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150 Section 8: Aortoiliac Disease
Access artery injuries include iliac artery dissection, rupture, and thrombosis. Transfemoral access is feasible in only 70% of cases undergoing TEVAR. Thrombosis of the access arteries occurs in the setting of inadequate intraoperative anticoagulation and an occlusive or near­occlusive sheath.
Factors associated with access artery dissection and rupture include:
A. Inadequate iliac artery diameter B. High-grade and/or long-segment stenosis C. Severe calcification D. Tortuosity of iliac arteries
For access, the iliac artery diameter must be 7 mm or greater. When these concerns are identified preoperatively, it is advisable to consider adjunctive measures to mitigate the risk of access artery injury. Specifically, small iliac diameter may be overcome with the use of serial hydrophilic dilators as long as there is no concomitant severe calcifi­cation. Open or endovascular conduits should also be considered. Open conduits may utilize the use of either an aortic or a common iliac proximal anastomosis exposure via a retroperitoneal approach. Endovascular conduits typically span from the common iliac to distal external iliac or even common femoral artery; a 12-mm-diameter graft is selected due to the additional friction imparted, as compared to the diameter of the native iliac arter y.
Correct Answer C Severe calcification
Reference
Jackson, B. M., Woo, E. Y., Bavaria, J. E., & Fairman, R. M. (2011). Gender analysis of the pivotal results
of the Medtronic Talent Thoracic Stent Graft System (VALOR) trial. J Vasc Surg, 54(2), 358–363,
363.e351. PMID: 21397440
65. RATIONALE
A type IA or type IB endoleak should be treated intraoperatively. In a large international registry of patients undergoing TEVAR, the incidences of type IA or type IB was <1%. These endoleaks are the result of inadequate oversizing or implantation of the device in an unin­tended segment where the aortic diameter is larger than expected. Careful preoperative planning based on high-quality axial imaging with adherence to IFU should help prevent this complication. Adjunctive measures to enhance the precision of deployment such as rapid ventricular pacing or use of adenosine to temporarily halt the aortic impulse can be implemented. If type IA or type IB endoleak is identified on completion of the aortogram, balloon molding of the seal zone or extension of coverage with additional components should be performed. Balloon molding of the proximal seal should be avoided in cases of TEVAR performed for aortic dissection.
Correct Answer A <1%
Reference
Tsilimparis, N., Debus, S., Chen, M., et al. (2018). Results from the study to assess outcomes after endo-
vascular repair for multiple thoracic aortic diseases (SUMMIT). J Vasc Surg, 68(5), 1324–1334. PMID: 29748101
Section 8: Aortoiliac Disease 151
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66. RATIONALE
Perioperative stroke as a complication of TEVAR occurs in 3%–5% of cases with an associated mortality of 16%–20%. Most are embolic strokes and may occur inadvertently as a result of endo­vascular manipulation in the arch and ascending aorta. While the incidence of clinically signif­icant stroke is low, postoperative diffusion-weighted MRIs show small “silent” embolic strokes in as many as 60% of TEVAR patients. A prior history of stroke is associated with at least fivefold higher odds of stroke. History of coronary artery disease, renal failure, and female gender also increase the incidence of stroke. Longer operative times and inadequate anticoagulation are other factors that may be associated with perioperative strokes in patients undergoing TEVAR. Perioperative hypotension and anemia also contribute to stroke by reducing intracranial perfu­sion pressure. Intraoperative blood loss greater than 800 cc is also associated with increased stroke risk. Analysis of the Eurostar Registry showed that a “shaggy aorta” was associated with a 30-fold increase in the odds of perioperative stroke. Extending the coverage to the left common carotid (zone 1) or left subclavian (zone 2) in order to obtain an adequate seal is associated with an increased risk of perioperative stroke either due to malperfusion or embolization.
