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164 Left-sided pulmonary resections
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The airway is now ready to be divided. However,
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tinue ventilation. (a) Use the existing endotracheal tube, with­drawing it temporarily whilst resecting the airway and working around it whilst undertaking the anastomosis. The bulkiness of an endobronchial double-lumen tube makes this difficult. However, if the strictured area could only accom­modate a narrow endotracheal tube, this should be left full length so that it can be advanced into the distal trachea or left main bronchus to continue ventilation during the anastomo­sis. (b) The tube, whether endobronchial or endotracheal, is withdrawn and ventilation continued using an armored, small caliber tube across the operating field into the distal trachea or left main bronchus. This prevents blood spilling into the left lung but is obtrusive and has to be removed at some stage dur­ing the anastomosis. This method is the one of choice when undertaking a Barclay reconstruction (see later). (c) The tube, endotracheal or endobronchial, is withdrawn. A nasogastric tube is inserted through the original tube into the distal tra­chea or left main bronchus and used to provide ventilation using a Venturi injector. The nasogastric tube is sutured in place to prevent it flailing around. Hemostasis is important to limit the amount of blood insufflated into the left lung. This is probably the method of choice for uncomplicated segmen­tal resection of the lower trachea or carinal reconstruction.
will allow sufficient apnea time for the surgeon to transect the trachea, decide upon the length of resection, and restore ven­tilation using one of these techniques. As always the surgeon should resect to macroscopically normal airway, supplement­ing this assessment with frozen section histology in malignant cases.
before doing so it should be decided how best to con-
If the surgeon forewarns the anesthetist, pre-oxygenation
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The anesthetist should flex the
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before the surgeon begins the anastomo­sis. The anastomosis is similar to that described for segmental resection in the neck. A continuous suture commences at the far, posterior horn of the tracheal cartilage, continuing around the front wall to the posterior cornu at the near side. The standing end is then continued across the membranous wall and tied at the right posterior cornu. Reinforcing sutures are used at each quadrant, inserted ahead of the continuous suture to avoid damaging this suture.
neck, supporting it with a pillow,
Operations 165
14a
14b
The mediastinal pleura is closed over the repair, a drain is inserted and the thoracotomy closed. The patient is rolled into the supine position with the neck fixed in moderate flex­ion. A minitracheostomy tube, a corrugated drain, and the neck restraining sutures are inserted.
Carinal resection and reconstruction
Resection of the carina is undertaken using a right
15
tion by the Venturi method described above. Reconstruction is achieved by first recreating a new carina using the medial third of the circumference of both main bronchi, and anasto­mosing this double-barrelled lumen to the distal trachea as described above.
thoracotomy approach, providing continued ventila-
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166 Tracheal resection
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A variation of this technique allows resection of the
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mediate bronchus and the left main bronchus to recreate the carina. If the right upper lobe bronchus can be preserved it can be subsequently anastomosed to the side of the trachea a centimeter above the main anastomosis. A small, semicircu­lar defect is created in the cartilage of the lateral wall of the trachea, at its junction with the membranous part of the tra­cheal wall.
right main bronchus and anastomosis of the inter-
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After carinal resection, elevation of the left main
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sive resection of the trachea or left main bronchus is neces­sary this double-barrelled reconstruction is not possible. The reconstruction described by Barclay allows an end-to-end anastomosis in such circumstances. In this, the right main bronchus, or the intermediate bronchus, is anastomosed to the distal trachea whilst the left lung is ventilated using a small armored endotracheal tube across the operative field.
bronchus is limited by the aortic arch. If more exten-
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The left main bronchus is then anastomosed to the
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creating a small semicircular defect in the cartilage at its junc­tion with the membranous portion of the airway.
medial aspect of the intermediate bronchus after
Operations 167
The mediastinal pleura is closed over the repair and the thoracotomy closed. The patient is rolled into the supine position with the neck held flexed. A minitracheostomy tube, a corrugated drain, and the neck restraining sutures are inserted.
