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Internal Medicine
forDental
Treatments
Patients withMedical Diseases
ToshimiChiba
HiroyukiYamada
Editors
123
Internal Medicine for Dental Treatments
Toshimi Chiba • Hiroyuki Yamada
Editors
Internal Medicine for
Dental Treatments
Patients withMedical Diseases
Editors
Toshimi Chiba
Division of Internal Medicine of
Dentistry, Department of Oral Medicine
School of Dentistry, Iwate Medical
University, Morioka
Iwate, Japan
Hiroyuki Yamada
Division of Oral and Maxillofacial
Surgery, Department of Oral and
Maxillofacial Reconstructive Surgery
School of Dentistry
Iwate Medical University, Morioka
Iwate, Japan
ISBN 978-981-99-3295-5 ISBN 978-981-99-3296-2 (eBook)
https://doi.org/10.1007/978-981-99-3296-2
Translation from the Japanese language edition: “Shika Ishi no tameno Naikagaku” by Toshimi
Chiba and Hiroyuki Yamada, © Ishiyaku Pub,Inc. 2021. Published by Ishiyaku Pub,Inc.. All
Rights Reserved.
This is a translated version of the book originally published in Japanese language. This has been
facilitated using machine translation (by the service DeepL.com) followed by authors revising,
editing and verifying the translated manuscript.
© The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature
Singapore Pte Ltd. 2023
This work is subject to copyright. All rights are solely and exclusively licensed by the Publisher,
whether the whole or part of the material is concerned, specically the rights of reprinting, reuse
of illustrations, recitation, broadcasting, reproduction on microlms or in any other physical
way, and transmission or information storage and retrieval, electronic adaptation, computer
software, or by similar or dissimilar methodology now known or hereafter developed.
The use of general descriptive names, registered names, trademarks, service marks, etc. in this
publication does not imply, even in the absence of a specic statement, that such names are
exempt from the relevant protective laws and regulations and therefore free for general use.
The publisher, the authors, and the editors are safe to assume that the advice and information in
this book are believed to be true and accurate at the date of publication. Neither the publisher nor
the authors or the editors give a warranty, expressed or implied, with respect to the material
contained herein or for any errors or omissions that may have been made. The publisher remains
neutral with regard to jurisdictional claims in published maps and institutional afliations.
This Springer imprint is published by the registered company Springer Nature Singapore Pte Ltd.
The registered company address is: 152 Beach Road, #21-01/04 Gateway East, Singapore
189721, Singapore
Paper in this product is recyclable.
Preface for the English Version
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It is my great pleasure to publish Internal Medicine for Dental Treatments:
Patients with Medical Diseases from Japan to the world. This is a very valu-
able book that describes diseases from the viewpoints of both physicians and
dentists, and we believe that it will be shared by doctors from many
countries.
While there are many books on internal medicine, not many have been
written with a focus on dental problems. This book is a bidirectional book
that is useful as a guide to deal with dental treatment problems that have
emerged from the medical viewpoint. In Japan’s super-aging society, the
number of patients with various diseases is increasing even in dentistry, and
knowledge of internal medicine is essential for dentists. However, there is a
large gap between the knowledge of internal medicine learned in dental medical education and the individual events that require immediate judgment in
the clinical dental practice. It is currently left to the dentist’s own study to ll
this gap. This book clearly describes the methods, rationale, and specic
measures for approaching medical problems that arise during dental treatment, and is expected to become a must-have book for dentists to improve
their skills and perform more patient-based dental care.
Currently, dentistry is mainly concerned with therapeutics, but we believe
that diagnostics of lesions will become more useful in the future. In other
words, in addition to early detection and early diagnosis of oral lesions, further minimally invasive treatment will be demanded by patients, and we
believe there are already requests for such treatment. In order to respond to
these demands, it will be even more desirable in the future to understand the
pathophysiology of diseases and to proceed with dental treatment with
knowledge of patients’ comorbidities. This book adequately covers these
demands of dental treatments. We are convinced that this book will be a textbook for dentists, dental students, and related professions, and we believe that
it will also be useful for physicians. In keeping with its status as a specialized
book, the descriptions are more in-depth and technical terms are used
appropriately.
