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95. Kakkar A, Antony VM, Pramanik R, Sakthivel P, Singh CA, Jain D. SMARCB1 (INI1)- decient sinonasal carcinoma: a series of 13 cases with assessment of histological patterns. Hum Pathol. 2018;83:59–67.
96. Agaimy A, Hartmann A, Antonescu CR, Chiosea SI, El-Mofty SK, Geddert H, etal. SMARCB1 (INI-1)­decient Sinonasal carcinoma: a series of 39 cases expanding the morphologic and Clinicopathologic Spectrum of a recently described entity. Am J Surg Pathol. 2017;41:458–71.
97. Kakkar A, Antony VM, Irugu DVK, Adhikari N, Jain D.NUT midline carcinoma: a series of ve cases, including one with unusual clinical course. Head Neck Pathol. 2018;12:230–6.
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https://doi.org/10.1007/s12105- 019- 01094- 2.
https://doi.org/10.1097/
Extended Procedures
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PankuriMittal, HiteshVerma, AmitKesari, R.S.Virk, KshitizCharya, SmritiPanda, AlokThakar, RajeshKumarMeena, RameshS.Doddamani, ManishGupta, RohitVerma, VikasGupta, GanakalyanBehera, AmitShanker, NamritaMahmi, M.RaviSankar, and ArulalanMathialagan
Contents
7.1 Part A: Extended Endoscopic Approach 205
7.1.1 Contraindications ofEEAs 213
7.1.2 Limits ofEEAs 214
7.2
Part B: Anatomy andSurgical Approaches toPterygopalatine Fossa,
Pterygomaxillary Fissure andInfratemporal Fossa
7.2.1 Surgical Approach toPPF andITF 215
7.3
Part C: Pituitary Tumours andSurgical Management 220
7.3.1 Anatomy 220
7.3.2 Physiology 221
7.3.3 Postoperative Care 225
7.3.4 Pearls ofPituitary Surgery 225
7.4
Part D: Open Techniques forNose andParanasal Sinuses 225
Indications forOpen Approaches 226
7.4.1
7.4.2 Relative Contraindications forSurgical Resection ofNose/Paranasal Sinus Tumours 226
214
7
P. Mittal · H. Verma (*) · S. Panda · A. Thakar N. Mahmi Department of ENT, AIIMS, New Delhi, India e-mail: drhitesh10@gmail.com
A. Kesari · M. R. Sankar · A. Mathialagan Neurootology, SGPGIMS, Lucknow, UP, India
R. S. Virk ENT, PGIMER, Chandigarh, India
K. Charya Indus Hospital, Mohali, Punjab, India
R. K. Meena · R. S. Doddamani Neurosurgery, AIIMS, New Delhi, India
© The Author(s), under exclusive license to Springer Nature Singapore Pte Ltd. 2021 H. Verma, A. Thakar (eds.), Essentials of Rhinology, https://doi.org/10.1007/978-981-33-6284-0_7
M. Gupta ENT, MMIMSR, MMU, Ambala, Haryana, India
R. Verma ENT, DMC, Ludhiana, Punjab, India
V. Gupta · G. Behera ENT, AIIMS, Bhopal, MP, India
A. Shanker ENT, Brighton and Sussex University Hospital NHS, Brighton, UK
203
204
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7.4.3 Preoperative Work-Up 227
Classication ofApproaches toNose andPNS 227
7.4.4
7.4.5
Soft Tissue Approaches 227 Bony Approaches 229
7.4.6
7.5
Part E: Open Anterior Skull Base Approaches: Indications
andComplications
Diagnostic Work-Up 234
7.5.1
7.5.2
The Subcranial Approach 236 Reconstruction 236
7.5.3
7.5.4
Complications 238
Part F: Lacrimal Sac Anatomy andDCR 238
7.6
7.6.1
Pathology—Dacryocystitis 238 Preoperative Tests/Investigations 238
7.6.2
7.7
Part G: Sinus Mucocele 243
7.7.1 Aetiology 243
7.7.2 Pathology 243
7.7.3 Clinical Features 243
7.7.4 Imaging 244
7.7.5 Treatment 244
7.7.6 Results 244
7.7.7 Complications 245
7.8
Part H: Choanal Atresia andManagement 245
Aetiology 246
7.8.1
7.8.2 Patho-physiology 246
7.8.3 Clinical Presentation 246
7.8.4 Diagnosis andEvaluation 247
7.8.5 Treatment 247
7.8.6 Preliminary Airway Management 248
7.8.7 Denitive Surgical Management 248
7.8.8 Prevention ofRestenosis After Surgery 250
7.8.9 Use ofLaser inSurgery 250
7.8.10 Syndromes Associated withChoanal Atresia 250
7.9
Part I: Cerebrospinal Fluid Rhinorrhea 250
Applied Physiology 251
7.9.1
7.9.2 Applied Anatomy 251
7.9.3 Classication 251
7.9.4 Patient Evaluation 252
7.9.5 Differential Diagnosis 252
7.9.6 Investigations 252
7.9.7 Treatment 254
7.9.8 Grafting Techniques 258
7.10 Part J: Optic Nerve Anatomy andManagement 259
7.11
Part K: Skull Base Reconstruction inExtended
Endoscopic Approaches 264
Introduction 264
7.11.1
7.11.2 Principles ofSkull Base Reconstruction 264
7.11.3 Endonasal Mucosal Flaps 265
References 270
233
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205