Correct Answer B 3%–5% of cases
Reference
Leurs, L. J., Bell, R., Degrieck, Y., et al. (2004). Endovascular treatment of thoracic aortic diseases:
combined experience from the EUROSTAR and United Kingdom Thoracic Endograft registries. J Vasc Surg, 40(4), 670–679; discussion 679–680. PMID: 15472593
67. RATIONALE
To obtain a distal seal during performance of TEVAR, intentional coverage of the celiac artery was performed in 4% of cases from a large reported series. Manifestations of foregut ischemia are variable, including ischemic pancreatitis, perforated gastric ulcer, splenic infarction, acal­culus cholecystitis, shock liver, and multiorgan failure resulting in mortality. Adequate evalua­tion of the mesenteric circulation is imperative prior to intentional coverage of the celiac artery. In patients with an ectatic visceral segment, postoperative mesenteric ischemia may result from the distal migration of the endograft with inadvertent coverage of the celiac artery. In patients where the distal seal is tenuous due to ectasia, alternative strategies such as fenestrated or branched endovascular aneurysm repair may be a better option to avoid a serious complication of foregut ischemia. Clinically significant foregut ischemia has been reported in up to 12% of patients following TEVAR.
Correct Answer B 0%–12% of patients
Reference
Rose, M. K., Pearce, B. J., Matthews, T. C., et al. (2015). Outcomes after celiac artery coverage during
thoracic endovascular aortic aneurysm repair. J Vasc Surg, 62(1), 36–42. PMID: 25937603
68. RATIONALE
In acute type B aortic dissection, great care should be taken to ensure deployment of the endo­graft in the true lumen, with catastrophic consequences if deployed in the false lumen, namely malperfusion of the critical branch vessel and death. Therefore, identification of the true and false lumen is of paramount importance. Even with open exposure of the femoral artery, it may
152 Section 8: Aortoiliac Disease
be difficult to identify the true and false lumen even on inspection. Given that multiple fenes­trations exist even if the true lumen is definitively assessed in the groin, that may not ensure that the guide wire will remain in the true lumen as it is advanced cephalad. Therefore, careful evaluation of preoperative CTA, intravascular ultrasound, and angiography via the sheath at the level of each branch vessel is necessary.
Correct Answer D Careful evaluation of preoperative CTA, use of intravascular ultrasound, and intraoperative angiography at the level of each branch vessel
Reference
Han, S. M., Gasper, W. J., & Chuter, T. A. (2016). Endovascular rescue after inadvertent false lumen stent
graft implantation. J Vasc Surg, 63(2), 518–522. PMID: 25595403
69. RATIONALE
Inferior mesenteric artery reconstruction.
In a large systemic review of EVAR and TEVAR infections, the mean time to presentation ranged from 115 to 991 days with incidence of <1%. Diagnosis is usually confirmed by the presence of perigraft inflammation or air. Mechanisms of graft infection include seeding from a blood­stream infection, contamination from an infection in an adjacent structure, or a break in the sterile technique at the time of implantation. The most frequently isolated microorganisms were staphylococcal species (30.1%), streptococcus (14.8%), and fungus (9.2%). Most patients (90%) require stent graft removal and in situ reconstruction or extra-anatomical bypass and a secondary endovascular procedure. The survival rate is higher in the patients with infected EVAR (58%) than TEVAR (27% P = 0.000). Patients with aortoenteric fistula (AEF) have the
Section 8: Aortoiliac Disease 153
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worst prognosis. Consultation with an infectious disease specialist for consideration of long­term treatment of antibiotics and/or antifungals should be obtained.
Correct Answer A <1%
Reference
Li, H. L., Chan, Y. C., & Cheng, S. W. (2018). Current evidence on management of aortic stent-graft
infection: a systematic review and meta-analysis. Ann Vasc Surg, 51, 306–313. PMID: 29772328
70. RATIONALE
As thoracic endografts are subject to a more forceful aortic impulse than infrarenal endografts, over a long period this may result in device migration (>10 mm) or component separation. The incidence of migration has been reported at 7% in a series of 123 patients over a median follow­up of 3 years and associated incidence of type I or type III endoleak of 44%.
