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464 Challenging Concepts in Urological Surgery
(a) (b)
(b)(a)
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Figure 48.3 CT of the pelvis showing (a) pelvic collection; (b) CT- guided drainage of pelvic collection
with the pigtail.
On a follow- up nephrostogram, contrast continued to leak into the pelvis from a point near the right ureteroileal anastomosis. This resulted in a persistent presacral pelvic collection. This was drained for the third time under CT guidance.
One week later, the patient underwent bilateral retrograde ureteric stent insertion by interventional radiology (Figure 48.5) utilizing an antegrade approach through the nephrostomies. This procedure helped to further divert urine away from the de­fective ileal conduit. The internal– external urinary stents negated the ongoing need for nephrostomy drains and are much better tolerated by the patient with drainage in to the stoma bag.
Figure 48.4 Nephrostograms showing (a) a leak close to the right ureteroileal anastomosis; (b) a
stricture proximal to the left ureteroileal anastomosis. A CT scan on follow- up showed an ongoing pelvic collection measuring 3 × 6 × 11 cm which was drained a second time under CT guidance by interventional radiologists.
Figure 48.5 Static image during fluoroscopy showing bilateral retrograde ureteric stents.
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465Case 48 Acute interventional radiology procedures in urology
A year later, the patient continued to have intermittent septic episodes and the small bowel stoma output was high. Following which, he had a laparotomy, reversal of ileostomy, and ileocolic anastomosis. In addition, the chronic pelvic collection was drained intraoperatively.
A solitary metastasis in the right lobe of the liver has increased in size on MRI follow­up, measuring 4 cm, and the patient underwent a liver resection (metastatectomy) as the lesion was not amenable to radiofrequency ablation due to its proximity to the diaphragm and the risk of potential thermal injury.
On the latest follow- up CT scan, the pelvic collection was found to be small and no further drainage was undertaken. The patient undergoes urinary stent exchange in radiology every 6 weeks.
Learning point Ureteric stents
Antegrade, retrograde, or internal (double J) stents are routinely placed by interventional radiologists.
Retrograde (transileal conduit) ureteric stent insertion
A retrograde stent is a catheter placed in patients who have undergone surgical treatment, such as cystectomy with ileal conduit formation in which it exits from the conduit and extends retrogradely to the renal pelvis.
It is estimated that 15% of patients develop complications in the form of a stricture at the ureteroenteric junction causing obstruction. hydronephrosis by percutaneous methods can reach up to 100%. In addition, placement of retrograde transileal conduit stents can be successful in 90– 95% of cases.
6– 8
Treatment success of ureteric strictures and subsequent
9
466 Challenging Concepts in Urological Surgery
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A retrograde (transileal conduit) ureteric stent can be placed by an antegrade method if the patient has a nephrostomy in situ or by a retrograde approach, if not, through the stoma.
Retrograde placement of a retrograde (transileal conduit) ureteric stent technique
The ileal conduit is opacified by contrast that is allowed to reflux through the ureteroenteric junction leading to visualization of the ureter with success rates ranging from 14% to 86%. This can be performed by inserting a Foley catheter alongside an angle- tipped catheter in to the ileal loop. A guidewire is introduced through the catheter to access the ureteroenteric anastomosis and advanced up the ureter. The catheter is advanced into the renal pelvis and exchanged for a stiff guidewire. A catheter can then be advanced over the wire and its pigtail is formed within the renal pelvis. The distal end of the catheter can be cut to an appropriate length and left within the stoma bag for drainage.
Antegrade placement of a retrograde ureteric stent technique
The patient can be placed initially in a lateral oblique position or can be rotated from a prone position after obtaining initial access to the pelvicalyceal system. The renal collecting system is accessed under ultrasound guidance and contrast is injected, providing visualization of the urinary tract to the ileal conduit. A guidewire is advanced through the collecting system and manipulated using a catheter down the ureter and out the stoma. An angled- tip hydrophilic wire can be used. Once the wire is out through the stoma, providing through and through access, tension should be maintained on both ends of the wire and an antegrade or retrograde catheter can be advanced to allow guidewire exchange for a stiffer working wire to allow stent insertion through the stoma to form the pigtail within the renal pelvis. The wire can be removed once the catheter is adequately positioned. If there is a need to leave a covering nephrostomy then the wire can be pulled back to the renal pelvis and a nephrostomy tube can then be placed.
