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Файл:Ординатура / Хирургия / Библиотека им академика М.И. Перельмана / Книга_747_Библиотеки_им_академика_М_И_Перельмана
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164 Left-sided pulmonary resections
https://t.me/med1917
The airway is now ready to be divided. However,
13
tinue ventilation. (a) Use the existing endotracheal tube, withdrawing it temporarily whilst resecting the airway and
working around it whilst undertaking the anastomosis. The
bulkiness of an endobronchial double-lumen tube makes this
difficult. However, if the strictured area could only accommodate a narrow endotracheal tube, this should be left full
length so that it can be advanced into the distal trachea or left
main bronchus to continue ventilation during the anastomosis. (b) The tube, whether endobronchial or endotracheal, is
withdrawn and ventilation continued using an armored, small
caliber tube across the operating field into the distal trachea or
left main bronchus. This prevents blood spilling into the left
lung but is obtrusive and has to be removed at some stage during the anastomosis. This method is the one of choice when
undertaking a Barclay reconstruction (see later). (c) The tube,
endotracheal or endobronchial, is withdrawn. A nasogastric
tube is inserted through the original tube into the distal trachea or left main bronchus and used to provide ventilation
using a Venturi injector. The nasogastric tube is sutured in
place to prevent it flailing around. Hemostasis is important to
limit the amount of blood insufflated into the left lung. This
is probably the method of choice for uncomplicated segmental resection of the lower trachea or carinal reconstruction.
will allow sufficient apnea time for the surgeon to transect the
trachea, decide upon the length of resection, and restore ventilation using one of these techniques. As always the surgeon
should resect to macroscopically normal airway, supplementing this assessment with frozen section histology in malignant
cases.
before doing so it should be decided how best to con-
If the surgeon forewarns the anesthetist, pre-oxygenation
13

The anesthetist should flex the
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14
before the surgeon begins the anastomosis. The anastomosis is similar to that
described for segmental resection in the
neck. A continuous suture commences at
the far, posterior horn of the tracheal
cartilage, continuing around the front
wall to the posterior cornu at the near
side. The standing end is then continued
across the membranous wall and tied at
the right posterior cornu. Reinforcing
sutures are used at each quadrant,
inserted ahead of the continuous suture
to avoid damaging this suture.
neck, supporting it with a pillow,
Operations 165
14a
14b
The mediastinal pleura is closed over the repair, a drain is
inserted and the thoracotomy closed. The patient is rolled
into the supine position with the neck fixed in moderate flexion. A minitracheostomy tube, a corrugated drain, and the
neck restraining sutures are inserted.
Carinal resection and reconstruction
Resection of the carina is undertaken using a right
15
tion by the Venturi method described above. Reconstruction
is achieved by first recreating a new carina using the medial
third of the circumference of both main bronchi, and anastomosing this double-barrelled lumen to the distal trachea as
described above.
thoracotomy approach, providing continued ventila-
15

166 Tracheal resection
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A variation of this technique allows resection of the
16
mediate bronchus and the left main bronchus to recreate the
carina. If the right upper lobe bronchus can be preserved it
can be subsequently anastomosed to the side of the trachea a
centimeter above the main anastomosis. A small, semicircular defect is created in the cartilage of the lateral wall of the
trachea, at its junction with the membranous part of the tracheal wall.
right main bronchus and anastomosis of the inter-
16
After carinal resection, elevation of the left main
17
sive resection of the trachea or left main bronchus is necessary this double-barrelled reconstruction is not possible. The
reconstruction described by Barclay allows an end-to-end
anastomosis in such circumstances. In this, the right main
bronchus, or the intermediate bronchus, is anastomosed to
the distal trachea whilst the left lung is ventilated using a
small armored endotracheal tube across the operative field.
bronchus is limited by the aortic arch. If more exten-
17

The left main bronchus is then anastomosed to the
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18
creating a small semicircular defect in the cartilage at its junction with the membranous portion of the airway.
medial aspect of the intermediate bronchus after
Operations 167
The mediastinal pleura is closed over the repair and the
thoracotomy closed. The patient is rolled into the supine
position with the neck held flexed. A minitracheostomy tube,
a corrugated drain, and the neck restraining sutures are
inserted.