We hope you will read this book and make use of it in your daily practice
and in the education of your students.
Morioka, Iwate, Japan ToshimiChiba
Morioka, Iwate, Japan HiroyukiYamada
v
Preface
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This book is written by specialists in internal medicine, surgery, psychiatry,
and obstetrics, and gynecology from all over Japan who are familiar with
dental care, as well as dentists who are promoting cutting-edge dental care,
and provides more practical contents for dental practice. The authors have
been asked to write about typical diseases in each eld that are often seen in
actual practice, and to include recent topics that are suitable for medical doctors to read. Dentists, on the other hand, were asked to provide more detailed
descriptions of items to be considered in actual clinical practice, including the
dosages of drugs actually used in practice. We have also asked them to include
as many clinical photographs as possible. The skin manifestations that correlate with visceral diseases are known as dermadrome. Similarly, ndings on
the oral mucosa are said to lead to the detection and diagnosis of systemic
diseases, and recently the term “Oradrome” has been proposed, drawing further attention to the approach from oral symptoms to systemic diseases. This
is the rst book in Japan written by dentists and physicians on a single disease
from this perspective. Another feature of this book is the inclusion of symptomatology. The background and mechanism of symptoms are essential for
understanding the pathophysiology of the disease, so they are included in this
book.
The aging of the population is the backdrop for the need for medical collaboration. In fact, it is my strong impression that the percentage of patients
who have comorbidities and take multiple medications is increasing. It is
common in daily medical practice to identify comorbidities and conrm
pathophysiological conditions based on the medications taken. In such cases,
it is necessary to check the patient’s medication notebook, diabetes notebook,
blood pressure notebook, warfarin notebook, osteoporosis-related medication record notebook, etc., and patients themselves have a wide range of
information. Symptoms and conditions change on a daily basis, so it is always
important to keep this information in mind. In addition, new drugs such as
molecular-targeted drugs via various receptors have recently appeared on the
market, not only for malignant diseases but also for lifestyle-related diseases,
and it is necessary to keep up with medical information.
This book was written by doctors and dentists, so there is some overlap in
content, but it is an important reminder of the importance of the subject matter. This book is highly recommended not only for dental students who aspire
to become dentists, but also for dentists in clinical training, and dentists and
dental hygienists who are active in the front line of dental care. It is also
vii
viii
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highly recommended for all doctors involved in dental care, as well as for all
professionals working in medical facilities such as elderly care facilities. We
are pleased to publish the rst edition of this book, and we are condent that
it will be of constant use to you. We hope that the contents of this book will
be further developed and enhanced in the future.
Finally, I would like to express my sincere gratitude to the authors of this
book.
Morioka, Iwate, Japan ToshimiChiba
Preface
Contents
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Part I Symptomatology
1 Respiratory/Infection Symptoms . . . . . . . . . . . . . . . . . . . . . . . . . . 3
Norihiko Funaguchi, Masahito Ogasawara, Takuji Kiryu,
Takeshi Terashima, Yasuhiro Gon, Tetsuo Shimizu, and
Hirofumi Sawai
2 Cardiovascular Symptoms . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 13
Masashi Watanabe, Hiroshige Ohashi, Tomonori Segawa,