A final word from the expert
This patient required multiple interventional radiology procedures and the diversion of urine away from the postoperative pelvis allowed an attempt at a corrective laparotomy (although sadly this was only partially successful) and has allowed wound healing and a return to a relatively normal life for the patient at home.
Urinary diversion through the stents into the ileal conduit (urostomy) bag is much better managed by the patient at home than bilateral nephrostomy drains which impact heavily on the activities of daily living such as dressing and bathing. The risk of inadvertent nephrostomy tube displacement despite locking pigtail mechanisms, sutures and dressings can be up to 14.5%.
Although better tolerated, ureteric stents draining in to a stoma bag can become encrusted by lithogenic urine and require regular exchanges every 2– 3 months. Accidental displacement when changing the stoma bag is rarely complete and salvage via a retrogradely introduced guidewire under fluoroscopic guidance is usually successful. One of the few advantages of nephrostomies over stents draining in to a single stoma bag is the difficulty with the latter of recognizing reduced output from one or other kidney in the context of drain blockage or displacement.
Urinary leaks post cystectomy/ pelvic exenteration and ileal conduit urinary diversion are uncommon (approximately 2%) but usually arise from the ureteroileal anastomosis and an early clinical presentation is a predictor for the need for adjuvant upstream urinary diversion with nephrostomies.11 Ischaemic breakdown of the proximal ileal conduit itself is very uncommon but patient frailty and chemoradiotherapy are likely to have played a role.
Ultimately, if the surgeon is prepared to operate, the interventional radiologist should be prepared to provide all necessary support as required.
10
467Case 48 Acute interventional radiology procedures in urology
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References
1. PelvEx Collaborative. Factors affecting outcomes following pelvic exenteration for locally
recurrent rectal cancer. Br J Surg. 2018;105(6):650– 657.
2. Goodwin WE, Casey WC, Woolf W. Percutaneous trocar (needle) nephrostomy in
hydronephrosis. J Am Med Assoc. 1955;157(11):891– 894.
3. Ramchandani P, Cardella JF, Grassi CJ, et al. Quality improvement guidelines for percutan-
eous nephrostomy. J Vasc Interv Radiol. 2003;14(9 Pt 2):S277– S281.
4. Zagoria RJ, Dyer RB. Do’s and don’t’s of percutaneous nephrostomy. Acad Radiol
1999;6(6):370– 377.
5. Dagli M, Ramchandani P. Percutaneous nephrostomy: technical aspects and indications.
Semin Intervent Radiol. 2011;28(4):424– 437.
6. Pappas P, Stravodimos KG, Kapetanakis T, et al. Ureterointestinal strictures following
Bricker ileal conduit: management via a percutaneous approach. Int Urol Nephrol. 2008;40(3):621– 627.
7. Alago W Jr, Sofocleous CT, Covey AM, et al. Placement of transileal conduit retrograde
nephroureteral stents in patients with ureteral obstruction after cystectomy: technique and outcome. AJR Am J Roentgenol. 2008;191(5):1536– 1539.
8. Tal R, Bachar GN, Baniel J, Belenky A. External- internal nephro- uretero- ileal stents in pa-
tients with an ileal conduit: long- term results. Urology. 2004;63(3):438– 441.
9. Makramalla A, Zuckerman DA. Nephroureteral stents: principles and techniques. Semin
Intervent Radiol. 2011;28(4):367– 379.
10. Wah TM, Weston MJ, Irving HC. Percutaneous nephrostomy insertion: outcome data from a
prospective multi- operator study at a UK training centre. Clin Radiol. 2004;59(3):255– 261.