Slide tracheoplasty
This operation was originally devised to cope with congenital
funnel (stove-pipe) trachea involving greater than 50% of the
total tracheal length. It was accepted at that time that this was
the maximum length of trachea that could be resected with
end-to-end anastomosis. Various on-lay grafts using periosteum or rib had been tried with varied success. The concept of
18
the slide tracheoplasty is simple – one halves the length of the
trachea and doubles its circumference. The initial success of
this operation infers that the trachea in this condition has an
unusual, circumferential blood supply. However, the operation has since been used successfully in long, benign, acquired
strictures in adults.
The operation is usually undertaken through a cervical
approach, allowing access to the whole of the trachea to the
level of the carina. If the stenotic segment extends onto one of
the main bronchi, especially when associated with an aberrant left pulmonary artery, the procedure can be undertaken
through a right thoracotomy. Ventilation is difficult when
operating upon such tight stenoses in a tiny patient, but the
operation is possible with intermittent apnea, and cardiopulmonary bypass has been avoided.

168 Tracheal resection
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Once the full extent of the stenotic area has been
19
transversely at the midpoint of the stenosis. The posterior
wall of the distal segment is incised longitudinally until a
normal caliber airway has been reached. The anterior wall
of the upper segment is incised over a similar length. The
ends of each segment may be trimmed slightly to create
more of a pointed end on each flap. The proximal segment of trachea is drawn behind the distal segment, the
anastomosis begins on the posterior aspect of the distal
segment and spirals around each side of the reconstructed airway and is completed anteriorly.
exposed circumferentially the trachea is divided
A
B
B
A
19

Further reading 169
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POSTOPERATIVE MANAGEMENT
After most airway reconstructions the patient can usually be
extubated at the end of the procedure. If a supralaryngeal Ttube is inserted, the closing minutes of the operation can be
conducted using Venturi ventilation through the transverse
limb of the tube. If there is any need to continue assisted ventilation a laryngeal mask is preferred, thus avoiding an endotracheal tube across the anastomosis. Sputum clearance is
facilitated by the minitracheostomy tube or T-tube.
Prophylactic antibiotics are continued for 3–4 days.
Once speech has been assessed and adequate laryngeal
function seems assured, the patient is allowed nourishing fluids, usually from the first postoperative morning. The use of a
drinking straw is helpful until the patient becomes used to the
neck restraining sutures. A normal oral diet is usually established within 24 hours. A supralaryngeal T-tube may require
more caution but it is surprising how well patients swallow
without any aspiration.
The wound drainage ceases over the first 24 hours but
removal of the drain is delayed until the eighth day when the
minitracheostomy tube and neck-restraining sutures are also
removed. The patient should be warned to protect the anastomosis from undue neck extension for a few weeks, particularly when sleeping. A U-shaped pillow is helpful. By the time
they return to the clinic at 3–4 weeks they have lost cautious
approach and will be moving their necks normally.
In situations in which a T-tube is considered necessary the
patient returns for endoscopic review under general anesthesia after 6 weeks. The tube is removed, and healing and laryngeal function are assessed. If there is any concern a clean
T-tube is inserted for a further period, usually of 6 weeks, and
the assessment repeated.
Other postoperative problems are rare, but dysrhythmias
can occur.
OUTCOMES
Postoperative mortality and morbidity depend upon co-morbid conditions, patient fitness, the length of airway resected,
and the complexity of the reconstruction. Emergency resection can be avoided by the measures described previously.
Most benign lesions, and almost all postintubation strictures, can be resected, unless complicated by previous failed
surgery or laser treatment. The perioperative mortality for
such surgery is usually less than 2%. Good to excellent functional results are obtained in 90–95% of patients.
The perioperative mortality for surgery in malignant cases,
in which more extensive resections are required, is higher, in
the region of 5–6%. It is difficult to give estimates of prognosis after resection of malignancy, as even in large series the
numbers in subgroups become small. The natural history of
adenoid cystic carcinoma is often one of slow progression.
