Добавил:
Sekretar
kiopkiopkiop18@yandex.ru
t.me/Prokururor I Вовсе не секретарь, но почту проверяю
Опубликованный материал нарушает ваши авторские права? Сообщите нам.
Вуз:
Предмет:
Файл:Ординатура / Хирургия / Библиотека им академика М.И. Перельмана / Книга_5592_Библиотеки_им_академика_М_И_Перельмана
.pdf
Laboratory Testing
https://t.me/medicina_free
139
Clinical Practice
145
Cannabis and Opioids
187
Side Effects Of Cannabis Use
199
Medical Marijuana Myths And Facts
211
Glossary of Terms
224
Index
235
x
OVERVIEW OF CHAPTERS
https://t.me/medicina_free
CHAPTER 1: LEGAL LANDSCAPE
Overview of Cannabis Laws and Regulations
This introductory chapter is intended to enable medical professionals to better understand the legal terrain of
medical cannabis. It provides clinicians with an overview from a legal perspective of relevant medical cannabis
regulations and what clinicians may and may not do when discussing cannabis in the context of a patient visit.
INTRODUCTION 3
FEDERAL LEGAL OVERVIEW 3
Other Patent and Trademark Consideration 5
FEDERAL LAW OUTLINE 5
Controlled Substances Act (CSA) (21 USCV 801, et. seq.) 5
Ogden Memo 5
Cole Memo 6
Wilkinson Memo 6
The Rohrabacher-Farr Amendment 6
Taxes 7
No Bankruptcy Protection for Cannabis Businesses 7
Employment Law 7
Access to Banking 7
Additional Legal Considerations for Medical Professionals 7
Conant V. Walters—Healthcare Professionals Recommendations 8
Affirmative Defense 8
MEDICAL PROFESSIONALS (MAY AND MAY NOT) 9
REFERENCE LIST 10
xi
CHAPTER 2: AN ANCIENT PLANT FOR MODERN ILLNESSES
https://t.me/medicina_free
A Short Version of the Long History of Cannabis as Medicine
This chapter charts the development and spread of cannabis and its various uses as a fiber, as a food, and as
a medicine as far back as 5,000 years ago. Cannabis was an essential treatment for the ancient Chinese, the
Indian Ayurvedics, as well as the Victorians who adopted it into the Western Pharmacopoeia in the mid-1850s.
It was used in Europe and North America as a household tonic until its prohibition in 1937 in the United States.
EARLY HISTORY OF CANNABIS USE 15
Sativa 15
Indica 15
Cannabis Timeline 17
CANNABIS IN THE WEST 18
U.S. PROHIBITION 19
THE MEDICAL IMPLICATIONS OF U.S. PROHIBITION 20
CLASS OF DRUG 21
HOW DRUGS ARE CLASSIFIED IN THE U.S. 22
MEDICAL CANNABIS TODAY 24
HEMP VERSUS CANNABIS 24
Ruderalis 24
REFERENCE LIST 26
CHAPTER 3: THE DISCOVERY OF THE ENDOCANNABINOID SYSTEM
The Largest Receptor System in the Human Body
This chapter charts how the 1964 discovery of tetrahydrocannabinol (THC) and cannabidiol (CBD) led to the
1988 discovery of the Endocannabinoid System (ECS), the largest receptor system and the master regulator
of homeostasis in the human body. This chapter also discusses how and why cannabinoids (endogenous and
external) interact with CB1 and CB2 receptors to treat a vast number of illnesses.