Slide tracheoplasty
This operation was originally devised to cope with congenital funnel (stove-pipe) trachea involving greater than 50% of the total tracheal length. It was accepted at that time that this was the maximum length of trachea that could be resected with end-to-end anastomosis. Various on-lay grafts using perios­teum or rib had been tried with varied success. The concept of
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the slide tracheoplasty is simple – one halves the length of the trachea and doubles its circumference. The initial success of this operation infers that the trachea in this condition has an unusual, circumferential blood supply. However, the opera­tion has since been used successfully in long, benign, acquired strictures in adults.
The operation is usually undertaken through a cervical approach, allowing access to the whole of the trachea to the level of the carina. If the stenotic segment extends onto one of the main bronchi, especially when associated with an aber­rant left pulmonary artery, the procedure can be undertaken through a right thoracotomy. Ventilation is difficult when operating upon such tight stenoses in a tiny patient, but the operation is possible with intermittent apnea, and cardiopul­monary bypass has been avoided.
168 Tracheal resection
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Once the full extent of the stenotic area has been
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transversely at the midpoint of the stenosis. The posterior wall of the distal segment is incised longitudinally until a normal caliber airway has been reached. The anterior wall of the upper segment is incised over a similar length. The ends of each segment may be trimmed slightly to create more of a pointed end on each flap. The proximal seg­ment of trachea is drawn behind the distal segment, the anastomosis begins on the posterior aspect of the distal segment and spirals around each side of the recon­structed airway and is completed anteriorly.
exposed circumferentially the trachea is divided
A
B
B
A
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Further reading 169
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POSTOPERATIVE MANAGEMENT
After most airway reconstructions the patient can usually be extubated at the end of the procedure. If a supralaryngeal T­tube is inserted, the closing minutes of the operation can be conducted using Venturi ventilation through the transverse limb of the tube. If there is any need to continue assisted ven­tilation a laryngeal mask is preferred, thus avoiding an endo­tracheal tube across the anastomosis. Sputum clearance is facilitated by the minitracheostomy tube or T-tube. Prophylactic antibiotics are continued for 3–4 days.
Once speech has been assessed and adequate laryngeal function seems assured, the patient is allowed nourishing flu­ids, usually from the first postoperative morning. The use of a drinking straw is helpful until the patient becomes used to the neck restraining sutures. A normal oral diet is usually estab­lished within 24 hours. A supralaryngeal T-tube may require more caution but it is surprising how well patients swallow without any aspiration.
The wound drainage ceases over the first 24 hours but removal of the drain is delayed until the eighth day when the minitracheostomy tube and neck-restraining sutures are also removed. The patient should be warned to protect the anas­tomosis from undue neck extension for a few weeks, particu­larly when sleeping. A U-shaped pillow is helpful. By the time they return to the clinic at 3–4 weeks they have lost cautious approach and will be moving their necks normally.
In situations in which a T-tube is considered necessary the patient returns for endoscopic review under general anesthe­sia after 6 weeks. The tube is removed, and healing and laryn­geal function are assessed. If there is any concern a clean T-tube is inserted for a further period, usually of 6 weeks, and the assessment repeated.
Other postoperative problems are rare, but dysrhythmias can occur.
OUTCOMES
Postoperative mortality and morbidity depend upon co-mor­bid conditions, patient fitness, the length of airway resected, and the complexity of the reconstruction. Emergency resec­tion can be avoided by the measures described previously.
Most benign lesions, and almost all postintubation stric­tures, can be resected, unless complicated by previous failed surgery or laser treatment. The perioperative mortality for such surgery is usually less than 2%. Good to excellent func­tional results are obtained in 90–95% of patients.