Such patients can live for several years after radiotherapy
alone, and asphyxia can be prevented by disobliteration techniques, stenting, and brachytherapy. In one series mean survival after treatment of presumably more advanced disease by
radiotherapy alone was 6.4 years, compared with 9.8 years
after complete resection and 7.5 years after incomplete resection and radiotherapy. As in other cancer procedures the surgeon should strive for complete resection but it is clearly
unjustified to imperil the patient by striving for this if wider
excision complicates the reconstruction and adds appreciably
to perioperative risk. Such a delicately balanced decision
requires experience. There are fewer statistics on survival
after resection of squamous carcinomas, but survival in the
region of 35% at 5 years has been reported.
Anastomotic problems, such as dehiscence or stricture,
occur in less than 5% of operations performed in experienced
units.
FURTHER READING
Barclay RS, McSwann N, Welsh TM. Tracheal reconstruction with the
use of grafts. Thorax 1957; 12: 177–80.
Goldstraw P. Endobronchial stents. In: Hetzel M ed. Minimally invasive
techniques in thoracic medicine and surgery. 1st edn. London:
Chapman and Hall, 1994.
Grillo HC. Development of tracheal surgery: a historical review. Part 1:
techniques of tracheal surgery. Annals of Thoracic Surgery 2003; 75:
610–19.
Grillo HC, Wright CD, Vlahakes GJ, MacGillivray TE. Management of
congenital tracheal stenosis by means of slide tracheoplasty or
resection and reconstruction, with long-term follow-up of growth
after slide tracheoplasty.
Surgery 2002; 123: 145–52.
Kutlu CA, Goldstraw P. Tracheo-bronchial sleeve resection using a
continuous anastomosis: results of 100 consecutive cases. Journal of
Thoracic and Cardiovascular Surgery 1999; 117: 1112–17.
Maddaus MA, Toth JLR, Gullane PJ, Pearson FG. Subglottic tracheal
resection and synchronous laryngeal reconstruction. Journal of
Thoracic and Cardiovascular Surgery 1992; 104: 1443–50.
Shankar S, George PJ, Hetzel MR, Goldstraw P. Elective resection of
tumors of the trachea and main carina after endoscopic laser
therapy. Thorax 1990; 45: 493–5.
Tsang V, Murday AJ, Gillbe C, Goldstraw P. Slide tracheoplasty for
congenital funnel-shaped tracheal stenosis. Annals of Thoracic
Surgery 1989; 48: 632–5.
Journal of Thoracic and Cardiovascular

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17
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Lung volume reduction surgery
JOSEPH B. SHRAGER MD
Associate Professor, Department of Surgery, University of Pennsylvania School of Medicine; Chief of Thoracic Surgery Hospital of the
University of Pennsylvania and Pennsylvania Hospital, Philadelphia, Pennsylvania, USA
HISTORY
Lung volume reduction surgery (LVR) is an old operation
that was recently revived as a treatment for emphysema. Otto
Brantigan pioneered the procedure and performed it on a
group of patients in the 1950s, reporting symptomatic
improvement in 75%. However, the inability to objectively
document improvements in pulmonary function and the
early mortality rate of 16% in Brantigan’s series led to abandonment of the operation. In the early 1990s, Joel Cooper
reintroduced the procedure in a series of 20 highly selected
patients operated on with no mortality and with dramatic
improvements in dyspnea, pulmonary function, and quality
of life. Although the procedure has continued to engender
significant controversy, resulting in the establishment of several multicenter randomized clinical trials in an attempt to
rigorously determine its efficacy, a plethora of evidence now
exists that selected patients with emphysema benefit from
LVR. The National Emphysema Treatment Trial (NETT) has
established that most hyper expanded patients with FEV, less
than 45% predicted, who have apical predominate disease,
and even some patients with homogeneous disease and very
low exercise capacity as measured by bicycle ergometry are
candidates for the operation.
