Ординатура / Хирургия / Библиотека им академика М.И. Перельмана / Книга_5354_Библиотеки_им_академика_М_И_Перельмана

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β- Carbolines

β- Carbolines: A Privileged Scaffold for Modern Drug Discovery provides a summary of methods for the synthesis of various natural products engineered with the diverse

β- carboline scaffold and their biological evaluation.

β- carboline and its derivatives have generated considerable interest in recent years

for their versatile properties in chemistry and pharmacology. This is due to their ability to act as agonists to benzodiazepine receptors, hydroxy serotonin receptors, and intercalate into DNA and to inhibit CDK, topisomerase, and monoamine oxidase enzymes. Their pharmacological properties include anxiolytic, hypnotic, anticonvul­sant, antiviral, antiparasitic, and antimicrobial attributes. This book provides a sum­mary of methods for the synthesis of various natural products engineered with the diverse β- carboline scaffold and their biological evaluation.

• Provides a summary of methods for the synthesis of various natural products engineered with the diverse β- carbolines.

• Discusses methods of biological evaluation of β- carbolines.

• Explores different chemical transformations occurring with synthesis using β- carbolines.

• Covers both heterocyclic synthesis and multicomponent synthesis related to β- carboline.

This text is key reading for researchers in medicinal chemistry and drug discovery looking to understand the broad potential of β- carbolines.

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Contents

Foreword ...................................................................................................................ix

Dattatraya Pansare, Rohini Shelke, Rajita Ingle, Shankar Thopate, Mubarak Shaikh, Aniket Sarkate, and Rajendra P. Pawar

Jagannath S. Godse, Santosh B. Gaikwad, Sunil U. Tekale, Sanjay B. Ubale, and Rajendra P. Pawar

Foreword

In the ever- expanding realm of chemistry of bioactive heterocycles and its applications, the exploration of β- carboline skeleton, representing the basic structural unit of many bioactive heterocycles, stands as a captivating journey into the intricate tapestry of molecular diver­sity. As we embark on this intellectual odyssey through the pages of β- Carboline: A Privileged Scaffold for Modern Drug Discovery, we nd ourselves immersed in a world where bioactive heterocycles create symphonies

The chapters within this book are not mere compilations of data or just lists of facts; rather, they are thought- provoking journeys of researchers who understand the complexities of synthesis, characterization, and biological study of differently substituted β- carbolines. From foundational ideas to state- of- the- art developments, the authors have expertly constructed a timeline that pushes the limits of human com­prehension and goes beyond accepted wisdom. I extend my gratitude to the contributors who have shared their intellectual jewels, shaping this book into a treasure trove of knowledge. May the readers nd inspiration within these pages, sparking new ideas and forging ahead on their own quests for understanding.

Vice- Chancellor, Central University of Gujarat, Gandhinagar, Bharat- 382030.

Preface

Heterocycles offer an extensive variety of structural variations that facilitate the development of varied chemical libraries. The hunt for new medications with enhanced efcacy, fewer side effects, and unique methods of action benets from this diversity. Heterocycles are found in many therapeutic products. To optimize their interactions with target biomolecules, increase bioavailability, and improve pharma­cological characteristics, medicinal chemists often add heterocyclic moieties to drug candidates. Biologically active heterocyclic compounds have been a primary area of interest for organic chemists for many years due to their numerous medicinal prop­erties. In the realm of medicinal chemistry, nitrogen, sulfur, and oxygen- containing ve- and six- membered heterocyclic molecules have held great importance.

β- carbolines are a large group of natural and synthetic indole alkaloids having common tricyclic pyrido[3,4- b]indole ring motif with varying degrees of aromati­city, some of which are widely distributed in nature including various plants, marine creatures, insects, foodstuffs, mammalians as well as human tissues and body uids. This group has occupied an exceptional position in heterocyclic chemistry, and its derivatives have fascinated considerable interests in recent years for their versatile properties in chemistry and pharmacology. β- carboline is a modern artist of current drug discovery architectures. However, in the last 50 years, with the introduction of different biological evaluation, the importance of β- carboline scaffold for drug discovery has been recognized and considerable efforts from both academic and industrial researchers have been focused especially on the design and development of natural product inspire divers β- carboline scaffold.