The perioperative mortality for surgery in malignant cases,
in which more extensive resections are required, is higher, in the region of 5–6%. It is difficult to give estimates of progno­sis after resection of malignancy, as even in large series the numbers in subgroups become small. The natural history of adenoid cystic carcinoma is often one of slow progression. Such patients can live for several years after radiotherapy alone, and asphyxia can be prevented by disobliteration tech­niques, stenting, and brachytherapy. In one series mean sur­vival after treatment of presumably more advanced disease by radiotherapy alone was 6.4 years, compared with 9.8 years after complete resection and 7.5 years after incomplete resec­tion and radiotherapy. As in other cancer procedures the sur­geon should strive for complete resection but it is clearly unjustified to imperil the patient by striving for this if wider excision complicates the reconstruction and adds appreciably to perioperative risk. Such a delicately balanced decision requires experience. There are fewer statistics on survival after resection of squamous carcinomas, but survival in the region of 35% at 5 years has been reported.
Anastomotic problems, such as dehiscence or stricture, occur in less than 5% of operations performed in experienced units.
FURTHER READING
Barclay RS, McSwann N, Welsh TM. Tracheal reconstruction with the
use of grafts. Thorax 1957; 12: 177–80.
Goldstraw P. Endobronchial stents. In: Hetzel M ed. Minimally invasive
techniques in thoracic medicine and surgery. 1st edn. London: Chapman and Hall, 1994.
Grillo HC. Development of tracheal surgery: a historical review. Part 1:
techniques of tracheal surgery. Annals of Thoracic Surgery 2003; 75: 610–19.
Grillo HC, Wright CD, Vlahakes GJ, MacGillivray TE. Management of
congenital tracheal stenosis by means of slide tracheoplasty or resection and reconstruction, with long-term follow-up of growth after slide tracheoplasty. Surgery 2002; 123: 145–52.
Kutlu CA, Goldstraw P. Tracheo-bronchial sleeve resection using a
continuous anastomosis: results of 100 consecutive cases. Journal of Thoracic and Cardiovascular Surgery 1999; 117: 1112–17.
Maddaus MA, Toth JLR, Gullane PJ, Pearson FG. Subglottic tracheal
resection and synchronous laryngeal reconstruction. Journal of Thoracic and Cardiovascular Surgery 1992; 104: 1443–50.
Shankar S, George PJ, Hetzel MR, Goldstraw P. Elective resection of
tumors of the trachea and main carina after endoscopic laser therapy. Thorax 1990; 45: 493–5.
Tsang V, Murday AJ, Gillbe C, Goldstraw P. Slide tracheoplasty for
congenital funnel-shaped tracheal stenosis. Annals of Thoracic
Surgery 1989; 48: 632–5.
Journal of Thoracic and Cardiovascular
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Lung volume reduction surgery
JOSEPH B. SHRAGER MD
Associate Professor, Department of Surgery, University of Pennsylvania School of Medicine; Chief of Thoracic Surgery Hospital of the University of Pennsylvania and Pennsylvania Hospital, Philadelphia, Pennsylvania, USA
HISTORY
Lung volume reduction surgery (LVR) is an old operation that was recently revived as a treatment for emphysema. Otto Brantigan pioneered the procedure and performed it on a group of patients in the 1950s, reporting symptomatic improvement in 75%. However, the inability to objectively document improvements in pulmonary function and the early mortality rate of 16% in Brantigan’s series led to aban­donment of the operation. In the early 1990s, Joel Cooper reintroduced the procedure in a series of 20 highly selected patients operated on with no mortality and with dramatic improvements in dyspnea, pulmonary function, and quality of life. Although the procedure has continued to engender significant controversy, resulting in the establishment of sev­eral multicenter randomized clinical trials in an attempt to rigorously determine its efficacy, a plethora of evidence now exists that selected patients with emphysema benefit from LVR. The National Emphysema Treatment Trial (NETT) has established that most hyper expanded patients with FEV, less than 45% predicted, who have apical predominate disease, and even some patients with homogeneous disease and very low exercise capacity as measured by bicycle ergometry are candidates for the operation.