PRINCIPLES AND JUSTIFICATION
The physiological rationale for the procedure is elegant, particularly in light of the fact that the removal of lung tissue in
patients who already suffer from a lack of functioning lung
appears at first glance to be counter intuitive. In emphysema,
parenchymal destruction results in loss of the normal elastic
recoil of the lung. This situation has the dual effect of reducing expiratory driving force and decreasing the external
mechanical support provided to the airways, which results in
decreased expiratory airflows. The lung progressively distends, depressing the diaphragm and forcing it and the other
respiratory muscles to operate at a mechanical disadvantage,
reducing inspiratory muscle force and efficiency. The overall
work of breathing is markedly increased. By removing the
most diseased areas of lung that provide little contribution to
gas exchange, LVR improves the elastic recoil of the remaining lung and returns the inspiratory muscles and chest wall to
more physiological positions. The work of breathing is
diminished, and the severe dyspnea experienced by these
patients is ameliorated.
LVR is offered to selected patients with severe emphysema
less than 45% of predicted value) and hyperinflation
(FEV
1
(residual volume greater than 180% of predicted value in my
practice) that results in markedly diminished quality of life.
Patient selection is as critical to a favorable outcome after
LVR as the technical performance of the procedure – the latter being fairly straightforward. Criteria for patient selection
continue to undergo refinement, but several principles have
become clear from clinical series involving the operation.
First, NETT identified a high risk group who should not be
operated upon because the mortality is 16%. This group consists of individuals with FEV less than 20% predicted and
either a diffusing capacity less than 20% predicted or homogeneous distribution of disease.
Secondly, the operation is most beneficial in patients whose
chronic obstructive pulmonary disease approaches the ‘pure
emphysematous’ type. Those with predominant chronic
bronchitis, with copious sputum production, inflammatory
airway narrowing, and reactive airways, tend not to do well.
We have found that a postbronchodilator improvement in
FEV
of greater than 30% is a strong predictor of a suboptimal
1
outcome. Certainly, patients whose emphysema is most severe
in one portion of the lung, with other areas (usually the lower

172 Lung volume reduction surgery
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lobes) left with relatively preserved parenchyma, do better
because in these patients resection can be targeted to the more
diseased areas. In addition, patients with markedly elevated
PCO2, in the opinion of the author and many others, are at
higher risk after the operation. Similarly, patients with
markedly elevated pulmonary artery pressures and those who
are severely depleted nutritionally are not good candidates. No
fixed age limit exists, but the operation should be approached
with caution in patients older than 70 years. Patients who have
had previous thoracotomy cannot safely undergo LVR on that
side, and patients who have undergone previous sternotomy
are also poor candidates due to difficulty with adhesions and
subsequent prolonged air leaks.
Pulmonary complications are common after LVR, and
patients should be informed preoperatively of the risks of
mucous plugging requiring bronchoscopy and/or minitracheostomy placement, pneumonia, and prolonged air leaks.
When LVR is performed by median sternotomy, imperfect
sternal healing may occur because these patients have a high
work of breathing, but this problem virtually always presents
as only a minor ‘click’ without instability. We have had one
case of frank mediastinitis in over 200 LVRs performed at our
institution. The most common major morbidity of the operation is respiratory failure with prolonged mechanical ventilation, and this complication often leads ultimately to the
death of the patient, if not within 30 days of the procedure.
Published series of LVRs report operative mortality rates of
0–10%, with a mean of 6%. These rates may be significantly
higher without careful patient selection.
LVR can be performed unilaterally or bilaterally, and the
surgical approach can be via median sternotomy or videoassisted thoracoscopy (VATS). A growing consensus favors
the bilateral procedure in the vast majority of patients, but
the question of the best incision(s) for the bilateral procedure
remains unsettled. We present the bilateral operation first as
it is performed by sternotomy, then as it is performed by thoracoscopy.
PREOPERATIVE ASSESSMENT AND
PREPARATION
Patients must have quit smoking at least 3 months before the
operation and preferably earlier. They all complete at least 6
weeks of a vigorous pulmonary rehabilitation program to
maximize their physical conditioning before surgery.
