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https://doi.org/10.1097/

Extended Procedures
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PankuriMittal, HiteshVerma, AmitKesari,
R.S.Virk, KshitizCharya, SmritiPanda,
AlokThakar, RajeshKumarMeena,
RameshS.Doddamani, ManishGupta,
RohitVerma, VikasGupta, GanakalyanBehera,
AmitShanker, NamritaMahmi, M.RaviSankar,
and ArulalanMathialagan
Contents
7.1 Part A: Extended Endoscopic Approach 205
7.1.1 Contraindications ofEEAs 213
7.1.2 Limits ofEEAs 214
7.2
Part B: Anatomy andSurgical Approaches toPterygopalatine Fossa,
Pterygomaxillary Fissure andInfratemporal Fossa
7.2.1 Surgical Approach toPPF andITF 215
7.3
Part C: Pituitary Tumours andSurgical Management 220
7.3.1 Anatomy 220
7.3.2 Physiology 221
7.3.3 Postoperative Care 225
7.3.4 Pearls ofPituitary Surgery 225
7.4
Part D: Open Techniques forNose andParanasal Sinuses 225
Indications forOpen Approaches 226
7.4.1
7.4.2 Relative Contraindications forSurgical Resection ofNose/Paranasal
Sinus Tumours 226
214
7
P. Mittal · H. Verma (*) · S. Panda · A. Thakar
N. Mahmi
Department of ENT, AIIMS, New Delhi, India
e-mail: drhitesh10@gmail.com
A. Kesari · M. R. Sankar · A. Mathialagan
Neurootology, SGPGIMS, Lucknow, UP, India
R. S. Virk
ENT, PGIMER, Chandigarh, India
K. Charya
Indus Hospital, Mohali, Punjab, India
R. K. Meena · R. S. Doddamani
Neurosurgery, AIIMS, New Delhi, India
© The Author(s), under exclusive license to Springer Nature Singapore Pte Ltd. 2021
H. Verma, A. Thakar (eds.), Essentials of Rhinology, https://doi.org/10.1007/978-981-33-6284-0_7
M. Gupta
ENT, MMIMSR, MMU, Ambala, Haryana, India
R. Verma
ENT, DMC, Ludhiana, Punjab, India
V. Gupta · G. Behera
ENT, AIIMS, Bhopal, MP, India
A. Shanker
ENT, Brighton and Sussex University Hospital NHS,
Brighton, UK
203

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7.4.3 Preoperative Work-Up 227
Classication ofApproaches toNose andPNS 227
7.4.4
7.4.5
Soft Tissue Approaches 227
Bony Approaches 229
7.4.6
7.5
Part E: Open Anterior Skull Base Approaches: Indications
andComplications
Diagnostic Work-Up 234
7.5.1
7.5.2
The Subcranial Approach 236
Reconstruction 236
7.5.3
7.5.4
Complications 238
Part F: Lacrimal Sac Anatomy andDCR 238
7.6
7.6.1
Pathology—Dacryocystitis 238
Preoperative Tests/Investigations 238
7.6.2
7.7
Part G: Sinus Mucocele 243
7.7.1 Aetiology 243
7.7.2 Pathology 243
7.7.3 Clinical Features 243
7.7.4 Imaging 244
7.7.5 Treatment 244
7.7.6 Results 244
7.7.7 Complications 245
7.8
Part H: Choanal Atresia andManagement 245
Aetiology 246
7.8.1
7.8.2 Patho-physiology 246
7.8.3 Clinical Presentation 246
7.8.4 Diagnosis andEvaluation 247
7.8.5 Treatment 247
7.8.6 Preliminary Airway Management 248
7.8.7 Denitive Surgical Management 248
7.8.8 Prevention ofRestenosis After Surgery 250
7.8.9 Use ofLaser inSurgery 250
7.8.10 Syndromes Associated withChoanal Atresia 250
7.9
Part I: Cerebrospinal Fluid Rhinorrhea 250
Applied Physiology 251
7.9.1
7.9.2 Applied Anatomy 251
7.9.3 Classication 251
7.9.4 Patient Evaluation 252
7.9.5 Differential Diagnosis 252
7.9.6 Investigations 252
7.9.7 Treatment 254
7.9.8 Grafting Techniques 258
7.10 Part J: Optic Nerve Anatomy andManagement 259
7.11
Part K: Skull Base Reconstruction inExtended
Endoscopic Approaches 264
Introduction 264
7.11.1
7.11.2 Principles ofSkull Base Reconstruction 264
7.11.3 Endonasal Mucosal Flaps 265
References 270
233