PRINCIPLES AND JUSTIFICATION
The physiological rationale for the procedure is elegant, par­ticularly in light of the fact that the removal of lung tissue in patients who already suffer from a lack of functioning lung appears at first glance to be counter intuitive. In emphysema, parenchymal destruction results in loss of the normal elastic recoil of the lung. This situation has the dual effect of reduc­ing expiratory driving force and decreasing the external
mechanical support provided to the airways, which results in decreased expiratory airflows. The lung progressively dis­tends, depressing the diaphragm and forcing it and the other respiratory muscles to operate at a mechanical disadvantage, reducing inspiratory muscle force and efficiency. The overall work of breathing is markedly increased. By removing the most diseased areas of lung that provide little contribution to gas exchange, LVR improves the elastic recoil of the remain­ing lung and returns the inspiratory muscles and chest wall to more physiological positions. The work of breathing is diminished, and the severe dyspnea experienced by these patients is ameliorated.
LVR is offered to selected patients with severe emphysema
less than 45% of predicted value) and hyperinflation
(FEV
1
(residual volume greater than 180% of predicted value in my practice) that results in markedly diminished quality of life. Patient selection is as critical to a favorable outcome after LVR as the technical performance of the procedure – the lat­ter being fairly straightforward. Criteria for patient selection continue to undergo refinement, but several principles have become clear from clinical series involving the operation.
First, NETT identified a high risk group who should not be operated upon because the mortality is 16%. This group con­sists of individuals with FEV less than 20% predicted and either a diffusing capacity less than 20% predicted or homo­geneous distribution of disease.
Secondly, the operation is most beneficial in patients whose chronic obstructive pulmonary disease approaches the ‘pure emphysematous’ type. Those with predominant chronic bronchitis, with copious sputum production, inflammatory airway narrowing, and reactive airways, tend not to do well. We have found that a postbronchodilator improvement in FEV
of greater than 30% is a strong predictor of a suboptimal
1
outcome. Certainly, patients whose emphysema is most severe in one portion of the lung, with other areas (usually the lower
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lobes) left with relatively preserved parenchyma, do better because in these patients resection can be targeted to the more diseased areas. In addition, patients with markedly elevated PCO2, in the opinion of the author and many others, are at higher risk after the operation. Similarly, patients with markedly elevated pulmonary artery pressures and those who are severely depleted nutritionally are not good candidates. No fixed age limit exists, but the operation should be approached with caution in patients older than 70 years. Patients who have had previous thoracotomy cannot safely undergo LVR on that side, and patients who have undergone previous sternotomy are also poor candidates due to difficulty with adhesions and subsequent prolonged air leaks.
Pulmonary complications are common after LVR, and patients should be informed preoperatively of the risks of mucous plugging requiring bronchoscopy and/or minitra­cheostomy placement, pneumonia, and prolonged air leaks. When LVR is performed by median sternotomy, imperfect sternal healing may occur because these patients have a high work of breathing, but this problem virtually always presents as only a minor ‘click’ without instability. We have had one case of frank mediastinitis in over 200 LVRs performed at our institution. The most common major morbidity of the oper­ation is respiratory failure with prolonged mechanical venti­lation, and this complication often leads ultimately to the death of the patient, if not within 30 days of the procedure. Published series of LVRs report operative mortality rates of 0–10%, with a mean of 6%. These rates may be significantly higher without careful patient selection.
LVR can be performed unilaterally or bilaterally, and the surgical approach can be via median sternotomy or video­assisted thoracoscopy (VATS). A growing consensus favors the bilateral procedure in the vast majority of patients, but the question of the best incision(s) for the bilateral procedure remains unsettled. We present the bilateral operation first as it is performed by sternotomy, then as it is performed by tho­racoscopy.
PREOPERATIVE ASSESSMENT AND PREPARATION
Patients must have quit smoking at least 3 months before the operation and preferably earlier. They all complete at least 6
weeks of a vigorous pulmonary rehabilitation program to maximize their physical conditioning before surgery. Nutritional deficiencies are corrected to achieve a body weight within 20% of the ideal value. Medical treatment of the emphysema is optimized; an attempt is made to wean patients off steroids, but those who are only able to get as low as 5 mg daily are accepted for surgery.
