Добавил:
kiopkiopkiop18@yandex.ru t.me/Prokururor I Вовсе не секретарь, но почту проверяю Опубликованный материал нарушает ваши авторские права? Сообщите нам.
Вуз: Предмет: Файл:

Ординатура / Хирургия / Библиотека им академика М.И. Перельмана / Книга_5210_Библиотеки_им_академика_М_И_Перельмана

.pdf
Скачиваний:
0
Добавлен:
31.08.2026
Размер:
38 Мб
Скачать
Pathological Basis ofOral andMaxillofacial Diseases
t.me/Dr_Mouayyad_AlbtousH
Pathological Basis of Oral and Maxillofacial Diseases
S. R. Prabhu
BDS, MDS (Oral Path), FFDRCSI (Oral Med), FDSRCS (Edin), FDSRCPS (Glasgow), FDSRCS (Eng), FFGDP RCS (UK), MOMed RCS (Edin), FICD The University of Queensland School of Dentistry, Brisbane, Australia
Syed Ali Khurram
BDS, MSc., PhD., MFDS RCS (Edinburgh), CiLT, FHEA, FRC Path. Unit of Oral and Maxillofacial Pathology School of Clinical Dentistry, The University of Sheffield, Claremont Crescent, Sheffield, UK
Omar Kujan
BDS, DipOPath, MDSc, PhD, MFDS RCPS (Glasgow), FRCPath (UK), FFOMP RCPA (Australasia)
Merva Soluk Tekkesin
DDS, PhD. Department of Oral Pathology, Faculty of Dentistry, Istanbul University, Türkiye
t.me/Dr_Mouayyad_AlbtousH
This edition first published 2025 © 2025John Wiley & Sons Ltd
All rights reserved, including rights for text and data mining and training of artificial technologies or similar technologies. No part of this publication may be reproduced, stored in a retrieval system, or transmitted, in any form or by any means, electronic, mechanical, photocopying, recording or otherwise, except as permittedbylaw. Advice on how to obtain permission to reuse material from this title is available at http://www.wiley.com/go/permissions.
The right of S. R. Prabhu, Syed Ali Khurram, Omar Kujan and Merva Soluk Tekkesin to be identified as the authors of the editorial material in this work has been asserted in accordance with law.
Registered Offices
John Wiley & Sons, Inc., 111 River Street, Hoboken, NJ 07030, USA John Wiley & Sons Ltd, The Atrium, Southern Gate, Chichester, West Sussex, PO19 8SQ, UK
For details of our global editorial offices, customer services, and more information about Wiley products visit us at www.wiley.com.
Wiley also publishes its books in a variety of electronic formats and by print- on- demand. Some content that appears in standard print versions of this book may not be available in other formats.
Trademarks: Wiley and the Wiley logo are trademarks or registered trademarks of John Wiley & Sons, Inc. and/or its affiliates in the United States and other countries and may not be used without written permission. All other trademarks are the property of their respective owners. John Wiley & Sons, Inc. is not associated with any product or vendor mentioned in this book.
Limit of Liability/Disclaimer of Warranty
The contents of this work are intended to further general scientific research, understanding, and discussion only and are not intended and should not be relied upon as recommending or promoting scientific method, diagnosis, or treatment by physicians for any particular patient. In view of ongoing research, equipment modifications, changes in governmental regulations, and the constant flow of information relating to the use of medicines, equipment, and devices, the reader is urged to review and evaluate the information provided in the package insert or instructions for each medicine, equipment, or device for, among other things, any changes in the instructions or indication of usage and for added warnings and precautions. While the publisher and authors have used their best efforts in preparing this work, they make no representations or warranties with respect to the accuracy or completeness of the contents of this work and specifically disclaim all warranties, including without limitation any implied warranties of merchantability or fitness for a particular purpose. No warranty may be created or extended by sales representatives, written sales materials or promotional statements for this work. This work is sold with the understanding that the publisher is not engaged in rendering professional services. The advice and strategies contained herein may not be suitable for your situation. You should consult with a specialist where appropriate. The fact that an organization, website, or product is referred to in this work as a citation and/or potential source of further information does not mean that the publisher and authors endorse the information or services the organization, website, or product may provide or recommendations it may make. Further, readers should be aware that websites listed in this work may have changed or disappeared between when this work was written and when it is read. Neither the publisher nor authors shall be liable for any loss of profit or any other commercial damages, including but not limited to special, incidental, consequential, or other damages.
Library of Congress Cataloging-in-Publication Data
Names: Prabhu, S. R., editor. | Khurram, Syed Ali, editor. | Kujan, Omar,
editor. | Soluk Tekkesin, Merva, editor.
Title: Pathological basis of oral and maxillofacial diseases / edited by
S R Prabhu, Syed Ali Khurram, Omar Kujan, Merva Soluk Tekkesin.
Description: First edition. | Hoboken, NJ : Wiley-Blackwell 2025. |
Includes index.
