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Pathological Basis ofOral
andMaxillofacial Diseases
t.me/Dr_Mouayyad_AlbtousH

Pathological Basis of Oral
and Maxillofacial Diseases
Edited by
S. R. Prabhu
BDS, MDS (Oral Path), FFDRCSI (Oral Med), FDSRCS (Edin), FDSRCPS (Glasgow),
FDSRCS (Eng), FFGDP RCS (UK), MOMed RCS (Edin), FICD
The University of Queensland School of Dentistry, Brisbane, Australia
Syed Ali Khurram
BDS, MSc., PhD., MFDS RCS (Edinburgh), CiLT, FHEA, FRC Path.
Unit of Oral and Maxillofacial Pathology
School of Clinical Dentistry, The University of Sheffield, Claremont Crescent, Sheffield, UK
Omar Kujan
BDS, DipOPath, MDSc, PhD, MFDS RCPS (Glasgow), FRCPath (UK),
FFOMP RCPA (Australasia)
Merva Soluk Tekkesin
DDS, PhD.
Department of Oral Pathology, Faculty of Dentistry,
Istanbul University, Türkiye
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This edition first published 2025
© 2025John Wiley & Sons Ltd
All rights reserved, including rights for text and data mining and training of artificial technologies or similar
technologies. No part of this publication may be reproduced, stored in a retrieval system, or transmitted, in any form
or by any means, electronic, mechanical, photocopying, recording or otherwise, except as permittedbylaw. Advice
on how to obtain permission to reuse material from this title is available at http://www.wiley.com/go/permissions.
The right of S. R. Prabhu, Syed Ali Khurram, Omar Kujan and Merva Soluk Tekkesin to be identified as the authors
of the editorial material in this work has been asserted in accordance with law.
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John Wiley & Sons, Inc., 111 River Street, Hoboken, NJ 07030, USA
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Limit of Liability/Disclaimer of Warranty
The contents of this work are intended to further general scientific research, understanding, and discussion only
and are not intended and should not be relied upon as recommending or promoting scientific method, diagnosis,
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Library of Congress Cataloging-in-Publication Data
Names: Prabhu, S. R., editor. | Khurram, Syed Ali, editor. | Kujan, Omar,
editor. | Soluk Tekkesin, Merva, editor.
Title: Pathological basis of oral and maxillofacial diseases / edited by
S R Prabhu, Syed Ali Khurram, Omar Kujan, Merva Soluk Tekkesin.
Description: First edition. | Hoboken, NJ : Wiley-Blackwell 2025. |
Includes index.
Identifiers: LCCN 2024025361 (print) | LCCN 2024025362 (ebook) | ISBN
9781119989202 (paperback) | ISBN 9781119989219 (adobe pdf) | ISBN
9781119989226 (epub)
Subjects: MESH: Stomatognathic Diseases–pathology
Classification: LCC RK301 (print) | LCC RK301 (ebook) | NLM WU 140 | DDC
617.5/22–dc23/eng/20240807
LC record available at https://lccn.loc.gov/2024025361
LC ebook record available at https://lccn.loc.gov/2024025362
Cover Design: Wiley
Cover Images: Courtesy of Soluk Tekkesin, Courtesy of Hannah Walsh, Courtesy of Nagamani Narayana,
Courtesy of Omar Kujan
Set in 9.5/12.5pt STIXTwoText by Straive, Pondicherry, India
t.me/Dr_Mouayyad_AlbtousH

This book is dedicated to the memory of Newell W Johnson for his enormous contribution to Oral
and Maxillofacial Pathology.
t.me/Dr_Mouayyad_AlbtousH


Contents
About the Editors xi
List of Contributors xiii
Foreword xviii
Preface xix
vii
Section 1
1 IntroductiontoPathology 3
S. R. Prabhu and Suja Pillai
2 Global Scenario, Aetiology and Risk Factors Associated with Oral and Maxillofacial
Diseases: An Overview 11
Nesa Aurlene Jayadhas and Santosh Kumar Tadakamadla
3 The Role of Laboratory Diagnosis in Oral and Maxillofacial Pathology: An Overview 27
Hannah Walsh and Daniel J. Brierley
Section 2
4 HomeostasisandInfluencesofEnvironmentandNutrition 41
A. V. Chalapathi Rao and S. R. Prabhu
5 CellularStructureandFunction 51
Suheyla Kaya
6 CellInjury:Causes,MechanismsandResponses 64
S. R. Prabhu
Pathology as the Foundation of Medicine 1
HomeostasisandCellularPathology 39
7 TheStructureandFunctionoftheOralMucosa 82
Gargi Sarode and Sachin Sarode
8 CellularMechanismsofAgeingofOralTissues 99
Jeremy Lau, Agnieszka Frydrych and Omar Kujan
t.me/Dr_Mouayyad_AlbtousH