Masahito Ogasawara, Akihiko Hasegawa, and Shin Inoue
3 Digestive Symptoms . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 25
Shogo Ohkoshi, Jiro Nishida, Takahiko Kudo,
Tatsushi Omatsu, Shinya Maejima, and Yukihide Nishimura
4 Neurological and Psychosomal Symptoms . . . . . . . . . . . . . . . . . . 37
Hiroaki Ooboshi, Kotaro Otsuka, Kenzo Koizumi,
Masayo Fukuhara, Hideo Niwa, Kazuhiro Muramatsu, and
Toshimi Chiba
5 Endocrine/Renal/Blood/Other Symptoms . . . . . . . . . . . . . . . . . . 53
Yoshiharu Yajima, Keiko Naruse, Kimihiro Matsumoto,
Masahiro Ieko, Toshimi Chiba, Yoshihiro Matsukawa,
Natsumi Ikumi, and Ryoichi Tanaka
Part II Diseases
6 Respiratory Diseases . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 71
Norihiko Funaguchi, Noritaka Ohga, Yoshimasa Kitagawa,
Takuji Kiryu, Tadahide Noguchi, Yoshiyuki Mori,
Takeshi Terashima, Hitoshi Miyashita, Tetsu Takahashi,
Yasuhiro Gon, Tetsuo Shimizu, Yu Ohashi, Keisuke
Hosokawa, Shigeru Sakurai, Kazuro Satoh, Toshimi Chiba,
and Atsushi Ogawa
7 Endocrine Diseases . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 99
Haruhiro Sato, Yoshiki Sugiyama, Tomoko Hashimoto,
Toshie Segawa, and Hiroki Bukawa
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8 Cardiovascular Diseases . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 117
Genzou Takemura, Izumi Yoshioka, Shinichiro Tanaka,
Masayo Fukuhara, Masayuki Fukuda, Tatsuaki Matsubara,
Shigeo Ishikawa, Mitsuyoshi Iino, Hiromi Mitsubayashi,
Hiroki Miyate, Akihiko Hasegawa, Kenichi Sato, Shin Inoue,
and Masahito Sato
9 Cerebrovascular Diseases . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 155
Hiroaki Ooboshi and Takahiro Kanno
10 Digestive Diseases . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 167
Takahiko Kudo, Hirotaka Sakaki, Shogo Ohkoshi,
Akira Tanaka, Jiro Nishida, Takashi Muramatsu,
Katsuhiko Hasegawa, Wataru Kobayashi, Hiroshi Kishikawa,
Ryosuke Abe, Toshimi Chiba, and Seiji Nakamura
11 Malignant Diseases . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 197
Takeshi Terashima, Nobuaki Yagi, Shinya Maejima, and
Hiroyuki Harada
12 Metabolic Diseases . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 213
Kazutaka Aoki, Koichiro Ueki, Kunio Yoshizawa,
Tadashi Toyama, Yasushi Ishigaki, Takayoshi Sakai,
Masashi Watanabe, Ikuya Miyamoto, Fumiko Miyanaga, and
Hiroyuki Yamada
Contents
13 Kidney Diseases . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 239
Masanori Tokumoto, Koichi Hayashi, Hiroshige Ohashi, and
Akira Sasaki
14 Hematologic Diseases . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 251
Hirofumi Sawai, Masaatsu Yagi, Kimihiro Matsumoto,
Masahiro Ieko, Satoshi Goto, Shigeki Ito, and Daishi Saito
15 Immune System Diseases . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 271
Yoshihiro Matsukawa, Natsumi Ikumi, Yoshiki Hamada,
Noriyuki Seta, Keiko Aota, Masayuki Azuma, Yuh Baba, and
Satoshi Takada
16 Neurological Diseases . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 295
Makiko Nishina, Tomoaki Shintani, Tetsuji Okamoto,
Kazuhiro Muramatsu, Tadashi Kawai, Kanako Yamahara,
Tetsuya Maeda, Yasuo Terayama, Satoshi Okada, and
Takaaki Kamatani
17 Neuropsychiatry Diseases . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 315
Kotaro Otsuka, Seigo Ohba, Asaki Matsuzaki, Tetsuaki Arai,
Tadaharu Kobayashi, and Norifumi Nakamura
18 Infectious Diseases . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 329
Yuki Yamada, Akira Suwabe, Toshihiro Ito, and Satoshi Goto
Contents
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xi
19 Pregnancy and Breastfeeding . . . . . . . . . . . . . . . . . . . . . . . . . . . . 337
Rie Oyama and Tetsuro Ikebe
20 Organ Transplantation (Bone Marrow Transplantation, Liver
Transplantation) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 351
Akira Sasaki, Takeshi Takahara, Tadahide Noguchi, and
Yoshiyuki Mori
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