Risk factors for graft migration include:
A. Neck angulation >60 degrees B. Neck length <15 mm C. Inadequate overlap between components (<5 cm) D. Extreme tortuosity in the thoracic segment
154 Section 8: Aortoiliac Disease
In patients with dissection and associated aneur ysm, the aortic wall may be diseased over a long segment and subject to progressive degeneration, which can manifest as either dilatation or elonga­tion of the aorta, which in turn, can cause loss of the proximal/distal seal, device migration, or both. Bird beaking/lack of apposition to the aortic wall along the lesser curvature has been associated with device migration. The bird beak effect was significantly more frequent after traumatic aortic rupture treatment. Aortic angle of greater than 50 degrees is predictive of bird beak occurrence.
Correct Answer C 7%
Reference
Geisbüsch, P., Skrypnik, D., Ante, M., et al. (2019). Endograft migration after thoracic endovascular
aortic repair. J Vasc Surg, 69(5), 1387–1394. PMID: 30553729
71. RATIONALE
CTA of the chest showing ruptured large right aberrant subclav ian aneur ysm with hemothora x (2018).
The symptoms of aberrant subclavian artery are most often related to the development of aneurysmal disease occurring at its origin. The aneur ysm develops in 60% of cases and is known as Kommerell diverticulum. Verzini et al. reported the results from a multicenter registry (2007–2013) from seven centers in Italy with the findings that the mean diameter of 4.2 cm is an indication for repair. Most patients had hybrid intervention, with a TEVAR covering the origin of the right subclav ian arter y and carotid-to-subclavian bypass or transposition on both sides in most patients in order to achieve an adequate landing zone and the prevent bird-beak ing phenomenon seen in the tight “gothic arch.” There are several options available to address this dilemma: the first option of simply covering the necessary branch has the potential for increased risk of stroke and in the instance of extended descending aorta coverage, spinal cord ischemia. Another option in the current era is to involve a snorkel for at least one of the arch vessels. In the future, branched endovascular aortic repair may be a better option than TEVAR, but this may result in endoleaks with subsequent risk of rupture.
Correct Answer D 4 cm or greater in AP/transverse diameter
Reference
Verzini, F., Isernia, G., Simonte, G., et al. (2015). Results of aberrant right subclavian artery aneurysm
repair. J Vasc Surg, 62(2), 343–350. PMID: 26211377
72. RATIONALE
Current guidelines suggest repair for:
A. All symptomatic descending thoracic aortic aneurysm (TAA) patients B. Asymptomatic patients with aneurysm diameter 55–60 mm
Section 8: Aortoiliac Disease 155
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C. Rapidly extending aneurysm D. In Marfan syndrome or in a patient with positive family history of descending thoracic aortic
aneurysm with a diameter of 50 mm
Open surgical repair is more durable in younger patients and is mandatory in patients with aneurysms resulting from chronic dissection. Simultaneous abdominal and thoracic aneu­rysms are seen in 20%–25% of patients.