Nutritional deficiencies are corrected to achieve a body
weight within 20% of the ideal value. Medical treatment of
the emphysema is optimized; an attempt is made to wean
patients off steroids, but those who are only able to get as low
as 5 mg daily are accepted for surgery.
Targets to be resected are determined by careful examination of computed tomograms of the chest and quantitative
perfusion scans. In addition, all patients undergo full pulmonary function testing with plethysmographic measurement of lung volumes, arterial blood gas testing, cardiac
echocardiography with estimation of pulmonary artery pressures and right heart catheterization if indicated, and cardiac
stress testing.
ANESTHESIA
The placement of a thoracic epidural catheter for postoperative pain management is critical to allow optimal clearance
of secretions and prevent postoperative atelectasis or pneumonia. General anesthesia is provided through a doublelumen endotracheal tube with the distal balloon placed in
the left main stem bronchus, which allows sequential collapse of each lung. Inspiratory pressures must be assiduously monitored and minimized (less than 25 cm H2O) in
the ventilated lung. This monitoring is particularly important during ventilation of the lung that has been operated
on first and has fresh staple lines, to prevent rupture of
these staple lines. Minimizing inspiratory pressures may
prevent the unlikely but potentially catastrophic occurrence
of an intraoperative pneumothorax prior to opening the
chest. Any increase in peak airway pressures noted by the
anesthesiologist after the institution of positive pressure
ventilation calls for immediate assessment to rule out such
an event. The inspiratory:expiratory ratio often must be
decreased in these patients, as a longer expiratory phase is
necessary to prevent the auto–positive end-expiratory pressure phenomenon.

OPERATION
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Median sternotomy
INCISION
Before incision, flexible fiberoptic bronchoscopy is per-
1
formed through a single-lumen endotracheal tube to rule
out unexpected malignancy or active infection that would
preclude proceeding with the operation. A sputum sample is
sent for microbiological study for use in guiding initial
antimicrobial therapy should the patient develop an infiltrate
in the early postoperative period. After placement of the double-lumen tube, the patient is positioned, prepared, and
draped for sternotomy. Antibiotics covering both Gram-positive and Gram-negative organisms are administered before
the incision.
A median sternotomy is performed with complete division
of the bone from the sternal notch to the xiphoid process. The
skin incision may be kept as much as 10 cm shorter without
compromising exposure. Subcutaneous flaps may be raised to
expose the full extent of the bone incision. The lungs should
be left unventilated for at least 10 seconds before division of
the sternum to avoid injuring the lungs, which usually are so
hyperexpanded that they abut in the midline. Care is taken
throughout the procedure to handle the sternum gently; the
divided sternum is spread slowly to avoid fracture, and devascularization is minimized by only judicious use of electrocautery, as these patients are prone to sternal healing
complications because of the high stress imposed on the sternal closure by their increased work of breathing.
2
Operation 173
1
PLEURAL ENTRY
We prefer using a Buggie sternal retractor, which allows
2
sequential elevation of each hemisternum without having to replace the retractor on the opposite side of the table
after completion of one side, as is required with the type of
retractors used for mammary harvest.
The side with the more severe disease is operated on first so
that single-lung ventilation is maintained for the shortest
possible time on this lung. Ventilation to this side is discontinued as the bone incision is being made, which provides
sufficient time for the slowly deflating, emphysematous lung
to collapse. Usually by the time the pleural space is entered,
the areas with the most perfusion are well deflated by absorption atelectasis, whereas the most severely diseased areas, usually at the apex, remain partially inflated.
The pleura on the side of interest is opened close to the
anterior chest wall to be as far from the phrenic nerve as possible. The pleural opening is begun inferiorly and extended
superiorly. At the craniad end of the incision, where the
phrenic nerve is most anterior and, thus, most at risk, the
pleura is bluntly reflected off the anterior chest wall for several centimeters before it is incised. This maneuver facilitates
identification of the nerve and careful avoidance of injury to
it. Electrocautery should not be used during the incision of
the craniad portion of pleura.
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