar Pradesh, India, Phone: 8936935838, E-mail: salmanali.ali32@gmail.com
Sultan Alshehri
College of Pharmacy, King Saud University, Riyadh, Saudi Arabia
Kumar Anand
Department of Pharmaceutical Technology, Jadavpur University, Kolkata – 700032, West Bengal, India
Mohd. Aqil
Department of Pharmaceutics, School of Pharmacy, Glocal University, Saharanpur – 247121,
Uttar Pradesh, India
Sandeep Arora
Department of Pharmacology, Chitkara College of Pharmacy, Chitkara University, NH-64,
Jansla, Rajpura, Punjab – 140401, India
Mohammad Atif
Department of Pharmaceutical Sciences, Shalom Institute of Health and Allied Sciences,
Sam Higginbottom University of Agriculture, Technology, and Sciences, Allahabad,
Uttar Pradesh, India
xii Contributors
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Sarwar Beg
Department of Pharmaceutics, School of Pharmaceutical Education and Research,
Nanomedicine Research Lab, Jamia Hamdard (Hamdard University), New Delhi – 110062, India
Snigdha Bhardwaj
ITS College of Pharmacy, Delhi-Meerut Road, Murad Nagar, Ghaziabad – 201206, Uttar Pradesh, India
Rudranil Bhowmik
Department of Pharmaceutical Technology, Jadavpur University, Kolkata – 700032,
West Bengal, India
Sabya Sachi Das
Department of Pharmaceutical Sciences and Technology, Birla Institute of Technology, Mesra – 835215,
Ranchi, Jharkhand, India
Syed Azizullah Ghori
Department of Pharmacy Practice, College of Clinical Pharmacy,
Imam Abdulrahman Bin Faisal University, P.O. Box 1982, Dammam – 31441, Saudi Arabia
Sadaf Jamal Gilani
College of Pharmacy, Jouf University, Aljouf, Sakaka, Saudi Arabia
Monalisha Sen Gupta
Department of Pharmaceutical Technology, Jadavpur University, Kolkata, West Bengal, India
Chowdhury Mobaswar Hossain
Bengal School of Technology, Chinsurah, Hooghly, West Bengal, India
Syed Sarim Imam
Associate Professor, Department of Pharmaceutics, College of Pharmacy, King Saud University,
Riyadh, Saudi Arabia; School of Pharmacy, Glocal University,
Delhi-Yamunotri Marg (State Highway 57), Mirzapur Pole, Saharanpur – 247121,
Uttar Pradesh, India, E-mail:
sarimimam@gmail.com
Mohammed Jafar
Assistant Professor, Department of Pharmaceutics, College of Clinical Pharmacy,
Imam Abdulrahman Bin Faisal University, P.O. Box 1982, Dammam – 31441,
Saudi Arabia, Mobile: +966502467326, E-mail: mjomar@iau.edu.sa
Mohammed Asadullah Jahangir
Department of Pharmaceutics, Nibha Institute of Pharmaceutical Sciences, Rajgir, Nalanda – 803116,
Bihar, India
Chandra Kala
Glocal School of Pharmacy, The Glocal University, Delhi-Yamunotri Marg (State Highway 57),
Mirzapur Pole, Saharanpur – 247121, Uttar Pradesh, India
Sanmoy Karmakar
Department of Pharmaceutical Technology, Jadavpur University, Kolkata – 700032, West Bengal, India,
Tel.: +91-8017136385, E-mail: sanmoykarmakar@gmail.com
S. M. Kawish
Nanomedicine Research Lab., Department of Pharmacy, School of Pharmaceutical Education and
Research, Jamia Hamdard, New Delhi – 110025, India
Imran Kazmi
Glocal School of Pharmacy, Glocal University, Mirzapur Pole, Saharanpur, Uttar Pradesh, India,
E-mail: kazmiimran2005@gmail.com
xiii Contributors
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Najam Ali Khan
Faculty of Pharmacy, IFTM University, Lodhipur Rajput, Delhi Road (NH-24), Moradabad – 244102,
Uttar Pradesh, India
Ruqaiyah Khan
Department of Pharmacology, Chitkara College of Pharmacy, Chitkara University, NH-64,
Jansla, Rajpura, Punjab – 140401, India
Abdul Muheem
Department of Pharmaceutics, School of Pharmaceutical Education and Research,
Jamia Hamdard, New Delhi – 110062, India
Himani Nautiyal
Siddhartha Institute of Pharmacy, Dobachi, Dehradun, Uttarakhand, India
Mahfoozur Rahman
Assistant Professor and Researcher at Department of Pharmaceutical Sciences,
