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Ординатура / Хирургия / Библиотека им академика М.И. Перельмана / Книга_3734_Библиотеки_им_академика_М_И_Перельмана

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Long-Term Imaging oftheAorta: Considerations andComparison ofModalities
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approach can lead to signicant measurement variability (on the order of 5–10mm) related to the degree of aortic obliquity, particularly at the root and arch segments [38]. With the advent of medical image analysis software, multi-planer reformats (MPR) can be generated that allow for measurement of the aortic diameter orthogo­nal to the vessel axis (i.e. double-oblique plane), and these orthogonal measurement planes can be generated either manually, or more recently with the assistance of semi-automated image analysis software that rst generates a centerline through geometric center of the vessel lumen (Fig.5). However, despite optimal centerline assessment technique, measurement variability remains within the ±2mm range for TAA even in the setting of highly standardized measurement protocols [39, 40]. Measurement variability is further increased when the aortic wall geometry is non­circular/ovoid or the aortic wall is difcult to clearly visualize, as is often the case with aortic dissection. Measurement variability alone often precludes condent determination of aortic enlargement considering that aortic growth rates commonly fall within the range of 1–3mm per year.
Methods toImprove Quality ofImaging Surveillance
Considering that aortic diameter is the gold standard metric for assessment of aortic disease, it is important for both imagers and surgeons to understand and utilize best practices for aortic measurement in order to ensure the most reliable aortic growth
ab c
Fig. 5 Aortic Measurement Techniques: The simplest method of measurement involves measuring the shortest dimension of the aorta on standard axial images (a), although this method can lead to signicant measurement variability. Double-oblique measurement technique minimize inaccuracy related to measurement plane obliquity and can either be performed manually using multi-planar reformats (b) or using a semi-automated centerline approach (c)
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assessment possible. The key to minimizing measurement variability is to minimize any differences in measurement technique between two different scans. Specically, it is ideal to have both prior and current scans measured using the same measure­ment technique (e.g. centerline versus manual MPR versus axial), and using the most comparable images in terms of contrast phase, slice thickness and gating parameters. Any areas of maximal aortic dimension should be directly compared between the prior and current scans by the same person, using the same software, at as close to the same anatomic location as possible, and ideally in a side-by-side fashion to allow for conrmation of the visual similarity of measurement planes. Additionally, all readers should be instructed to use the same measurement land­marks along the length of the aorta, and diameter measurements should extend from the outer aortic wall to outer aortic wall have been shown to be most reproducible in TAA, although outer aortic wall can be difcult to locate in aortic dissection if the false lumen enhancement is low [3, 15]. Furthermore, it important that if prior CT images/measurements were obtained a different institution, that the measurements on the external prior study be repeated by the current institution, as signicant inter­institutional measurement variability has been documented, mostly owing to differ­ences in institutional specic measurement protocols [41]. Lastly, to maximize the interpretability and comparability of documented aortic measurements, it is ideal to utilize a standardized measurement reporting/storage format, and many image anal­ysis programs currently support generation of standardized measurement reports.