Good radiology, better-quality visualization, advances in technology and in-depth anatomical knowledge allows removal of central skull base lesion by transnasal route. CECT and MRI scan in all planes at 1mm interval is required to map the extent of the lesion. The diagnostic cerebral angiography (DSA) is indicated in selected cases, to obtain information regarding vascularity of the lesion and possible involvement of surrounding major neurovascular bundle. Extended endo­scopic approaches are divided into median and paramedian type. Median approaches are for midline lesions. It is further divided on the basis of site of involvement such as frontal sinus, crib­riform plate, planum sphenoidalis, etc. Paramedian approaches are for lateral lesions. It is further divided into anterior, middle and poste­rior approaches. Intraorbiral and transorbital comes under the anterior subtype. Cavernous sinus, petrous apex and infratemporal area lesions are managed by the middle approach. Condylar, hypoglossal canal and jugular fossa lesions are delt by posterior approach. Pituitary gland lies behind and above the sphenoid sinus. Number of hormones are secreted by the pituitary gland. Pituitary adenomas are dealt by both medical and surgical ways. These adenomas are the most common lesions managed by extended endo­scopic approaches. Tumours involving the skin, extending beyond the mid-pupillary line, tumour inltration into the orbital tissue and palatal bone erosion are the indications for open approaches. Open extra-cranial approaches are further subdi­vided into soft tissue and bony approaches. Moure’s Lateral Rhinotomy Incision and Weber– Ferguson incisions are the most commonly used soft tissue approaches. Transcranial approaches to the anterior skull base are divided into anterior and anterolateral approaches depending upon the tumour extensions. The lacrimal system is for sucking the tears. The obstruction of nasolacri­mal duct requires the creation of new communi­cation between the sac and nasal cavity. Dacryocystorhinostomy is of two types: endo­scopic and external. The endoscopic method pro­vides almost equal results with an open approach. The endoscopic approach is devoid of complica­tions of external approach such as lacrimal pump
mechanism violation and external scar. The proper surgical technique and regular follow-up reduces the risk of restenosis. Choanal atresia is the stenosis/atresia of the posterior choana. It can present in isolation or as a part of the syndrome. It can be bony, membranous or mixed types. Endoscopic direct visualization is the gold stan­dard way to conrm the diagnosis. Transnasal and transpalatal are the most accepted approaches.
CSF rhinorrhea is developed by the abnormal communication of the nasal cavity with the cra­nial cavity. The aetiology is broadly classied into traumatic and non-traumatic types. The numbers of haematological and biochemical parameters are mentioned for conrmation of the presence of CSF uid within the nasal cavity but β-2-transferrin is the most specic for CSF.HRCT temporal bone with MR cisternography is the most accepted radiological investigation combi­nation to localize the site of leak. Traumatic ones are mainly managed by a conservative approach but non-traumatic ones require surgical repair. Optic nerve comes in a lateral relationship with the posterior ethmoid and sphenoid sinus. Direct and indirect injuries are the types of optic nerve injury. No management option is available for direct injury. The indirect optic neuropathy is managed by both medical and surgical way. The extended surgical approaches create a large sur­gical cavity and iatrogenic communication of the nasal cavity with the cranial cavity. The aps are used to separate these cavities and to improve the outcome of repairs.
7.1 Part A: Extended Endoscopic
Approach
Extended endoscopic endonasal approaches (EEAs) have come up as a good substitute to tra­ditional open approaches. Advance technology allows superior visualization and better control of instruments with precision in disease clear­ance. The extent of EEAs is from cribriform plate to clivus and C2 vertebrae. The major drawback of open approaches is the manipulation of the cerebrum, blood vessels and cranial nerves. The other disadvantages of traditional approaches are
206
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P. Mittal et al.