Faculty of Health Sciences, Shalom Institute of Health and Allied Sciences,
Sam Higginbottom University of Agriculture, Technology, and Sciences (SHUATS), Allahabad,
Uttar Pradesh – 211007, India, Mobile: +91-8627985598, E-mail:
mahfoozkaifi@gmail.com
Subhabrata Ray
Dr. B. C. Roy College of Pharmacy and Allied Health Sciences, Durgapur, West Bengal – 713206, India
Suma Saad
Nanomedicine Research Lab., Department of Pharmacy, School of Pharmaceutical Education and
Research, Jamia Hamdard, New Delhi – 110025, India
Ankit Sahoo
Department of Pharmaceutical Sciences, Faculty of Health Sciences, Shalom Institute of Health and
Allied Sciences, Sam Higginbottom University of Agriculture, Technology, and Sciences (SHUATS),
Allahabad – 211007, Uttar Pradesh, India
Shakir Saleem
Department of Pharmacology, Chitkara College of Pharmacy, Chitkara University, NH-64, Jansla,
Rajpura, Punjab – 140401, India, E-mails: shakirsaleem@gmail.com; shakir.saleem@chitkara.edu.in
Md. Adil Shaharyar
Bengal School of Technology, Chinsurah, Hooghly, West Bengal, India;
Department of Pharmaceutical Technology, Jadavpur University, Kolkata – 700032,
West Bengal, India, Tel.: +91-9748902723, E-mail: adil503@yahoo.co.in
Alankar Shrivastva
Faculty of Pharmacy, IFTM University, Lodhipur Rajput, Delhi Road (NH-24), Moradabad – 244102,
Uttar Pradesh, India
Sandeep Kumar Singh
Department of Pharmaceutical Sciences and Technology, Birla Institute of Technology,
Mesra – 835215, Ranchi, Jharkhand, India, E-mail: dr.sandeep_pharmaceutics@yahoo.com
Md. Taleuzzaman
Faculty of Pharmacy, Maulana Azad University, Jodhpur, Rajasthan, India
P. R. P. Verma
Department of Pharmaceutical Sciences and Technology, Birla Institute of Technology,
Mesra – 835215, Ranchi, Jharkhand, India
Sobiya Zafar
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Nanomedicine Research Lab., Department of Pharmacy, School of Pharmaceutical Education and
Research, Jamia Hamdard, New Delhi – 110025, India
Abbreviations
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AA arachidonic acid
AB aortic banding
AD Alzheimer disease
ADR adriamycin
AG andrographolide
Ag-CurNCs silver-curcumin nanoconjugates
AIA adjuvant-induced arthritis
ALD anti-leishmanial drugs
ALP alkaline phosphatase
ALT alanine aminotransferase
AMA antimalarial activity
AMD age-associated macular degeneration
AMI acute myocardial infarction
AmP B amphotericin B
API apigenin
APP amyloid-β precursor protein
ARM Artemisinin
ASSOCHAM Associated Chambers of Commerce and Industry
in India
AST aspartate aminotransferase
AzA azelaic acids
Aβ amyloid-β
BAL bronchoalveolar lavage
BA-SLN solid lipid nanoparticles of baicalin
BA-SOL baicalin ophthalmic solutions
BBD Box-Behnken design
BGs bioglass
BITC benzyl isothiocyanate
BMDCs bone marrow-derived dendritic cells
BP blood pressure
BS Boswellia serrata
BW body weight
C. decidue Capparis decidue
xvi Abbreviations
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CAA
CA-CNP
CA-NP
CAT
CAT
CBER
CBGA
CCBs
CCD
CCRD
CDER
CDRH
CHA
CHF
CIA
CN
CNT
COA
COMP
CPL
CS
CSIR
CSLN
CTnI
Cu
CUR
CUR-NEM
CurNisNp
Cur-PLGA-NPs
CV
CVDs
CVF
CVM
CVMP
CXCR4
CYPs
DBT
caffeic acid
calceinlabeled CNP
calceinlabeled NP
catalase
Committee for Advanced Therapies
Center for Biological Evaluations and Research
cannabigerolic acid
calcium channel blockers
central composite design
central composite rotatable design
Center for Drug Evaluation and Research
Center for Device and Radiological Health
carbonated hydroxyapatite
congestive heart failure
collagen-induced arthritis
curcumin-stacked nanocatalysts
carbon nanotubes
coumaric acid
Committee for Orphan Medicinal Products
cephaeline
chitosan
Council of Scientific and Industrial Research
cationic solid lipid nanoparticles
cardiac troponin I
copper