N. S. Burris et al.
Advances andFuture Directions
While seemingly a simple task, long-term imaging surveillance of aortic disease struggles with measurement inaccuracies and can be exceedingly time consuming, particularly in the aortic dissection or post-endograft settings where patient-specic considerations, and variations in aortic anatomy, image quality and measurement technique are accentuated. There are two areas in which we believe ongoing advancements in aortic imaging will have a signicant impact on the quality of aortic imaging surveillance in the future. First, while MRA is clearly a secondary modality to CTA in majority of institutions due to issues of time, cost and image quality, given MRI’s inherent ability to resolve the aortic blood pool and aortic wall without the need for radiation or contrast, and given its ability to provide a dynamic assessment of aortic morphology, distensibility and blood ow, MRI/MRA may be an ideal method to more fully characterize aortic disease. While further advance­ments are needed to shorten acquisition times for MRI/MRA and to establish the clinical relevance of dynamic aortic parameters in aortic dissection (e.g., distensi­bility, blood ow, ap motion), active research in these areas has shown promising results [4244]. Secondly, there is a critical need to advance the speed and accuracy of aortic size and growth assessment in long-term imaging surveillance. Advanced computational methods in the elds of computer vision and machine learning may
ab
Long-Term Imaging oftheAorta: Considerations andComparison ofModalities
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Fig. 6 Future Directions to Improve Aortic Measurements and Imaging Surveillance: Software exists that permits tabulation and graphical representation of aortic measurements along the length of the aorta at each surveillance imaging study allowing for improved depiction of long-term growth trends. A sample report is shown from a patient with acute type A aortic dissection treated with ascending aortic repair, with residual dissection involving the arch and descending thoracoab­dominal aorta. Five series follow-up studies demonstrate gradual increase in maximum diameter of the proximal descending thoracic aorta over two years. Courtesy of Dominik Fleischman, Stanford 3D/Quantitative Imaging Laboratory (a). Image analysis tools are being developed that allow for a three-dimensional analysis of aortic growth in aortic dissection that overcomes many of the limitations of diameter measurements, and an example of such a 3D analysis in a repaired type A dissection patient with stable aortic dimensions is shown (b)
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be ideal solutions. Preliminary studies have shown that automated segmentation and classication of aortic aneurysms as well as three-dimensional deformation analysis of aortic growth are both possible, and suggest the possibility that the future of aor­tic imaging surveillance may evolve from the hands of human readers to the servers of medical imaging software companies (Fig.6) [45, 46].
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Part III
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Treatment of Acute Thoracic Aortic
Syndromes
Blunt Traumatic Aortic Injury: Etiology,
https://t.me/med1917
Diagnosis, andManagement
BruceL.Tjaden andAnthonyL.Estrera
History
The rst report of a BTAI is widely attributed to Andreas Vesalius in 1557. However, this is factually incorrect. The case was rst brought to Vesalius’ attention in 1555, and it was not until 1609 when a report by Dr. Adolph Occo III (a friend and colleague of Vesalius) was posthumously published describing the situation in detail.
While references to this famous injury abound, nding the actual text of the case report can be challenging, due to its age. Thankfully, Drs. Suy and Fourneau of the University of Leuven in Belgium recently provided an excellent English translation of Dr. Occo III’s “Famous Case of an Aneurysm,” which is reproduced here with permission:
Leonard Welser, a gentleman of Augsburg, [had] sustained a violent concussion when han-
dling an agitated horse. He became ill with pertinent sickness, whose principal symptom
was excruciating pain in the dorsal region. He failed to respond to any of the medicines
proposed by his physicians, and so the advice of Vesalius from Belgium, who then taught
anatomy, was sought. This illustrious man instantly recognised the symptoms of an aortic
aneurysm, which he predicted would be fatal. Immediately on discovering a small pulsating
tumour under the dorsal spine, he declared it to be an aneurysm caused by dilation of
the aorta.
Given that this resulted from a concussion, it was incurable. He also stated that he had seen such a disease in the neck, the chest, the popliteal space, and the arm, and that it always was associated with excruciating pain, and at the end, sideration [gangrene]. [Vesalius stated that] this condition is incurable unless it is possible to remove it, and that these aneurysms frequently contain a concrete uid resembling ice or the crystalline humour, sometimes coagulated blood, or a polypous substance. [He also stated that] while alive, the aneurysmal blood remains uid, but that is black and sidareted [sic] after death, [and that the] patient dies suffering from exquisite pain, [and that] sometimes these vascular
B. L. Tjaden · A. L. Estrera (*) Department of Cardiothoracic and Vascular Surgery, McGovern Medical School at The University of Texas Health Science Center at Houston (UTHealth), Houston, TX, USA e-mail: Anthony.L.Estrera@uth.tmc.edu
J. S. Coselli et al. (eds.), Aortic Dissection and Acute Aortic Syndromes,
https://doi.org/10.1007/978-3-030-66668-2_14
209© Springer Nature Switzerland AG 2021
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dilatations form spontaneously, sometimes they are the results of an external cause, as in the present case. Two years after the consultation, the patient nally ran out of patience in the face of this pain, which had resisted all medical treatment. [The patient] ultimately threw himself into the hands of an empiric [a charlatan], who administered certain catapotia [internal remedies], the use of which was soon followed by expectoration of blood, causing the patient to choke on his own blood, resulting in sudden death on June 25, 1557. From the section of the body we found, as predicted by Vesalius, a very large, cavernous, eshy, tumour protruding from the aorta, which was the source of the pain and the pulsations in the back. As predicted by Vesalius, the good man died from this incurable disease [
B. L. Tjaden and A. L. Estrera
1].