xii
DISCOVERING THE ENDOCANNABINOID SYSTEM 29
https://t.me/medicina_free
Raphael Mechoulam, PhD 29
Brain’s Chemical – Anandamide 30
Drug – THC 30
THE ENDOCANNABINOID SYSTEM: THE BODY’S SUPERCOMPUTER 31
Location of CB1 and CB2 Receptors 32
WHY THE ENDOCANNABINOID SYSTEM ISN’T TAUGHT IN MEDICAL SCHOOLS 34
The Molecular Structure 34
2-AG (2-Arachidonoylglycerol) 34
Anandamide (N-Arachidonoylethanolamine) 34
How THC Attaches to Receptors 35
REFERENCE LIST 36
CHAPTER 4: THE ENDOCANNABINOID SYSTEM
Master Regulator of the Body
The Endocannabinoid System is deeply involved in maintaining homeostasis, neuroprotection, and other regulatory
functions, many of which have yet to be discovered. It consists of endocannabinoids produced by the brain and a
network of cannabinoid receptors located throughout the body. This chapter will provide an overview of how this
system functions and how it is involved in so many disease states.
THE ENDOCANNABINOID SYSTEM 39
ENDOCANNABINOIDS 40
ECS RECEPTORS 40
HOW CANNABINOIDS ATTACH TO RECEPTORS 41
Receptors Are Found on All Cell Surfaces 42
xiii
THE HUMAN ENDOCANNABINOID SYSTEM 43
https://t.me/medicina_free
CB1 & CB2 Receptors – CBD, CBN and THC Fit Like a “Lock & Key” 43
RETROGRADE INHIBITION 44
A SPRAWLING SYSTEM UNLIKE OTHERS 44
ENDOCANNABINOIDS AND HUMAN THRIVING BEHAVIOR 45
INFANT AND EARLY CHILDHOOD DEVELOPMENT 48
REFERENCE LIST 50
CHAPTER 5: CANNABINOIDS AND TERPENES
One Plant, One Very Complex Chemical Factory
This chapter discusses endogenous and exogenous cannabinoids and the mechanisms through which they interact
with the vast network of receptors in the Endocannabinoid System (ECS). It also discusses some of the other
cannabinoids and terpenes naturally occurring in cannabis and the differences between treating with botanical
medicines versus single molecule compounds.
MAJOR CANNABINOIDS 55
THC (Tetrahydrocannabinol) 55
CBD (Cannabidiol) 55
MINOR CANNABINOIDS AND TERPENES 56
Minor Cannabinoids 56
CBG (Cannabigerol) 56
CBC (Cannabichromenic) 57
CBN (Cannabinol) 57
THCV (Tetrahydrocannabivarinic) 57
xiv
CANNABINOID GUIDE 58
https://t.me/medicina_free
Non-Psychoactive Cannabinoids 58
Psychoactive Cannabinoids 59
TERPENES 60
The 411 on Terpenes 61
Trichomes 61
Terpene Chart 62
Limonene 62
Myrcene 62
Pinene 62
Ocimene 62
Linalool 62
b-Caryophyllene 62
Terpinolene 62
a-Humulene 62
Nerolidol 62
THE ENTOURAGE EFFECT 64
TOLERANCE AND ENDOCANNABINOID SYSTEM DOWN REGULATION 65
CAUSES OF DEATH BY DRUG (1999–2017) 66
BOTANICAL VERSUS SINGLE MOLECULE COMPOUNDS 68
CANNABINOIDS AND OPIOIDS 68
REFERENCE LIST 70
Terpene Reference List 72
xv
CHAPTER 6: CANNABINOID PHARMACEUTICALS
https://t.me/medicina_free
This chapter is an educational overview listing the research, intended use, and availability of all FDA approved
cannabinoid medications in the U.S. today. It is a resource for medical professionals who may prescribe these FDAapproved cannabinoids or who are assisting patients that are currently taking these cannabinoids as part of their
prescribed treatment plan.