EEA
Approaches to the median skull
base (access to structures in the
Fig. 7.1 Extended endoscopic approaches
sagittal plane)
• Transfrontal
• Transcribriform
• Transtuberculum/ Transplanum
• Transsellar
• Transclival
• Transodontoid
• Anterior coronal plane
• Supraorbital
• Transorbital
large incision size, prolonged exposure time, bleeding, frontal lobe symptoms, prolonged hos­pitalization and medical care, etc. The rate of complications is drastically reduced by endo­scopic approaches. In the last two decades, more and more centres have moved towards endo­scopic approaches to the skull base and intracra­nial lesion because of the improvement in knowledge in endoscopic anatomy, hi-tech endo­scopic equipment, micro-instruments, rening the expertise of the surgeon and EEAs have a lack of disadvantages of open approaches. Sphenoid sinus is the entry route for the majority of skull base lesions. Internal carotid artery, cav­ernous sinus, optic nerve and maxillary division of trigeminal nerve are the close-by vital struc­tures, so good preoperative radiological assess­ment and selection of correct instruments with copious saline irrigation to prevent thermal trauma is the key for surgical success in EEAs. The complexity of lesion is the deciding factor for two-hands or four-hands technique.
EEA can be classied into approaches to median skull base and paramedian skull base, according to the orientation of the surgical eld (target area) under two main categories and are
Approaches to the paramedian
skull base (access to structures
in the coronal plane)
Middle coronal
plane
Petrous apex Petroclival Quadrangular space Superior cavernous sinus Infratemporal approach
Posterior coronal
plane
• Transcondylar
• Transhypoglossal
• Jugular foramen
further dened based on the anatomy of the cor­ridor and target areas and their relationship with critical structures (Fig.7.1) [1, 2]. The choice of approach is based on the extent of the lesion and in a number of situations; a combination of close­ by approaches is required.
1. Access to the median skull base (sagittal
plane): anterior to posterior direction
(A) Transfrontal Approach (Fig. 7.2)
The indications are chronic refractory frontal sinusitis not responding to other management, bro-osseous lesions of frontal sinus, posterior table CSF rhinor­rhoea, recurrent mucoceles, and other lesions of frontal sinus like dermoid. The surgery starts with complete exposure of bilateral frontal recesses. Superior septal window is created anterior to anterior attachment of middle turbinate and ante­rior to cribriform plate area to visulaized both frontal sinuses. The nal step is the removal of the interfrontal sinus septum to create one large frontal sinus. It pro­vides wide access to remove the disease and to deal with posterior table.
ab c
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Frontal sinues
Cribriform plate
Fig. 7.2 CT scan of nose & PNS revealing heterogenous mass lling fronal sinuses, nasal cavity with surrounding osteogenesis. Right gure is showing healed postoperative cavity after transfrontal approach
207
Fig. 7.3 Recurrent adenocarcinoma of left olfactory cleft. (a) endoscopic photo, (b) contrast-enhancing mass in the left nasal cavity and olfactory cleft, (c) healed postoperative cavity
(B) Transcribriform Approach [3]
Indications
It is indicated for tumours involving the central part of the frontal lobe and the olfactory bulb region (e.g. olfactory groove meningioma, esthesioneuroblas­toma, adenocarcinoma) (Fig.7.3).
(i) Debulking of intranasal mass may
Steps
(iii) An endoscopic modied Lothrop required to expose the cribriform plate region.
(ii) Complete anterior and posterior eth-
(iv) Bone lateral to tumour is drilled moidectomy with wide sphenoidot-
Septal perforation
Left olfactory cleft
omy and middle turbinate removal for exposure of the entire skull base is done to dene the posterior limit of the lesion. Anterior and posterior ethmoid arteries are cauterized to de- vascularize the lesion. In selected cases, preservation of olfaction is possible on the other side.
procedure (Draf III) is performed to label the anterior limit.
out and removed from frontal
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Fig. 7.4 Esthesioneuroblastoma. (a) sagittal MRI T2 images (Kadish stage 3 lesion), (b) surgical cavity (NCCT head) after combined transcribriform and transplanar approach
P. Mittal et al.
sinus posterior wall to planum sphenoidalis. Lateral limit of drill is orbital medial wall.
(v) Nasal septum is removed with
1cm healthy margin from tumour to sphenoid sinus posteriorly and cribriform plate superiorly.
(vi) Dura mater is cauterized peri-
tumourally with preservation of deep cortical vessels. Crista galli, olfactory nerve bres, and falx are separated from tumour by inferior displacement.
(vii) The nal defect is from the median
orbital margin on both sides and from the posterior table of the frontal sinus till planum sphenoi­dalis in anteroposterior direction.
(viii) Closure of defect in layers with
vascularized ap.
(C) Transplanar Approach
The limit of the corridor is from fovea ethmoidalis over posterior ethmoid and cribriform plate anteriorly. The posterior limit is the sella and the lateral limit is the optic nerve. It can combine with anterior or posterior extended approaches for sur-
gical exposure (Fig. 7.4). Suprasellar lesions are managed by this approach by cauterization of superior inter-cavernous sinus.