While most patients with BTAI injuries now sustain their injury in motor vehicle accidents rather than equestrian misadventures, this famous rst account of the pathology sheds light on the timeless features of aortic trauma.
Epidemiology andTerminology
In general, penetrating trauma has accounted for the majority of historic aortic inju­ries (83% in one large trauma registry [2].) However, due to the predominance of blunt traumatic mechanisms—along with the survivability of BTAI—most trau­matic aortic injuries that surgeons encounter will be BTAI.
The vast majority of these BTAI involve the descending thoracic aorta [2]. This
has the potential to lead to confusion, as blunt traumatic aortic injury (which can also include the abdominal aorta) and blunt thoracic aortic injury have both been abbreviated BTAI. Authors have historically used these terms interchangeably in the literature because, again, they are epidemiologically nearly synonymous. In light of that, we will not draw distinctions in our review of the literature between the two concepts. In our text, we will use the abbreviation BTAI to mean blunt thoracic aortic injury, exclusive of abdominal injury.
Motor vehicle crashes account for the largest subset of BTAI cases [3]. While
BTAI are infrequent overall (incidence <0.5% of trauma patients in our registry [4]), they carry a high mortality risk. They are the second-most common cause of blunt traumatic fatalities [3]. In fact, nearly one-third of blunt trauma-related deaths were associated with BTAI on in an autopsy study [5].
As trauma patients are younger on average than most other patients suffering
from acute aortic syndromes, it should come as no surprise that most patients with BTAI are young. One 18-year institutional review found an average age of 38years [6]. This has implications for device selection and treatment strategies [7], and will be discussed later.
Diagnosis: Physical Exam andImaging Modality
Physical exam is not reliable in ruling in or ruling out BTAI [8]. For this reason, virtually all patients with BTAI will be diagnosed by virtue of imaging. A widened mediastinum on chest x-ray (CXR) may be present, though in isolation, this nding
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is not particularly useful. Even when considering multiple radiographic ndings in aggregate, CXR is not an adequate test for diagnosing BTAI [9], and has been shown to have a sensitivity as low as 41% [10]. A multicenter study found that the constellation of several CXR ndings, in addition to other organ injury and clinical criteria (“widened mediastinum, hypotension less than 90 mmHg, long bone fracture, pulmonary contusion, left scapula fracture, hemothorax, and pelvic fracture”) could be used to diagnose BTAI with a sensitivity of 92% and specicity of 85% [11].
As early as 1996, contrast-enhanced CT of the chest was found to be 97% sensi-
tive and 99.8% specic for BTAI [12]. Over the ensuing decade, from 1997–2007, there was a fundamental shift in the diagnosis of BTAI [13]. CT has become the new gold standard for identifying this injury, and is the modality according to which most diagnostic and treatment decisions are made [13]. Recent work also supports the adequacy of CT with venous contrast instead of formal CT angiography (CTA) in diagnosing BTAI [14]. CT allows for excellent visualization of the injury in axial, coronal, and parasagittal projections, as well as 3D reconstruction of the injury and accurate measurements of the aortic diameter and lengths along centerline, greater curve, and lesser curve using specialized software. (Fig.1).
If the diagnosis of BTAI is equivocal, adjunctive tests can be performed to rule
aortic injury in or out. When comparing CTA, angiogram, and IVUS, IVUS has been shown to be the least equivocal in cases of BTAI [15]. One observational study suggested that IVUS has a sensitivity of 91.7% and specicity of 100% for BTAI. The same publication found transesophageal echocardiography (TEE) to have a 60% sensitivity and 66.7% specicity [16].
BTAI most often occurs in the proximal descending thoracic aorta at the level of
the aortic isthmus, but concomitant injury in other locations, such as the ascending, arch, and distal descending thoracic aorta, may be present as well. The adoption of the Ishimaru zones of the aorta may be used in order to more accurately categorize the location of BTAI [17]. According to this schema, the common locations of BTAI would be classied as zone 2 and 3 [7].
Fig. 1 From left: Axial, parasagittal, and reconstructed images from a computed tomographic angiogram of the chest, demonstrating a severe (Grade IV) blunt thoracic aortic injury