Correct Answer C Open repair
Reference
Hiratzka, L. F., Bakris, G. L., Beckman, J. A., et al. (2010). 2010 ACCF/AHA/AATS/ACR/ASA/SCA/SCAI/
SIR/STS/SVM guidelines for the diagnosis and management of patients with Thoracic Aortic Disea se: a report of the A merican College of Cardiolog y Foundat ion/A merican Heart Ass ociation Task Force on Prac tice Guidel ines, Amer ican Assoc iation for Thorac ic Surgery, Amer ican Colle ge of Radiolog y, American Stroke Association, Society of Cardiovascular Anesthesiologists, Society for Cardiovascular Angiography and Interventions, Society of Interventional Radiology, Society of Thoracic Surgeons, and Society for Vascular Medicine. Circulation, 121(13), e266–e369. PMID: 20233780
73. RATIONALE
156 Section 8: Aortoiliac Disease
For an isolated descending thoracic artery aneurysm, the patient is placed in a right lateral decubi­tus position with the left thorax upwards. At the discretion of the surgeon, a lumbar spinal drain is used to prevent spinal cord ischemia (SCI). A left posterolateral thoracotomy is performed, and the left chest is entered via the fourth intercostal space if the transverse aortic arch is to be intervened upon or via the eighth intercostal space for the distal descending thoracic aortic aneurysm tho­racic. The left femoral vessels are exposed using a transverse inguinal incision for cannulation in readiness for cardiopulmonary bypass (CPB). The descending thoracic aorta is mobilized for resec­tion. When a large aneurysm that contains debris is mobilized, atheromatous emboli can travel retrograde to the cranial vessels; therefore, the aorta should not be touched until an appropriate time of circulatory arrest. If there is insufficient room to cross-clamp the aorta proximally, cardio­pulmonary bypass with deep hypothermic circulatory arrest (DHCA) is usually recommended. Otherwise, left heart bypass or femoral artery–femoral vein bypass (partial CPB) techniques can be used. This does not necessitate circulatory arrest. When CPB is performed, 2–3 units of autologous blood are withdrawn for later reinfusion. After heparinization, a venous cannula is inserted under transesophageal echography (TEE) guidance into the right atrium using a Seldinger technique via the left common femoral vein. The left common femoral artery is isolated, and an 8-mm Dacron graft is sewn in an end-to-side manner via a transverse arteriotomy for arterial return. W hen the long segments of the aorta are to be replaced, the distal clamp is initially set at approximately T5 to maintain lower intercostal artery perfusion; the distal clamp is then repositioned at the distal tho­racic aorta when constructing the distal anastomosis. After proximal and distal anastomoses are constructed, the intercostal arteries are reattached, if felt necessary, by isolating a segment of the graft. Alternatively, the intercostal artery patch reimplantation can occur before the distal anasto­mosis to reduce the SCI time. The clamps are removed, and the CPB is stopped when the patient is normothermic. The left femoral arter y is primarily repaired. Hemostasis is assured with protamine sulfate and autologous blood. The native aneurysm is closed over the graft to separate from adja­cent viscera, chest tubes are placed, and thoracotomy and groin wounds are closed.
Correct Answer A Posterolateral thoracotomy via 8th intercostal space
Reference
Patel, H. J., Shillingford, M. S., Mihalik, S., et al. (2006). Resection of the descending thoracic aorta:
outcomes after use of hypothermic circulatory arrest. Ann Thorac Surg, 82(1), 90–95; discussion 95–96. PMID: 16798196
74. RATIONALE
The most common complication following open descending thoracic aortic aneur ysm repair is post­operative respiratory failure. Risk factors for postoperative respiratory failure include active cigarette smoking, COPD, coronar y artery disease, chronic kidney disease, or bleeding complications. Early ambulation and incentive spirometr y in addition to ensuring tobacco cessation prior to surgery are important strategies to decrease the incidence of respirator y failure. Intraoperative intercostal nerve cryoablation reduces narcotic use and postoperative pain, thus leading to deep inspiration and expi­ration following thoracotomy and help reduce the incidence of respiratory failure.
Correct Answer B Respiratory failure
Reference
Patel, H. J., Shillingford, M. S., Mihalik, S., et al. (2006). Resection of the descending thoracic aorta:
outcomes after use of hypothermic circulatory arrest. Ann Thorac Surg, 82(1), 90–95; discussion 95–96. PMID: 16798196
Section 8: Aortoiliac Disease 157
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75. RATIONALE
Duplex imaging showing par tially thrombosed subclavian and axillar y artery aneurysm w ith tortuosity.
CTA showing large subclavian and axillary artery aneurysm with tortuosity.
158 Section 8: Aortoiliac Disease
Postoperative CTA showing patent interposition graft (within arrows) and partial claviculectomy.