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Good radiology, better-quality visualization,
advances in technology and in-depth anatomical
knowledge allows removal of central skull base
lesion by transnasal route. CECT and MRI scan
in all planes at 1mm interval is required to map
the extent of the lesion. The diagnostic cerebral
angiography (DSA) is indicated in selected cases,
to obtain information regarding vascularity of the
lesion and possible involvement of surrounding
major neurovascular bundle. Extended endoscopic approaches are divided into median and
paramedian type. Median approaches are for
midline lesions. It is further divided on the basis
of site of involvement such as frontal sinus, cribriform plate, planum sphenoidalis, etc.
Paramedian approaches are for lateral lesions. It
is further divided into anterior, middle and posterior approaches. Intraorbiral and transorbital
comes under the anterior subtype. Cavernous
sinus, petrous apex and infratemporal area lesions
are managed by the middle approach. Condylar,
hypoglossal canal and jugular fossa lesions are
delt by posterior approach. Pituitary gland lies
behind and above the sphenoid sinus. Number of
hormones are secreted by the pituitary gland.
Pituitary adenomas are dealt by both medical and
surgical ways. These adenomas are the most
common lesions managed by extended endoscopic approaches. Tumours involving the skin,
extending beyond the mid-pupillary line, tumour
inltration into the orbital tissue and palatal bone
erosion are the indications for open approaches.
Open extra-cranial approaches are further subdivided into soft tissue and bony approaches.
Moure’s Lateral Rhinotomy Incision and Weber–
Ferguson incisions are the most commonly used
soft tissue approaches. Transcranial approaches
to the anterior skull base are divided into anterior
and anterolateral approaches depending upon the
tumour extensions. The lacrimal system is for
sucking the tears. The obstruction of nasolacrimal duct requires the creation of new communication between the sac and nasal cavity.
Dacryocystorhinostomy is of two types: endoscopic and external. The endoscopic method provides almost equal results with an open approach.
The endoscopic approach is devoid of complications of external approach such as lacrimal pump
mechanism violation and external scar. The
proper surgical technique and regular follow-up
reduces the risk of restenosis. Choanal atresia is
the stenosis/atresia of the posterior choana. It can
present in isolation or as a part of the syndrome.
It can be bony, membranous or mixed types.
Endoscopic direct visualization is the gold standard way to conrm the diagnosis. Transnasal
and transpalatal are the most accepted approaches.
CSF rhinorrhea is developed by the abnormal
communication of the nasal cavity with the cranial cavity. The aetiology is broadly classied
into traumatic and non-traumatic types. The
numbers of haematological and biochemical
parameters are mentioned for conrmation of the
presence of CSF uid within the nasal cavity but
β-2-transferrin is the most specic for CSF.HRCT
temporal bone with MR cisternography is the
most accepted radiological investigation combination to localize the site of leak. Traumatic ones
are mainly managed by a conservative approach
but non-traumatic ones require surgical repair.
Optic nerve comes in a lateral relationship with
the posterior ethmoid and sphenoid sinus. Direct
and indirect injuries are the types of optic nerve
injury. No management option is available for
direct injury. The indirect optic neuropathy is
managed by both medical and surgical way. The
extended surgical approaches create a large surgical cavity and iatrogenic communication of the
nasal cavity with the cranial cavity. The aps are
used to separate these cavities and to improve the
outcome of repairs.
7.1 Part A: Extended Endoscopic
Approach
Extended endoscopic endonasal approaches
(EEAs) have come up as a good substitute to traditional open approaches. Advance technology
allows superior visualization and better control
of instruments with precision in disease clearance. The extent of EEAs is from cribriform plate
to clivus and C2 vertebrae. The major drawback
of open approaches is the manipulation of the
cerebrum, blood vessels and cranial nerves. The
other disadvantages of traditional approaches are