11. Farnham SB, Cookson MS. Surgical complications of urinary diversion. World J Urol
2004;22(3):157– 167.
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INDEX
For the benefit of digital users, indexed terms that span two pages (e.g., 52– 53) may, on occasion, appear on only one of those pages.
Tables, figures, and boxes are indicated by t, f, and b following the page number
A
AAST see American Association for the
Surgery of Trauma (AAST)
abdominal sacrocolpopexy, vaginal
sacrospinous fixation vs. 276
abiraterone
adverse effects 101t bone metastases management in prostate
cancer 99
metastatic prostate cancer 96 ABP (acute bacterial prostatitis) 11 acquired cryptorchidism 425 acupuncture, bladder pain syndrome 250 acute bacterial prostatitis (ABP) 11 acute interventional radiology 461– 67 acute kidney injury (AKI) 300– 1, 302 acute (T- cell)- mediated rejection 413 acute urinary diversion 120 acute urinary retention (AUR) 211– 20
bladder stones 47– 49
definition 221
initial treatment 223
risk factors 213, 213t
see also benign prostatic enlargement adjuvant chemotherapy, metastatic penile
cancer 178 adrenalectomy 148 Adriamycin see MVAC (methotrexate/ vinblastine/
Adriamycin (doxorubicin)/ cisplatin) ADT see androgen deprivation therapy (ADT) advanced pelvic malignancy, radiotherapy 313 AFP see alpha- fetoprotein (AFP) age
non- muscle- invasive bladder cancer 108
testicular cancer 185 AKI (acute kidney injury) 300– 1, 302 alpha- adrenergic agonists 355t alpha- fetoprotein (AFP)
metastatic testicular cancer 199
testicular cancer 189t
testis cancer 185 alprostadil 335 ALS/ MPCA trial 100
American Association for the Surgery of
Trauma (AAST) bladder and ureteric trauma 390, 390t renal trauma scale 381
American Urological Association 366t amitriptyline 249 AML see angiomyolipoma (AML) amoxycillin resistance 3 Amplatz, small- volume neobladders 56 AMR (antimicrobial resistance) 3, 4 anaemia 97 anaesthetics
examination of impalpable testes 428 orchidopexy 427
anastomoses, ketamine- induced bilateral
urinary tract injury 305
Anderson– Hynes pyeloplasty 65– 66 androgen deprivation therapy (ADT) 89
adverse effects 97 bone health management 98 continuous vs. intermittent 97 metastatic prostate cancer 95 timing of 96
anejaculation 352 angiomyolipoma (AML) 149
computed tomography 150f epithelioid type see epithelioid
angiomyolipoma radiology 150
anorgasmia (AO) 352
causes and treatment 356, 356t
antegrade placement, retrograde (transileal
conduit) ureteric stent insertion 466
antenatal hydronephrosis 449 anterior colporrhaphy 274 anterior enterocele 272 anterior vaginal wall prolapse 272 anthracyclines 111 anti- androgens 95, 96 antibiotics, vesicoureteral reflux 453 antibodies
renal transplantation management 411 renal transplantation rejection 413
470 Index
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anticholinergic drugs
dementia 231 discontinuation of 231 neurogenic bladder 263, 438 retrograde ejaculation management 355t urge urinary incontinence 230– 31
anti- incontinence surgery, urethral
diverticulum surgery and 294 antimetabolites, renal transplantation 411 antimicrobial resistance (AMR) 3, 4 antimuscarinic therapy 438 anti- sacrococcygeal ligament 272f AO see anorgasmia (AO) apalutamide 96 APGAR (Appearance, Pulse, Grimace, Activity,
and Respiration) scores 449 ARASENS trial 96 L- arginine, bladder pain syndrome 249– 50 artificial urinary sphincter 52– 56, 53f ascending testis 425 aspiration, priapism 376 ASSURE trial 148 asymptomatic inflammatory prostatitis 19 atezolizumab 131, 132 audiological studies 190 augmentation cystoplasty 233, 263 augmented bladders 55– 56 AUR see acute urinary retention (AUR) autoimmune arthritis 311 autologous fascial sling (AFS)