curcumin
curcumin-loaded nanoemulsion
curcumin and nisin loaded polylactic acid
nanoparticle
curcumin-encapsulated PLGA nanoparticles
capillary vascularity
cardiovascular diseases
cobra venom factor
Center for Veterinary
Committee for Medicinal Products for Veterinary
Use
chemokine receptor 4
cytochrome P
Department of Biotechnology
Abbreviations xvii
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DENA
DL
DLPC
DM
DMARDs
DMBA
DMSO
DOX
DPPC
DQ
DRDO
DSC
DST
ECG
ECM
EDHF
EE
EGCG
EMA
EO
ESF
FA
FDA
Fe
FFR
FGF
FICCI
FP6
FPF
Fpn
GA
GAE
GCs
GEH-RGD NPs
GJIC
GP
GSE
GTE
diethylnitrosamine
drug loading
1,2-dilinoleoyl-sn-glycero-3-phosphocholine
diabetes mellitus
disease modifying anti-rheumatic drugs
7,12-dimethylbenz anthracene
dimethylsulfoxide
doxorubicin
1,2-dipalmitoyl-sn-glycerol-3-phosphocholine
quaternization
Defense Research and Development Organization
differential scanning calorimetry
Department of Science and Technology
electrocardiogram
extracellular matrix
endothelium-dependent hyperpolarizing factor
encapsulation effectivity
epigallocatechin gallate
European Medicines Agency
essential oil
European Science Foundation
ferulic acid
Food and Drug Administration
iron
fructose-fed rats
fibroblast growth factor
Federation of Indian Chambers of Commerce and
Industry
six framework programme
fine particle fraction
ferroportin
gambogic acid
gallic acid
glucocorticoids
gelatin/EGCG self-assembly nanoparticles
gap-junctional intercellular communication
genipin
Gleditsia sinensis extract
green tea extract
xviii Abbreviations
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H2O
2
HA
HA-PLA
HCC
HCS
HFCD
HMPC
HTN
HTS
HUVEC
I.M
I.P
I.V
ICMR
ICP
IDE
IFN
IL-1Ra
ILO
IMQ
iNOS
IR
ISG
ISO
ITCs
IV
IVIC
KIM-1
KVL
LAL
LBL
LDH
LDH
LDL
LH
LNs
LOX
LPO
LPS
hydrogen peroxide
hyaluronic acid
hyaluronate-polylactide
hepatocellular carcinoma
high content screening
high-fat cholesterol diet
Committee on Herbal Medicinal Products
hypertension
high throughput screening
human umbilical vein endothelial cells
intramuscularly
intraperitoneal
intravenously
Indian Council of Medical Research
isocephaeline
insulin-degrading enzyme
interferon
IL-1 receptor antagonist
International Labor Organization
imiquimod
inhibits nitric oxide synthase
ischemia-reperfusion
in situ gels
International Organization for Standardization
isothiocyanates
intravenous
in vitro-in vivo correlation
kidney injury molecule-1
klaivanolide
limulus amebocyte lysate
layer by layer
lactate dehydrogenase
layered double hydroxides
low-density lipoprotein
luteinizing hormone and estradiol
lymph nodes
lipoxygenase
lipid peroxidation
lipopolysaccharide
xix Abbreviations
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LRP1
MA-chitosan
MBG
MC
MCL
MCT
MDA
ME
MetS
MMAD
MMP
MPO
NCL
NCLN
NCs
NDA
NE
NF-Kβ
NHANES
NIPAAM
NLC
NMG
NMs
NNI
NO
NPs
NS
NS
NSAIDs
NSET
NSO
NSSEO
NTF
NTQ
NV
OA
OECD
OHT
lipoprotein receptor-related protein 1
myristic acid-chitosan
mesoporous bioglass
methylcellulose
mucocutaneous leishmaniasis
monocrotaline
malondialdehyde
marigold extract
metabolic syndrome
mass median aerodynamic diameter
matrix metalloproteinase
myeloperoxidase
neocryptolepine
nano-sized clinoptilolite
nanocapsules
new drug application
nano-emulsion
nuclear factor-Kβ
National Health and Nutrition Examination
N-isopropyl acrylamide
nanostructured lipid carriers
N-methylglucamine
nanomaterials
National Nanotechnology Initiative
nitric oxide
nanoparticles
nanosphere
Nigella sativa
nonsteroidal anti-inflammatory drugs
nanoscale science, engineering, and technology
N. sativa oil
N. sativa L. seeds essential oil
nanotechnology task force
nanothymoquinone
neovascularization
oleanolic acid
Development
ocular hypertension
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