206
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P. Mittal et al.
EEA
Approaches to the median skull
base (access to structures in the
Fig. 7.1 Extended endoscopic approaches
sagittal plane)
• Transfrontal
• Transcribriform
• Transtuberculum/
Transplanum
• Transsellar
• Transclival
• Transodontoid
• Anterior coronal
plane
• Supraorbital
• Transorbital
large incision size, prolonged exposure time,
bleeding, frontal lobe symptoms, prolonged hospitalization and medical care, etc. The rate of
complications is drastically reduced by endoscopic approaches. In the last two decades, more
and more centres have moved towards endoscopic approaches to the skull base and intracranial lesion because of the improvement in
knowledge in endoscopic anatomy, hi-tech endoscopic equipment, micro-instruments, rening
the expertise of the surgeon and EEAs have a
lack of disadvantages of open approaches.
Sphenoid sinus is the entry route for the majority
of skull base lesions. Internal carotid artery, cavernous sinus, optic nerve and maxillary division
of trigeminal nerve are the close-by vital structures, so good preoperative radiological assessment and selection of correct instruments with
copious saline irrigation to prevent thermal
trauma is the key for surgical success in EEAs.
The complexity of lesion is the deciding factor
for two-hands or four-hands technique.
EEA can be classied into approaches to
median skull base and paramedian skull base,
according to the orientation of the surgical eld
(target area) under two main categories and are
Approaches to the paramedian
skull base (access to structures
in the coronal plane)
Middle coronal
plane
Petrous apex
Petroclival
Quadrangular space
Superior cavernous
sinus
Infratemporal
approach
Posterior coronal
plane
• Transcondylar
• Transhypoglossal
• Jugular foramen
further dened based on the anatomy of the corridor and target areas and their relationship with
critical structures (Fig.7.1) [1, 2]. The choice of
approach is based on the extent of the lesion and
in a number of situations; a combination of close by approaches is required.
1. Access to the median skull base (sagittal
plane): anterior to posterior direction
(A) Transfrontal Approach (Fig. 7.2)
The indications are chronic refractory
frontal sinusitis not responding to other
management, bro-osseous lesions of
frontal sinus, posterior table CSF rhinorrhoea, recurrent mucoceles, and other
lesions of frontal sinus like dermoid. The
surgery starts with complete exposure of
bilateral frontal recesses. Superior septal
window is created anterior to anterior
attachment of middle turbinate and anterior to cribriform plate area to visulaized
both frontal sinuses. The nal step is the
removal of the interfrontal sinus septum
to create one large frontal sinus. It provides wide access to remove the disease
and to deal with posterior table.

ab c
7 Extended Procedures
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Frontal sinues
Cribriform plate
Fig. 7.2 CT scan of nose & PNS revealing heterogenous mass lling fronal sinuses, nasal cavity with surrounding
osteogenesis. Right gure is showing healed postoperative cavity after transfrontal approach
207
Fig. 7.3 Recurrent adenocarcinoma of left olfactory cleft. (a) endoscopic photo, (b) contrast-enhancing mass in the left
nasal cavity and olfactory cleft, (c) healed postoperative cavity
(B) Transcribriform Approach [3]
Indications
It is indicated for tumours involving the
central part of the frontal lobe and the
olfactory bulb region (e.g. olfactory
groove meningioma, esthesioneuroblastoma, adenocarcinoma) (Fig.7.3).
(i) Debulking of intranasal mass may
Steps
(iii) An endoscopic modied Lothrop
required to expose the cribriform
plate region.
(ii) Complete anterior and posterior eth-
(iv) Bone lateral to tumour is drilled
moidectomy with wide sphenoidot-
Septal
perforation
Left
olfactory
cleft
omy and middle turbinate removal
for exposure of the entire skull base
is done to dene the posterior limit
of the lesion. Anterior and posterior
ethmoid arteries are cauterized to
de- vascularize the lesion. In selected
cases, preservation of olfaction is
possible on the other side.
procedure (Draf III) is performed
to label the anterior limit.
out and removed from frontal

208
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Fig. 7.4 Esthesioneuroblastoma. (a) sagittal MRI T2 images (Kadish stage 3 lesion), (b) surgical cavity (NCCT head)
after combined transcribriform and transplanar approach
P. Mittal et al.
sinus posterior wall to planum
sphenoidalis. Lateral limit of drill
is orbital medial wall.
(v) Nasal septum is removed with
1cm healthy margin from tumour
to sphenoid sinus posteriorly and
cribriform plate superiorly.
(vi) Dura mater is cauterized peri-
tumourally with preservation of
deep cortical vessels. Crista galli,
olfactory nerve bres, and falx are
separated from tumour by inferior
displacement.
(vii) The nal defect is from the median
orbital margin on both sides and
from the posterior table of the
frontal sinus till planum sphenoidalis in anteroposterior direction.
(viii) Closure of defect in layers with
vascularized ap.
(C) Transplanar Approach
The limit of the corridor is from fovea
ethmoidalis over posterior ethmoid and
cribriform plate anteriorly. The posterior
limit is the sella and the lateral limit is the
optic nerve. It can combine with anterior
or posterior extended approaches for sur-
gical exposure (Fig. 7.4). Suprasellar
lesions are managed by this approach by
cauterization of superior inter-cavernous
sinus.
(D) Trans-sphenoidal Approaches
The sphenoid sinus is the entry point for
a number of trans-sphenoid approaches.
Sphenoid bone is located in the centre of
the cranial base in intimate contact with
many important arterial, venous and neural structures. The pneumatization of the
sphenoid bone creates a natural corridor.
The next step is the identication of
sphenoid ostium. The nasal septum is
separated from the sphenoid rostrum.
The anterior wall of the sphenoidal sinus
is enlarged circumferentially and sphenoidal septae is drilled. The posterior and
lateral walls of the sphenoidal sinus
should be visible laterally; the sellar oor
inferiorly, the sphenoethmoid planum
above (Fig.7.5) [4–6].
(i) Trans-sellar Approach
Indications
It allows access to pathologies of
the pituitary gland such as pituitary
adenomas, Rathke’s cleft cysts, etc.