mid- urethral tape vs. 240 stress urinary incontinence
management 239– 40 autotransplantation 158, 159f, 159
surgery 158 avelumab 132 axitinib 140 azoospermic patient 321– 29
genetic abnormalities 324
hormone levels 324t
semen fluid analysis 322, 323, 323t
B
bacterial prostatitis 12, 16 balanitis xerotica obliterans (BXO) 444
appearance of 445f
circumcision and 443
histology 444f, 444 balloon dilatation, small- volume
neobladders 56
BCG
adverse effects 110
contraindications 110
durvalumab and, non- muscle- invasive
bladder cancer 112 failure 110 high- grade non- muscle- invasive bladder
cancer 128– 29 non- muscle- invasive bladder cancer
management 109 outcomes of 130 palliative cystectomy 123
behavioural techniques, bladder pain
syndrome 250
bell clapper deformity 363 benign prostate hyperplasia (BPH)
bladder stones 48 definition 215
benign prostate obstruction (BPO) 216 benign prostatic enlargement 211– 20
see also acute urinary retention (AUR)
BEP (bleomycin, etoposide, cisplatin)
metastatic NSGCT 190 non- seminomatous germ cell tumour 200
beta human chorionic gonadotropin (β- HCG)
metastatic testicular cancer 199 testicular cancer 185, 189t
bilateral nephrostogram 303f bilateral orchidectomy 95 bilateral retrograde ureteric stents 465f bilateral ureteric reimplantation 301 bilateral ureteric stents 301, 302f biomarkers, bladder pain syndrome 250 biopsy, percutaneous in oncocytoma 72, 75– 76 bisphosphonates 98 bivalving, bladder 391 bladder
augmented bladders 55– 56, 438 bivalving of 391 cancer see bladder cancer capacity 420, 437 closure of 392 congenital neuropathic bladder
dysfunction 433 drainage in urinary retention 255 drainage post repair 392 filling rate measurement 422 function assessment 420 grossly trabeculated bladder 422f hydrodistension 250 large volume neobladder see large- volume
neobladder neurogenic bladder see neurogenic bladder non- neurogenic neurogenic see non-
neurogenic neurogenic bladder overactive see overactive bladder (OAB)
471Index
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pain see bladder pain syndrome (BPS) small- volume neobladder see small- volume
neobladder thickened walls 420f trauma see bladder and ureteric trauma
bladder and ureteric trauma 389– 95
bladder drainage post- repair 392 examination 389 imaging 390f initial assessment 389 see also ureteric trauma
bladder cancer
diagnosis 118 genetic classification 119 histological staging 120 muscle- invasive see muscle- invasive
bladder cancer (MIBC) non- muscle invasive see non- muscle-
invasive bladder cancer (NMIBC) pathology subtypes 119 pT1 tumours 119 staging 118 transitional cell carcinoma 130 transurethral resection see transurethral
resection of the bladder tumour (TURBT) see also high- grade non- muscle- invasive
bladder cancer
bladder diary 212 bladder neck (BN) procedures 439 bladder outflow obstruction (BOO) 215– 16 Bladder Outflow Obstruction Index
(BOOI) 214, 215
bladder pain syndrome (BPS) 247– 52
clinical assessment 248 diagnosis 248 differential diagnosis 247b, 247 investigations 248 management 249 pathophysiology 251
bladder stones 47– 60
acute urinary retention 47– 49 benign prostate hyperplasia 48 clinical features 48 mesh on 49f, 49– 50 risk factors 48 size effects 54, 55f treatment options 48 urethral strictures 50– 51, 51f see also small- volume neobladder
Blaivas classification, stress urinary