FDA-APPROVED CANNABINOID MEDICATIONS 75
Current FDA Approved Medications 75
Dronabinol (Marinol®)
Nabilone (Cesamet®)
Dronabinol oral solution (Syndros®)
Cannabidiol (Epidiolex®)
DRONABINOL (MARINOL®) CAPSULES 75
Dronabinol Facts 75
NABILONE (CESAMET®) CAPSULES 77
Nabilone Facts 77
DRONABINOL ORAL SOLUTION (SYNDROS®) 78
Dronabinol Oral Solution Facts 78
CANNABIDIOL (EPIDIOLEX®) 79
Cannabidiol Facts 79
CANNABIDIOL EXTRACT RESEARCH 80
NABIXIMOLS (SATIVEX®) 81
Nabiximols Facts 81
xvi
FUTURE CANNABINOID PHARMACEUTICALS 82
https://t.me/medicina_free
Isolate Versus Whole Plant Extract Dosing Curve 83
2018 FEDERAL FARM BILL AND ACCESS TO CANNABIDIOL 83
REFERENCE LIST 84
CHAPTER 7: GETTING CANNABINOIDS INTO THE BLOODSTREAM
Delivery Systems for Cannabis
This chapter familiarizes medical professionals with the many methods of delivering cannabinoids into the bloodstream —
inhalation, oral mucosal absorption, edibles, and topicals — plus the advantages and disadvantages of each. Included
are written and visual descriptions of all of forms of medical cannabis that a patient might encounter in a dispensary, plus
the instruments that deliver them. This section also includes guides to onset times, duration of effects, and bioavailability
with each method.
THE ROLE OF THE DISPENSARY 87
What Dispensary Consultants Can Say 87
What Dispensary Consultants Cannot Say 87
FLOWER VERSUS CONCENTRATES 88
Flower 88
Advantages Versus Disadvantages of Flower 89
CONCENTRATES: DABS, SHATTER, WAX, BUDDER, BHO, ROSIN 90
Different Forms of Concentrates 90
Advantages Versus Disadvantages of Concentrates 91
EXTRACTION METHODS 92
Advantages Versus Disadvantages of Extraction Methods 93
How to Dab in Three Easy Steps 95
xvii
FORMS OF MEDICATING 96
https://t.me/medicina_free
Inhalation/Smoking 96
Onset, Duration and Bioavailability 96
Advantages Versus Disadvantages of Inhalation/Smoking 97
Anatomy of A Bong 98
Tube 98
Ice Pinch 98
Diffused Downstem 98
Bowl 98
Beaker Base 98
Inhalation/Vaporization 100
Onset, Duration and Bioavailability 100
Different Types of Vaporizers 100
Myth Versus Fact 100
Advantages Versus Disadvantages of Inhalation/Vaporization 101
Anatomy of A Vape Pen 102
Battery 102
Button 102
Tank/Chamber 102
Atomizer 102
Mouth Piece 102
Edibles 104
Onset, Duration and Bioavailability 104
Advantages Versus Disadvantages of Edibles 105
Know Your Edibles 106
New to Edibles (Dosing Guide) 107
xviii
Oral, Mucosal: Tinctures, Sprays, Sublingual Drops 108
https://t.me/medicina_free
Onset, Duration and Bioavailability 108
Advantages Versus Disadvantages of Oral Mucosal 109
Topicals 110
Onset, Duration and Bioavailability 110
Advantages Versus Disadvantages of Topicals 111
Suppositories 112
Onset, Duration and Bioavailability 112
Advantages Versus Disadvantages of Suppositories 113
Delivery Methods and Timing 115
Inhalation 115
Tincture 115
Topical 115
Ingestion 115
REFERENCE LIST 116
CHAPTER 8: PATIENT CENTERED DOSING
Considerations Before Medicating With Cannabis
This chapter gives medical professionals a method of assisting patients to self-administer consistent, measurable
doses of a cannabis remedy that includes as much THC as the patient is comfortable taking. It also includes
the latest research on drug-drug interactions and spells out the patients for whom cannabis is a relative
contraindication.
INTRODUCTION 121
SET AND SETTING 122
DRUG-DRUG INTERACTIONS 122
xix
Соседние файлы в папке Библиотека им академика М.И. Перельмана