Targets to be resected are determined by careful examina­tion of computed tomograms of the chest and quantitative perfusion scans. In addition, all patients undergo full pul­monary function testing with plethysmographic measure­ment of lung volumes, arterial blood gas testing, cardiac echocardiography with estimation of pulmonary artery pres­sures and right heart catheterization if indicated, and cardiac stress testing.
ANESTHESIA
The placement of a thoracic epidural catheter for postopera­tive pain management is critical to allow optimal clearance of secretions and prevent postoperative atelectasis or pneu­monia. General anesthesia is provided through a double­lumen endotracheal tube with the distal balloon placed in the left main stem bronchus, which allows sequential col­lapse of each lung. Inspiratory pressures must be assidu­ously monitored and minimized (less than 25 cm H2O) in the ventilated lung. This monitoring is particularly impor­tant during ventilation of the lung that has been operated on first and has fresh staple lines, to prevent rupture of these staple lines. Minimizing inspiratory pressures may prevent the unlikely but potentially catastrophic occurrence of an intraoperative pneumothorax prior to opening the chest. Any increase in peak airway pressures noted by the anesthesiologist after the institution of positive pressure ventilation calls for immediate assessment to rule out such an event. The inspiratory:expiratory ratio often must be decreased in these patients, as a longer expiratory phase is necessary to prevent the auto–positive end-expiratory pres­sure phenomenon.
OPERATION
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Median sternotomy
INCISION
Before incision, flexible fiberoptic bronchoscopy is per-
1
formed through a single-lumen endotracheal tube to rule out unexpected malignancy or active infection that would preclude proceeding with the operation. A sputum sample is sent for microbiological study for use in guiding initial antimicrobial therapy should the patient develop an infiltrate in the early postoperative period. After placement of the dou­ble-lumen tube, the patient is positioned, prepared, and draped for sternotomy. Antibiotics covering both Gram-pos­itive and Gram-negative organisms are administered before the incision.
A median sternotomy is performed with complete division of the bone from the sternal notch to the xiphoid process. The skin incision may be kept as much as 10 cm shorter without compromising exposure. Subcutaneous flaps may be raised to expose the full extent of the bone incision. The lungs should be left unventilated for at least 10 seconds before division of the sternum to avoid injuring the lungs, which usually are so hyperexpanded that they abut in the midline. Care is taken throughout the procedure to handle the sternum gently; the divided sternum is spread slowly to avoid fracture, and devas­cularization is minimized by only judicious use of electro­cautery, as these patients are prone to sternal healing complications because of the high stress imposed on the ster­nal closure by their increased work of breathing.
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Operation 173
1
PLEURAL ENTRY
We prefer using a Buggie sternal retractor, which allows
2
sequential elevation of each hemisternum without hav­ing to replace the retractor on the opposite side of the table after completion of one side, as is required with the type of retractors used for mammary harvest.
The side with the more severe disease is operated on first so that single-lung ventilation is maintained for the shortest possible time on this lung. Ventilation to this side is discon­tinued as the bone incision is being made, which provides sufficient time for the slowly deflating, emphysematous lung to collapse. Usually by the time the pleural space is entered, the areas with the most perfusion are well deflated by absorp­tion atelectasis, whereas the most severely diseased areas, usu­ally at the apex, remain partially inflated.
The pleura on the side of interest is opened close to the anterior chest wall to be as far from the phrenic nerve as pos­sible. The pleural opening is begun inferiorly and extended superiorly. At the craniad end of the incision, where the phrenic nerve is most anterior and, thus, most at risk, the pleura is bluntly reflected off the anterior chest wall for sev­eral centimeters before it is incised. This maneuver facilitates identification of the nerve and careful avoidance of injury to it. Electrocautery should not be used during the incision of the craniad portion of pleura.