incontinence 241t
bleomycin
contraindications 201
metastatic prostate cancer 178– 79
see also BEP (bleomycin, etoposide, cisplatin) blood gas analysis, priapism 376 blood groups, renal transplantation 410 blood tests
ketamine- induced bilateral urinary tract
injury 299 muscle- invasive bladder cancer 117 urinary retention 222
BMG (buccal mucosal graft) 286, 287t BN (bladder neck) procedures 439 bone metastases 99 BOO (bladder outflow obstruction) 215– 16 BOOI (Bladder Outflow Obstruction
Index) 214, 215
botulinum toxin A
bladder pain syndrome 250 intradetrusor 263 neurogenic bladder 438
BPO (benign prostate obstruction) 216 BPS see bladder pain syndrome (BPS) brain death examination 408 BRAVO randomized controlled trial 119 buccal mucosal graft (BMG) 286, 287t Bulkamid® 239 bulking materials, vesicoureteral reflux
correction 453
BXO balanitis xerotica obliterans (BXO)
C
cabazitaxel 101t CAD (coronary artery disease) 332 calcineurin inhibitors 411 calcium supplements 98 carboplatin 130, 131 cardiac function tests, pre- chemotherapy 190 cardiovascular system, androgen deprivation
therapy 97
CARD trial 100 castration
medical castration 95 metastatic prostate cancer 95 surgical castration 95
catheterization
clean intermittent catheterization 423 clean intermittent self- catheterization 261 haematuria 389 haematuria after 223 indwelling catheters 263 intermittent self- catheterization 226 removal 312 self catheterization 263 transurethral catheter 389
472 Index
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cauda equina syndrome (CES) 255 cervical prolapse 272 CFTR gene mutations 324 CHAARTED trial 96 checkpoint inhibitors 113 chemotherapy
high- grade non- muscle- invasive bladder
cancer 132
metastatic bladder transitional cell
carcinoma 131 metastatic penile cancer 178 neoadjuvant chemotherapy see neoadjuvant
chemotherapy (NAC) non- muscle- invasive bladder
cancer 111, 112 non- seminomatous germ cell
tumour 200, 202 pre- testing 190 residual masses in testicular
cancer 199– 207 second- line 132 serum tumour markers 201
children
neurogenic bladder 433– 41 vesicoureteral reflux 449– 57
chronic kidney disease (CKD)
aetiology 405 definition 405
chronic prostatitis/ chronic pelvic pain
syndrome (CP/ CPPS) aetiology 16 clinical evaluation 16 subtype classification 18t therapy 18
chronic urinary retention (CUR) 221– 28
definition 221 definitive management 226 initial treatment 223 therapy 225
ciprofloxacin 12 circumcision
balanitis xerotica obliterans and 443 indications for 444 monitoring after 445 penile cancer 166 urinary tract infection prevention 453
CISC (clean intermittent
self- catheterization) 261
cisplatin
metastatic bladder transitional cell
carcinoma 131 metastatic prostate cancer 178– 79 muscle- invasive bladder cancer 117
TIP (paclitaxel, ifosfamide, cisplatin) 179 see also BEP (bleomycin, etoposide,
cisplatin); MVAC (methotrexate/ vinblastine/ Adriamycin (doxorubicin)/
cisplatin) CKD see chronic kidney disease (CKD) clam ileocystoplasty 265f
ileal chimney with 301 clean intermittent catheterization 423 clean intermittent self- catheterization
(CISC) 261 Coaptite® 239 coccygeus muscle 272f coccyx 272f Cochrane review, pelvic floor muscle
training 238 colosuspension
mid- urethral tape vs. 240 stress urinary incontinence
management 240 colour Doppler ultrasound, testicular
torsion 365 colpocleisis 276 colporrhaphy, anterior 274 ComBAT study 213 combination chemotherapy, non- muscle-
invasive bladder cancer 112 complement- dependent cytotoxicity test 410 complex urethral diverticulum 295 computed tomography (CT)