Identifiers: LCCN 2024025361 (print) | LCCN 2024025362 (ebook) | ISBN
9781119989202 (paperback) | ISBN 9781119989219 (adobe pdf) | ISBN
9781119989226 (epub) Subjects: MESH: Stomatognathic Diseases–pathology Classification: LCC RK301 (print) | LCC RK301 (ebook) | NLM WU 140 | DDC
617.5/22–dc23/eng/20240807 LC record available at https://lccn.loc.gov/2024025361 LC ebook record available at https://lccn.loc.gov/2024025362
Cover Design: Wiley Cover Images: Courtesy of Soluk Tekkesin, Courtesy of Hannah Walsh, Courtesy of Nagamani Narayana, Courtesy of Omar Kujan
Set in 9.5/12.5pt STIXTwoText by Straive, Pondicherry, India
t.me/Dr_Mouayyad_AlbtousH
This book is dedicated to the memory of Newell W Johnson for his enormous contribution to Oral and Maxillofacial Pathology.
t.me/Dr_Mouayyad_AlbtousH
Contents
About the Editors xi List of Contributors xiii Foreword xviii Preface xix
vii
Section 1
1 IntroductiontoPathology 3
S. R. Prabhu and Suja Pillai
2 Global Scenario, Aetiology and Risk Factors Associated with Oral and Maxillofacial
Diseases: An Overview 11
Nesa Aurlene Jayadhas and Santosh Kumar Tadakamadla
3 The Role of Laboratory Diagnosis in Oral and Maxillofacial Pathology: An Overview 27
Hannah Walsh and Daniel J. Brierley
Section 2
4 HomeostasisandInfluencesofEnvironmentandNutrition 41
A. V. Chalapathi Rao and S. R. Prabhu
5 CellularStructureandFunction 51
Suheyla Kaya
6 CellInjury:Causes,MechanismsandResponses 64
S. R. Prabhu
Pathology as the Foundation of Medicine 1
HomeostasisandCellularPathology 39
7 TheStructureandFunctionoftheOralMucosa 82
Gargi Sarode and Sachin Sarode
8 CellularMechanismsofAgeingofOralTissues 99
Jeremy Lau, Agnieszka Frydrych and Omar Kujan
t.me/Dr_Mouayyad_AlbtousH
Contents
viii
9 EndocrineandMetabolicDysfunctionandOro-FacialDiseases 108
Prazwala Chirravur and Pradeep Chirravur
Section 3
10 ImmunityandHostDefenceMechanismsinOralHealthandDisease 135
Irene Lafuente- Ibáñez de Mendoza and José M. Aguirre- Urizar
11 ImmuneDysfunctionsAffectingtheOro-FacialComplex 147
Yeshwant Rawal
12 Pathology of Inflammation and Inflammatory Diseases of
theOro-FacialComplex:AnOverview 175
S. R. Prabhu
13 CellularandMolecularMechanismsofHealingofCutaneousandOralMucosal
Wounds 196
H. Ibrahim Korkmaz and Susan Gibbs
14 HealingoftheDentalPulpandPeriodontalTissues,ExtractionSocketandBone
Fracture 204
Sachin Sarode and Gargi Sarode
Section 4
Defence Mechanisms Against Disease 133
ClinicalGeneticsandDevelopmentalPathology 227
15 TheHumanGenomeandInheritance:KeyConcepts 229
Yucel Erbilgin and Muge Sayitoglu
16 HeritableDiseaseswithExamplesInvolvingtheOro-FacialComplex 245
Fadi Titinchi and Johan Opperman
17 Non-heritableDevelopmentalDisorderswithExamplesInvolvingtheOral-Maxillofacial
Complex 274
John Anthony Ozolek
Section 5
18 HumanMicrobiomeinHealthandDiseasewithReferencetoDysbiosisinDentalCaries
andPeriodontalDiseases 295
Preethi Balan, Nadeeka Udawatte and Chaminda Jayampath Seneviratne
19 PathologyofInfectionandInfectiousDiseasesoftheOro-FacialComplex 310
Nagamani Narayana and John Casey
InfectiousandSystemicDiseases 293
t.me/Dr_Mouayyad_AlbtousH
20 Oral-systemicLinkandItsImpactonGeneralandOralHealth 339
Dáire Shanahan and Sarah Jane George
21 OrofacialManifestationsofSystemicDiseases:AnOverview 362
Philip Atkin
22 AdverseDrugReactionsintheOrofacialComplex 377
Sue- Ching Yeoh
Contents
ix
Section 6
23 Neoplasia:BasicConcepts 409
Omar Kujan and Philip Sloan
24 MolecularBasisofCancer 415
Lalima Tiwari and Omar Kujan
25 Host Defences Against Cancer 429
Andreia Bufalino
26 WHO Classification of Tumours: An Overview 440
Muhammed Yakin and Richard Logan
27 Dysplasia,PrecancerandOralPotentiallyMalignantDisorders 449
Agnieszka Frydrych and Omar Kujan
Section 7
28 GlobalBurden,RiskfactorsandPathobiologyofMalignantNeoplasmsofthe
OralMucosaandtheOropharynx 477
Paul Hankinson and Syed Ali Khurram
DisordersofCellandTissueGrowth 407
NeoplasticDiseasesoftheOralMucosaandSalivaryGlands 475
29 Presentation,DiagnosisandPrognosisofSquamousCellCarcinomasof
theOralMucosaandOropharynx 498
Selvam Thavaraj and Adam Jones
30 GlobalBurden,Classification,Pathobiology,GeneticsandPrognosisofSalivaryGland
Neoplasms 531
Lucas Lacerda de Souza, Marcio Ajudarte Lopes, Pablo Agustin Vargas and Syed Ali Khurram
Section 8
31 ClassificationandPathogenesisofOdontogenicandNon-odontogenicJawCysts 569
Paul M. Speight and Merva Soluk Tekkesin
DiseasesoftheOralandMaxillofacialSkeleton 567
t.me/Dr_Mouayyad_AlbtousH