Contents
viii
9 EndocrineandMetabolicDysfunctionandOro-FacialDiseases 108
Prazwala Chirravur and Pradeep Chirravur
Section 3
10 ImmunityandHostDefenceMechanismsinOralHealthandDisease 135
Irene Lafuente- Ibáñez de Mendoza and José M. Aguirre- Urizar
11 ImmuneDysfunctionsAffectingtheOro-FacialComplex 147
Yeshwant Rawal
12 Pathology of Inflammation and Inflammatory Diseases of
theOro-FacialComplex:AnOverview 175
S. R. Prabhu
13 CellularandMolecularMechanismsofHealingofCutaneousandOralMucosal
Wounds 196
H. Ibrahim Korkmaz and Susan Gibbs
14 HealingoftheDentalPulpandPeriodontalTissues,ExtractionSocketandBone
Fracture 204
Sachin Sarode and Gargi Sarode
Section 4
Defence Mechanisms Against Disease 133
ClinicalGeneticsandDevelopmentalPathology 227
15 TheHumanGenomeandInheritance:KeyConcepts 229
Yucel Erbilgin and Muge Sayitoglu
16 HeritableDiseaseswithExamplesInvolvingtheOro-FacialComplex 245
Fadi Titinchi and Johan Opperman
17 Non-heritableDevelopmentalDisorderswithExamplesInvolvingtheOral-Maxillofacial
Complex 274
John Anthony Ozolek
Section 5
18 HumanMicrobiomeinHealthandDiseasewithReferencetoDysbiosisinDentalCaries
andPeriodontalDiseases 295
Preethi Balan, Nadeeka Udawatte and Chaminda Jayampath Seneviratne
19 PathologyofInfectionandInfectiousDiseasesoftheOro-FacialComplex 310
Nagamani Narayana and John Casey
InfectiousandSystemicDiseases 293
t.me/Dr_Mouayyad_AlbtousH

20 Oral-systemicLinkandItsImpactonGeneralandOralHealth 339
Dáire Shanahan and Sarah Jane George
21 OrofacialManifestationsofSystemicDiseases:AnOverview 362
Philip Atkin
22 AdverseDrugReactionsintheOrofacialComplex 377
Sue- Ching Yeoh
Contents
ix
Section 6
23 Neoplasia:BasicConcepts 409
Omar Kujan and Philip Sloan
24 MolecularBasisofCancer 415
Lalima Tiwari and Omar Kujan
25 Host Defences Against Cancer 429
Andreia Bufalino
26 WHO Classification of Tumours: An Overview 440
Muhammed Yakin and Richard Logan
27 Dysplasia,PrecancerandOralPotentiallyMalignantDisorders 449
Agnieszka Frydrych and Omar Kujan
Section 7
28 GlobalBurden,RiskfactorsandPathobiologyofMalignantNeoplasmsofthe
OralMucosaandtheOropharynx 477
Paul Hankinson and Syed Ali Khurram
DisordersofCellandTissueGrowth 407
NeoplasticDiseasesoftheOralMucosaandSalivaryGlands 475
29 Presentation,DiagnosisandPrognosisofSquamousCellCarcinomasof
theOralMucosaandOropharynx 498
Selvam Thavaraj and Adam Jones
30 GlobalBurden,Classification,Pathobiology,GeneticsandPrognosisofSalivaryGland
Neoplasms 531
Lucas Lacerda de Souza, Marcio Ajudarte Lopes, Pablo Agustin Vargas
and Syed Ali Khurram
Section 8
31 ClassificationandPathogenesisofOdontogenicandNon-odontogenicJawCysts 569
Paul M. Speight and Merva Soluk Tekkesin
DiseasesoftheOralandMaxillofacialSkeleton 567
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