acute interventional radiology 461, 462f angiomyolipoma 148, 150f bladder and ureteric trauma 390f bladder stones 47f, 47 bladder stones on mesh 49f, 49 growing teratoma syndrome 187f, 194– 95 guidance in laparotomy 463, 464f high- grade non- muscle- invasive bladder
cancer 127f, 127, 129f, 130f, 130, 132f
hydronephrosis 38f ketamine- induced bilateral urinary tract
injury 300
large- volume neobladder 57f localized renal cancer with vena cava
tumour thrombosis 137f, 137
metastatic germ cell cancer 191f, 191 metastatic testicular cancer 201f, 201 muscle- invasive bladder cancer 117 oncocytoma 71f, 74 prostatitis 12f, 12, 13f renal masses 75 renal stones 25, 26f renal trauma 381, 382f
473Index
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ureteric stones 36f, 36, 37 ureteropelvic junction obstruction 65f, 65 ureteropelvic junction obstruction
(UPJO) 63, 64f
computed tomography urogram
(CTU) 155f, 155
congenital neuropathic bladder
dysfunction 433 congenital penile curvature 345 connective tissue
pelvis 273
vesicovaginal fistula 311 conservative surgery, penile cancer 168, 169 continuous isoperistaltic ileal segment 302– 4,
303f, 304f contralateral fixation, testicular torsion 367 contralateral testis biopsy 187 contrast enhanced ultrasonography 365 coronary artery disease (CAD) 332 counselling, urethral diverticulum 292 CP see chronic prostatitis/ chronic pelvic pain
syndrome (CP/ CPPS) CPPS see chronic prostatitis/ chronic pelvic
pain syndrome (CP/ CPPS) cranberry supplements 5– 6 creatinine
ketamine- induced bilateral urinary tract
injury 305
renal failure 224t Crohn’s disease 43 cryptorchidism 425
acquired 425
effects of 426
testicular cancer 186 CT see computed tomography (CT) CTU (computed tomography
urogram) 155f, 155 cutaneous loop ureterostomy 454 cyclosporine 249 cystectomy
palliative 123
radical 122f cystitis, interstitial see interstitial cystitis cystocele 272
ureterovaginal prolapse 271f cystography
bladder and ureteric trauma 392f, 392
flexible see flexible cystoscopy cystometry, voiding 81 cystoplasty, augmentation 233, 263 cystoprostatectomy, radical 117 cystoscopy
bladder pain syndrome 248– 49
bladder stones on mesh 50 rigid 117
vesicovaginal fistula 312f, 312 cystourethrocele 272 cystourethrography, voiding 261
D
dapoxetine 357 darolutamide 96 daytime urination frequency 229 deceased donors, renal
transplantation 407, 408f DeLancey’s supports 273 delayed ejaculation 352
causes and treatment 356, 356t delayed orgasmia (DO) 352 dementia, anticholinergic drugs 231 denosumab 98 detrusor leak point pressure (DLPP) 261 detrusor overactivity (DO)
definition 216
urodynamics 232f detrusor sphincter dyssynergia 254 detrusor underactivity (DUA) 216 diabetes 355 diclofenac 36 dimercaptosuccinic acid (DMSA) scan
neurogenic bladder 436f, 436, 437f
vesicoureteral reflux 453, 454, 455f dimethylsulfoxide 306 direct visual internal urethrotomy
(DVIU) 282, 287 disorder of sex differentiation (DSD) 427 diuresis, post- obstruction 224 DLPP (detrusor leak point pressure) 261 DMSA scan see dimercaptosuccinic acid
(DMSA) scan DNA damage 100 DO (delayed orgasmia) 352 docetaxel
adverse effects 101t bone metastases in prostate cancer 99 metastatic prostate cancer 95, 96
donor nephrectomy, renal
transplantation 409– 10 Doppler ultrasound, priapism 377 doxorubicin 111
see also MVAC (methotrexate/ vinblastine/
Adriamycin (doxorubicin)/ cisplatin) drug history, ejaculatory orgasmic
disorders 353 drug- induced urinary retention 254 DSD (disorder of sex differentiation) 427