(D) Trans-sphenoidal Approaches
The sphenoid sinus is the entry point for a number of trans-sphenoid approaches. Sphenoid bone is located in the centre of the cranial base in intimate contact with many important arterial, venous and neu­ral structures. The pneumatization of the sphenoid bone creates a natural corridor. The next step is the identication of sphenoid ostium. The nasal septum is separated from the sphenoid rostrum. The anterior wall of the sphenoidal sinus is enlarged circumferentially and sphe­noidal septae is drilled. The posterior and lateral walls of the sphenoidal sinus should be visible laterally; the sellar oor inferiorly, the sphenoethmoid planum above (Fig.7.5) [46].
(i) Trans-sellar Approach
Indications
It allows access to pathologies of the pituitary gland such as pituitary adenomas, Rathke’s cleft cysts, etc.
Optic
Greater
plate
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wing
Foramen
rotundum
Pterygoid canal
Lateral pterygoid
plate
Pterygoid notch
Superior orbital
fissure
foramen
sinus ostium
Sphenoidal
rostrum
Medial pterygoid
Sphenoid
Lesser wing
Orbital surface
Infratemporal
fossa crest
Spine of
sphenoid
Vaginal process
Hamulus of
medial pterygoid
OP
LOCR
CPs
CPc
PS
TS
SF
C
OP
LOCR
CPs
CPc
Fig. 7.5 The natural anatomy of sphenoid bone and endoscopic view of sphenoid sinus after wide sphenoidotomy and removal of posterior septum (Courtesy for line diagram—Dr. Arulalan Mathialagan- Senior Resident SGPGI, Lucknow)
It provides access to the medial cav­ernous sinus for pituitary adenomas that extend laterally behind the cav­ernous ICA. The rst step is the completion of the trans-sphenoidal approach. Bone removal over the sellar face extends laterally beyond the medial aspect of the cavernous sinuses (CS) and superiorly and inferiorly to expose both the inter­cavernous sinuses. Further extended approaches require the creation of a wider surgical corridor to expose and work in the different areas around the sella (Fig.7.6).
(ii) Trans-tuberculum/Transplanum
Approach Indications
The indications are extracellular pituitary adenomas with suprasellar extension, meningiomas and select craniopharyngiomas. The access is obtained through a more anterior trajectory compared with the one used to reach the sellar region. This route requires a wider opening of the anterior wall of the sphenoidal sinus, which is obtained by remov­ing the superior (supreme) turbi­nates and the posterior ethmoid air cells. Above the sellar oor, the
(iii) Trans-clival Approach
angle formed by the convergence of the sphenoid planum with the sellar oor is recognizable; from the intra­cranial view, this corresponds to the tuberculum sellae. As one moves the endoscope in an anterior direc­tion, the sphenoid planum is visible. The opening of the planum starts with the removal of the tuberculum sellae, extended bilaterally in the direction of the optico-carotid recesses. The lateral extension of the opening is limited by the protu­berances of the optic nerves (Fig.7.6).
The surgical corridor is extending from dorsal sellae to the foreman magnum. It provides a head-on view to the brainstem and vertebrobasilar vascular network. It can further be divided into superior, middle and inferior approaches by location of dural opening of abducent and glos­sopharyngeal nerve. The internal carotid artery is the lateral limit for middle and inferior approaches. Vidian artery, intraoperative naviga­tion system with carotid doppler helps in identication of carotid artery [6]. The limit of bone removal
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P. Mittal et al.
a
d
g
bc
e
f
h
Fig. 7.6 Extended endoscopic trans-seller approach (courtesy—Dr. Ramesh Doddamani, Associate Professor, AIIMS, New Delhi). (a) Endoscopic view of right sphe­noid ostium, (b) separation of posterior septum from ros­trum of sphenoid sinus, (c) wide sphenoidotomy, (d)
can be tailored. Abducent nerve is at risk while working in the region of paraclival carotid [7].
(iv) Transodontoid Approach
The indications are decompres­sion of the brainstem in rheuma­toid arthritis and disintegration of the upper cervical spine. The limit of the surgical corridor is anterior limit of the foramen magnum to
drilling of intersphenoid septum with bone over sella, (e)
line diagram of gure d, (f) entry into sella turcica and
ap creation, (g) line diagram of gure f, (h) adenomatous
tissue is visible through entry site
the body of C2 cervical vertebrae. Access is achieved by removal of nasal septum till floor of nasal cavity. Nasopharyngeal mucosa with underlying muscles is removed from one side eustachian tube opening to the other side [8]. C1 vertebral ring is removed after elevation of fascia and clival bone drilling.