Optic
Greater
plate
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209
wing
Foramen
rotundum
Pterygoid canal
Lateral pterygoid
plate
Pterygoid notch
Superior orbital
fissure
foramen
sinus ostium
Sphenoidal
rostrum
Medial pterygoid
Sphenoid
Lesser wing
Orbital surface
Infratemporal
fossa crest
Spine of
sphenoid
Vaginal process
Hamulus of
medial pterygoid
OP
LOCR
CPs
CPc
PS
TS
SF
C
OP
LOCR
CPs
CPc
Fig. 7.5 The natural anatomy of sphenoid bone and endoscopic view of sphenoid sinus after wide sphenoidotomy and
removal of posterior septum (Courtesy for line diagram—Dr. Arulalan Mathialagan- Senior Resident SGPGI, Lucknow)
It provides access to the medial cavernous sinus for pituitary adenomas
that extend laterally behind the cavernous ICA. The rst step is the
completion of the trans-sphenoidal
approach. Bone removal over the
sellar face extends laterally beyond
the medial aspect of the cavernous
sinuses (CS) and superiorly and
inferiorly to expose both the intercavernous sinuses. Further extended
approaches require the creation of a
wider surgical corridor to expose
and work in the different areas
around the sella (Fig.7.6).
(ii) Trans-tuberculum/Transplanum
Approach
Indications
The indications are extracellular
pituitary adenomas with suprasellar
extension, meningiomas and select
craniopharyngiomas. The access is
obtained through a more anterior
trajectory compared with the one
used to reach the sellar region. This
route requires a wider opening of
the anterior wall of the sphenoidal
sinus, which is obtained by removing the superior (supreme) turbinates and the posterior ethmoid air
cells. Above the sellar oor, the
(iii) Trans-clival Approach
angle formed by the convergence of
the sphenoid planum with the sellar
oor is recognizable; from the intracranial view, this corresponds to the
tuberculum sellae. As one moves
the endoscope in an anterior direction, the sphenoid planum is visible.
The opening of the planum starts
with the removal of the tuberculum
sellae, extended bilaterally in the
direction of the optico-carotid
recesses. The lateral extension of
the opening is limited by the protuberances of the optic nerves
(Fig.7.6).
The surgical corridor is extending
from dorsal sellae to the foreman
magnum. It provides a head-on view
to the brainstem and vertebrobasilar
vascular network. It can further be
divided into superior, middle and
inferior approaches by location of
dural opening of abducent and glossopharyngeal nerve. The internal
carotid artery is the lateral limit for
middle and inferior approaches.
Vidian artery, intraoperative navigation system with carotid doppler
helps in identication of carotid
artery [6]. The limit of bone removal

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P. Mittal et al.
a
d
g
bc
e
f
h
Fig. 7.6 Extended endoscopic trans-seller approach
(courtesy—Dr. Ramesh Doddamani, Associate Professor,
AIIMS, New Delhi). (a) Endoscopic view of right sphenoid ostium, (b) separation of posterior septum from rostrum of sphenoid sinus, (c) wide sphenoidotomy, (d)
can be tailored. Abducent nerve is at
risk while working in the region of
paraclival carotid [7].
(iv) Transodontoid Approach
The indications are decompression of the brainstem in rheumatoid arthritis and disintegration of
the upper cervical spine. The limit
of the surgical corridor is anterior
limit of the foramen magnum to
drilling of intersphenoid septum with bone over sella, (e)
line diagram of gure d, (f) entry into sella turcica and
ap creation, (g) line diagram of gure f, (h) adenomatous
tissue is visible through entry site
the body of C2 cervical vertebrae.
Access is achieved by removal of
nasal septum till floor of nasal
cavity. Nasopharyngeal mucosa
with underlying muscles is
removed from one side eustachian
tube opening to the other side [8].
C1 vertebral ring is removed after
elevation of fascia and clival bone
drilling.
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