The majority (39%) of subclavian artery aneurysm (SAAs) are located in the proximal segment (39%). The middle segment accounts for 25% and the distal segment 24%, with associated involvement of the proximal axillary artery. Indications for subclavian artery aneurysm repair include size >2 cm, symptoms, or size >1.5 cm and concurrent opera­tion for other aortic pathology. Proximal aneurysms are mostly caused by atheroscle­rotic disease, collagen disorders, trauma, and infection. The middle-segment SAAs are mainly caused by collagen disorders and trauma. Distal SAAs are mostly described in relation to thoracic outlet syndrome or as a consequence of blunt or penetrating trauma. Most patients present with a pulsating mass and shoulder pain. Other symptoms include pain from embolization before local compression, embolization, thrombosis, and rup­ture. Duplex ultrasound scanning for distal SCCA, CTA, and catheter-based angiography are often necessary prior to open repair. Despite the increasing interest in endovascular repair of the aneurysm, open repair of the subclavian artery is preferable and requires thoracotomy. For repair of proximal SAAs, sternotomy with or without supraclavicular and transclavicular/infraclavicular incision with partial resection of the clavicle may be necessary. The majority of subclavian artery aneurysm and nearly all aberrant subclavian artery aneurysms can now be repaired using a TEVAR-based approach without the need for sternotomy or thoracotomy.
Correct Answer A To prevent thromboembolic complications
Reference
Andersen, N. D., Barfield, M. E., Hanna, J. M., et al. (2013). Intrathoracic subclavian artery aneu-
rysm repair in the thoracic endovascular aortic repair era. J Vasc Surg, 57(4), 915–925. PMID: 23375432
Section 8: Aortoiliac Disease 159
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76. RATIONALE
Recurrent laryngeal nerve is the most common nerve to be injured during open repair of a subclavian artery aneurysm, resulting in hoarseness. Stent graft repair is being increas­ingly utilized, but these options are dependent on the anatomical characteristics of the aneurysm and vascular access. Traumatic subclavian artery aneurysm and iatrogenic subclavian artery aneurysm are best repaired using endovascular techniques. Patency of the reconstruction following endovascular repair may further improve with the develop­ment of better stent grafts, as in-stent stenosis and thrombosis were reported in an early series.
Correct Answer B Recurrent laryngeal
Reference
Vierhout, B. P., Zeebregts, C. J., van den Dungen, J. J., & Reijnen, M. M. (2010). Changing profiles of
diagnostic and treatment options in subclavian artery aneurysms. Eur J Vasc Endovasc Surg, 40(1), 27–34. PMID: 20399124
77. RATIONALE
Most aneurysms involving the upper extremity arteries are posttraumatic or secondary to connective tissue disorders or congenital in origin. These aneurysms are relatively uncommon and account for <1% of all peripheral artery aneurysms. Chronic repetitive trauma from the use of crutches can cause aneurysmal degeneration in the proximity arteries (axillary and high brachial) in the upper extremity. All symptomatic true and all pseudoaneurysms in axillary and brachial artery distribution should be repaired. Brachial and radial artery pseudoaneurysms may be secondary to vascular access for coronary or peripheral arteriography with or without associated intervention. Mycotic pseudoaneurysms have also been reported in patients with a history of intravenous drug abuse. During repair of axillary and brachial artery aneurysms, the median nerve needs to be protected, as the median nerve lies lateral to the brachial artery in the upper arm. However, the nerve crosses the artery from the lateral to medial side as it descends. Just before it enters the forearm, the medial nerve passes between the tendons of the biceps brachii and brachialis.
Correct Answer A <1%
Reference
Gray, R. J., Stone, W. M., Fowl, R. J., Cherry, K. J., & Bower, T. C. (1998). Management of true aneurysms
distal to the axillary artery. J Vasc Surg, 28(4), 606–610. PMID: 9786253
78. RATIONALE
All symptomatic true or pseudoaneurysms involving the axillary and brachial artery should be repaired. The most common presentation of axillary and brachial artery aneurysms is distal embolization resulting in hand ischemia. Patients may also present with neurological symp­toms associated with brachial plexus (axillary artery) or median nerve (brachial artery) com­pression. Pseudoaneurysm due to infection can be safely ligated due to abundant collaterals. Asymptomatic true aneurysms should be repaired if equal to or greater than 2 cm in the trans­verse/AP diameter. Primary repair, resection with end-to-end anastomosis, patch angioplasty,